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Protein

Membrane progestin receptor alpha

Gene

Paqr7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway. May be involved in oocyte maturation. Involved in neurosteroid inhibition of apoptosis. Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone.By similarity

Miscellaneous

Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).By similarity

GO - Molecular functioni

  • signaling receptor activity Source: GO_Central
  • steroid binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Receptor
Biological processDifferentiation, Oogenesis
LigandLipid-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane progestin receptor alphaBy similarity
Short name:
mPR alphaBy similarity
Alternative name(s):
Membrane progesterone P4 receptor alphaBy similarity
Membrane progesterone receptor alphaBy similarity
PPAR-gamma-induced liver protein1 Publication
Progesterone and adipoQ receptor family member 7
Progestin and adipoQ receptor family member 7By similarity
Progestin and adipoQ receptor family member VII
Gene namesi
Name:Paqr7Imported
Synonyms:Mpra, Pglp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1919154 Paqr7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 74CytoplasmicSequence analysisAdd BLAST74
Transmembranei75 – 95Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini96 – 102ExtracellularSequence analysis7
Transmembranei103 – 123Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini124 – 136CytoplasmicSequence analysisAdd BLAST13
Transmembranei137 – 157Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini158 – 168ExtracellularSequence analysisAdd BLAST11
Transmembranei169 – 189Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini190 – 243CytoplasmicSequence analysisAdd BLAST54
Transmembranei244 – 264Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini265 – 268ExtracellularSequence analysis4
Transmembranei269 – 289Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini290 – 315CytoplasmicSequence analysisAdd BLAST26
Transmembranei316 – 336Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini337 – 345ExtracellularSequence analysis9

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002188361 – 345Membrane progestin receptor alphaAdd BLAST345

Proteomic databases

MaxQBiQ80ZE4
PaxDbiQ80ZE4
PRIDEiQ80ZE4

PTM databases

iPTMnetiQ80ZE4
PhosphoSitePlusiQ80ZE4

Expressioni

Tissue specificityi

Detected in most adult tissues. Higher expression found in white fat and liver than brown fat and skeletal muscle.1 Publication

Inductioni

Up-regulated in PPAR gamma 1-induced adipogenic liver.1 Publication

Gene expression databases

BgeeiENSMUSG00000037348 Expressed in 228 organ(s), highest expression level in zone of skin
CleanExiMM_PAQR7
ExpressionAtlasiQ80ZE4 baseline and differential
GenevisibleiQ80ZE4 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080240

Structurei

3D structure databases

ProteinModelPortaliQ80ZE4
SMRiQ80ZE4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0748 Eukaryota
COG1272 LUCA
GeneTreeiENSGT00530000062965
HOGENOMiHOG000230872
HOVERGENiHBG052504
InParanoidiQ80ZE4
OMAiYCLDISP
OrthoDBiEOG091G0QDA
PhylomeDBiQ80ZE4
TreeFamiTF319738

