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Entry version 145 (16 Oct 2019)
Sequence version 2 (27 Jul 2011)
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Protein

Rabankyrin-5

Gene

Ankfy1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI3P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport (By similarity). Involved in macropinocytosis; the function is dependent on Rab5-GTP.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1104 – 1164FYVE-typePROSITE-ProRule annotationAdd BLAST61

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processEndocytosis
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rabankyrin-51 Publication
Short name:
Rank-5
Alternative name(s):
Ankyrin repeat and FYVE domain-containing protein 1
Ankyrin repeats hooked to a zinc finger motif
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ankfy1
Synonyms:Ankhzn, Kiaa1255
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1337008 Ankfy1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endosome, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000668912 – 1169Rabankyrin-5Add BLAST1168

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei270PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q810B6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q810B6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q810B6

PeptideAtlas

More...
PeptideAtlasi
Q810B6

PRoteomics IDEntifications database

More...
PRIDEi
Q810B6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q810B6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q810B6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in kidney proximal tubule epithelial cells; at protein level.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000020790 Expressed in 306 organ(s), highest expression level in tracheobronchial tree

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q810B6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RAB5A (in GTP-bound form).

Interacts with RHOD (independent of GTP-loaded status).

Interacts with EHD1.

Interacts with VPS26A; the interaction is indepenedent of EHD1 and is indicative for an association with the cargo recognition subcomplex of the retromer complex.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
198103, 8 interactors

Protein interaction database and analysis system

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IntActi
Q810B6, 6 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000118751

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q810B6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini68 – 130BTBPROSITE-ProRule annotationAdd BLAST63
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati217 – 247ANK 1Add BLAST31
Repeati255 – 284ANK 2Add BLAST30
Repeati288 – 317ANK 3Add BLAST30
Repeati322 – 362ANK 4Add BLAST41
Repeati366 – 396ANK 5Add BLAST31
Repeati490 – 519ANK 6Add BLAST30
Repeati542 – 572ANK 7Add BLAST31
Repeati588 – 617ANK 8Add BLAST30
Repeati621 – 650ANK 9Add BLAST30
Repeati654 – 683ANK 10Add BLAST30
Repeati687 – 716ANK 11Add BLAST30
Repeati724 – 753ANK 12Add BLAST30
Repeati769 – 798ANK 13Add BLAST30
Repeati802 – 832ANK 14Add BLAST31
Repeati836 – 865ANK 15Add BLAST30
Repeati870 – 899ANK 16Add BLAST30
Repeati905 – 934ANK 17Add BLAST30
Repeati938 – 967ANK 18Add BLAST30
Repeati971 – 1001ANK 19Add BLAST31
Repeati1005 – 1037ANK 20Add BLAST33
Repeati1043 – 1072ANK 21Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni650 – 759Interaction with RHOD and RAB5ABy similarityAdd BLAST110

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi421 – 423NPF3

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1104 – 1164FYVE-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0504 Eukaryota
KOG4591 Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156179

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000022583

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q810B6

KEGG Orthology (KO)

