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Entry version 113 (16 Oct 2019)
Sequence version 1 (01 Jun 2003)
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Protein

Sodium-driven chloride bicarbonate exchanger

Gene

Slc4a10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH (PubMed:10993873, PubMed:20566632, PubMed:23409100). Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (PubMed:10993873, PubMed:20566632). Has also been shown to act as a sodium/biocarbonate cotransporter which does not couple net influx of bicarbonate to net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange (By similarity). Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid (By similarity). Reduces the excitability of CA1 pyramidal neurons and modulates short-term synaptic plasticity (By similarity). Required in retinal cells to maintain normal pH which is necessary for normal vision (By similarity). In the kidney, likely to mediate bicarbonate reclamation in the apical membrane of the proximal tubules (PubMed:28280139).By similarity4 Publications

Caution

Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (PubMed:10993873, PubMed:20566632). Has also been shown to act as a sodium/biocarbonate cotransporter which is not responsible for net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange (By similarity).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiport, Ion transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-425381 Bicarbonate transporters

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium-driven chloride bicarbonate exchanger1 Publication
Alternative name(s):
Solute carrier family 4 member 10Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc4a10Imported
Synonyms:Ncbe1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Rat genome database

More...
RGDi
631407 Slc4a10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 508CytoplasmicSequence analysisAdd BLAST508
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei509 – 529HelicalSequence analysisAdd BLAST21
Topological domaini530 – 537ExtracellularSequence analysis8
Transmembranei538 – 558HelicalSequence analysisAdd BLAST21
Topological domaini559 – 561CytoplasmicSequence analysis3
Transmembranei562 – 582HelicalSequence analysisAdd BLAST21
Topological domaini583 – 595ExtracellularSequence analysisAdd BLAST13
Transmembranei596 – 616HelicalSequence analysisAdd BLAST21
Topological domaini617 – 625CytoplasmicSequence analysis9
Transmembranei626 – 646HelicalSequence analysisAdd BLAST21
Topological domaini647 – 719ExtracellularSequence analysisAdd BLAST73
Transmembranei720 – 740HelicalSequence analysisAdd BLAST21
Topological domaini741 – 761CytoplasmicSequence analysisAdd BLAST21
Transmembranei762 – 782HelicalSequence analysisAdd BLAST21
Topological domaini783 – 808ExtracellularSequence analysisAdd BLAST26
Transmembranei809 – 829HelicalSequence analysisAdd BLAST21
Topological domaini830 – 854CytoplasmicSequence analysisAdd BLAST25
Transmembranei855 – 875HelicalSequence analysisAdd BLAST21
Topological domaini876 – 911ExtracellularSequence analysisAdd BLAST36
Transmembranei912 – 932HelicalSequence analysisAdd BLAST21
Topological domaini933 – 934CytoplasmicSequence analysis2
Transmembranei935 – 955HelicalSequence analysisAdd BLAST21
Topological domaini956 – 997ExtracellularSequence analysisAdd BLAST42
Transmembranei998 – 1018HelicalSequence analysisAdd BLAST21
Topological domaini1019 – 1117CytoplasmicSequence analysisAdd BLAST99

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002452421 – 1117Sodium-driven chloride bicarbonate exchangerAdd BLAST1117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei89PhosphoserineCombined sources1
Modified residuei94PhosphothreonineBy similarity1
Modified residuei275PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi676N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi686N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi696N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1056PhosphoserineBy similarity1
Modified residuei1084PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q80ZA5

PRoteomics IDEntifications database

More...
PRIDEi
Q80ZA5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q80ZA5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q80ZA5

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q80ZA5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In the brain, detected in cerebral cortex, subcortex, cerebellum, hippocampus and medulla (at protein level) (PubMed:18061361). Expressed in neurons but not in astrocytes (at protein level) (PubMed:18061361). Isoforms starting with Met-Glu-Ile-Lys are found predominantly in the brain with lower levels in the eye while isoforms starting with Met-Cys-Asp-Leu are most abundant in the kidney with lower levels in the duodenum, jejunum and ileum (at protein level) (PubMed:23409100). In the kidney, isoforms starting with Met-Cys-Asp-Leu are primarily expressed in the cortex, the outer stripe of the outer medulla and the inner stripe of the outer medulla (ISOM) but are not detectable in the inner medulla (IM) while isoforms starting with Met-Glu-Ile-Lys are predominantly expressed in the ISOM and IM (PubMed:28280139). Expressed in the brain, in the hippocampus as well as in dentate gyrus, cortical layers, cerebellum, olfactory bulb and in the epithelial cells of the choroid plexus. Detected in pituitary, testis, kidney and ileum. Detected also in spleen and lung.6 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in spinal cord and brain at E19 through adulthood.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000005307 Expressed in 4 organ(s), highest expression level in Ammon's horn

