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Entry version 128 (13 Feb 2019)
Sequence version 2 (27 Jul 2011)
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Protein

Tenascin-N

Gene

Tnn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (By similarity) (PubMed:14709716). Involved in neurite outgrowth and cell migration in hippocampal explants (PubMed:12812753). During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling (PubMed:17395156). In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (By similarity). Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells (PubMed:15592496).By similarity4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-3000178 ECM proteoglycans

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tenascin-NImported
Short name:
TN-N
Alternative name(s):
Tenascin-W1 Publication
Short name:
TN-W1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TnnImported
Synonyms:Tnw1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2665790 Tnn

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000774627 – 1560Tenascin-NAdd BLAST1534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi171 ↔ 181PROSITE-ProRule annotation
Disulfide bondi175 ↔ 186PROSITE-ProRule annotation
Disulfide bondi188 ↔ 197PROSITE-ProRule annotation
Disulfide bondi202 ↔ 212PROSITE-ProRule annotation
Disulfide bondi206 ↔ 217PROSITE-ProRule annotation
Disulfide bondi219 ↔ 228PROSITE-ProRule annotation
Disulfide bondi233 ↔ 243PROSITE-ProRule annotation
Disulfide bondi237 ↔ 248PROSITE-ProRule annotation
Disulfide bondi250 ↔ 259PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi1411N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q80Z71

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q80Z71

PRoteomics IDEntifications database

More...
PRIDEi
Q80Z71

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q80Z71

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q80Z71

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest expression in kidney followed by spleen and brain. In brain, highest expression is found in hippocampus, cerebellum and olfactory bulb. Expressed in aortic valve, corneal limbus (PubMed:14709716). Expressed in ribs periosteum. During a fracture repair process, expression increases in cells of newly formed perichondrium/peristeum surrounding the cartalaginous callus (PubMed:14709716, PubMed:17395156).3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Hardly detectable at embryonic day (E) 14, then increases until postnatal day 17 and remains detectable in the adult (PubMed:12812753). Expressed as early as 11.5 dpc in the maxillary process until 16.5 dpc when is expressed in the newly formed mandible. At 14.5 dpc is detected in smooth muscle cells of the stomach and intestine and at 15.5, in the periosteum of the ribs. At 16.5 dpc the expression is restricted to mandible, palate and teeth (PubMed:14709716). During endochondral bone formation, first expressed at 13.5 dpc in the perichondrium. At E 16.5, detected in perichondrium and periosteum (PubMed:17395156).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000026725 Expressed in 53 organ(s), highest expression level in diaphysis of femur

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q80Z71 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q80Z71 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homohexamer.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1013 Tenascin-W complex

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000039452

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q80Z71

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q80Z71

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini167 – 198EGF-like 1Add BLAST32
Domaini199 – 229EGF-like 2Add BLAST31
Domaini230 – 260EGF-like 3Add BLAST31
Domaini264 – 353Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST90
Domaini354 – 444Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST91
Domaini445 – 532Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST88
Domaini533 – 622Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST90
Domaini623 – 706Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST84
Domaini709 – 798Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST90
Domaini799 – 882Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST84
Domaini885 – 970Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST86
Domaini973 – 1062Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST90
Domaini1063 – 1144Fibronectin type-III 10PROSITE-ProRule annotationAdd BLAST82
Domaini1149 – 1238Fibronectin type-III 11PROSITE-ProRule annotationAdd BLAST90
Domaini1239 – 1325Fibronectin type-III 12PROSITE-ProRule annotationAdd BLAST87
Domaini1323 – 1540Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST218

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tenascin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1225 Eukaryota
KOG2579 Eukaryota
KOG3544 Eukaryota
ENOG410ZYS4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160553

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234355

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG106611

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q80Z71

KEGG Orthology (KO)

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KOi
K06252

Identification of Orthologs from Complete Genome Data

More...
OMAi
YKLQYGP

Database of Orthologous Groups

More...
OrthoDBi
18592at2759

TreeFam database of animal gene trees

More...
TreeFami
TF329915

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 12 hits
cd00087 FReD, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 12 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00147 Fibrinogen_C, 1 hit
PF00041 fn3, 12 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 3 hits
SM00186 FBG, 1 hit
SM00060 FN3, 12 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 7 hits
SSF56496 SSF56496, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 3 hits
PS01186 EGF_2, 3 hits
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit
PS50853 FN3, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: A number of isoforms are produced.1 Publication

