UniProtKB - Q810C1 (SLIK1_MOUSE)
Protein
SLIT and NTRK-like protein 1
Gene
Slitrk1
Organism
Mus musculus (Mouse)
Status
Functioni
It is involved in synaptogenesis and promotes excitatory synapse differentiation (By similarity). Enhances neuronal dendrite outgrowth (PubMed:14550773).By similarity1 Publication
GO - Biological processi
- adult behavior Source: MGI
- axonogenesis Source: MGI
- homeostatic process Source: MGI
- multicellular organism growth Source: MGI
- nervous system development Source: MGI
- positive regulation of axonogenesis Source: UniProtKB
- positive regulation of synapse assembly Source: MGI
- regulation of presynapse assembly Source: MGI
- regulation of synapse organization Source: MGI
- synapse assembly Source: MGI
- synaptic membrane adhesion Source: MGI
Enzyme and pathway databases
Reactomei | R-MMU-388844, Receptor-type tyrosine-protein phosphatases |
Names & Taxonomyi
Protein namesi | Recommended name: SLIT and NTRK-like protein 1 |
Gene namesi | Name:Slitrk1 Synonyms:Sltk1 |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2679446, Slitrk1 |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Other locations
- Membrane By similarity; Single-pass type I membrane protein By similarity
- synapse 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Plasma Membrane
Other locations
- GABA-ergic synapse Source: MGI
- glutamatergic synapse Source: MGI
- integral component of membrane Source: MGI
- synapse Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 18 – 622 | ExtracellularSequence analysisAdd BLAST | 605 | |
Transmembranei | 623 – 643 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 644 – 696 | CytoplasmicSequence analysisAdd BLAST | 53 |
Keywords - Cellular componenti
Cell junction, Membrane, Secreted, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_0000032674 | 18 – 696 | SLIT and NTRK-like protein 1Sequence analysisAdd BLAST | 679 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 695 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Undergoes proteolytic cleavage that results in shedding of the ectodomain and cleavage of the C-terminal cytoplasmic tail. Glycosylated. Phosphorylation at Ser-695 is necessary for proper function in promoting neurite outgrowth.By similarity
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
MaxQBi | Q810C1 |
PaxDbi | Q810C1 |
PRIDEi | Q810C1 |
PTM databases
iPTMneti | Q810C1 |
PhosphoSitePlusi | Q810C1 |
Expressioni
Tissue specificityi
In the adult, significant expression is detected only in the brain. Broadly expressed in embryonic brain with highest expression in subventricular zone, subplate, cortical plate, pyramidal cell layer of hippocampus, thalamus and hypothalamus where levels are highest in ventromedial hypothalamus and medial part of periaqueductal gray matter. Also expressed in mantle layer of spinal cord and in lateral and medial motor columns.1 Publication
Developmental stagei
In the embryo, expressed from day 10-12 and continues through later gestational development and into adulthood.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000075478, Expressed in lateral septal nucleus and 173 other tissues |
ExpressionAtlasi | Q810C1, baseline and differential |
Genevisiblei | Q810C1, MM |
Interactioni
Subunit structurei
Can form homodimers; homodimerization requires repeat LRR 2 (By similarity).
Interacts with YWHAB, YWHAE, YWHAG, YWHAH, SFN, YWHAQ and YWHAZ (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000097897 |
Miscellaneous databases
RNActi | Q810C1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 57 | LRRNT 1Add BLAST | 40 | |
Repeati | 59 – 80 | LRR 1Add BLAST | 22 | |
Repeati | 83 – 104 | LRR 2Add BLAST | 22 | |
Repeati | 106 – 128 | LRR 3Add BLAST | 23 | |
Repeati | 131 – 152 | LRR 4Add BLAST | 22 | |
Repeati | 155 – 176 | LRR 5Add BLAST | 22 | |
Repeati | 178 – 199 | LRR 6Add BLAST | 22 | |
Domaini | 212 – 263 | LRRCT 1Add BLAST | 52 | |
Domaini | 332 – 373 | LRRNT 2Add BLAST | 42 | |
Repeati | 376 – 397 | LRR 7Add BLAST | 22 | |
Repeati | 400 – 421 | LRR 8Add BLAST | 22 | |
Repeati | 424 – 445 | LRR 9Add BLAST | 22 | |
Repeati | 448 – 469 | LRR 10Add BLAST | 22 | |
Repeati | 472 – 493 | LRR 11Add BLAST | 22 | |
Repeati | 495 – 516 | LRR 12Add BLAST | 22 | |