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Slc9a3r1P704413EBI-8613086,EBI-1184085From Mus musculus.

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q80ZA5, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000059155

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q80ZA5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal cytoplasmic domain is likely to have a high level of intrinsic disorder.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1172 Eukaryota
ENOG410XPHD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156972

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q80ZA5

KEGG Orthology (KO)

More...
KOi
K13861

Identification of Orthologs from Complete Genome Data

More...
OMAi
LMDFFFT

Database of Orthologous Groups

More...
OrthoDBi
265068at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q80ZA5

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013769 Band3_cytoplasmic_dom
IPR011531 HCO3_transpt_C
IPR003020 HCO3_transpt_euk
IPR003024 Na/HCO3_transpt
IPR016152 PTrfase/Anion_transptr

The PANTHER Classification System

More...
PANTHERi
PTHR11453 PTHR11453, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07565 Band_3_cyto, 1 hit
PF00955 HCO3_cotransp, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01231 HCO3TRNSPORT
PR01232 NAHCO3TRSPRT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55804 SSF55804, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00834 ae, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (11+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 11 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket
Note: The use of 2 alternative promoters gives rise to isoforms which differ at the N-terminus. In addition, alternative splicing gives rise to further isoform diversity.1 Publication

This entry has 11 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q80ZA5-1) [UniParc]FASTAAdd to basket
Also known as: rb1NCBE

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEIKDQGAQM EPLLPTRNDE EAVVDRGGTR SILKTHFEKE DLEGHRTLFI
60 70 80 90 100
GVHVPLGGRK SHRRHRHRGH KHRKRDRERD SGLEDGGESP SFDTPSQRVQ
110 120 130 140 150
FILGTEDDDE EHIPHDLFTE LDEICWREGE DAEWRETARW LKFEEDVEDG
160 170 180 190 200
GERWSKPYVA TLSLHSLFEL RSCILNGTVL LDMHANTLEE IADMVLDQQV
210 220 230 240 250
SSGQLNEDVR HRVHEALMKQ HHHQSQKKLT NRIPIVRSFA DIGKKQSEPN
260 270 280 290 300
SMDKNGQVVS PQSAPACAEN KNDVSRENST VDFSKGLGGQ QKGHTSPCGM
310 320 330 340 350
KQRLDKGPPH QQEREVDLHF MKKIPPGAEA SNILVGELEF LDRTVVAFVR
360 370 380 390 400
LSPAVLLQGL AEVPIPSRFL FILLGPLGKG QQYHEIGRSI ATLMTDEVFH
410 420 430 440 450
DVAYKAKDRN DLVSGIDEFL DQVTVLPPGE WDPSIRIEPP KNVPSQEKRK
460 470 480 490 500
TPSLPNGTAA HGGPEQHGGH SGPELQRTGR IFGGLILDIK RKAPFFWSDF
510 520 530 540 550
RDAFSLQCLA SFLFLYCACM SPVITFGGLL GEATEGRISA IESLFGASMT
560 570 580 590 600
GIAYSLFGGQ PLTILGSTGP VLVFEKILFK FCKEYGLSYL SLRASIGLWT
610 620 630 640 650
ATLCIILVAT DASSLVCYIT RFTEEAFASL ICIIFIYEAL EKLFELSESY
660 670 680 690 700
PINMHNDLEL LTQYSCNCME PHSPSNDTLK EWRESNISAS DIIWGNLTVS
710 720 730 740 750
ECRSLHGEYV GRACGHGHPY VPDVLFWSVI LFFSTVTMSA TLKQFKTSRY
760 770 780 790 800
FPTKVRSIVS DFAVFLTILC MVLIDYAIGI PSPKLQVPSV FKPTRDDRGW
810 820 830 840 850
FVTPLGPNPW WTIIAAIIPA LLCTILIFMD QQITAVIINR KEHKLKKGCG
860 870 880 890 900
YHLDLLMVAV MLGVCSIMGL PWFVAATVLS ITHVNSLKLE SECSAPGEQP
910 920 930 940 950
KFLGIREQRV TGLMIFILMG SSVFMTSILK FIPMPVLYGV FLYMGASSLK
960 970 980 990 1000
GIQLFDRIKL FWMPAKHQPD FIYLRHVPLR KVHLFTVIQM SCLGLLWIIK
1010 1020 1030 1040 1050
VSRAAIVFPM MVLALVFVRK LMDFLFTKRE LSWLDDLMPE SKKKKLEDAE
1060 1070 1080 1090 1100
KEEEQSMLAM EDEGTVQLPL EGHYRDDPSV INISDEMSKT AMWGNLLVTA
1110
DNSKEKESRF PSKSSPS
Length:1,117
Mass (Da):125,639
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i51A27EFE653C3232
GO
Isoform 2 (identifier: Q80ZA5-2) [UniParc]FASTAAdd to basket
Also known as: rb4NCBE

