UniProtKB - Q810T5 (KAT7_RAT)
Histone acetyltransferase KAT7
Kat7
Functioni
Catalytic activityi
Activity regulationi
: proteasomal ubiquitin-dependent pathway Pathwayi
This protein is involved in the pathway proteasomal ubiquitin-dependent pathway, which is part of Protein degradation.By similarityView all proteins of this organism that are known to be involved in the pathway proteasomal ubiquitin-dependent pathway and in Protein degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 369 | ZincBy similarity | 1 | |
Metal bindingi | 372 | ZincBy similarity | 1 | |
Metal bindingi | 385 | ZincBy similarity | 1 | |
Metal bindingi | 389 | ZincBy similarity | 1 | |
Active sitei | 509 | Proton donor/acceptorBy similarity | 1 | |
Binding sitei | 513 | acetyl-CoABy similarity | 1 | |
Binding sitei | 522 | acetyl-CoABy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 177 – 220 | CCHHC-typePROSITE-ProRule annotationAdd BLAST | 44 | |
Zinc fingeri | 366 – 391 | C2HC MYST-typePROSITE-ProRule annotationAdd BLAST | 26 |
GO - Molecular functioni
- DNA replication origin binding Source: RGD
- histone acetyltransferase activity Source: UniProtKB
- histone binding Source: GO_Central
- transcription coregulator activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- DNA repair Source: UniProtKB-KW
- DNA replication Source: UniProtKB
- histone H3 acetylation Source: UniProtKB
- histone H3-K14 acetylation Source: UniProtKB
- histone H4 acetylation Source: UniProtKB
- histone H4-K12 acetylation Source: UniProtKB
- histone H4-K5 acetylation Source: UniProtKB
- histone H4-K8 acetylation Source: UniProtKB
- internal peptidyl-lysine acetylation Source: UniProtKB
- natural killer cell differentiation Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: GO_Central
- positive regulation of DNA replication Source: UniProtKB
- positive regulation of DNA-templated transcription, elongation Source: UniProtKB
- positive regulation of erythrocyte differentiation Source: UniProtKB
- positive regulation of hematopoietic stem cell proliferation Source: UniProtKB
- positive regulation of histone H4 acetylation Source: RGD
- positive regulation of protein localization to nucleus Source: RGD
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB-UniPathway
- regulation of DNA-dependent DNA replication initiation Source: UniProtKB
- regulation of nucleotide-excision repair Source: UniProtKB
- response to actinomycin D Source: RGD
- response to anisomycin Source: RGD
- response to dithiothreitol Source: RGD
- response to hydroxyurea Source: RGD
- response to sorbitol Source: RGD
- stress-activated protein kinase signaling cascade Source: RGD
Keywordsi
Molecular function | Acyltransferase, Chromatin regulator, Transferase |
Biological process | DNA damage, DNA repair, DNA replication, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-RNO-3214847, HATs acetylate histones |
UniPathwayi | UPA00144 |
Names & Taxonomyi
Protein namesi | Recommended name: Histone acetyltransferase KAT7Curated (EC:2.3.1.48By similarity)Alternative name(s): Histone acetyltransferase binding to ORC11 Publication Lysine acetyltransferase 7 MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2 Short name: MYST-2 |
Gene namesi | |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 727966, Kat7 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytosol
- cytosol By similarity
Other locations
- Chromosome By similarity
- centromere By similarity