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KOi
K20129

Identification of Orthologs from Complete Genome Data

More...
OMAi
MHVLGHY

Database of Orthologous Groups

More...
OrthoDBi
1115202at2759

TreeFam database of animal gene trees

More...
TreeFami
TF351263

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 6 hits
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023 Ank, 2 hits
PF12796 Ank_2, 3 hits
PF00651 BTB, 1 hit
PF01363 FYVE, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 20 hits
SM00225 BTB, 1 hit
SM00064 FYVE, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 3 hits
SSF54695 SSF54695, 1 hit
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 11 hits
PS50097 BTB, 1 hit
PS50178 ZF_FYVE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q810B6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEEEVAKLE KHLMLLRQEY VKLQKKLAET EKRCTLLAAQ ANKENSNESF
60 70 80 90 100
ISRLLAIVAG LYEQEQYSDL KIKVGDRHIS AHKFVLAARS DSWSLANLSS
110 120 130 140 150
TEEIDLSDAN PEVTMTMLRW IYTDELEFRE DDVFLTELMK LANRFQLQLL
160 170 180 190 200
RERCEKGVMS LVNVRNCIRF YQTAEELNAS TLMNYCAEII ASHWDDLRKE
210 220 230 240 250
DFSSLSAQLL YKMIKSKTEY PLHKAIKVER EDVVFLYLIE MDSQLPGKLN
260 270 280 290 300
ETDHNGDLAL DLALSRRLES IATTLVSHKA DVDMVDKNGW SLLHKGIQRG
310 320 330 340 350
DLFASTFLIK NGALVNAATA GAQETPLHLV ALYSPKKYSA DVMSEMAQIA
360 370 380 390 400
EALLQAGANP NMQDSKGRTP LHLSIMARND CVFSQLLQCK QLDLELKDHE
410 420 430 440 450
GSTALWLAVQ YITVSSDQSV NPFEDLPVVN GTSFDENSFA ARLIQRGSNT
460 470 480 490 500
DAPDVMTGNC LLQRAAGAGN EAAALFLATS GAHANHRNKW GETPLHTACR
510 520 530 540 550
HGLANLTAEL LQQGANPNLQ TEEALPVPKE SPVLMSSADS IYLQTPLHMA
560 570 580 590 600
IAYNHPDVVS VILEQKANAL HATNNLQIIP DFSLKDSRDQ TVLGLALWTG
610 620 630 640 650
MHTIAAQLLG SGASINDTMS DGQTLLHMAI QRQDSKSALF LLEHQADINV
660 670 680 690 700
RTQDGETALQ LAIKHQLPLV VDAICTRGAD MSVPDEKGNP PLWLALASNL
710 720 730 740 750
EDIASTLVRH GCDATCWGPG PSGCLQTLLH RAVDENNEST ACFLIRSGCD
760 770 780 790 800
VNSPRQPGTN GEGEEEARDG QTPLHLAASW GLEETVQCLL EFGANVNAQD
810 820 830 840 850
AEGRTPVHVA ISNQHSVIIQ LLISHPNIEL SVRDRQGLTP FACAMTYKNN
860 870 880 890 900
KAAEAILKRE SGAAEQVDNK GRNFLHVAVQ NSDIESVLFL ISVQANVNSR
910 920 930 940 950
VQDASKLTPL HLAVQAGSEI IVRNLLLAGA KVNELTKHRQ TALHLAAQQD
960 970 980 990 1000
LPTICSVLLE NGVDFAAVDE NGNNALHLAV MHGRLNNIRA LLTECTVDAE
1010 1020 1030 1040 1050
AFNLRGQSPL HILGQYGKEN AAAIFDLFLE CMPEYPLDKP DAEGNTVLLL
1060 1070 1080 1090 1100
AYMKGNANLC RAIVRSGVRL GVNNNQGVNI FNYQVATKQL LFRLLDMLSK
1110 1120 1130 1140 1150
EPPWCDGSNC YECTAKFGVT TRKHHCRHCG RLLCHKCSTK EIPIIKFDLN
1160
KPVRVCNICF DVLTLGGVS
Length:1,169
Mass (Da):128,653
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAAFBB2D66739CA2F
GO
Isoform 2 (identifier: Q810B6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     392-439: LDLELKDHEG...NGTSFDENSF → YVGRPGEMQS...CVFRPVCKPL
     440-1169: Missing.

Show »
Length:439
Mass (Da):49,771
Checksum:iD2639C8A99B71C70
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti117 – 118ML → IV in BAA24980 (PubMed:10092534).Curated2
Sequence conflicti117 – 118ML → IV in BAC67211 (Ref. 2) Curated2
Sequence conflicti117 – 118ML → IV in BAC67388 (Ref. 2) Curated2
Sequence conflicti117 – 118ML → IV in BAC67389 (Ref. 2) Curated2
Sequence conflicti439F → L in BAC67211 (Ref. 2) Curated1
Sequence conflicti448S → T in BAC67389 (Ref. 2) Curated1
Sequence conflicti502G → V in BAC67389 (Ref. 2) Curated1
Sequence conflicti526 – 527PV → TL in BAC67211 (Ref. 2) Curated2
Sequence conflicti526P → T in BAC67389 (Ref. 2) Curated1
Sequence conflicti840P → S in BAC67389 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_007917392 – 439LDLEL…DENSF → YVGRPGEMQSGCEGGIIRFR AERSRRQHCTLAGRPVHHCV FRPVCKPL in isoform 2. 2 PublicationsAdd BLAST48
Alternative sequenceiVSP_007918440 – 1169Missing in isoform 2. 2 PublicationsAdd BLAST730