The sequence of this isoform differs from the canonical sequence as follows:
     255-255: N → NA
     286-315: Missing.
     1115-1117: SPS → IESRKEKKADSGKGVDRETCL

Show »
Length:1,106
Mass (Da):124,503
Checksum:iCAB2CBDFB0876AC5
GO
Isoform 3 (identifier: Q80ZA5-3) [UniParc]FASTAAdd to basket
Also known as: rb2NCBE

The sequence of this isoform differs from the canonical sequence as follows:
     286-315: Missing.
     1115-1117: SPS → IESRKEKKADSGKGVDRETCL

Show »
Length:1,105
Mass (Da):124,432
Checksum:i50357AD41747F888
GO
Isoform 4 (identifier: Q80ZA5-4) [UniParc]FASTAAdd to basket
Also known as: rb5NCBE

The sequence of this isoform differs from the canonical sequence as follows:
     255-255: N → NA
     286-315: Missing.

Show »
Length:1,088
Mass (Da):122,442
Checksum:iF676A4A5382C6F94
GO
Isoform 5 (identifier: Q80ZA5-5) [UniParc]FASTAAdd to basket
Also known as: rb3NCBE

The sequence of this isoform differs from the canonical sequence as follows:
     255-255: N → NA
     1053-1053: E → H
     1054-1117: Missing.

Show »
Length:1,054
Mass (Da):118,620
Checksum:i2B28DC19A9796AC7
GO
Isoform 6 (identifier: Q80ZA5-6) [UniParc]FASTAAdd to basket
Also known as: rb6NCBE

The sequence of this isoform differs from the canonical sequence as follows:
     255-255: N → NA
     286-315: Missing.
     603-607: LCIIL → FLPLT
     608-1117: Missing.

Show »
Length:578
Mass (Da):64,626
Checksum:iB2CCECF7A9D82529
GO
Isoform 7 (identifier: Q80ZA5-7) [UniParc]FASTAAdd to basket
Also known as: rb7NCBE

The sequence of this isoform differs from the canonical sequence as follows:
     255-255: N → NA
     286-315: Missing.
     481-498: IFGGLILDIKRKAPFFWS → SPISGIFASPEFFHRLCG
     499-1117: Missing.

Show »
Length:469
Mass (Da):52,759
Checksum:iC527F48F7343A7E0
GO
Isoform 8 (identifier: Q80ZA5-8) [UniParc]FASTAAdd to basket
Also known as: NBCn2-E1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MEIKDQGAQMEPLLPT → MCDLAGISGNRKVMQPGTCEHFQSLGQE
     255-255: N → NA
     286-315: Missing.