Family and domain databases

InterProiView protein in InterPro
IPR004254 AdipoR/HlyIII-related
PANTHERiPTHR20855 PTHR20855, 1 hit
PfamiView protein in Pfam
PF03006 HlyIII, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q80ZE4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMAVAQKFN HLLSSLWHVG QKPPQPEPVF TVDRAQVPPL FWKPYIYAGY
60 70 80 90 100
RPLHQNWCFY FRTLFQRHNE AVNVWTHLLA ALALLLRLIG LAASVDFRED
110 120 130 140 150
PHALPLFFIV LASFTYLSFS AVAHLLQAKS EFWHYSFFFL DYVGVAVYQF
160 170 180 190 200
GSALAHFYYA IEPSWHDKVQ AIFLPTAAFL AWLSCAGSCY NKYSQKPGLL
210 220 230 240 250
GRIFQEAPSA LAYVLDISPV LHRIIVSPLP AEEDPALLYH KCQVVFFLLA
260 270 280 290 300
AAFFSTVMPE SWFPGSCHIF GQGHQVFHVF LVLCTLAQLE AVTLDYQARR
310 320 330 340
GIYEPLHARW PHNFSGLFLL TVASSSLTAL LLSQLVRRKL HQKTK
Length:345
Mass (Da):39,306
Last modified:August 16, 2004 - v2
Checksum:iE7618A57C57B417B
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z7K5D3Z7K5_MOUSE
Membrane progestin receptor alpha
Paqr7
237Annotation score:
D3Z5A3D3Z5A3_MOUSE
Membrane progestin receptor alpha
Paqr7
147Annotation score:
D3YZW6D3YZW6_MOUSE
Membrane progestin receptor alpha
Paqr7
127Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti280F → L in AAO47231 (PubMed:12601167).Curated1
Sequence conflicti312H → R in AAO47231 (PubMed:12601167).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF313618 mRNA Translation: AAO47231.1
AY278956 mRNA Translation: AAP35062.1
AY424296 mRNA Translation: AAR08384.1
AK009450 mRNA Translation: BAB26296.1
AK170307 mRNA Translation: BAE41704.1
BC022922 mRNA Translation: AAH22922.1
CCDSiCCDS18773.1
RefSeqiNP_001272774.1, NM_001285845.1
NP_001272775.1, NM_001285846.1
NP_001272776.1, NM_001285847.1
NP_001272778.1, NM_001285849.1
NP_082271.1, NM_027995.3
XP_006539254.1, XM_006539191.3
UniGeneiMm.142343

Genome annotation databases

EnsembliENSMUST00000081525; ENSMUSP00000080240; ENSMUSG00000037348
ENSMUST00000095074; ENSMUSP00000125932; ENSMUSG00000037348
GeneIDi71904
KEGGimmu:71904
UCSCiuc008vfd.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF313618 mRNA Translation: AAO47231.1
AY278956 mRNA Translation: AAP35062.1
AY424296 mRNA Translation: AAR08384.1
AK009450 mRNA Translation: BAB26296.1
AK170307 mRNA Translation: BAE41704.1
BC022922 mRNA Translation: AAH22922.1
CCDSiCCDS18773.1
RefSeqiNP_001272774.1, NM_001285845.1
NP_001272775.1, NM_001285846.1
NP_001272776.1, NM_001285847.1
NP_001272778.1, NM_001285849.1
NP_082271.1, NM_027995.3
XP_006539254.1, XM_006539191.3
UniGeneiMm.142343

3D structure databases

ProteinModelPortaliQ80ZE4
SMRiQ80ZE4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080240

PTM databases

iPTMnetiQ80ZE4
PhosphoSitePlusiQ80ZE4

Proteomic databases

MaxQBiQ80ZE4
PaxDbiQ80ZE4
PRIDEiQ80ZE4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000081525; ENSMUSP00000080240; ENSMUSG00000037348
ENSMUST00000095074; ENSMUSP00000125932; ENSMUSG00000037348
GeneIDi71904
KEGGimmu:71904
UCSCiuc008vfd.2 mouse

Organism-specific databases

CTDi164091
MGIiMGI:1919154 Paqr7

Phylogenomic databases

eggNOGiKOG0748 Eukaryota
COG1272 LUCA
GeneTreeiENSGT00530000062965
HOGENOMiHOG000230872
HOVERGENiHBG052504
InParanoidiQ80ZE4
OMAiYCLDISP
OrthoDBiEOG091G0QDA
PhylomeDBiQ80ZE4
TreeFamiTF319738

Miscellaneous databases

ChiTaRSiPaqr7 mouse
PROiPR:Q80ZE4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037348 Expressed in 228 organ(s), highest expression level in zone of skin
CleanExiMM_PAQR7
ExpressionAtlasiQ80ZE4 baseline and differential
GenevisibleiQ80ZE4 MM

Family and domain databases

InterProiView protein in InterPro
IPR004254 AdipoR/HlyIII-related
PANTHERiPTHR20855 PTHR20855, 1 hit
PfamiView protein in Pfam
PF03006 HlyIII, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPAQR7_MOUSE
AccessioniPrimary (citable) accession number: Q80ZE4
Secondary accession number(s): Q3TDA0, Q8BNZ7, Q9D790
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 7, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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