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q80Z71-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLWGMLAFP LGFLLASVLL VASAPATPES PGCSNKEQQV TVSHTYKIDV
60 70 80 90 100
PKSALVQVET DPQSLSDDGT SLLAPGEDGE EQNIIFRHNI RLQTPQKNCD
110 120 130 140 150
LADSVQDLLA RMKKLEEEMA ELKEQCNTNR CCQGAADLSR HCSGHGTFLP
160 170 180 190 200
ETCSCHCDQG WEGADCDQPT CPGACNGHGR CVDGQCVCDA PYVGVDCAYA
210 220 230 240 250
ACPQDCSGHG VCVQGVCQCH EDFTAEDCSE QRCPGDCSGN GFCDTGECYC
260 270 280 290 300
EMGFTGPDCS QVVAPQGLQL LKSTENSLLV SWEPSSEVDY YLLSYYPLGK
310 320 330 340 350
EQATKQVRVP KEQHTYDITG LLPGTKYIVT LRNVKKDISS SPQHLLATTD
360 370 380 390 400
LAVVGTAWVN EETETSLDVE WENPLTEVDY YKLRYGPLTG QEVTEVTVPK
410 420 430 440 450
SRDPKSRYDI TGLQPGTEYK ITVVPIRGDL EGKPILLNGR TEIDGPTNVV
460 470 480 490 500
TNQVTEDTAS VSWDPVRADI DKYVVRYIAP DGETKEKAVP KDQSSTVLTG
510 520 530 540 550
LKPGEAYKVF VWAERGNQGS KKADTKALTE IDSPENLVTD RVTENSLSVS
560 570 580 590 600
WDPVEADIDR YVVSYTSVDG ETKQVPVKKD QRSTVLTGLS PGVEYKVYVW
610 620 630 640 650
AEKGDRESKK ANTKAPTDID SPKNLVTDQV TENTLSVSWD PVQANIDRYM
660 670 680 690 700
VSYTSADGET REVPVPKEKS STVLTGLRPG VEYKVHVWAQ KGTQESRKAN
710 720 730 740 750
TKAPTDIDGP KNLVTDQVTE TTLSVSWDPV EADIDRYMVR YTSPDGETKE
760 770 780 790 800
VPVSKDKSST VLRGLRPGVE YKVDVWAQKG AQDSRKANTK APTDIDSPKN
810 820 830 840 850
LVTEQVTEST ATVSWDPVEA DIDRYVVRYT SVDGETREFL VGKDQTSTVL
860 870 880 890 900
TGMRPGVEYQ VDVWAQKGTQ ESRKTSTKAP TDIDGPKNLV TDQVTETTLS
910 920 930 940 950
VSWDPVEADI DRYMVRYTSP DGETKEVPVS KDKSSTVLRG LRPGVEYKVD
960 970 980 990 1000
VWAQKGAQDS RKANTKAPTD IDSPKNLAID QVTETTLSVS WDPVQADIDR
1010 1020 1030 1040 1050
YVVRYTSADG ESKEFLIGKE QRSTVLTGLR PGVEYKVEVW AQKGARESKK
1060 1070 1080 1090 1100
ANTEGHTDID SPKNLVTNQV TENTATISWD PVQADIDRYM VRYTSADGET
1110 1120 1130 1140 1150
REIPVRKEKS STVLTGLRPG VEYTVQVWAQ KGARESKKAK TKAPTEIDSP
1160 1170 1180 1190 1200
KNLVTNRVTE NTATISWDPV RANIDRYMVR YTSADGETKE IPVSKDQSST
1210 1220 1230 1240 1250
ILTGLKPGME YTIHVWAQKG ARESKKADTK ALTEIDPPRN LRPFGVTHSG
1260 1270 1280 1290 1300
GVLTWLPPSA QIDGYILTYQ FPNGTVKEVE LPRGQQRFEL QDLEQGVTYP
1310 1320 1330 1340 1350
VSLVAFKGNQ RSRTVSTTLS TVDARFPHPS DCSQVQQNTN AASGLYTIYL
1360 1370 1380 1390 1400
NGDASRPMQV YCDMDTDGGG WIVFQRRNTG QLDFFKRWRS YVEGFGDPMK
1410 1420 1430 1440 1450
EFWLGLDKLH NLTTGTTTRY EVRADLQTFN ESAYAVYDFF QVASSKERYK
1460 1470 1480 1490 1500
LSVGKYRGTA GDALTYHNGW KFTTFDRDND IALSNCALTH HGGWWYKNCH
1510 1520 1530 1540 1550
LANPNGKYGE TKHSEGVNWE PWKGHEFSIP YVELKIRPFG YSRDRFSGRK
1560
KRSIGKARMF
Length:1,560
Mass (Da):173,090
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i672FBADBC2DAFCB2
GO
Isoform 2 (identifier: Q80Z71-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     832-1095: Missing.

