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Protein

Neurofascin

Gene

Nfasc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions.By similarity

GO - Molecular functioni

  • protein binding involved in heterotypic cell-cell adhesion Source: MGI
  • protein domain specific binding Source: MGI

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-447043 Neurofascin interactions
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Neurofascin
Gene namesi
Name:Nfasc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:104753 Nfasc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 1110ExtracellularSequence analysisAdd BLAST1086
Transmembranei1111 – 1131HelicalSequence analysisAdd BLAST21
Topological domaini1132 – 1240CytoplasmicSequence analysisAdd BLAST109

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001505025 – 1240NeurofascinAdd BLAST1216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi63 ↔ 118PROSITE-ProRule annotation
Disulfide bondi162 ↔ 213PROSITE-ProRule annotation
Disulfide bondi268 ↔ 316PROSITE-ProRule annotation
Glycosylationi305N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi358 ↔ 408PROSITE-ProRule annotation
Glycosylationi409N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi446N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi452 ↔ 501PROSITE-ProRule annotation
Modified residuei481PhosphotyrosineBy similarity1
Glycosylationi483N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei485PhosphoserineBy similarity1
Disulfide bondi543 ↔ 592PROSITE-ProRule annotation
Glycosylationi752N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi778N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi866N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi881N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1160PhosphoserineCombined sources1
Modified residuei1174PhosphoserineBy similarity1
Modified residuei1187PhosphoserineBy similarity1
Modified residuei1190PhosphoserineBy similarity1
Modified residuei1226PhosphoserineCombined sources1
Modified residuei1227PhosphoserineCombined sources1
Modified residuei1231PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ810U3
PaxDbiQ810U3
PeptideAtlasiQ810U3
PRIDEiQ810U3

PTM databases

iPTMnetiQ810U3
PhosphoSitePlusiQ810U3
SwissPalmiQ810U3

Expressioni

Gene expression databases

BgeeiENSMUSG00000026442 Expressed in 144 organ(s), highest expression level in brain
CleanExiMM_NFASC
ExpressionAtlasiQ810U3 baseline and differential
GenevisibleiQ810U3 MM

Interactioni

Subunit structurei

Horseshoe-shaped homodimer. Probable constituent of a NFASC/NRCAM/ankyrin-G complex. Associates with the sodium channel beta-1 (SCN1B) and beta-3 (SCN3B) subunits. Interacts with GLDN/gliomedin (By similarity). Interacts with MYOC.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi234609, 1 interactor
DIPiDIP-31976N
IntActiQ810U3, 5 interactors
STRINGi10090.ENSMUSP00000092148

Structurei

3D structure databases

ProteinModelPortaliQ810U3
SMRiQ810U3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 137Ig-like C2-type 1Add BLAST97
Domaini143 – 230Ig-like C2-type 2Add BLAST88
Domaini244 – 332Ig-like C2-type 3Add BLAST89
Domaini337 – 424Ig-like C2-type 4Add BLAST88
Domaini430 – 517Ig-like C2-type 5Add BLAST88
Domaini521 – 603Ig-like C2-type 6Add BLAST83
Domaini630 – 725Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini727 – 823Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST97
Domaini827 – 923Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST97
Domaini1007 – 1099Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST93

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi924 – 1006Thr-richAdd BLAST83

Domaini

Homophilic adhesion is primarily mediated by the interaction of the second Ig-like domains.By similarity

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3513 Eukaryota
ENOG410XSVG LUCA
GeneTreeiENSGT00760000118840
HOGENOMiHOG000231380
HOVERGENiHBG000144
InParanoidiQ810U3
KOiK06757
PhylomeDBiQ810U3
TreeFamiTF351098