Show »
Length:1,100
Mass (Da):123,679
Checksum:i5E64245CC65A492E
GO
Isoform 9 (identifier: Q80ZA5-9) [UniParc]FASTAAdd to basket
Also known as: NBCn2-F1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MEIKDQGAQMEPLLPT → MCDLAGISGNRKVMQPGTCEHFQSLGQE

Show »
Length:1,129
Mass (Da):126,875
Checksum:iDD4C89A3A0093B5E
GO
Isoform 10 (identifier: Q80ZA5-10) [UniParc]FASTAAdd to basket
Also known as: NBCn2-G1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MEIKDQGAQMEPLLPT → MCDLAGISGNRKVMQPGTCEHFQSLGQE
     255-255: N → NA
     286-315: Missing.
     1115-1117: SPS → IESRKEKKADSGKGVDRETCL

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Length:1,118
Mass (Da):125,739
Checksum:iCBE167A1C8C3F529
GO
Isoform 11 (identifier: Q80ZA5-11) [UniParc]FASTAAdd to basket
Also known as: NBCn2-H1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MEIKDQGAQMEPLLPT → MCDLAGISGNRKVMQPGTCEHFQSLGQE
     1115-1117: SPS → IESRKEKKADSGKGVDRETCL

Show »
Length:1,147
Mass (Da):128,936
Checksum:i3E9223CCC4594811
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
W0NXI0W0NXI0_RAT
Anion exchange protein
Slc4a10 NCBE
954Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D4AD03D4AD03_RAT
Anion exchange protein
Slc4a10
1,101Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JYF0A0A0G2JYF0_RAT
Anion exchange protein
Slc4a10
1,118Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
W0NT44W0NT44_RAT
Anion exchange protein
Slc4a10 NCBE
915Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0601351 – 16MEIKD…PLLPT → MCDLAGISGNRKVMQPGTCE HFQSLGQE in isoform 8, isoform 9, isoform 10 and isoform 11. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_019655255N → NA in isoform 2, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 10. 2 Publications1
Alternative sequenceiVSP_019656286 – 315Missing in isoform 2, isoform 3, isoform 4, isoform 6, isoform 7, isoform 8 and isoform 10. 3 PublicationsAdd BLAST30
Alternative sequenceiVSP_019657481 – 498IFGGL…PFFWS → SPISGIFASPEFFHRLCG in isoform 7. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_019658499 – 1117Missing in isoform 7. 1 PublicationAdd BLAST619
Alternative sequenceiVSP_019659603 – 607LCIIL → FLPLT in isoform 6. 1 Publication5
Alternative sequenceiVSP_019660608 – 1117Missing in isoform 6. 1 PublicationAdd BLAST510
Alternative sequenceiVSP_0196611053E → H in isoform 5. 1 Publication1
Alternative sequenceiVSP_0196621054 – 1117Missing in isoform 5. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_0196631115 – 1117SPS → IESRKEKKADSGKGVDRETC L in isoform 2, isoform 3, isoform 10 and isoform 11. 3 Publications3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF439855 mRNA Translation: AAO59639.1
AF439856 mRNA Translation: AAO59640.1
JX073715 mRNA Translation: AFP48940.1
JX073716 mRNA Translation: AFP48941.2
JX073717 mRNA Translation: AFP48942.1
JX073718 mRNA Translation: AFP48943.2
KF305251 mRNA Translation: AGX00872.1
KJ452197 mRNA Translation: AHX56802.1
AY579373 mRNA Translation: AAS89262.1
AY579374 mRNA Translation: AAS89263.1
AY579375 mRNA Translation: AAS89264.1
AY579376 mRNA Translation: AAS89265.1
AY579377 mRNA Translation: AAS89266.1
AABR07052345 Genomic DNA No translation available.
AABR07052346 Genomic DNA No translation available.
AABR07052347 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
NP_835193.1, NM_178092.2 [Q80ZA5-1]
XP_006234338.1, XM_006234276.3 [Q80ZA5-11]
XP_006234341.1, XM_006234279.3 [Q80ZA5-9]
XP_006234342.1, XM_006234280.3 [Q80ZA5-10]
XP_006234344.1, XM_006234282.3 [Q80ZA5-2]
XP_006234345.1, XM_006234283.3 [Q80ZA5-3]
XP_006234346.1, XM_006234284.3 [Q80ZA5-8]
XP_006234347.1, XM_006234285.3 [Q80ZA5-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSRNOT00000044638; ENSRNOP00000045491; ENSRNOG00000005307 [Q80ZA5-8]
ENSRNOT00000064344; ENSRNOP00000059915; ENSRNOG00000005307 [Q80ZA5-11]
ENSRNOT00000068238; ENSRNOP00000062481; ENSRNOG00000005307 [Q80ZA5-9]

