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Protein

BPI fold-containing family B member 3

Gene

Bpifb3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
BPI fold-containing family B member 3
Alternative name(s):
Ligand-binding protein RYA3
Long palate, lung and nasal epithelium carcinoma-associated protein 3
Gene namesi
Name:Bpifb3
Synonyms:Lplunc3, Rya3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2675077 Bpifb3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001717121 – 473BPI fold-containing family B member 3Add BLAST453

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi161 ↔ 196By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ80ZU7
PRIDEiQ80ZU7

PTM databases

PhosphoSitePlusiQ80ZU7

Expressioni

Gene expression databases

BgeeiENSMUSG00000068008 Expressed in 18 organ(s), highest expression level in olfactory epithelium
GenevisibleiQ80ZU7 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000086342

Structurei

3D structure databases

ProteinModelPortaliQ80ZU7
SMRiQ80ZU7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4160 Eukaryota
ENOG410Z88E LUCA
GeneTreeiENSGT00730000110772
HOGENOMiHOG000231741
HOVERGENiHBG050718
InParanoidiQ80ZU7
OMAiEWLSHVV
OrthoDBiEOG091G048N
PhylomeDBiQ80ZU7
TreeFamiTF315617

Family and domain databases

InterProiView protein in InterPro
IPR017943 Bactericidal_perm-incr_a/b_dom
IPR032942 BPI/LBP/Plunc
IPR032951 BPIFB3
IPR001124 Lipid-bd_serum_glycop_C
IPR017942 Lipid-bd_serum_glycop_N
PANTHERiPTHR10504 PTHR10504, 1 hit
PTHR10504:SF42 PTHR10504:SF42, 1 hit
PfamiView protein in Pfam
PF01273 LBP_BPI_CETP, 1 hit
PF02886 LBP_BPI_CETP_C, 1 hit
SMARTiView protein in SMART
SM00328 BPI1, 1 hit
SM00329 BPI2, 1 hit
SUPFAMiSSF55394 SSF55394, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80ZU7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMLGVYTLLL LWGLATPCLG LLETVGTLAR IDKDELGKAI QNSLVGGPIL
60 70 80 90 100
QNVLGTVTSV NQGLLGAGGL LGGGGLLSYG GIFSLVEELS GLKIEELTLP
110 120 130 140 150
KVSLKLLPGV GVQLNLHTKV SLHGSGPLVG LLQLAAEVNV SSKVALGMSP
160 170 180 190 200
RGTPILVLKR CSTLLGHISL MSGLLPTPIF GLVEQTLCKV LPGLLCPVVD
210 220 230 240 250
SVLSVVNELL GATLSLVPLG PLGSVEFTLA TLPLISNQYI ELDINPIVKS
260 270 280 290 300
IAGDVIDFPK PRIPVKVPPK EDHTSQVTVP LYLFSTVFGL LQTNGALDLD
310 320 330 340 350
ITPEMVPRNV PLTTTDLAAL APEALGKLPP AQHLLLSLRV TKSPMVLLQN
360 370 380 390 400
KKATVSIPVT IHVLSSVPQG TPVALFQLNG VMTLNAHLAP SSTKLHISLS
410 420 430 440 450
LERLSVQLAS SFPQPFDASR LEEWLSDVVR AAYMQRLNEH LEVGIPLPKI
460 470
LNVNFANSVV DIIENAVVLT VAP
Length:473
Mass (Da):49,885
Last modified:May 24, 2005 - v2
Checksum:i246BF7BAEB328913
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833803 Genomic DNA No translation available.
BC048084 mRNA Translation: AAH48084.2
CCDSiCCDS16921.1
RefSeqiNP_919338.2, NM_194357.1
XP_006499875.1, XM_006499812.1
UniGeneiMm.55392

Genome annotation databases

EnsembliENSMUST00000088950; ENSMUSP00000086342; ENSMUSG00000068008
ENSMUST00000109760; ENSMUSP00000105382; ENSMUSG00000068008
GeneIDi378700
KEGGimmu:378700
UCSCiuc008nip.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833803 Genomic DNA No translation available.
BC048084 mRNA Translation: AAH48084.2
CCDSiCCDS16921.1
RefSeqiNP_919338.2, NM_194357.1
XP_006499875.1, XM_006499812.1
UniGeneiMm.55392

3D structure databases

ProteinModelPortaliQ80ZU7
SMRiQ80ZU7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000086342

PTM databases

PhosphoSitePlusiQ80ZU7

Proteomic databases

PaxDbiQ80ZU7
PRIDEiQ80ZU7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000088950; ENSMUSP00000086342; ENSMUSG00000068008
ENSMUST00000109760; ENSMUSP00000105382; ENSMUSG00000068008
GeneIDi378700
KEGGimmu:378700
UCSCiuc008nip.1 mouse

Organism-specific databases

CTDi359710
MGIiMGI:2675077 Bpifb3

Phylogenomic databases

eggNOGiKOG4160 Eukaryota
ENOG410Z88E LUCA
GeneTreeiENSGT00730000110772
HOGENOMiHOG000231741
HOVERGENiHBG050718
InParanoidiQ80ZU7
OMAiEWLSHVV
OrthoDBiEOG091G048N
PhylomeDBiQ80ZU7
TreeFamiTF315617

Miscellaneous databases

PROiPR:Q80ZU7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000068008 Expressed in 18 organ(s), highest expression level in olfactory epithelium
GenevisibleiQ80ZU7 MM

Family and domain databases

InterProiView protein in InterPro
IPR017943 Bactericidal_perm-incr_a/b_dom
IPR032942 BPI/LBP/Plunc
IPR032951 BPIFB3
IPR001124 Lipid-bd_serum_glycop_C
IPR017942 Lipid-bd_serum_glycop_N
PANTHERiPTHR10504 PTHR10504, 1 hit
PTHR10504:SF42 PTHR10504:SF42, 1 hit
PfamiView protein in Pfam
PF01273 LBP_BPI_CETP, 1 hit
PF02886 LBP_BPI_CETP_C, 1 hit
SMARTiView protein in SMART
SM00328 BPI1, 1 hit
SM00329 BPI2, 1 hit
SUPFAMiSSF55394 SSF55394, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiBPIB3_MOUSE
AccessioniPrimary (citable) accession number: Q80ZU7
Secondary accession number(s): A2APD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: May 24, 2005
Last modified: September 12, 2018
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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