Slitrk1

Functionⁱ

It is involved in synaptogenesis and promotes excitatory synapse differentiation (By similarity). Enhances neuronal dendrite outgrowth (PubMed:14550773).By similarity1 Publication

GO - Biological processⁱ

adult behavior
Source: MGI
Inferred from mutant phenotypeⁱ
- 18794888
axonogenesis
Source: MGI
Inferred from direct assayⁱ
- 14550773
homeostatic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 18794888
multicellular organism growth
Source: MGI
Inferred from mutant phenotypeⁱ
- 18794888
nervous system development
Source: MGI
Inferred from mutant phenotypeⁱ
- 18794888
positive regulation of axonogenesis Source: UniProtKB
positive regulation of synapse assembly
Source: MGI
Inferred from direct assayⁱ
- 24613359
regulation of presynapse assembly Source: MGI
regulation of synapse organization Source: MGI
synapse assembly Source: MGI
synaptic membrane adhesion Source: MGI

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-MMU-388844 Receptor-type tyrosine-protein phosphatases

Reactomeⁱ

R-MMU-388844 Receptor-type tyrosine-protein phosphatases

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: SLIT and NTRK-like protein 1
Gene namesⁱ	Name:Slitrk1 Synonyms:Sltk1
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 14

Organism-specific databases

MGIⁱ	MGI:2679446 Slitrk1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	18 – 622	ExtracellularSequence analysisAdd BLAST	605
Transmembraneⁱ	623 – 643	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	644 – 696	CytoplasmicSequence analysisAdd BLAST	53

Keywords - Cellular componentⁱ

Cell junction, Membrane, Secreted, Synapse

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 17	Sequence analysisAdd BLAST		17
ChainⁱPRO_0000032674	18 – 696	SLIT and NTRK-like protein 1Sequence analysisAdd BLAST		679

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	695	PhosphoserineBy similarity		1

Post-translational modificationⁱ

Undergoes proteolytic cleavage that results in shedding of the ectodomain and cleavage of the C-terminal cytoplasmic tail. Glycosylated. Phosphorylation at Ser-695 is necessary for proper function in promoting neurite outgrowth.By similarity

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q810C1
PaxDbⁱ	Q810C1
PRIDEⁱ	Q810C1

PTM databases

iPTMnetⁱ	Q810C1
PhosphoSitePlusⁱ	Q810C1

Expressionⁱ

Tissue specificityⁱ

In the adult, significant expression is detected only in the brain. Broadly expressed in embryonic brain with highest expression in subventricular zone, subplate, cortical plate, pyramidal cell layer of hippocampus, thalamus and hypothalamus where levels are highest in ventromedial hypothalamus and medial part of periaqueductal gray matter. Also expressed in mantle layer of spinal cord and in lateral and medial motor columns.1 Publication

Developmental stageⁱ

In the embryo, expressed from day 10-12 and continues through later gestational development and into adulthood.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000075478 Expressed in 156 organ(s), highest expression level in lateral septal nucleus
CleanExⁱ	MM_SLITRK1
ExpressionAtlasⁱ	Q810C1 baseline and differential
Genevisibleⁱ	Q810C1 MM

Interactionⁱ

Subunit structureⁱ

Can form homodimers; homodimerization requires repeat LRR 2 (By similarity). Interacts with YWHAB, YWHAE, YWHAG, YWHAH, SFN, YWHAQ and YWHAZ (By similarity).By similarity

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000097897

STRINGⁱ

10090.ENSMUSP00000097897

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q810C1
SMRⁱ	Q810C1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	18 – 57	LRRNT 1Add BLAST	40
Repeatⁱ	59 – 80	LRR 1Add BLAST	22
Repeatⁱ	83 – 104	LRR 2Add BLAST	22
Repeatⁱ	106 – 128	LRR 3Add BLAST	23
Repeatⁱ	131 – 152	LRR 4Add BLAST	22
Repeatⁱ	155 – 176	LRR 5Add BLAST	22
Repeatⁱ	178 – 199	LRR 6Add BLAST	22
Domainⁱ	212 – 263	LRRCT 1Add BLAST	52
Domainⁱ	332 – 373	LRRNT 2Add BLAST	42
Repeatⁱ	376 – 397	LRR 7Add BLAST	22
Repeatⁱ	400 – 421	LRR 8Add BLAST	22
Repeatⁱ	424 – 445	LRR 9Add BLAST	22
Repeatⁱ	448 – 469	LRR 10Add BLAST	22
Repeatⁱ	472 – 493	LRR 11Add BLAST	22
Repeatⁱ	495 – 516	LRR 12Add BLAST	22
Domainⁱ	529 – 580	LRRCT 2Add BLAST	52