Show »
Length:1,296
Mass (Da):143,741
Checksum:i80BE424EDB69FA91
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q1F6E9Q1F6_MOUSE
Tenascin-N
Tnn
1,296Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti354V → L in CAE45651 (PubMed:14709716).Curated1
Sequence conflicti807T → A in CAE45651 (PubMed:14709716).Curated1
Sequence conflicti1199S → N in CAE45651 (PubMed:14709716).Curated1
Sequence conflicti1221A → P in AAO63807 (PubMed:12812753).Curated1
Sequence conflicti1278E → G in CAE45651 (PubMed:14709716).Curated1
Sequence conflicti1479N → S in CAE45651 (PubMed:14709716).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_058850832 – 1095Missing in isoform 2. Add BLAST264

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF455756 mRNA Translation: AAO63807.1
AJ580920 mRNA Translation: CAE45651.1
BC138335 mRNA Translation: AAI38336.1
BC138336 mRNA Translation: AAI38337.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS15404.1 [Q80Z71-1]

NCBI Reference Sequences

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RefSeqi
NP_808507.2, NM_177839.3 [Q80Z71-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.90140

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000039178; ENSMUSP00000039452; ENSMUSG00000026725 [Q80Z71-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
329278

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:329278

UCSC genome browser

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UCSCi
uc007dee.2 mouse [Q80Z71-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF455756 mRNA Translation: AAO63807.1
AJ580920 mRNA Translation: CAE45651.1
BC138335 mRNA Translation: AAI38336.1
BC138336 mRNA Translation: AAI38337.1
CCDSiCCDS15404.1 [Q80Z71-1]
RefSeqiNP_808507.2, NM_177839.3 [Q80Z71-1]
UniGeneiMm.90140

3D structure databases

ProteinModelPortaliQ80Z71
SMRiQ80Z71
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-1013 Tenascin-W complex
STRINGi10090.ENSMUSP00000039452

PTM databases

iPTMnetiQ80Z71
PhosphoSitePlusiQ80Z71

Proteomic databases

MaxQBiQ80Z71
PaxDbiQ80Z71
PRIDEiQ80Z71

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039178; ENSMUSP00000039452; ENSMUSG00000026725 [Q80Z71-1]
GeneIDi329278
KEGGimmu:329278
UCSCiuc007dee.2 mouse [Q80Z71-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
63923
MGIiMGI:2665790 Tnn

Phylogenomic databases

eggNOGiKOG1225 Eukaryota
KOG2579 Eukaryota
KOG3544 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00940000160553
HOGENOMiHOG000234355
HOVERGENiHBG106611
InParanoidiQ80Z71
KOiK06252
OMAiYKLQYGP
OrthoDBi18592at2759
TreeFamiTF329915

Enzyme and pathway databases

ReactomeiR-MMU-3000178 ECM proteoglycans

Miscellaneous databases

Protein Ontology

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PROi
PR:Q80Z71

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000026725 Expressed in 53 organ(s), highest expression level in diaphysis of femur
ExpressionAtlasiQ80Z71 baseline and differential
GenevisibleiQ80Z71 MM

Family and domain databases

CDDicd00063 FN3, 12 hits
cd00087 FReD, 1 hit
Gene3Di2.60.40.10, 12 hits
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00147 Fibrinogen_C, 1 hit
PF00041 fn3, 12 hits
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00186 FBG, 1 hit
SM00060 FN3, 12 hits
SUPFAMiSSF49265 SSF49265, 7 hits
SSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 3 hits
PS01186 EGF_2, 3 hits
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit
PS50853 FN3, 12 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTENN_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80Z71
Secondary accession number(s): B9EHR3, Q70HX0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: July 27, 2011
Last modified: February 13, 2019
This is version 128 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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