Family and domain databases

CDDicd00063 FN3, 4 hits
Gene3Di2.60.40.10, 10 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR026966 Neurofascin/L1/NrCAM_C
IPR026965 NFASC
PANTHERiPTHR43951:SF4 PTHR43951:SF4, 2 hits
PfamiView protein in Pfam
PF13882 Bravo_FIGEY, 1 hit
PF00041 fn3, 4 hits
PF07679 I-set, 2 hits
PF00047 ig, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 4 hits
SM00409 IG, 6 hits
SM00408 IGc2, 6 hits
SUPFAMiSSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 4 hits
PS50835 IG_LIKE, 6 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q810U3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARQQAPPWV HIALILFLLS LGGAIEIPMD PSIQNELTQP PTITKQSVKD
60 70 80 90 100
HIVDPRDNIL IECEAKGNPA PSFHWTRNSR FFNIAKDPRV SMRRRSGTLV
110 120 130 140 150
IDFRSGGRPE EYEGEYQCFA RNKFGTALSN RIRLQVSKSP LWPKENLDPV
160 170 180 190 200
VVQEGAPLTL QCNPPPGLPS PVIFWMSSSM EPITQDKRVS QGHNGDLYFS
210 220 230 240 250
NVMLQDMQTD YSCNARFHFT HTIQQKNPFT LKVLTTRGVA ERTPSFMYPQ
260 270 280 290 300
GTSSSQMVLR GMDLLLECIA SGVPTPDIAW YKKGGDLPSN KAKFENFNKA
310 320 330 340 350
LRITNVSEED SGEYFCLASN KMGSIRHTIS VRVKAAPYWL DEPKNLILAP
360 370 380 390 400
GEDGRLVCRA NGNPKPTVQW MVNGEPLQSA PPNPNREVAG DTIIFRDTQI
410 420 430 440 450
SSRAVYQCNT SNEHGYLLAN AFVSVLDVPP RMLSARNQLI RVILYNRTRL
460 470 480 490 500
DCPFFGSPIP TLRWFKNGQG SNLDGGNYHV YENGSLEIKM IRKEDQGIYT
510 520 530 540 550
CVATNILGKA ENQVRLEVKD PTRIYRMPED QVAKRGTTVQ LECRVKHDPS
560 570 580 590 600
LKLTVSWLKD DEPLYIGNRM KKEDDSLTIF GVAERDQGSY TCMASTELDQ
610 620 630 640 650
DLAKAYLTVL ADQATPTNRL AALPKGRPDR PRDLELTDLA ERSVRLTWIP
660 670 680 690 700
GDDNNSPITD YVVQFEEDQF QPGVWHDHSR FPGSVNSAVL HLSPYVNYQF
710 720 730 740 750
RVIAVNEVGS SHPSLPSERY RTSGAPPESN PSDVKGEGTR KNNMEITWTP
760 770 780 790 800
MNATSAFGPN LRYIVKWRRR ETRETWNNVT VWGSRYVVGQ TPVYVPYEIR
810 820 830 840 850
VQAENDFGKG PEPDTIIGYS GEDLPSAPRR FRVRQPNLET INLEWDHPEH
860 870 880 890 900
PNGILIGYIL RYVPFNGTKL GKQMVENFSP NQTKFSVQRA DPVSRYRFSL
910 920 930 940 950
SARTQVGSGE AATEESPAPP NEATPTAAPP TLPPTTVGTT GLVSSTDATA
960 970 980 990 1000
LAATSEATTV PIIPTVVPTT VATTIATTTT TTAATTTTTT TESPPTTTAG
1010 1020 1030 1040 1050
TKIHETAPDE QSIWNVTVLP NSKWANITWK HNFRPGTDFV VEYIDSNHTK
1060 1070 1080 1090 1100
KTVPVKAQAQ PIQLTDLFPG MTYTLRVYSR DNEGISSTVI TFMTSTAYTN
1110 1120 1130 1140 1150
NQADIATQGW FIGLMCAIAL LVLILLIVCF IKRSRGGKYP VREKKDVPLG
1160 1170 1180 1190 1200
PEDPKEEDGS FDYSDEDNKP LQGSQTSLDG TIKQQESDDS LVDYGEGGEG
1210 1220 1230 1240
QFNEDGSFIG QYTVKKDKEE TEGNESSEAT SPVNAIYSLA
Length:1,240
Mass (Da):137,975
Last modified:June 1, 2003 - v1
Checksum:i6DE8935B5B02E965
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PW06E9PW06_MOUSE
Neurofascin
Nfasc
1,174Annotation score:
E9Q171E9Q171_MOUSE
Neurofascin
Nfasc
1,157Annotation score:
A0A087WPX3A0A087WPX3_MOUSE
Neurofascin
Nfasc
1,347Annotation score:
A0A087WR56A0A087WR56_MOUSE
Neurofascin
Nfasc
1,159Annotation score:
A0A087WNW2A0A087WNW2_MOUSE
Neurofascin
Nfasc
899Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ543322 mRNA Translation: CAD65849.1
CCDSiCCDS35707.1
RefSeqiNP_874385.1, NM_182716.4
UniGeneiMm.326702

Genome annotation databases

EnsembliENSMUST00000094569; ENSMUSP00000092148; ENSMUSG00000026442
GeneIDi269116
KEGGimmu:269116
UCSCiuc007cpe.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ543322 mRNA Translation: CAD65849.1
CCDSiCCDS35707.1
RefSeqiNP_874385.1, NM_182716.4
UniGeneiMm.326702

3D structure databases

ProteinModelPortaliQ810U3
SMRiQ810U3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi234609, 1 interactor
DIPiDIP-31976N
IntActiQ810U3, 5 interactors
STRINGi10090.ENSMUSP00000092148

PTM databases

iPTMnetiQ810U3
PhosphoSitePlusiQ810U3
SwissPalmiQ810U3

Proteomic databases

MaxQBiQ810U3
PaxDbiQ810U3
PeptideAtlasiQ810U3
PRIDEiQ810U3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094569; ENSMUSP00000092148; ENSMUSG00000026442
GeneIDi269116
KEGGimmu:269116
UCSCiuc007cpe.2 mouse

Organism-specific databases

CTDi23114
MGIiMGI:104753 Nfasc

Phylogenomic databases

eggNOGiKOG3513 Eukaryota
ENOG410XSVG LUCA
GeneTreeiENSGT00760000118840
HOGENOMiHOG000231380
HOVERGENiHBG000144
InParanoidiQ810U3
KOiK06757
PhylomeDBiQ810U3
TreeFamiTF351098

Enzyme and pathway databases

ReactomeiR-MMU-447043 Neurofascin interactions
R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiNfasc mouse
PROiPR:Q810U3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026442 Expressed in 144 organ(s), highest expression level in brain
CleanExiMM_NFASC
ExpressionAtlasiQ810U3 baseline and differential
GenevisibleiQ810U3 MM

Family and domain databases

CDDicd00063 FN3, 4 hits
Gene3Di2.60.40.10, 10 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR026966 Neurofascin/L1/NrCAM_C
IPR026965 NFASC
PANTHERiPTHR43951:SF4 PTHR43951:SF4, 2 hits
PfamiView protein in Pfam
PF13882 Bravo_FIGEY, 1 hit
PF00041 fn3, 4 hits
PF07679 I-set, 2 hits
PF00047 ig, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 4 hits
SM00409 IG, 6 hits
SM00408 IGc2, 6 hits
SUPFAMiSSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 4 hits
PS50835 IG_LIKE, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiNFASC_MOUSE
AccessioniPrimary (citable) accession number: Q810U3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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