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Entry version 104 (08 May 2019)
Sequence version 1 (01 Jun 2003)
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Protein

Fibrocystin-L

Gene

Pkhd1l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fibrocystin-L
Alternative name(s):
Polycystic kidney and hepatic disease 1-like protein 1
Short name:
PKHD1-like protein 1
Protein D86
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pkhd1l1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2183153 Pkhd1l1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 4222ExtracellularSequence analysisAdd BLAST4202
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4223 – 4243HelicalSequence analysisAdd BLAST21
Topological domaini4244 – 4249CytoplasmicSequence analysis6

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031857321 – 4249Fibrocystin-LAdd BLAST4229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi1297O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1359O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1838O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi3735O-linked (GalNAc...) threonineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q80ZA4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q80ZA4

PRoteomics IDEntifications database

More...
PRIDEi
Q80ZA4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q80ZA4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q80ZA4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q80ZA4 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000129522

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q80ZA4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 132IPT/TIG 1Add BLAST102
Domaini146 – 255IPT/TIG 2Add BLAST110
Domaini270 – 361IPT/TIG 3Add BLAST92
Domaini337 – 492PA14PROSITE-ProRule annotationAdd BLAST156
Domaini1067 – 1153IPT/TIG 4Add BLAST87
Domaini1155 – 1234IPT/TIG 5Add BLAST80
Domaini1240 – 1323IPT/TIG 6Add BLAST84
Domaini1329 – 1468IPT/TIG 7Add BLAST140
Domaini1565 – 1648IPT/TIG 8Add BLAST84
Domaini1658 – 1742IPT/TIG 9Add BLAST85
Domaini1748 – 1827IPT/TIG 10Add BLAST80
Domaini1830 – 1909IPT/TIG 11Add BLAST80
Domaini1915 – 1996IPT/TIG 12Add BLAST82
Domaini1998 – 2084IPT/TIG 13Add BLAST87
Domaini2090 – 2175IPT/TIG 14Add BLAST86
Domaini2183 – 2303G8 1PROSITE-ProRule annotationAdd BLAST121
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati2484 – 2506PbH1 1Add BLAST23
Repeati2507 – 2529PbH1 2Add BLAST23
Repeati2565 – 2587PbH1 3Add BLAST23
Repeati2664 – 2686PbH1 4Add BLAST23
Repeati2732 – 2755PbH1 5Add BLAST24
Domaini3035 – 3173G8 2PROSITE-ProRule annotationAdd BLAST139
Repeati3292 – 3314PbH1 6Add BLAST23
Repeati3354 – 3376PbH1 7Add BLAST23
Repeati3415 – 3437PbH1 8Add BLAST23
Repeati3470 – 3492PbH1 9Add BLAST23
Repeati3493 – 3514PbH1 10Add BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4178 – 4210Ser-richAdd BLAST33

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IEIF Eukaryota
ENOG410XQ01 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157594

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000010311

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q80ZA4

Identification of Orthologs from Complete Genome Data

More...
OMAi
FSSCWAN

Database of Orthologous Groups

More...
OrthoDBi
323806at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q80ZA4

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.160.20.10, 1 hit
2.60.40.10, 14 hits
2.60.40.420, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039448 Beta_helix
IPR008972 Cupredoxin
IPR019316 G8_domain
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR037524 PA14/GLEYA
IPR011658 PA14_dom
IPR006626 PbH1
IPR012334 Pectin_lyas_fold
IPR011050 Pectin_lyase_fold/virulence
IPR029927 PKHDL1

