Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Membrane progestin receptor beta

Gene

Paqr8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway (By similarity). May be involved in oocyte maturation (PubMed:12601167). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (By similarity).By similarity1 Publication

Miscellaneous

Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).By similarity

GO - Molecular functioni

  • signaling receptor activity Source: GO_Central
  • steroid binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Receptor
Biological processDifferentiation, Oogenesis
LigandLipid-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane progestin receptor betaBy similarity
Short name:
mPR betaBy similarity
Alternative name(s):
Lysosomal membrane protein in brain 11 Publication
Membrane progesterone P4 receptor betaBy similarity
Membrane progesterone receptor betaBy similarity
Progesterone and adipoQ receptor family member 8
Progestin and adipoQ receptor family member 8By similarity
Progestin and adipoQ receptor family member VIII
Gene namesi
Name:Paqr8Imported
Synonyms:Mprb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1921479 Paqr8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 76CytoplasmicSequence analysisAdd BLAST76
Transmembranei77 – 97Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini98 – 111ExtracellularSequence analysisAdd BLAST14
Transmembranei112 – 132Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini133 – 173CytoplasmicSequence analysisAdd BLAST41
Transmembranei174 – 194Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini195 – 213ExtracellularSequence analysisAdd BLAST19
Transmembranei214 – 234Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini235 – 243CytoplasmicSequence analysis9
Transmembranei244 – 264Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini265 – 283ExtracellularSequence analysisAdd BLAST19
Transmembranei284 – 304Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini305 – 315CytoplasmicSequence analysisAdd BLAST11
Transmembranei316 – 336Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini337 – 354ExtracellularSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002188411 – 354Membrane progestin receptor betaAdd BLAST354

Proteomic databases

MaxQBiQ80ZE5
PaxDbiQ80ZE5
PRIDEiQ80ZE5

PTM databases

iPTMnetiQ80ZE5
PhosphoSitePlusiQ80ZE5

Expressioni

Tissue specificityi

Expressed in brain and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000025931 Expressed in 198 organ(s), highest expression level in cerebellum
CleanExiMM_PAQR8
GenevisibleiQ80ZE5 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069127

Structurei

3D structure databases

ProteinModelPortaliQ80ZE5
SMRiQ80ZE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0748 Eukaryota
COG1272 LUCA
GeneTreeiENSGT00530000062965
HOGENOMiHOG000230872
HOVERGENiHBG052504
InParanoidiQ80ZE5
OMAiREPYIHA
OrthoDBiEOG091G0QDA
PhylomeDBiQ80ZE5
TreeFamiTF319738

Family and domain databases

InterProiView protein in InterPro
IPR004254 AdipoR/HlyIII-related
PANTHERiPTHR20855 PTHR20855, 1 hit
PfamiView protein in Pfam
PF03006 HlyIII, 1 hit

Sequencei

Sequence statusi: Complete.

Q80ZE5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTAILERLS TLSMSGQQLR RLPKILEEGL PKMPCTVPET DVPQLFREPY
60 70 80 90 100
IHAGYRPTGH EWRYYFFSLF QKHNEVVNVW THLLAALAVL LRFWAFVEAG
110 120 130 140 150
ALQWASPHTL PLLLFILSSI TYLTCSLLAH LLQSKSELSH YTFYFVDYVG
160 170 180 190 200
VSVYQYGSAL AHFFYSSDQA WYELFWIFFL PAAAFCGWLS CAGCCYAKYR
210 220 230 240 250
YRRPYPVMRK ICQVVPAGLA FVLDISPVAH RVALCHLAGC QEQAAWYHTL
260 270 280 290 300
QILFFLVSAY FFSCPVPEKY FPGSCDIVGH GHQIFHAFLS VCTLSQLEAI
310 320 330 340 350
LLDYQGRHEI FLQRHGPLSV YSACLSFFVL AACSAATATL LRHKVKDRLI

KKDS
Length:354
Mass (Da):40,430
Last modified:August 16, 2004 - v2
Checksum:i14544CBB3338B538
GO

