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Protein

Cyclin-dependent kinase inhibitor 3

Gene

Cdkn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.By similarity
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei140Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase inhibitor 3By similarityImported (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
CDK2-associated dual-specificity phosphataseBy similarity
Kinase-associated phosphataseBy similarity
Gene namesi
Name:Cdkn3Imported
Synonyms:KapBy similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1919641 Cdkn3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003966371 – 211Cyclin-dependent kinase inhibitor 3Add BLAST211

Proteomic databases

PaxDbiQ810P3
PRIDEiQ810P3

PTM databases

PhosphoSitePlusiQ810P3

Expressioni

Gene expression databases

BgeeiENSMUSG00000037628 Expressed in 153 organ(s), highest expression level in testis
GenevisibleiQ810P3 MM

Interactioni

Subunit structurei

Interacts with cyclin-dependent kinases such as CDK1, CDK2 and CDK3. Does not interact with CDK4. Interacts (via C-terminus) with phosphorylated CDK2 (via C-terminal helix). Interacts with MS4A3 (via C-terminus); the interaction enhances CDKN3 enzymatic activity (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070575

Structurei

3D structure databases

ProteinModelPortaliQ810P3
SMRiQ810P3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 34Interaction with CDK2By similarityAdd BLAST34

Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family.Sequence analysis

Phylogenomic databases

eggNOGiKOG1720 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00390000004717
HOGENOMiHOG000060336
HOVERGENiHBG075798
InParanoidiQ810P3
KOiK14167
OMAiTVKQYNF
OrthoDBiEOG091G0MIF
PhylomeDBiQ810P3
TreeFamiTF101040

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR008425 CDK_inhib_3
IPR022778 CDKN3
IPR029021 Prot-tyrosine_phosphatase-like
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF05706 CDKN3, 1 hit
PIRSFiPIRSF037322 CDKN3, 1 hit
SMARTiView protein in SMART
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50056 TYR_PHOSPHATASE_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q810P3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPPISIQAS EFDSSDEEPV DEEQTPIQIS WLPLSRVNCS QFLGLCALPG
60 70 80 90 100
CKFKDVRRNI QKDTEELKSY GIQDVFVFCT RGELSKYRVP NLLDLYQQYG
110 120 130 140 150
IVTHHHPIPD GGTPDIGSCW EIMEELATCL KNNRKTLIHC YGGLGRSCLA
160 170 180 190 200
ACLLLYLSDS ISPQQAIDSL RDVRGSGAIQ TIKQYNYLHE FRDKLAAYLS
210
SRDSLSRSVS R
Length:211
Mass (Da):23,793
Last modified:June 1, 2003 - v1
Checksum:iA119D81C61A7F20F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BPS7A0A2I3BPS7_MOUSE
Cyclin-dependent kinase inhibitor 3
Cdkn3
197Annotation score:

Sequence cautioni

The sequence BAB26929 differs from that shown. Probable cloning artifact.Curated
The sequence BAC28238 differs from that shown. Probable cloning artifact.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010426 mRNA Translation: BAB26929.1 Sequence problems.
AK033341 mRNA Translation: BAC28238.1 Sequence problems.
AK146312 mRNA Translation: BAE27067.1
BC049694 mRNA Translation: AAH49694.1
CCDSiCCDS49466.1
RefSeqiNP_082498.1, NM_028222.1
UniGeneiMm.272394

Genome annotation databases

EnsembliENSMUST00000067426; ENSMUSP00000070575; ENSMUSG00000037628
GeneIDi72391
KEGGimmu:72391
UCSCiuc007the.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010426 mRNA Translation: BAB26929.1 Sequence problems.
AK033341 mRNA Translation: BAC28238.1 Sequence problems.
AK146312 mRNA Translation: BAE27067.1
BC049694 mRNA Translation: AAH49694.1
CCDSiCCDS49466.1
RefSeqiNP_082498.1, NM_028222.1
UniGeneiMm.272394

3D structure databases

ProteinModelPortaliQ810P3
SMRiQ810P3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070575

PTM databases

PhosphoSitePlusiQ810P3

Proteomic databases

PaxDbiQ810P3
PRIDEiQ810P3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067426; ENSMUSP00000070575; ENSMUSG00000037628
GeneIDi72391
KEGGimmu:72391
UCSCiuc007the.2 mouse

Organism-specific databases

CTDi1033
MGIiMGI:1919641 Cdkn3

Phylogenomic databases

eggNOGiKOG1720 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00390000004717
HOGENOMiHOG000060336
HOVERGENiHBG075798
InParanoidiQ810P3
KOiK14167
OMAiTVKQYNF
OrthoDBiEOG091G0MIF
PhylomeDBiQ810P3
TreeFamiTF101040

Miscellaneous databases

PROiPR:Q810P3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037628 Expressed in 153 organ(s), highest expression level in testis
GenevisibleiQ810P3 MM

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR008425 CDK_inhib_3
IPR022778 CDKN3
IPR029021 Prot-tyrosine_phosphatase-like
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF05706 CDKN3, 1 hit
PIRSFiPIRSF037322 CDKN3, 1 hit
SMARTiView protein in SMART
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50056 TYR_PHOSPHATASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCDKN3_MOUSE
AccessioniPrimary (citable) accession number: Q810P3
Secondary accession number(s): Q9CWS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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