The PANTHER Classification System

More...
PANTHERi
PTHR46769:SF2 PTHR46769:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13229 Beta_helix, 1 hit
PF10162 G8, 2 hits
PF07691 PA14, 1 hit
PF01833 TIG, 14 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01225 G8, 2 hits
SM00429 IPT, 10 hits
SM00758 PA14, 1 hit
SM00710 PbH1, 12 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49503 SSF49503, 1 hit
SSF51126 SSF51126, 1 hit
SSF81296 SSF81296, 14 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51484 G8, 2 hits
PS51820 PA14, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q80ZA4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGHLWLSGTW FLFGLLWCAA DSHKGSSETI PKVTEVIPKY GSINGATRLT
60 70 80 90 100
IKGEGFSQAS QFNYGADNTE LGNHVQLVSS FQSITCDVEK DSSHSTQITC
110 120 130 140 150
YTRAMPEDTY SVRVSVDGVP VAENNTCKGV ASSWACSFST KSFRTPTIRS
160 170 180 190 200
ITPLSGTPGT LITIKGRLFT DVYGSNTALS SNGRNVRILR IYIGGMPCEL
210 220 230 240 250
LIPHSDDLYG LKLDHANGDT GSVTCKTTGT YIGHHNVSFI LDSDYGRSFP
260 270 280 290 300
EKMTYFVSSL NKISMFQTYP EVVMVSPSKG STEGGTLLTI HGHFFDQTDL
310 320 330 340 350
PVRVLVGGQA CAILNVTENT IYCKTPPKPH ILKATYPGGR GLKVEVWNNS
360 370 380 390 400
RPAHLEDILE YNEHTPGYMG ATWTDSASYV WPIEQDTFVA RISGFLVPPD
410 420 430 440 450
SDVYRFYIRG DDRYAIYFSQ TGRTEDKVRI AYYSGNANTY FSNSTQRSDE
460 470 480 490 500
IHLQKGKEYY IEILLQEYTL SAFVDVGLYQ YKNVFTEQQT GDALNEEQVI
510 520 530 540 550
KSQSTVVPEV QIITLENWET ADVTNEVQQV TVTSPCVGAN SCSLSQYRFI
560 570 580 590 600
YNMEKTVWLP ADASDFTLKS ALNDLWSIKP DSVQVTSKRD LQSYIYTITF
610 620 630 640 650
VSTRGDFDLL GYEVFEGSNV TLSITEQTKG KPNLETFTLN WDGIASKPLT
660 670 680 690 700
PESSEAEFQV AVEEMVSAKC PPEIAHLEEG FLVKYFRDYE TDFELEHINR
710 720 730 740 750
GQKTAETDAY CGRYSLKNPA VLFDSTDVKP NKSPYGDILL FPYNQLCLAY
760 770 780 790 800
KGSLANFIDL KFKYQDSGKI IRSADVQFEY NFASGNKWTY TCIDLLDFLQ
810 820 830 840 850
TKYAGTSFSL QRITLQKSSE FQSIYVDAVY IGQTPTVSVL DDMPKRRPPA
860 870 880 890 900
LANKGIFLKH FQVNRTKLNG SAMTIQYSVT ITSYNCSHNI PMMAVSFGQI
910 920 930 940 950
ITNETKNELV YRGNNWPGES KIRIQKIQEA SPPISGSFDV QAYGHTLKGI
960 970 980 990 1000
PAAVPAADLQ FALQSLEEIE QVSVNREGTC AGYSWSIRWT SPRGKQPLLQ
1010 1020 1030 1040 1050
INDSNIIGEK ANVTVTTIKE GGLFRQRIPG DMLRTLNQQP QVEVYVNGIP
1060 1070 1080 1090 1100
AKCSGDCGFT WDAMITPLIL TTTPSEGSYA ESTILTIAGS GFSPTSAVSV
1110 1120 1130 1140 1150
SVGSTRCSLL SVEENEIKCQ ILNGSAGHVP VAVSIADVGL AQNLEGEGSH
1160 1170 1180 1190 1200
FIYRSQISHV WPDSGSLAGG TLLTISGFGF SENSTVLVGN ETCNVIEGDL
1210 1220 1230 1240 1250
NRITCRTSKR IEGTVDISVI TNGIQVTAKD SFSYSCLQTP VVTDFSPKER