Note: Associates with replication origins specifically during the G1 phase of the cell cycle. Localizes to transcription start sites. Localizes to ultraviolet-induced DNA damage sites following phosphorylation by ATR. Localizes to centromeres in G1 phase.By similarity
Cytosol
- cytosol Source: UniProtKB-SubCell
Nucleus
- histone acetyltransferase complex Source: UniProtKB
- histone H3-K14 acetyltransferase complex Source: UniProtKB
- nuclear chromatin Source: GO_Central
- nucleoplasm Source: UniProtKB
- nucleus Source: UniProtKB
Other locations
- chromosome Source: RGD
- chromosome, centromeric region Source: UniProtKB-SubCell
- site of DNA damage Source: UniProtKB
Keywords - Cellular componenti
Centromere, Chromosome, Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051571 | 1 – 612 | Histone acetyltransferase KAT7Add BLAST | 612 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 11 | PhosphoserineBy similarity | 1 | |
Modified residuei | 51 | PhosphoserineBy similarity | 1 | |
Modified residuei | 54 | PhosphoserineBy similarity | 1 | |
Modified residuei | 58 | PhosphoserineCombined sources | 1 | |
Modified residuei | 65 | PhosphoserineBy similarity | 1 | |
Modified residuei | 86 | Phosphothreonine; by CDK1By similarity | 1 | |
Modified residuei | 89 | Phosphothreonine; by CDK1By similarity | 1 | |
Modified residuei | 103 | PhosphoserineCombined sources | 1 | |
Modified residuei | 105 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 112 | PhosphoserineBy similarity | 1 | |
Modified residuei | 125 | PhosphoserineBy similarity | 1 | |
Modified residuei | 129 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 159 | PhosphoserineBy similarity | 1 | |
Modified residuei | 163 | PhosphoserineBy similarity | 1 | |
Modified residuei | 165 | PhosphoserineBy similarity | 1 | |
Modified residuei | 179 | PhosphoserineBy similarity | 1 | |
Modified residuei | 200 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 278 | N6-acetyllysineBy similarity | 1 | |
Cross-linki | 324 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 339 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Modified residuei | 433 | N6-acetyllysine; by autocatalysisBy similarity | 1 | |
Modified residuei | 507 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q810T5 |
PRIDEi | Q810T5 |
PTM databases
iPTMneti | Q810T5 |
PhosphoSitePlusi | Q810T5 |
Interactioni
Subunit structurei
Component of the HBO1 complex composed of KAT7/HBO1, MEAF6, ING4 or ING5, and one scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE scaffold (JADE1, JADE2 and JADE3) mediate acetylation of histone H4.
Interacts with MCM2 and ORC1.
Interacts with the androgen receptor (AR); in the presence of dihydrotestosterone.
Interacts with CDT1 (By similarity).
Interacts with MAP2K1 and CUL1 (By similarity).
Interacts with p53/TP53; leading to inhibit histone acetyltransferase activity.
Interacts with MIS18BP1 (By similarity).
By similarityGO - Molecular functioni
- histone binding Source: GO_Central
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 333 – 608 | MYST-type HATPROSITE-ProRule annotationAdd BLAST | 276 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 476 – 478 | acetyl-CoA bindingBy similarity | 3 | |
Regioni | 484 – 489 | acetyl-CoA bindingBy similarity | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 11 – 58 | Ser-richAdd BLAST | 48 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 177 – 220 | CCHHC-typePROSITE-ProRule annotationAdd BLAST | 44 | |
Zinc fingeri | 366 – 391 | C2HC MYST-typePROSITE-ProRule annotationAdd BLAST | 26 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
InParanoidi | Q810T5 |
OrthoDBi | 629545at2759 |