Sequence similaritiesⁱ

Belongs to the SLITRK family.Curated

Keywords - Domainⁱ

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IGN5 Eukaryota ENOG4111D19 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150809
HOVERGENⁱ	HBG056407
InParanoidⁱ	Q810C1
OMAⁱ	DLKCESP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02AI
PhylomeDBⁱ	Q810C1
TreeFamⁱ	TF351826

Family and domain databases

Gene3Dⁱ	3.80.10.10, 2 hits
InterProⁱ	View protein in InterPro IPR000483 Cys-rich_flank_reg_C IPR001611 Leu-rich_rpt IPR003591 Leu-rich_rpt_typical-subtyp IPR032675 LRR_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13855 LRR_8, 2 hits
SMARTⁱ	View protein in SMART SM00369 LRR_TYP, 11 hits SM00082 LRRCT, 2 hits
PROSITEⁱ	View protein in PROSITE PS51450 LRR, 12 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q810C1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLLWILLLET SLCFAAGNVT GDVCKEKICS CNEIEGDLHV DCEKKGFTSL 
        60         70         80         90        100
QRFTAPTSQF YHLFLHGNSL TRLFPNEFAN FYNAVSLHME NNGLHEIVPG 
       110        120        130        140        150
AFLGLQLVKR LHINNNKIKS FRKQTFLGLD DLEYLQADFN LLRDIDPGAF 
       160        170        180        190        200
QDLNKLEVLI LNDNLISTLP ANVFQYVPIT HLDLRGNRLK TLPYEEVLEQ 
       210        220        230        240        250
IPGIAEILLE DNPWDCTCDL LSLKEWLENI PKNALIGRVV CEAPTRLQGK 
       260        270        280        290        300
DLNETTEQDL CPLKNRVDSS LPAPPAQEET FAPGPLPTPF KTNGQDEHAT 
       310        320        330        340        350
PGAVPNGGTK IPGNWQLKIK PTPPIATGSA RNKPPVHGLP CPGGCSCDHI 
       360        370        380        390        400
PGSGLKMNCN NRNVSSLADL KPKLSNVQEL FLRDNKIHSI RKSHFVDYKN 
       410        420        430        440        450
LILLDLGNNN IANIENNTFK NLLDLRWLYM DSNYLDTLSR EKFAGLQNLE 
       460        470        480        490        500
YLNVEYNAIQ LILPGTFNAM PKLRILILNN NLLRSLPVDV FAGVSLSKLS 
       510        520        530        540        550
LHNNYFMYLP VAGVLDQLTS IIQIDLHGNP WECSCTIVPF KQWAERLGSE 
       560        570        580        590        600
VLMSDLKCET PVNFFRKDFM LLSNEEICPQ LYARISPTLT SHSKNSTGLA 
       610        620        630        640        650
ETGTHSNSYL DTSRVSISVL VPGLLLVFVT SAFTVVGMLV FILRNRKRSK 
       660        670        680        690 
RRDANSSASE INSLQTVCDS SYWHNGPYNA DGSHRVYDCG SHSLSD

Length:696

Mass (Da):77,817

Last modified:June 1, 2003 - v1

Checksum:ⁱB3F23AF1A28B9E1B

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB097570 Genomic DNA Translation: BAC67204.1 AK014285 mRNA Translation: BAB29244.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS27325.1
NCBI Reference Sequences More...RefSeqⁱ	NP_951020.1, NM_199065.2
UniGeneⁱ	Mm.257268