1260 1270 1280 1290 1300
TVLGKVNLTI KGYNFGNELA QNTVYVGRKH CQVLHSNFTD ITCLLPTLPP
1310 1320 1330 1340 1350
GKHDIYVKVR NWGLASTRNK LNASILYILE VIHMFPQRGS LYGGTEITIM
1360 1370 1380 1390 1400
GFGFSTIPTE NSVLLGSFPC DITSSSENVI KCTLHSTGTV FRITNNGSHL
1410 1420 1430 1440 1450
VHGLGYAWSP SVLNVTVGDT VVWSWQAHPF LRGIGYRIFS VSSPGSVTYD
1460 1470 1480 1490 1500
DKGFTNGRQK SASGSFSYQF TSPGIYYYSS GYVDEAHSIS LQGVINVFPA
1510 1520 1530 1540 1550
EARHIPLYLF VGNIEATYVP AGPAHLQLAS TAAGCLATEP LCGLNDTRVK
1560 1570 1580 1590 1600
HSNKLFFELS NCISPSIINI TPSTGTANEL ITIIGHGFSS LPCANKVTIG
1610 1620 1630 1640 1650
SYPCVVEESS ENSIICHIDP QNSMNVGIRE IVTLIVYNLG TAINTLTKAF
1660 1670 1680 1690 1700
DRRFVLLPNI DMVMPKAGST TGMTRVTIQG SGFMSSPEGV EVFMGDFPCK
1710 1720 1730 1740 1750
VLSVTYTAIE CETSPAPQQL VLVDILIHGV PAQCQSNCSF SYLENIAPYV
1760 1770 1780 1790 1800
TGIFPNSIQG YGNVLIKGER FGTVLEEISI FIGSQQFRVI DVNENNITVL
1810 1820 1830 1840 1850
MTPLEAGLHS LSVVVGSKGL ALGNLTISSP AVASVSPTSG SIAGGTTLMI
1860 1870 1880 1890 1900
TGNGFSPGNT TVTVGDQPCQ ITFISSSEVY CSTPAGRAGT ANLKISVNAI
1910 1920 1930 1940 1950
IYPPLSFTYA MEDTPFLKRI IPNRGLPGTE VEITGSNLGF AISDVSVMIK
1960 1970 1980 1990 2000
ESVCNVTTVN DTVLQCTVGE HAGGIFPVTM LHKTKGSAVS SVAFEYPLSI
2010 2020 2030 2040 2050
QNIYPTQGSF GGGQTLTVTG MGFDPWNSTI LVCNSECAVD KLRSNSTTLF
2060 2070 2080 2090 2100
CVIPPNNGKG HDQVCGVSVV NGKDSSHSTK LFTYTLSLTP LITEISPRRG
2110 2120 2130 2140 2150
STAGGTRLTV TGSGFSENTQ GVQVFVGNSK CDIQYSNKTH IVCMTSVHVP
2160 2170 2180 2190 2200
SGWVPVHVNI KNIGLAKLEN ADFLYADVWS ANSSWGGSPP PEEGSLAVIT
2210 2220 2230 2240 2250
KGQIILLDQS TPILKMLLIQ GGTLIFDEAN IELQAENILI TDGGVLQIGT
2260 2270 2280 2290 2300
EASPFQHRAV ITLHGHLRSP ELPVYGAKTL GVREGTLDLH GLPIPVVWTR
2310 2320 2330 2340 2350
LTHTANAGEW TLTVQEAVTW KAGDNIVIAS TGHRHSQAEN EKRTIASVSA
2360 2370 2380 2390 2400
DGMHITLTKP LNYTHLGITT TLPDGTVFEA RAEVGILTRN ILIRGSDNVE
2410 2420 2430 2440 2450
WNDKIPSCPD GFDTGEFATQ TCLQGKFGEE MGSDQFGGCI MLHAPLPGAD
2460 2470 2480 2490 2500
MVTGRIEYVE VFHAGQSFRL GRYPIHWHLL GDLQFKSYVK GCAIHQSYNR
2510 2520 2530 2540 2550
AITIHNTHHL LVERNIIYDI KGGAFFIEDG IEHGNILQYN LAVFVQQSTS
2560 2570 2580 2590 2600
LLNDDVTPAA FWVTNPNNTI RHNAAAGGTH FGFWYRMNDH PDGPSFDRNI
2610 2620 2630 2640 2650
CQKRIPLGEF FNNTVHSQGW FGLWIFEEYF PMQTGSCTST VPVPAIFNSL
2660 2670 2680 2690 2700
TVWNCQKGAE WVNGGALQFH NFVMVNNNEA GIETKRILAP YVGGWGESNG
2710 2720 2730 2740 2750
AVIKNAKIVG HLDELGMGPT FCTSKGLVLP FSQGLTVSSV HFMNFDRHAC
2760 2770 2780 2790 2800
VALGVTSITG VCNDRCGGWS AKFVGIRYFH APNKGGFRWE HEAVLIDVDG
2810 2820 2830 2840 2850
