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Protein

Inositol-trisphosphate 3-kinase C

Gene

Itpkc

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate.1 Publication

Catalytic activityi

ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.

Activity regulationi

Activated by Ca2+/calmodulin. Inhibited by high concentrations of the substrate Ins(1,2,4)P3, and allosterically activated by the product Ins(1,3,4,5)P4.

Kineticsi

  1. KM=0.2 µM for Ins(1,4,5)P31 Publication
  2. KM=1.5 µM for Ins(2,4,5)P31 Publication
  3. KM=33 µM for ATP1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Binding sitei426ATPBy similarity1
    Binding sitei479ATPBy similarity1
    Binding sitei481SubstrateBy similarity1
    Binding sitei553ATPBy similarity1
    Binding sitei633ATPBy similarity1
    Binding sitei636SubstrateBy similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Nucleotide bindingi466 – 468ATPBy similarity3

    GO - Molecular functioni

    GO - Biological processi

    Keywordsi

    Molecular functionCalmodulin-binding, Kinase, Transferase
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.1.127 5301
    SABIO-RKiQ80ZG2

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inositol-trisphosphate 3-kinase C (EC:2.7.1.127)
    Alternative name(s):
    Inositol 1,4,5-trisphosphate 3-kinase C
    Short name:
    IP3 3-kinase C
    Short name:
    IP3K C
    Short name:
    InsP 3-kinase C
    Gene namesi
    Name:Itpkc
    Synonyms:Ip3kc
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
    Proteomesi
    • UP000002494 Componenti: Chromosome 1

    Organism-specific databases

    RGDi631336 Itpkc

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Mutagenesisi318 – 326Missing : No export in the cytoplasm. 1 Publication9
    Mutagenesisi318 – 321LCPV → ACPA: No export in the cytoplasm. 1 Publication4

    Chemistry databases

    ChEMBLiCHEMBL2667

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00002340721 – 678Inositol-trisphosphate 3-kinase CAdd BLAST678

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei160PhosphoserineBy similarity1
    Modified residuei398PhosphoserineBy similarity1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ80ZG2
    PRIDEiQ80ZG2

    PTM databases

    CarbonylDBiQ80ZG2
    iPTMnetiQ80ZG2
    PhosphoSitePlusiQ80ZG2

    Expressioni

    Tissue specificityi

    Highly expressed in tongue epithelium, taste papilla, heart, brain and testis. Weakly expressed in lung, liver and kidney.1 Publication

    Gene expression databases

    BgeeiENSRNOG00000013945 Expressed in 10 organ(s), highest expression level in colon
    GenevisibleiQ80ZG2 RN

    Interactioni

    GO - Molecular functioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000018696

    Chemistry databases

    BindingDBiQ80ZG2

    Structurei

    3D structure databases

    ProteinModelPortaliQ80ZG2
    SMRiQ80ZG2
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Regioni502 – 508Substrate bindingBy similarity7
    Regioni504 – 512Calmodulin-bindingBy similarity9
    Regioni529 – 536Substrate bindingBy similarity8

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Motifi318 – 326Nuclear export signal9

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiKOG1621 Eukaryota
    ENOG410Y8AC LUCA
    GeneTreeiENSGT00390000017438
    HOGENOMiHOG000113089
    HOVERGENiHBG081804
    InParanoidiQ80ZG2
    KOiK00911
    OMAiMRRCPCR
    OrthoDBiEOG091G03J3
    PhylomeDBiQ80ZG2
    TreeFamiTF318394

    Family and domain databases

    Gene3Di1.10.510.50, 1 hit
    InterProiView protein in InterPro
    IPR005522 IPK
    IPR038286 IPK_sf
    PANTHERiPTHR12400 PTHR12400, 1 hit
    PfamiView protein in Pfam
    PF03770 IPK, 1 hit

    Sequencei

    Sequence statusi: Complete.