Domaini | 529 – 580 | LRRCT 2Add BLAST | 52 |
Sequence similaritiesi
Belongs to the SLITRK family.Curated
Keywords - Domaini
Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QTHH, Eukaryota |
GeneTreei | ENSGT00940000159810 |
HOGENOMi | CLU_012706_2_0_1 |
InParanoidi | Q810C1 |
OMAi | ELRWLYM |
OrthoDBi | 217854at2759 |
PhylomeDBi | Q810C1 |
TreeFami | TF351826 |
Family and domain databases
Gene3Di | 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR043326, Slitrk |
PANTHERi | PTHR45773, PTHR45773, 1 hit |
Pfami | View protein in Pfam PF13855, LRR_8, 2 hits |
SMARTi | View protein in SMART SM00369, LRR_TYP, 11 hits SM00082, LRRCT, 2 hits |
PROSITEi | View protein in PROSITE PS51450, LRR, 12 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q810C1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLWILLLET SLCFAAGNVT GDVCKEKICS CNEIEGDLHV DCEKKGFTSL
60 70 80 90 100
QRFTAPTSQF YHLFLHGNSL TRLFPNEFAN FYNAVSLHME NNGLHEIVPG
110 120 130 140 150
AFLGLQLVKR LHINNNKIKS FRKQTFLGLD DLEYLQADFN LLRDIDPGAF
160 170 180 190 200
QDLNKLEVLI LNDNLISTLP ANVFQYVPIT HLDLRGNRLK TLPYEEVLEQ
210 220 230 240 250
IPGIAEILLE DNPWDCTCDL LSLKEWLENI PKNALIGRVV CEAPTRLQGK
260 270 280 290 300
DLNETTEQDL CPLKNRVDSS LPAPPAQEET FAPGPLPTPF KTNGQDEHAT
310 320 330 340 350
PGAVPNGGTK IPGNWQLKIK PTPPIATGSA RNKPPVHGLP CPGGCSCDHI
360 370 380 390 400
PGSGLKMNCN NRNVSSLADL KPKLSNVQEL FLRDNKIHSI RKSHFVDYKN
410 420 430 440 450
LILLDLGNNN IANIENNTFK NLLDLRWLYM DSNYLDTLSR EKFAGLQNLE
460 470 480 490 500
YLNVEYNAIQ LILPGTFNAM PKLRILILNN NLLRSLPVDV FAGVSLSKLS
510 520 530 540 550
LHNNYFMYLP VAGVLDQLTS IIQIDLHGNP WECSCTIVPF KQWAERLGSE
560 570 580 590 600
VLMSDLKCET PVNFFRKDFM LLSNEEICPQ LYARISPTLT SHSKNSTGLA
610 620 630 640 650
ETGTHSNSYL DTSRVSISVL VPGLLLVFVT SAFTVVGMLV FILRNRKRSK
660 670 680 690
RRDANSSASE INSLQTVCDS SYWHNGPYNA DGSHRVYDCG SHSLSD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB097570 Genomic DNA Translation: BAC67204.1 AK014285 mRNA Translation: BAB29244.2 |
CCDSi | CCDS27325.1 |
RefSeqi | NP_951020.1, NM_199065.2 |
Genome annotation databases
Ensembli | ENSMUST00000100322; ENSMUSP00000097897; ENSMUSG00000075478 |
GeneIDi | 76965 |
KEGGi | mmu:76965 |
UCSCi | uc007uyc.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB097570 Genomic DNA Translation: BAC67204.1 AK014285 mRNA Translation: BAB29244.2 |
CCDSi | CCDS27325.1 |
RefSeqi | NP_951020.1, NM_199065.2 |
3D structure databases
SMRi | Q810C1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000097897 |
PTM databases
iPTMneti | Q810C1 |
PhosphoSitePlusi | Q810C1 |
Proteomic databases
MaxQBi | Q810C1 |
PaxDbi | Q810C1 |
PRIDEi | Q810C1 |
Protocols and materials databases
Antibodypediai | 2648, 264 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000100322; ENSMUSP00000097897; ENSMUSG00000075478 |
GeneIDi | 76965 |
KEGGi | mmu:76965 |
UCSCi | uc007uyc.1, mouse |
Organism-specific databases
CTDi | 114798 |
MGIi | MGI:2679446, Slitrk1 |
Phylogenomic databases
eggNOGi | ENOG502QTHH, Eukaryota |
GeneTreei | ENSGT00940000159810 |
HOGENOMi | CLU_012706_2_0_1 |
InParanoidi | Q810C1 |
OMAi | ELRWLYM |
OrthoDBi | 217854at2759 |
PhylomeDBi | Q810C1 |
TreeFami | TF351826 |
Enzyme and pathway databases
Reactomei | R-MMU-388844, Receptor-type tyrosine-protein phosphatases |
Miscellaneous databases
BioGRID-ORCSi | 76965, 0 hits in 17 CRISPR screens |
ChiTaRSi | Slitrk1, mouse |
PROi | PR:Q810C1 |
RNActi | Q810C1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000075478, Expressed in lateral septal nucleus and 173 other tissues |
ExpressionAtlasi | Q810C1, baseline and differential |
Genevisiblei | Q810C1, MM |
Family and domain databases
Gene3Di | 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR043326, Slitrk |
PANTHERi | PTHR45773, PTHR45773, 1 hit |
Pfami | View protein in Pfam PF13855, LRR_8, 2 hits |
SMARTi | View protein in SMART SM00369, LRR_TYP, 11 hits SM00082, LRRCT, 2 hits |
PROSITEi | View protein in PROSITE PS51450, LRR, 12 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SLIK1_MOUSE | |
Accessioni | Q810C1Primary (citable) accession number: Q810C1 Secondary accession number(s): Q9CXL0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | June 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families