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UniProtKB - Q80ZW7 (Q80ZW7_MOUSE)
Protein
Submitted name:
Nucleolysin TIA-1
Gene
Tia1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- RNA binding Source: UniProtKB-UniRule
Keywordsi
Molecular function | RNA-bindingPROSITE-ProRule annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Nucleolysin TIA-1ImportedSubmitted name: Tia1 proteinImported |
Gene namesi | Name:Tia1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:107914, Tia1 |
VEuPathDBi | HostDB:ENSMUSG00000071337 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000071337, Expressed in midbrain and 305 other tissues |
Interactioni
Binary interactionsi
Protein-protein interaction databases
IntActi | Q80ZW7, 3 interactors |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 85 | RRMInterPro annotationAdd BLAST | 79 | |
Domaini | 97 – 175 | RRMInterPro annotationAdd BLAST | 79 | |
Domaini | 205 – 277 | RRMInterPro annotationAdd BLAST | 73 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 346 – 367 | DisorderedSequence analysisAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 346 – 364 | Polar residuesSequence analysisAdd BLAST | 19 |
Phylogenomic databases
GeneTreei | ENSGT00940000154962 |
Family and domain databases
CDDi | cd12618, RRM2_TIA1, 1 hit cd12621, RRM3_TIA1, 1 hit |
Gene3Di | 3.30.70.330, 3 hits |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR003954, RRM_dom_euk IPR034830, TIA1_RRM2 IPR034832, TIA1_RRM3 |
Pfami | View protein in Pfam PF00076, RRM_1, 3 hits |
SMARTi | View protein in SMART SM00360, RRM, 3 hits SM00361, RRM_1, 3 hits |
SUPFAMi | SSF54928, SSF54928, 3 hits |
PROSITEi | View protein in PROSITE PS50102, RRM, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
Q80ZW7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEDEMPKTLY VGNLSRDVTE ALILQLFSQI GPCKNCKMIM DVRTAGNDPY
60 70 80 90 100
CFVEFHEHRH AAAALAAMNG RKIMGKEVKV NWATTPSSQK KDTSNHFHVF
110 120 130 140 150
VGDLSPEITT EDIKAAFAPF GRISDARVVK DMATGKSKGY GFVSFFNKWD
160 170 180 190 200
AENAIQQMGG QWLGGRQIRT NWATRKPPAP KSTYESNTKQ LSYDEVVSQS
210 220 230 240 250
SPNNCTVYCG GVTSGLTEQL MRQTFSPFGQ IMEIRVFPDK GYSFVRFSSH
260 270 280 290 300
ESAAHAIVSV NGTTIEGHVV KCYWGKETLD MINPVQQQNQ IGYPPTYGQW
310 320 330 340 350
GQWYGNAQQI GQYVPNGWQV PAYGVYGQPW SQQGFNQTQS SAPWMGPNYS
360 370
VPPPQGQNGS MLPSQPAGYR VAGYETQ
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP52912 | TIA1_MOUSE | Cytotoxic granule associated RNA bi... | Tia1 Tia | 386 | Annotation score: | ||
G5E8L2 | G5E8L2_MOUSE | Nucleolysin TIA-1 | Tia1 | 375 | Annotation score: | ||
Q8CII5 | Q8CII5_MOUSE | Nucleolysin TIA-1 | Tia1 | 285 | Annotation score: | ||
D3Z4H6 | D3Z4H6_MOUSE | Nucleolysin TIA-1 | Tia1 | 385 | Annotation score: | ||
D3YY02 | D3YY02_MOUSE | Nucleolysin TIA-1 | Tia1 | 212 | Annotation score: | ||
A0A0N4SUX1 | A0A0N4SUX1_MOUSE | Nucleolysin TIA-1 | Tia1 | 133 | Annotation score: | ||
A0A0N4SVR8 | A0A0N4SVR8_MOUSE | Nucleolysin TIA-1 | Tia1 | 93 | Annotation score: | ||
A0A0N4SW78 | A0A0N4SW78_MOUSE | Nucleolysin TIA-1 | Tia1 | 105 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC046812 mRNA Translation: AAH46812.1 |
RefSeqi | NP_001157550.1, NM_001164078.1 |
Genome annotation databases
Ensembli | ENSMUST00000113713; ENSMUSP00000109342; ENSMUSG00000071337 |
GeneIDi | 21841 |
UCSCi | uc009crq.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC046812 mRNA Translation: AAH46812.1 |
RefSeqi | NP_001157550.1, NM_001164078.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q80ZW7, 3 interactors |
Proteomic databases
ProteomicsDBi | 343080 |
Protocols and materials databases
Antibodypediai | 16302, 539 antibodies from 43 providers |
DNASUi | 21841 |
Genome annotation databases
Ensembli | ENSMUST00000113713; ENSMUSP00000109342; ENSMUSG00000071337 |
GeneIDi | 21841 |
UCSCi | uc009crq.2, mouse |
Organism-specific databases
CTDi | 7072 |
MGIi | MGI:107914, Tia1 |
VEuPathDBi | HostDB:ENSMUSG00000071337 |
Phylogenomic databases
GeneTreei | ENSGT00940000154962 |
Miscellaneous databases
BioGRID-ORCSi | 21841, 1 hit in 64 CRISPR screens |
ChiTaRSi | Tia1, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000071337, Expressed in midbrain and 305 other tissues |
Family and domain databases
CDDi | cd12618, RRM2_TIA1, 1 hit cd12621, RRM3_TIA1, 1 hit |
Gene3Di | 3.30.70.330, 3 hits |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR003954, RRM_dom_euk IPR034830, TIA1_RRM2 IPR034832, TIA1_RRM3 |
Pfami | View protein in Pfam PF00076, RRM_1, 3 hits |
SMARTi | View protein in SMART SM00360, RRM, 3 hits SM00361, RRM_1, 3 hits |
SUPFAMi | SSF54928, SSF54928, 3 hits |
PROSITEi | View protein in PROSITE PS50102, RRM, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | Q80ZW7_MOUSE | |
Accessioni | Q80ZW7Primary (citable) accession number: Q80ZW7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 1, 2003 |
Last sequence update: | June 1, 2003 | |
Last modified: | January 19, 2022 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |