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Protein

Juxtaposed with another zinc finger protein 1

Gene

Jazf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2 (By similarity). Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (PubMed:24380856). Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (PubMed:24930994). Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (PubMed:24380856, PubMed:25614086). Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity (PubMed:25614086, PubMed:24380856).By similarity3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri12 – 37C2H2-type 1Add BLAST26
Zinc fingeri173 – 198C2H2-type 2Add BLAST26
Zinc fingeri208 – 230C2H2-type 3; degenerateAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processLipid metabolism, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Juxtaposed with another zinc finger protein 1
Gene namesi
Name:Jazf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2141450 Jazf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000469861 – 243Juxtaposed with another zinc finger protein 1Add BLAST243

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei109PhosphothreonineCombined sources1
Modified residuei113PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ80ZQ5
PRIDEiQ80ZQ5

PTM databases

iPTMnetiQ80ZQ5
PhosphoSitePlusiQ80ZQ5

Expressioni

Tissue specificityi

Expressed in range of tissues with highest expression levels in testis, liver, muscle and fat and lowest levels in kidney (PubMed:25614086). Detected in liver and white adipose tissue (at protein level) (PubMed:24380856).2 Publications

Developmental stagei

Expression is gradually but significantly up-regulated during adipocyte differentiation.1 Publication

Gene expression databases

BgeeiENSMUSG00000063568 Expressed in 217 organ(s), highest expression level in brain
CleanExiMM_JAZF1
GenevisibleiQ80ZQ5 MM

Interactioni

Subunit structurei

Interacts with NR2C2 (via ligand-binding region).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074129

Structurei

3D structure databases

ProteinModelPortaliQ80ZQ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni39 – 79Required for interaction with NR2C2By similarityAdd BLAST41

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri12 – 37C2H2-type 1Add BLAST26
Zinc fingeri173 – 198C2H2-type 2Add BLAST26
Zinc fingeri208 – 230C2H2-type 3; degenerateAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG4124 Eukaryota
COG5189 LUCA
GeneTreeiENSGT00390000003635
HOGENOMiHOG000252946
HOVERGENiHBG052161
InParanoidiQ80ZQ5
KOiK19495
OMAiQHIEDNH
OrthoDBiEOG091G0WNP
PhylomeDBiQ80ZQ5
TreeFamiTF324161

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q80ZQ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTGIAAASFF SNTCRFGGCG LHFPTLADLI EHIEDNHIDT DPRVLEKQEL
60 70 80 90 100
QQPTYVALSY INRFMTDAAR REQESLKKKI QPKLSLTLSS SVSRGNVSTP
110 120 130 140 150
PRHSSGSLTP PVTPPITPSS SFRSSTPTGS EYDEEEVDYE ESDSDESWTT
160 170 180 190 200
ESAISSEAIL SSMCMNGGEE KPFACPVPGC KKRYKNVNGI KYHAKNGHRT
210 220 230 240
QIRVRKPFKC RCGKSYKTAQ GLRHHTINFH PPVSAEMIRK MQQ
Length:243
Mass (Da):27,098
Last modified:July 11, 2003 - v2
Checksum:i878A6EE3D82C0348
GO
Isoform 2 (identifier: Q80ZQ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     64-64: Missing.

Note: No experimental confirmation available.
Show »
Length:242
Mass (Da):26,950
Checksum:iFB1567AEEFE1A4AB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti211R → L in BAC34275 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00775664Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043767 mRNA Translation: BAC31649.1
AK050474 mRNA Translation: BAC34275.1
BC048577 mRNA Translation: AAH48577.1
CCDSiCCDS20152.1 [Q80ZQ5-1]
RefSeqiNP_001161749.1, NM_001168277.1
NP_775582.2, NM_173406.3 [Q80ZQ5-1]
XP_011239597.1, XM_011241295.2
UniGeneiMm.386865

Genome annotation databases

EnsembliENSMUST00000074541; ENSMUSP00000074129; ENSMUSG00000063568 [Q80ZQ5-1]
GeneIDi231986
KEGGimmu:231986
UCSCiuc009bza.2 mouse [Q80ZQ5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043767 mRNA Translation: BAC31649.1
AK050474 mRNA Translation: BAC34275.1
BC048577 mRNA Translation: AAH48577.1
CCDSiCCDS20152.1 [Q80ZQ5-1]
RefSeqiNP_001161749.1, NM_001168277.1
NP_775582.2, NM_173406.3 [Q80ZQ5-1]
XP_011239597.1, XM_011241295.2
UniGeneiMm.386865

3D structure databases

ProteinModelPortaliQ80ZQ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074129

PTM databases

iPTMnetiQ80ZQ5
PhosphoSitePlusiQ80ZQ5

Proteomic databases

PaxDbiQ80ZQ5
PRIDEiQ80ZQ5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074541; ENSMUSP00000074129; ENSMUSG00000063568 [Q80ZQ5-1]
GeneIDi231986
KEGGimmu:231986
UCSCiuc009bza.2 mouse [Q80ZQ5-1]

Organism-specific databases

CTDi221895
MGIiMGI:2141450 Jazf1

Phylogenomic databases

eggNOGiKOG4124 Eukaryota
COG5189 LUCA
GeneTreeiENSGT00390000003635
HOGENOMiHOG000252946
HOVERGENiHBG052161
InParanoidiQ80ZQ5
KOiK19495
OMAiQHIEDNH
OrthoDBiEOG091G0WNP
PhylomeDBiQ80ZQ5
TreeFamiTF324161

Miscellaneous databases

ChiTaRSiJazf1 mouse
PROiPR:Q80ZQ5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063568 Expressed in 217 organ(s), highest expression level in brain
CleanExiMM_JAZF1
GenevisibleiQ80ZQ5 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiJAZF1_MOUSE
AccessioniPrimary (citable) accession number: Q80ZQ5
Secondary accession number(s): Q8BLQ8, Q8BWN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: July 11, 2003
Last modified: November 7, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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