Database of genes from NCBI RefSeq genomes

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GeneIDi
295645

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:295645

UCSC genome browser

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UCSCi
RGD:631407 rat [Q80ZA5-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF439855 mRNA Translation: AAO59639.1
AF439856 mRNA Translation: AAO59640.1
JX073715 mRNA Translation: AFP48940.1
JX073716 mRNA Translation: AFP48941.2
JX073717 mRNA Translation: AFP48942.1
JX073718 mRNA Translation: AFP48943.2
KF305251 mRNA Translation: AGX00872.1
KJ452197 mRNA Translation: AHX56802.1
AY579373 mRNA Translation: AAS89262.1
AY579374 mRNA Translation: AAS89263.1
AY579375 mRNA Translation: AAS89264.1
AY579376 mRNA Translation: AAS89265.1
AY579377 mRNA Translation: AAS89266.1
AABR07052345 Genomic DNA No translation available.
AABR07052346 Genomic DNA No translation available.
AABR07052347 Genomic DNA No translation available.
RefSeqiNP_835193.1, NM_178092.2 [Q80ZA5-1]
XP_006234338.1, XM_006234276.3 [Q80ZA5-11]
XP_006234341.1, XM_006234279.3 [Q80ZA5-9]
XP_006234342.1, XM_006234280.3 [Q80ZA5-10]
XP_006234344.1, XM_006234282.3 [Q80ZA5-2]
XP_006234345.1, XM_006234283.3 [Q80ZA5-3]
XP_006234346.1, XM_006234284.3 [Q80ZA5-8]
XP_006234347.1, XM_006234285.3 [Q80ZA5-4]

3D structure databases

SMRiQ80ZA5
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ80ZA5, 1 interactor
STRINGi10116.ENSRNOP00000059155

PTM databases

iPTMnetiQ80ZA5
PhosphoSitePlusiQ80ZA5
SwissPalmiQ80ZA5

Proteomic databases

PaxDbiQ80ZA5
PRIDEiQ80ZA5

Genome annotation databases

EnsembliENSRNOT00000044638; ENSRNOP00000045491; ENSRNOG00000005307 [Q80ZA5-8]
ENSRNOT00000064344; ENSRNOP00000059915; ENSRNOG00000005307 [Q80ZA5-11]
ENSRNOT00000068238; ENSRNOP00000062481; ENSRNOG00000005307 [Q80ZA5-9]
GeneIDi295645
KEGGirno:295645
UCSCiRGD:631407 rat [Q80ZA5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57282
RGDi631407 Slc4a10

Phylogenomic databases

eggNOGiKOG1172 Eukaryota
ENOG410XPHD LUCA
GeneTreeiENSGT00940000156972
InParanoidiQ80ZA5
KOiK13861
OMAiLMDFFFT
OrthoDBi265068at2759
PhylomeDBiQ80ZA5

Enzyme and pathway databases

ReactomeiR-RNO-425381 Bicarbonate transporters

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q80ZA5

Gene expression databases

BgeeiENSRNOG00000005307 Expressed in 4 organ(s), highest expression level in Ammon's horn

Family and domain databases

InterProiView protein in InterPro
IPR013769 Band3_cytoplasmic_dom
IPR011531 HCO3_transpt_C
IPR003020 HCO3_transpt_euk
IPR003024 Na/HCO3_transpt
IPR016152 PTrfase/Anion_transptr
PANTHERiPTHR11453 PTHR11453, 1 hit
PfamiView protein in Pfam
PF07565 Band_3_cyto, 1 hit
PF00955 HCO3_cotransp, 1 hit
PRINTSiPR01231 HCO3TRNSPORT
PR01232 NAHCO3TRSPRT
SUPFAMiSSF55804 SSF55804, 1 hit
TIGRFAMsiTIGR00834 ae, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS4A10_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80ZA5
Secondary accession number(s): D3ZGB5
, D3ZY00, D4ADV4, J7FMV4, J7FPF5, J7FRI2, J7FTX0, Q6PU70, Q6PU71, Q6PU72, Q6PU73, Q6PU74, Q80ZA6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: June 1, 2003
Last modified: October 16, 2019
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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