Sequence cautioni

The sequence BAC27629 differs from that shown. Reason: Frameshift at position 324.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41D → G in AAR08385 (PubMed:16141072).Curated1
Sequence conflicti41D → G in BAC33221 (PubMed:16141072).Curated1
Sequence conflicti116I → V in AAO47230 (PubMed:12601167).Curated1
Sequence conflicti177I → L in AAO47230 (PubMed:12601167).Curated1
Sequence conflicti339T → S in AAO47230 (PubMed:12601167).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF313617 mRNA Translation: AAO47230.1
AY424297 mRNA Translation: AAR08385.1
AK006107 mRNA Translation: BAB24412.1
AK029772 mRNA Translation: BAC26609.1
AK031969 mRNA Translation: BAC27629.1 Frameshift.
AK048045 mRNA Translation: BAC33221.1
AK147376 mRNA Translation: BAE27872.1
BC059813 mRNA Translation: AAH59813.1
CCDSiCCDS14844.1
RefSeqiNP_083105.3, NM_028829.3
XP_006495640.1, XM_006495577.2
XP_006495641.1, XM_006495578.3
UniGeneiMm.40780

Genome annotation databases

EnsembliENSMUST00000068880; ENSMUSP00000069127; ENSMUSG00000025931
ENSMUST00000167119; ENSMUSP00000128781; ENSMUSG00000025931
ENSMUST00000187651; ENSMUSP00000140913; ENSMUSG00000025931
ENSMUST00000189400; ENSMUSP00000141054; ENSMUSG00000025931
GeneIDi74229
KEGGimmu:74229
UCSCiuc007ald.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF313617 mRNA Translation: AAO47230.1
AY424297 mRNA Translation: AAR08385.1
AK006107 mRNA Translation: BAB24412.1
AK029772 mRNA Translation: BAC26609.1
AK031969 mRNA Translation: BAC27629.1 Frameshift.
AK048045 mRNA Translation: BAC33221.1
AK147376 mRNA Translation: BAE27872.1
BC059813 mRNA Translation: AAH59813.1
CCDSiCCDS14844.1
RefSeqiNP_083105.3, NM_028829.3
XP_006495640.1, XM_006495577.2
XP_006495641.1, XM_006495578.3
UniGeneiMm.40780

3D structure databases

ProteinModelPortaliQ80ZE5
SMRiQ80ZE5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069127

PTM databases

iPTMnetiQ80ZE5
PhosphoSitePlusiQ80ZE5

Proteomic databases

MaxQBiQ80ZE5
PaxDbiQ80ZE5
PRIDEiQ80ZE5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068880; ENSMUSP00000069127; ENSMUSG00000025931
ENSMUST00000167119; ENSMUSP00000128781; ENSMUSG00000025931
ENSMUST00000187651; ENSMUSP00000140913; ENSMUSG00000025931
ENSMUST00000189400; ENSMUSP00000141054; ENSMUSG00000025931
GeneIDi74229
KEGGimmu:74229
UCSCiuc007ald.1 mouse

Organism-specific databases

CTDi85315
MGIiMGI:1921479 Paqr8

Phylogenomic databases

eggNOGiKOG0748 Eukaryota
COG1272 LUCA
GeneTreeiENSGT00530000062965
HOGENOMiHOG000230872
HOVERGENiHBG052504
InParanoidiQ80ZE5
OMAiREPYIHA
OrthoDBiEOG091G0QDA
PhylomeDBiQ80ZE5
TreeFamiTF319738

Miscellaneous databases

PROiPR:Q80ZE5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025931 Expressed in 198 organ(s), highest expression level in cerebellum
CleanExiMM_PAQR8
GenevisibleiQ80ZE5 MM

Family and domain databases

InterProiView protein in InterPro
IPR004254 AdipoR/HlyIII-related
PANTHERiPTHR20855 PTHR20855, 1 hit
PfamiView protein in Pfam
PF03006 HlyIII, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPAQR8_MOUSE
AccessioniPrimary (citable) accession number: Q80ZE5
Secondary accession number(s): Q3UHI5
, Q8C891, Q8CCW9, Q9DA71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 7, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again