Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neuronal growth regulator 1

Gene

Negr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain.1 Publication

GO - Biological processi

  • cell-cell adhesion Source: MGI
  • feeding behavior Source: MGI
  • locomotory behavior Source: MGI
  • positive regulation of neuron projection development Source: MGI

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal growth regulator 1
Alternative name(s):
Kindred of IgLON
Short name:
Kilon
Neurotractin
Gene namesi
Name:Negr1
Synonyms:Kiaa3001, Ntra
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2444846 Negr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31By similarityAdd BLAST31
ChainiPRO_000001503932 – 318Neuronal growth regulator 1Add BLAST287
PropeptideiPRO_0000015040319 – 348Removed in mature formSequence analysisAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 112PROSITE-ProRule annotation
Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi154 ↔ 197PROSITE-ProRule annotation
Modified residuei181PhosphotyrosineCombined sources1
Disulfide bondi239 ↔ 291PROSITE-ProRule annotation
Glycosylationi269N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi280N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi288N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi301N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi318GPI-anchor amidated glycineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ80Z24
PaxDbiQ80Z24
PeptideAtlasiQ80Z24
PRIDEiQ80Z24

PTM databases

iPTMnetiQ80Z24
PhosphoSitePlusiQ80Z24

Expressioni

Tissue specificityi

Expressed in brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000040037 Expressed in 234 organ(s), highest expression level in piriform cortex
CleanExiMM_NEGR1
ExpressionAtlasiQ80Z24 baseline and differential
GenevisibleiQ80Z24 MM

Interactioni

Protein-protein interaction databases

IntActiQ80Z24, 1 interactor
STRINGi10090.ENSMUSP00000073664

Structurei

3D structure databases

ProteinModelPortaliQ80Z24
SMRiQ80Z24
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 128Ig-like C2-type 1Add BLAST97
Domaini133 – 215Ig-like C2-type 2Add BLAST83
Domaini219 – 307Ig-like C2-type 3Add BLAST89

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410KD5Q Eukaryota
ENOG4110TBP LUCA
GeneTreeiENSGT00860000133697
HOGENOMiHOG000019085
HOVERGENiHBG017341
InParanoidiQ80Z24
KOiK06775
OrthoDBiEOG091G0B5D
PhylomeDBiQ80Z24
TreeFamiTF351104

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF07679 I-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q80Z24-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLLAQGACC SNQWLAAVLL SLCSCLPAGQ SVDFPWAAVD NMLVRKGDTA
60 70 80 90 100
VLRCYLEDGA SKGAWLNRSS IIFAGGDKWS VDPRVSISTL NKRDYSLQIQ
110 120 130 140 150
NVDVTDDGPY TCSVQTQHTP RTMQVHLTVQ VPPKIYDISN DMTINEGTNV
160 170 180 190 200
TLTCLATGKP EPVISWRHIS PSAKPFENGQ YLDIYGITRD QAGEYECSAE
210 220 230 240 250
NDVSFPDVKK VRVIVNFAPT IQEIKSGTVT PGRSGLIRCE GAGVPPPAFE
260 270 280 290 300
WYKGEKRLFN GQQGIIIQNF STRSILTVTN VTQEHFGNYT CVAANKLGTT
310 320 330 340
NASLPLNPPS TAQYGITGSA CDLFSCWSLA LTLSSVISIF YLKNAILQ
Length:348
Mass (Da):37,900
Last modified:June 1, 2003 - v1
Checksum:i30520A146A9FA198
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A4W9A0A4W9_MOUSE
Neuronal growth regulator 1
Negr1 mCG_141003
329Annotation score:
H3BKU7H3BKU7_MOUSE
Neuronal growth regulator 1
Negr1
122Annotation score:
D3Z4T6D3Z4T6_MOUSE
Neuronal growth regulator 1
Negr1 mCG_141003
329Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ487032 mRNA Translation: CAD31699.1
AK142298 mRNA Translation: BAE25018.1
AK147253 mRNA Translation: BAE27799.1
AK122576 mRNA Translation: BAC65858.2
CCDSiCCDS17930.1
RefSeqiNP_001034183.1, NM_001039094.3
NP_796248.1, NM_177274.4
UniGeneiMm.317293

Genome annotation databases

EnsembliENSMUST00000074015; ENSMUSP00000073664; ENSMUSG00000040037
GeneIDi320840
KEGGimmu:320840
UCSCiuc008rvc.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ487032 mRNA Translation: CAD31699.1
AK142298 mRNA Translation: BAE25018.1
AK147253 mRNA Translation: BAE27799.1
AK122576 mRNA Translation: BAC65858.2
CCDSiCCDS17930.1
RefSeqiNP_001034183.1, NM_001039094.3
NP_796248.1, NM_177274.4
UniGeneiMm.317293

3D structure databases

ProteinModelPortaliQ80Z24
SMRiQ80Z24
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ80Z24, 1 interactor
STRINGi10090.ENSMUSP00000073664

PTM databases

iPTMnetiQ80Z24
PhosphoSitePlusiQ80Z24

Proteomic databases

MaxQBiQ80Z24
PaxDbiQ80Z24
PeptideAtlasiQ80Z24
PRIDEiQ80Z24

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074015; ENSMUSP00000073664; ENSMUSG00000040037
GeneIDi320840
KEGGimmu:320840
UCSCiuc008rvc.2 mouse

Organism-specific databases

CTDi257194
MGIiMGI:2444846 Negr1
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410KD5Q Eukaryota
ENOG4110TBP LUCA
GeneTreeiENSGT00860000133697
HOGENOMiHOG000019085
HOVERGENiHBG017341
InParanoidiQ80Z24
KOiK06775
OrthoDBiEOG091G0B5D
PhylomeDBiQ80Z24
TreeFamiTF351104

Enzyme and pathway databases

ReactomeiR-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins

Miscellaneous databases

ChiTaRSiNegr1 mouse
PROiPR:Q80Z24
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040037 Expressed in 234 organ(s), highest expression level in piriform cortex
CleanExiMM_NEGR1
ExpressionAtlasiQ80Z24 baseline and differential
GenevisibleiQ80Z24 MM

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF07679 I-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiNEGR1_MOUSE
AccessioniPrimary (citable) accession number: Q80Z24
Secondary accession number(s): Q3UHQ8, Q80T70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again