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Protein

Serine/threonine-protein kinase 35

Gene

Stk35

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei236ATPPROSITE-ProRule annotation1
Active sitei365Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi213 – 221ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: GO_Central
  • protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 35
Alternative name(s):
Serine/threonine-protein kinase 35 L1 (EC:2.7.11.1)
Gene namesi
Name:Stk35
Synonyms:Stk35l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1914583 Stk35

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002776181 – 539Serine/threonine-protein kinase 35Add BLAST539

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ80ZW0
PaxDbiQ80ZW0
PRIDEiQ80ZW0

PTM databases

iPTMnetiQ80ZW0
PhosphoSitePlusiQ80ZW0

Expressioni

Gene expression databases

BgeeiENSMUSG00000037885 Expressed in 240 organ(s), highest expression level in retina
CleanExiMM_STK35
ExpressionAtlasiQ80ZW0 baseline and differential

Interactioni

Subunit structurei

Interacts with PDLIM1/CLP-36.By similarity

Protein-protein interaction databases

BioGridi212113, 3 interactors
STRINGi10090.ENSMUSP00000126541

Structurei

3D structure databases

ProteinModelPortaliQ80ZW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini207 – 535Protein kinasePROSITE-ProRule annotationAdd BLAST329

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi132 – 135Poly-Pro4
Compositional biasi196 – 199Poly-Gly4

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0595 Eukaryota
ENOG410XR01 LUCA
GeneTreeiENSGT00880000137951
HOGENOMiHOG000231155
HOVERGENiHBG056829
InParanoidiQ80ZW0
KOiK08859
OMAiVVQFEEC
OrthoDBiEOG091G07MU
PhylomeDBiQ80ZW0
TreeFamiTF105336

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q80ZW0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGHQESPLTR AAAGGAAYIK RLRKVLSWRE LGDGHGNLEA EASPGSVAVI
60 70 80 90 100
TRAAPRRATR SARLPASRPT RLCRQARLGT DHPPARAPRG NRFARKRNSA
110 120 130 140 150
GQITIQGPAP PHLGARRRDE ARGARAAPLL LPPPPAAMET GKENGARRGT
160 170 180 190 200
KSPERKRRSP VQRVLCEKLR PAAQAMDPAG AEVPGEAFLA RRRPDGGGGD
210 220 230 240 250
VPARPRYSLL AEIGRGSYGV VYEAVAGRSG ARVAVKKIRC DAPENVELAL
260 270 280 290 300
AEFWALTSLK RRHQNIVQFE ECVLQRNGLA QRMSHGNKNS QLYLRLVETS
310 320 330 340 350
LKGERILGYA EEPCYLWFVM EYCEGGDLNQ YVLSRRPDPA TNKSFMLQLT
360 370 380 390 400
SAIAFLHKNH IVHRDLKPDN ILITERSGTP ILKVADFGLS KVCAGLAPRG
410 420 430 440 450
KEGNQDNKNV NVNKYWLSSA CGSDFYMAPE VWEGHYTAKA DIFALGIIIW
460 470 480 490 500
AMIERITFID SETKKELLGT YIKQGTEIVP VGEALLENPK MELHIPQKRR
510 520 530
TSMSEGVKQL LKDMLAANPQ DRPDAFELET RMDQVTCAA
Length:539
Mass (Da):59,459
Last modified:March 23, 2010 - v3
Checksum:i66959648E99458B3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PXA2E9PXA2_MOUSE
Serine/threonine-protein kinase 35
Stk35
327Annotation score:

Sequence cautioni

The sequence AAI38905 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI38906 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC25152 differs from that shown. Reason: Frameshift at position 23.Curated
The sequence BAC25152 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE38504 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAM22106 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28W → G in BAE38504 (PubMed:16141072).Curated1
Sequence conflicti71R → G in BAE38504 (PubMed:16141072).Curated1
Sequence conflicti71R → G in BAC25152 (PubMed:16141072).Curated1
Sequence conflicti147R → S in BAC25152 (PubMed:16141072).Curated1
Sequence conflicti304 – 327ERILG…CEGGD → RSFGTHSLIVSRTGWQRVQV VVIS in BAE38504 (PubMed:16141072).CuratedAdd BLAST24
Sequence conflicti337P → A in BAC25152 (PubMed:16141072).Curated1
Sequence conflicti345F → V in BAC25152 (PubMed:16141072).Curated1
Sequence conflicti365 – 377DLKPD…ITERS → RPKARQHPDHRAV in BAC25152 (PubMed:16141072).CuratedAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL808137 Genomic DNA Translation: CAM22106.1 Different initiation.
BC047277 mRNA Translation: AAH47277.1
BC138904 mRNA Translation: AAI38905.1 Different initiation.
BC138905 mRNA Translation: AAI38906.1 Different initiation.
AK006778 mRNA Translation: BAC25152.1 Sequence problems.
AK165988 mRNA Translation: BAE38504.1 Different initiation.
CCDSiCCDS16732.2
RefSeqiNP_899085.3, NM_183262.3
UniGeneiMm.389329

Genome annotation databases

EnsembliENSMUST00000165413; ENSMUSP00000126541; ENSMUSG00000037885
GeneIDi67333
KEGGimmu:67333
UCSCiuc008mie.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL808137 Genomic DNA Translation: CAM22106.1 Different initiation.
BC047277 mRNA Translation: AAH47277.1
BC138904 mRNA Translation: AAI38905.1 Different initiation.
BC138905 mRNA Translation: AAI38906.1 Different initiation.
AK006778 mRNA Translation: BAC25152.1 Sequence problems.
AK165988 mRNA Translation: BAE38504.1 Different initiation.
CCDSiCCDS16732.2
RefSeqiNP_899085.3, NM_183262.3
UniGeneiMm.389329

3D structure databases

ProteinModelPortaliQ80ZW0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212113, 3 interactors
STRINGi10090.ENSMUSP00000126541

PTM databases

iPTMnetiQ80ZW0
PhosphoSitePlusiQ80ZW0

Proteomic databases

MaxQBiQ80ZW0
PaxDbiQ80ZW0
PRIDEiQ80ZW0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000165413; ENSMUSP00000126541; ENSMUSG00000037885
GeneIDi67333
KEGGimmu:67333
UCSCiuc008mie.2 mouse

Organism-specific databases

CTDi140901
MGIiMGI:1914583 Stk35

Phylogenomic databases

eggNOGiKOG0595 Eukaryota
ENOG410XR01 LUCA
GeneTreeiENSGT00880000137951
HOGENOMiHOG000231155
HOVERGENiHBG056829
InParanoidiQ80ZW0
KOiK08859
OMAiVVQFEEC
OrthoDBiEOG091G07MU
PhylomeDBiQ80ZW0
TreeFamiTF105336

Miscellaneous databases

PROiPR:Q80ZW0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037885 Expressed in 240 organ(s), highest expression level in retina
CleanExiMM_STK35
ExpressionAtlasiQ80ZW0 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTK35_MOUSE
AccessioniPrimary (citable) accession number: Q80ZW0
Secondary accession number(s): A2ANF2, Q3TMD8, Q8BIC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: March 23, 2010
Last modified: November 7, 2018
This is version 116 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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