    Q80ZG2-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MRRCPCRGSL SEAEAGALPA EARMGLEALR GGRRRQPGLQ RPGPGAGGPT
    60 70 80 90 100
    GRPEGGGPRA WIEGFSLHSE AERTDFGPAP CPDGPQAEPC GDEHEECEAA
    110 120 130 140 150
    GLGVASEKPS QNKELDGSNL QTHPKLSSPL AEMEMAGSWT DGFRTDLHRP
    160 170 180 190 200
    DLQARPKRAS LCTQPGFDES WTELDRSELW QTLPERDKPW VDHLRTHQDM
    210 220 230 240 250
    SRLQNHPACP SPEPSAGTSC KELSADGSRT PHDTDGFWIE SQTDGSLIGP
    260 270 280 290 300
    STQTACRQPA NDGFSAQDTD GTLIQPGTDD GPWVDSVLEK SNGDDPLMEP
    310 320 330 340 350
    EPRDLVTNLC SHLECSSLCP VPRLIITSES PEPGAQPLGP QARIEGGTGG
    360 370 380 390 400
    FSSASSFDES EDDLVAGGGG TSDPEDRSGS KPWKKLKTVL KYSPFVVSFH
    410 420 430 440 450
    KHYYPWVQLS GHAGNFQAGE DGRILKRFCQ CEQRSLELLM GDPLRPFVPT
    460 470 480 490 500
    YYGMVQRDGQ AFNQMEDLLA DFEGPSIMDC KMGSRTYLEE ELVKARERPK
    510 520 530 540 550
    PRKDMYEKMV AVDPGAPTPE EHAQGAVTKP RYMQWRETLS STSTLGFRIE
    560 570 580 590 600
    GIKKADGTCN TNFKKTQALE QVTKVLEDFV NGDVGILRKY VARLEDLRDT
    610 620 630 640 650
    LENSPFFKTH EVVGSSLLFV HDHTGLAKVW MIDFGKTVAL PDHQMLSHRL
    660 670
    PWAEGNREDG YLWGLDNLIC LLQGLAQS
    Length:678
    Mass (Da):74,463
    Last modified:June 1, 2003 - v1
    Checksum:i5EDEA14255DACD2B
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AY160770 mRNA Translation: AAO20335.1
    AJ440782 mRNA Translation: CAD29464.1
    RefSeqiNP_835195.1, NM_178094.3
    UniGeneiRn.85907

    Genome annotation databases

    EnsembliENSRNOT00000018696; ENSRNOP00000018696; ENSRNOG00000013945
    GeneIDi308451
    KEGGirno:308451
    UCSCiRGD:631336 rat

    Similar proteinsi

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AY160770 mRNA Translation: AAO20335.1
    AJ440782 mRNA Translation: CAD29464.1
    RefSeqiNP_835195.1, NM_178094.3
    UniGeneiRn.85907

    3D structure databases

    ProteinModelPortaliQ80ZG2
    SMRiQ80ZG2
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000018696

    Chemistry databases

    BindingDBiQ80ZG2
    ChEMBLiCHEMBL2667

    PTM databases

    CarbonylDBiQ80ZG2
    iPTMnetiQ80ZG2
    PhosphoSitePlusiQ80ZG2

    Proteomic databases

    PaxDbiQ80ZG2
    PRIDEiQ80ZG2

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENSRNOT00000018696; ENSRNOP00000018696; ENSRNOG00000013945
    GeneIDi308451
    KEGGirno:308451
    UCSCiRGD:631336 rat

    Organism-specific databases

    CTDi80271
    RGDi631336 Itpkc

    Phylogenomic databases

    eggNOGiKOG1621 Eukaryota
    ENOG410Y8AC LUCA
    GeneTreeiENSGT00390000017438
    HOGENOMiHOG000113089
    HOVERGENiHBG081804
    InParanoidiQ80ZG2
    KOiK00911
    OMAiMRRCPCR
    OrthoDBiEOG091G03J3
    PhylomeDBiQ80ZG2
    TreeFamiTF318394

    Enzyme and pathway databases

    BRENDAi2.7.1.127 5301
    SABIO-RKiQ80ZG2

    Miscellaneous databases

    PROiPR:Q80ZG2

    Gene expression databases

    BgeeiENSRNOG00000013945 Expressed in 10 organ(s), highest expression level in colon
    GenevisibleiQ80ZG2 RN

    Family and domain databases

    Gene3Di1.10.510.50, 1 hit
    InterProiView protein in InterPro
    IPR005522 IPK
    IPR038286 IPK_sf
    PANTHERiPTHR12400 PTHR12400, 1 hit
    PfamiView protein in Pfam
    PF03770 IPK, 1 hit
    ProtoNetiSearch...

    Entry informationi

    Entry nameiIP3KC_RAT
    AccessioniPrimary (citable) accession number: Q80ZG2
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: June 1, 2003
    Last modified: September 12, 2018
    This is version 95 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

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