SLTGHRGHTV VPHSSLLDPS HCTQEPAWSI GFPGSICDAS VSFHRLAFNK
2860 2870 2880 2890 2900
PSPVSLLEKD VVLSDSFGTS IVPFQKKRLT HMSGWMALIP NANHINWYFK
2910 2920 2930 2940 2950
GVEHLTNISY TSTFYGFKEE DYVIISHNFT QNPDMFNVVD MRNGSANPLN
2960 2970 2980 2990 3000
WNSSKNGDWH LEANTSTLYY LVSGRSDLPQ SQPISGTLDP GVKDVIINFQ
3010 3020 3030 3040 3050
AYCCVLQDCF PVHPPSRKPI PRKRPAAYNL WSNESFWQSS PENNYTVPRP
3060 3070 3080 3090 3100
GANVIIPEGT WIVADVDIPP VERLIIWGVL EMEDKSEIGV AGPTYRRVVL
3110 3120 3130 3140 3150
NATYISVQGG RLIGGWEDNP FKGELQIVLR GNHSTPEWAF PDGPNQGAKV
3160 3170 3180 3190 3200
LGVFGELDLH GLPHSVYKTK LLETAEAGSK ILSLVDAVDW QEGEDVVITT
3210 3220 3230 3240 3250
TSYDLHQTEI RRIAKILHGH KILILNDSLS YTHLAERQWI SGTAQSYTLS
3260 3270 3280 3290 3300
ADVGILSRNI KIVGDDYSVL SKDSFGARIL VGSFTGNMMT FKGNARISNV
3310 3320 3330 3340 3350
EFHHSGQEGY RDSTDPRYAV TFLNLGQIQD HGLSYVRGCA FHHVFSPAIG
3360 3370 3380 3390 3400
VFGTDGVDID DNIIYFTVGE GIRIWGDANR VRGNLVTLSV WPGTYQNRKD
3410 3420 3430 3440 3450
LSSTLWHAAI EINRGTNTVL QNNVVAGFGR VGYRIDGEPC SSQANSMENW
3460 3470 3480 3490 3500
FNNEAHGGLY GIYMNQDGLP GCSLIQGFTI WTCWDYGIYF QTTESVHIYN
3510 3520 3530 3540 3550
VTLVNNGMSI FSMVYMPPSV SHKISSKTVK IKNSLIVGSS PEFNCSDVLT
3560 3570 3580 3590 3600
NDSPDVELTS AHRSSRPPSG GRSGICWPTF ASAHNMAPRK PHAGIMSYNA
3610 3620 3630 3640 3650
ISGLLHVSDS TFVGFKDVCS GETNVIFITN PLNEDLQHPI HVKNVQLIDT
3660 3670 3680 3690 3700
IEQSKVFIHR PDISKVNPSD CVDMVCDAKR KSFLRDLDGS FLGNSGSVIP
3710 3720 3730 3740 3750
QAEYEWDGNS QLGIGDYRIP KAMLTYLNGS RIPVTEKAPH KGIIRDATCK
3760 3770 3780 3790 3800
YIPEWQSYQC SGMEYAMMVL ESLDSDTETR RLSPVAIMSN GYVDLINGPQ
3810 3820 3830 3840 3850
DHGWCAGYTC QRRLSLFHGI VALNKKYEVY FTGTSPQNLR LMLLNVEHNK
3860 3870 3880 3890 3900
AVLVGIFFST LQRLDVYVNN SLVCPKNTAW NAQKKHCELE RHLSTEQFLP
3910 3920 3930 3940 3950
NLGSTVPGEN YFDRTYQMLY LFLKGTTPVE VHTATVIFVS FHLPVMTADE
3960 3970 3980 3990 4000
FFSSHNLVRN LALFLKIPSD KIRVSRIIGA SLRKKRSTGH IMEFEIGAAP
4010 4020 4030 4040 4050
TQFLSNSTTG QMQLSELQEI TDSLGQAVVL GKISTILGFN ISSMSITSPI
4060 4070 4080 4090 4100
PQPTDSGWIK VTAQPVERSA FPVHYLALVS SLSVVAQPVA AQPGQPFPQQ
4110 4120 4130 4140 4150
PSVKAVDPEG NCVSVGITSL TLKAILKDSN NNQVGGLSGN TTIPFSTCWA
4160 4170 4180 4190 4200
NYTDLTPHRT GKNYKIEFVL DNTVRVDSRP FSLSAQSVPG GSGSSPGSGS
4210 4220 4230 4240
SSSGHSKASS VGTPVQTLAV ITACLVGRLL LLEVFMAAVF ILNTTVGIN
Length:4,249
Mass (Da):464,732
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i797F6AE92407B148
GO
Isoform 2 (identifier: Q80ZA4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1926-1944: LPGTEVEITGSNLGFAISD → TPASTCLFIYCIDVMLQLY
     1945-4249: Missing.