Genome annotation databases

Ensemblⁱ	ENSMUST00000100322; ENSMUSP00000097897; ENSMUSG00000075478
GeneIDⁱ	76965
KEGGⁱ	mmu:76965
UCSC genome browser More...UCSCⁱ	uc007uyc.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q810C1	MKIAA1910 protein (Fragment)		MOUSE		760	UniRef100_Q810C1
SLIT and NTRK-like family, member 1		MOUSE		696

Protein	Similar proteins		Species	Score	Length	Source
Q810C1	MKIAA1910 protein (Fragment)		MOUSE		760	UniRef90_Q810C1
SLIT and NTRK like family member 1		LOXAF		760
SLIT and NTRK like family member 1		BOVIN		696
SLIT and NTRK-like protein 1 (Fragment)		wild yak		760
Uncharacterized protein		SHEEP		696
+3

Protein	Similar proteins		Species	Score	Length	Source
Q810C1	SLIT and NTRK-like protein 1	)	HUMAN		696	UniRef50_Q96PX8
SLIT and NTRK-like protein 1		PONAB		696
SLIT and NTRK like family member 1		OTOGA		760
Uncharacterized protein		RABIT		706
Uncharacterized protein		MYOLU		698
+296

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB097570 Genomic DNA Translation: BAC67204.1 AK014285 mRNA Translation: BAB29244.2
CCDSⁱ	CCDS27325.1
RefSeqⁱ	NP_951020.1, NM_199065.2
UniGeneⁱ	Mm.257268

3D structure databases

ProteinModelPortalⁱ	Q810C1
SMRⁱ	Q810C1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000097897

STRINGⁱ

10090.ENSMUSP00000097897

PTM databases

iPTMnetⁱ	Q810C1
PhosphoSitePlusⁱ	Q810C1

Proteomic databases

MaxQBⁱ	Q810C1
PaxDbⁱ	Q810C1
PRIDEⁱ	Q810C1

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000100322; ENSMUSP00000097897; ENSMUSG00000075478
GeneIDⁱ	76965
KEGGⁱ	mmu:76965
UCSCⁱ	uc007uyc.1 mouse

Organism-specific databases

CTDⁱ	114798
MGIⁱ	MGI:2679446 Slitrk1

Phylogenomic databases

eggNOGⁱ	ENOG410IGN5 Eukaryota ENOG4111D19 LUCA
GeneTreeⁱ	ENSGT00930000150809
HOVERGENⁱ	HBG056407
InParanoidⁱ	Q810C1
OMAⁱ	DLKCESP
OrthoDBⁱ	EOG091G02AI
PhylomeDBⁱ	Q810C1
TreeFamⁱ	TF351826

Enzyme and pathway databases

Reactomeⁱ	R-MMU-388844 Receptor-type tyrosine-protein phosphatases

Reactomeⁱ

R-MMU-388844 Receptor-type tyrosine-protein phosphatases

Miscellaneous databases

ChiTaRSⁱ	Slitrk1 mouse
Protein Ontology More...PROⁱ	PR:Q810C1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000075478 Expressed in 156 organ(s), highest expression level in lateral septal nucleus
CleanExⁱ	MM_SLITRK1
ExpressionAtlasⁱ	Q810C1 baseline and differential
Genevisibleⁱ	Q810C1 MM

Family and domain databases

Gene3Dⁱ	3.80.10.10, 2 hits
InterProⁱ	View protein in InterPro IPR000483 Cys-rich_flank_reg_C IPR001611 Leu-rich_rpt IPR003591 Leu-rich_rpt_typical-subtyp IPR032675 LRR_dom_sf
Pfamⁱ	View protein in Pfam PF13855 LRR_8, 2 hits
SMARTⁱ	View protein in SMART SM00369 LRR_TYP, 11 hits SM00082 LRRCT, 2 hits
PROSITEⁱ	View protein in PROSITE PS51450 LRR, 12 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SLIK1_MOUSE
Accessionⁱ	Q810C1Primary (citable) accession number: Q810C1 Secondary accession number(s): Q9CXL0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
	Last sequence update:	June 1, 2003
	Last modified:	November 7, 2018
	This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q810C1 (SLIK1_MOUSE)

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SLIT and NTRK-like protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Other locations

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