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Protein

Glutamate-rich WD repeat-containing protein 1

Gene

Grwd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-rich WD repeat-containing protein 1
Alternative name(s):
Protein A301
Gene namesi
Name:Grwd1
Synonyms:A301
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2141989 Grwd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000510121 – 446Glutamate-rich WD repeat-containing protein 1Add BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphothreonineBy similarity1
Modified residuei119PhosphoserineBy similarity1
Modified residuei122PhosphoserineBy similarity1
Modified residuei344PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ810D6
MaxQBiQ810D6
PaxDbiQ810D6
PRIDEiQ810D6

PTM databases

iPTMnetiQ810D6
PhosphoSitePlusiQ810D6

Expressioni

Gene expression databases

BgeeiENSMUSG00000053801 Expressed in 286 organ(s), highest expression level in pancreas
CleanExiMM_GRWD1
ExpressionAtlasiQ810D6 baseline and differential
GenevisibleiQ810D6 MM

Interactioni

Subunit structurei

Interacts with METTL18. Interacts with CDT1; origin binding of GRWD1 is dependent on CDT1. Interacts with CDC6; origin binding of GRWD1 is dependent on CDC6. Binds to histone H2A-H2B and H3-H4 complexes.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ810D6, 1 interactor
STRINGi10090.ENSMUSP00000103351

Structurei

3D structure databases

ProteinModelPortaliQ810D6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati212 – 252WD 1Add BLAST41
Repeati259 – 299WD 2Add BLAST41
Repeati306 – 345WD 3Add BLAST40
Repeati351 – 391WD 4Add BLAST41
Repeati412 – 445WD 5Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi124 – 136Asp/Glu-rich (acidic)Add BLAST13

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0302 Eukaryota
ENOG410XPDB LUCA
GeneTreeiENSGT00550000075124
HOGENOMiHOG000036730
HOVERGENiHBG051847
InParanoidiQ810D6
KOiK14848
OMAiEWHPTED
OrthoDBiEOG091G07FI
TreeFamiTF312982

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR022052 Histone-bd_RBBP4_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12265 CAF1C_H4-bd, 1 hit
PF00400 WD40, 3 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q810D6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAARKGRSRT CETGEPMEAE TCDPGTEGPS QVYLPGRGPP LSEGEELVMD
60 70 80 90 100
EEAYVLYHRA QTGAPCLSFD IVRDHLGDNR TELPLSLYLC AGTQAESAQS
110 120 130 140 150
NRLMMLRMHN LHGTRPSPSE GSDDDEEDED EEDEEEQKPQ LELAMVPHYG
160 170 180 190 200
GINRVRVSWL GEEPVAGVWS EKGQVEVFAL RRLLQVVDDP QALAIFLRDE
210 220 230 240 250
QARIKPIFSF AGHMGEGFAL DWSPRVPGRL LTGDCQKNVH LWTPTEGGSW
260 270 280 290 300
NVDQRPFVGH TRSVEDLQWS PTEDTVFASC SADASIRIWD IRAAPGKACM
310 320 330 340 350
LTTATAHDGD VNVISWSRRE PFLLSGGDDG ALKVWDLRQF KSGSPVATFK
360 370 380 390 400
QHMAPVTSVE WHPQDSGVFA ASGADNQITQ WDLAVERDPE SGETETDPGL
410 420 430 440
AALPQQLLFV HQGETDLKEL HWHPQCPGVL ISTALSGFTV FRTISV
Length:446
Mass (Da):49,224
Last modified:October 3, 2012 - v2
Checksum:iB008DEE44FC98433
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GRR2A0A1B0GRR2_MOUSE
Glutamate-rich WD repeat-containing...
Grwd1
97Annotation score:
A0A1B0GSW5A0A1B0GSW5_MOUSE
Glutamate-rich WD repeat-containing...
Grwd1
63Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti391S → P in BAC66461 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001539 mRNA Translation: BAC66461.1
AC149053 Genomic DNA No translation available.
CH466603 Genomic DNA Translation: EDL22902.1
BC008121 mRNA Translation: AAH08121.1
CCDSiCCDS21266.2
RefSeqiNP_700468.2, NM_153419.2
UniGeneiMm.274847

Genome annotation databases

EnsembliENSMUST00000107723; ENSMUSP00000103351; ENSMUSG00000053801
ENSMUST00000131384; ENSMUSP00000116252; ENSMUSG00000053801
GeneIDi101612
KEGGimmu:101612
UCSCiuc009gxj.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001539 mRNA Translation: BAC66461.1
AC149053 Genomic DNA No translation available.
CH466603 Genomic DNA Translation: EDL22902.1
BC008121 mRNA Translation: AAH08121.1
CCDSiCCDS21266.2
RefSeqiNP_700468.2, NM_153419.2
UniGeneiMm.274847

3D structure databases

ProteinModelPortaliQ810D6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ810D6, 1 interactor
STRINGi10090.ENSMUSP00000103351

PTM databases

iPTMnetiQ810D6
PhosphoSitePlusiQ810D6

Proteomic databases

EPDiQ810D6
MaxQBiQ810D6
PaxDbiQ810D6
PRIDEiQ810D6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107723; ENSMUSP00000103351; ENSMUSG00000053801
ENSMUST00000131384; ENSMUSP00000116252; ENSMUSG00000053801
GeneIDi101612
KEGGimmu:101612
UCSCiuc009gxj.2 mouse

Organism-specific databases

CTDi83743
MGIiMGI:2141989 Grwd1

Phylogenomic databases

eggNOGiKOG0302 Eukaryota
ENOG410XPDB LUCA
GeneTreeiENSGT00550000075124
HOGENOMiHOG000036730
HOVERGENiHBG051847
InParanoidiQ810D6
KOiK14848
OMAiEWHPTED
OrthoDBiEOG091G07FI
TreeFamiTF312982

Miscellaneous databases

PROiPR:Q810D6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053801 Expressed in 286 organ(s), highest expression level in pancreas
CleanExiMM_GRWD1
ExpressionAtlasiQ810D6 baseline and differential
GenevisibleiQ810D6 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR022052 Histone-bd_RBBP4_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12265 CAF1C_H4-bd, 1 hit
PF00400 WD40, 3 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGRWD1_MOUSE
AccessioniPrimary (citable) accession number: Q810D6
Secondary accession number(s): G3UVT6, Q922H3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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