PhylomeDBi | Q810T5 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR016181, Acyl_CoA_acyltransferase IPR002717, HAT_MYST-type IPR036388, WH-like_DNA-bd_sf IPR040706, Zf-MYST IPR002515, Znf_C2H2C IPR036060, Znf_C2H2C_sf |
Pfami | View protein in Pfam PF01853, MOZ_SAS, 1 hit PF01530, zf-C2HC, 1 hit PF17772, zf-MYST, 1 hit |
SUPFAMi | SSF103637, SSF103637, 1 hit SSF55729, SSF55729, 1 hit |
PROSITEi | View protein in PROSITE PS51726, MYST_HAT, 1 hit PS51802, ZF_CCHHC, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAIGVKRNAG SSSDGTEDSD FSTDLEHTDS SESDGTSRRS ARVTRSSARL
60 70 80 90 100
SQSSQDSSPV RNLPSFGTEE PAYSTRRVTR SQQQPTPVTP KKYPLRQTRS
110 120 130 140 150
SGSETEQAVD FSDRETKNTA DHDESPPRTP TGNAPSSESD IDISSPNVSH
160 170 180 190 200
DESIAKDMSL KDSGSDLSHR PKRRRFHESY NFNMKCPTPG CNSLGHLTGK
210 220 230 240 250
HERHFSISGC PLYHNLSADE CKVRAQSRDK QIEERMLSHR QDDNNRHATR
260 270 280 290 300
HQAPTERQLR YKEKVAELRK KRNSGLSKEQ KEKYMEHRQT YGNTREPLLE
310 320 330 340 350
NLTSEYDLDL FRRAQARASE DLEKLRLQGQ ITEGSNMIKT IAFGRYELDT
360 370 380 390 400
WYHSPYPEEY ARLGRLYMCE FCLKYMKSQT ILRRHMAKCV WKHPPGDEIY
410 420 430 440 450
RKGSISVFEV DGKKNKIYCQ NLCLLAKLFL DHKTLYYDVE PFLFYVMTEA
460 470 480 490 500
DNTGCHLIGY FSKEKNSFLN YNVSCILTMP QYMRQGYGKM LIDFSYLLSK
510 520 530 540 550
VEEKVGSPER PLSDLGLISY RSYWKEVLLR YLHNFQGKEI SIKEISQETA
560 570 580 590 600
VNPVDIVSTL QALQMLKYWK GKHLVLKRQD LIDEWIAKEA KRSNSNKTMD
610
PSCLKWTPPK GT
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2K9F0 | A0A0G2K9F0_RAT | Histone acetyltransferase | Kat7 | 612 | Annotation score: | ||
D3ZCG0 | D3ZCG0_RAT | Histone acetyltransferase | Kat7 | 294 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_014585 | 223 – 252 | Missing in isoform 2. 1 PublicationAdd BLAST | 30 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY236854 mRNA Translation: AAO84914.1 AY241457 mRNA Translation: AAO86770.1 |
RefSeqi | NP_851595.1, NM_181081.2 [Q810T5-1] |
Genome annotation databases
GeneIDi | 303470 |
KEGGi | rno:303470 |
UCSCi | RGD:727966, rat [Q810T5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY236854 mRNA Translation: AAO84914.1 AY241457 mRNA Translation: AAO86770.1 |
RefSeqi | NP_851595.1, NM_181081.2 [Q810T5-1] |
3D structure databases
SMRi | Q810T5 |
ModBasei | Search... |
PTM databases
iPTMneti | Q810T5 |
PhosphoSitePlusi | Q810T5 |
Proteomic databases
jPOSTi | Q810T5 |
PRIDEi | Q810T5 |
Genome annotation databases
GeneIDi | 303470 |
KEGGi | rno:303470 |
UCSCi | RGD:727966, rat [Q810T5-1] |
Organism-specific databases
CTDi | 11143 |
RGDi | 727966, Kat7 |
Phylogenomic databases
InParanoidi | Q810T5 |
OrthoDBi | 629545at2759 |
PhylomeDBi | Q810T5 |
Enzyme and pathway databases
UniPathwayi | UPA00144 |
Reactomei | R-RNO-3214847, HATs acetylate histones |
Miscellaneous databases
PROi | PR:Q810T5 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR016181, Acyl_CoA_acyltransferase IPR002717, HAT_MYST-type IPR036388, WH-like_DNA-bd_sf IPR040706, Zf-MYST IPR002515, Znf_C2H2C IPR036060, Znf_C2H2C_sf |
Pfami | View protein in Pfam PF01853, MOZ_SAS, 1 hit PF01530, zf-C2HC, 1 hit PF17772, zf-MYST, 1 hit |
SUPFAMi | SSF103637, SSF103637, 1 hit SSF55729, SSF55729, 1 hit |
PROSITEi | View protein in PROSITE PS51726, MYST_HAT, 1 hit PS51802, ZF_CCHHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KAT7_RAT | |
Accessioni | Q810T5Primary (citable) accession number: Q810T5 Secondary accession number(s): Q80YN5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2005 |
Last sequence update: | June 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families