Note: No experimental confirmation available.
Show »
Length:1,944
Mass (Da):212,547
Checksum:i662DA57BDF9F282C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WH29F8WH29_MOUSE
Fibrocystin-L
Pkhd1l1
4,247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PUU8E9PUU8_MOUSE
Fibrocystin-L
Pkhd1l1
4,249Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0312261926 – 1944LPGTE…FAISD → TPASTCLFIYCIDVMLQLY in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_0312271945 – 4249Missing in isoform 2. 1 PublicationAdd BLAST2305

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY219182 mRNA Translation: AAO60073.1
AB055648 mRNA Translation: BAB32449.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS84169.1 [Q80ZA4-1]

NCBI Reference Sequences

More...
RefSeqi
NP_619615.2, NM_138674.2 [Q80ZA4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000209244; ENSMUSP00000147447; ENSMUSG00000038725 [Q80ZA4-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
192190

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:192190

UCSC genome browser

More...
UCSCi
uc007vpx.1 mouse [Q80ZA4-2]
uc007vpy.1 mouse [Q80ZA4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY219182 mRNA Translation: AAO60073.1
AB055648 mRNA Translation: BAB32449.1
CCDSiCCDS84169.1 [Q80ZA4-1]
RefSeqiNP_619615.2, NM_138674.2 [Q80ZA4-1]

3D structure databases

SMRiQ80ZA4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000129522

PTM databases

iPTMnetiQ80ZA4
PhosphoSitePlusiQ80ZA4

Proteomic databases

EPDiQ80ZA4
PaxDbiQ80ZA4
PRIDEiQ80ZA4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000209244; ENSMUSP00000147447; ENSMUSG00000038725 [Q80ZA4-1]
GeneIDi192190
KEGGimmu:192190
UCSCiuc007vpx.1 mouse [Q80ZA4-2]
uc007vpy.1 mouse [Q80ZA4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
93035
MGIiMGI:2183153 Pkhd1l1

Phylogenomic databases

eggNOGiENOG410IEIF Eukaryota
ENOG410XQ01 LUCA
GeneTreeiENSGT00940000157594
HOGENOMiHOG000010311
InParanoidiQ80ZA4
OMAiFSSCWAN
OrthoDBi323806at2759
PhylomeDBiQ80ZA4

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q80ZA4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

ExpressionAtlasiQ80ZA4 baseline and differential

Family and domain databases

Gene3Di2.160.20.10, 1 hit
2.60.40.10, 14 hits
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR039448 Beta_helix
IPR008972 Cupredoxin
IPR019316 G8_domain
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR037524 PA14/GLEYA
IPR011658 PA14_dom
IPR006626 PbH1
IPR012334 Pectin_lyas_fold
IPR011050 Pectin_lyase_fold/virulence
IPR029927 PKHDL1
PANTHERiPTHR46769:SF2 PTHR46769:SF2, 1 hit
PfamiView protein in Pfam
PF13229 Beta_helix, 1 hit
PF10162 G8, 2 hits
PF07691 PA14, 1 hit
PF01833 TIG, 14 hits
SMARTiView protein in SMART
SM01225 G8, 2 hits
SM00429 IPT, 10 hits
SM00758 PA14, 1 hit
SM00710 PbH1, 12 hits
SUPFAMiSSF49503 SSF49503, 1 hit
SSF51126 SSF51126, 1 hit
SSF81296 SSF81296, 14 hits
PROSITEiView protein in PROSITE
PS51484 G8, 2 hits
PS51820 PA14, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPKHL1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80ZA4
Secondary accession number(s): Q99PS9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2003
Last modified: May 8, 2019
This is version 104 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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