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB011370 mRNA Translation: BAA24980.2
AB098329 mRNA Translation: BAC67211.1
AB098157 Genomic DNA Translation: BAC67389.1
AB098157 Genomic DNA Translation: BAC67388.1
AL663082 Genomic DNA No translation available.
AL808023 Genomic DNA No translation available.
BC139231 mRNA Translation: AAI39232.1
AK122479 mRNA Translation: BAC65761.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS24989.1 [Q810B6-1]

Protein sequence database of the Protein Information Resource

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PIRi
T00253

NCBI Reference Sequences

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RefSeqi
NP_033801.4, NM_009671.5 [Q810B6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000127610; ENSMUSP00000118252; ENSMUSG00000020790 [Q810B6-2]
ENSMUST00000155998; ENSMUSP00000118751; ENSMUSG00000020790 [Q810B6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
11736

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:11736

UCSC genome browser

More...
UCSCi
uc007jzh.1 mouse [Q810B6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011370 mRNA Translation: BAA24980.2
AB098329 mRNA Translation: BAC67211.1
AB098157 Genomic DNA Translation: BAC67389.1
AB098157 Genomic DNA Translation: BAC67388.1
AL663082 Genomic DNA No translation available.
AL808023 Genomic DNA No translation available.
BC139231 mRNA Translation: AAI39232.1
AK122479 mRNA Translation: BAC65761.1
CCDSiCCDS24989.1 [Q810B6-1]
PIRiT00253
RefSeqiNP_033801.4, NM_009671.5 [Q810B6-1]

3D structure databases

SMRiQ810B6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi198103, 8 interactors
IntActiQ810B6, 6 interactors
STRINGi10090.ENSMUSP00000118751

PTM databases

iPTMnetiQ810B6
PhosphoSitePlusiQ810B6

Proteomic databases

EPDiQ810B6
jPOSTiQ810B6
PaxDbiQ810B6
PeptideAtlasiQ810B6
PRIDEiQ810B6

Genome annotation databases

EnsembliENSMUST00000127610; ENSMUSP00000118252; ENSMUSG00000020790 [Q810B6-2]
ENSMUST00000155998; ENSMUSP00000118751; ENSMUSG00000020790 [Q810B6-1]
GeneIDi11736
KEGGimmu:11736
UCSCiuc007jzh.1 mouse [Q810B6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51479
MGIiMGI:1337008 Ankfy1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
KOG4591 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000156179
HOGENOMiHOG000022583
InParanoidiQ810B6
KOiK20129
OMAiMHVLGHY
OrthoDBi1115202at2759
TreeFamiTF351263

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Ankfy1 mouse

Protein Ontology

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PROi
PR:Q810B6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000020790 Expressed in 306 organ(s), highest expression level in tracheobronchial tree
GenevisibleiQ810B6 MM

Family and domain databases

Gene3Di1.25.40.20, 6 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00023 Ank, 2 hits
PF12796 Ank_2, 3 hits
PF00651 BTB, 1 hit
PF01363 FYVE, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 20 hits
SM00225 BTB, 1 hit
SM00064 FYVE, 1 hit
SUPFAMiSSF48403 SSF48403, 3 hits
SSF54695 SSF54695, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 11 hits
PS50097 BTB, 1 hit
PS50178 ZF_FYVE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANFY1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q810B6
Secondary accession number(s): B1ATS3
, O54807, Q80TG6, Q80UH8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: July 27, 2011
Last modified: October 16, 2019
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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