Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q80Z10 (ASTN2_MOUSE)

Entry version 114 (02 Jun 2021)
Sequence version 2 (20 Feb 2007)
Previous versions | rss
Add a publicationFeedback
Protein

Astrotactin-2

Gene

Astn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (PubMed:20573900).

Selectively binds inositol-4,5-bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup (By similarity).

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Astrotactin-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Astn2
Synonyms:Kiaa0634
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1889277, Astn2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini52 – 218LumenalCuratedAdd BLAST167
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Topological domaini240 – 447CytoplasmicCuratedAdd BLAST208
Transmembranei448 – 468HelicalSequence analysisAdd BLAST21
Topological domaini469 – 1352Lumenal1 PublicationAdd BLAST884

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endosome, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 51Sequence analysisAdd BLAST51
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000030825352 – 1352Astrotactin-2Add BLAST1301

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi180N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi527 ↔ 539By similarity
Disulfide bondi535 ↔ 546By similarity
Disulfide bondi548 ↔ 562By similarity
Disulfide bondi668 ↔ 681By similarity
Disulfide bondi675 ↔ 692By similarity
Disulfide bondi694 ↔ 707By similarity
Disulfide bondi716 ↔ 728By similarity
Disulfide bondi724 ↔ 748By similarity
Disulfide bondi750 ↔ 763By similarity
Glycosylationi796N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi838 ↔ 1000By similarity
Disulfide bondi929 ↔ 990By similarity
Disulfide bondi996 ↔ 1003By similarity
Glycosylationi1033N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1049 ↔ 1060By similarity
Disulfide bondi1062 ↔ 1075By similarity
Disulfide bondi1149 ↔ 1171By similarity
Disulfide bondi1203 ↔ 1290By similarity
Disulfide bondi1311 ↔ 1334By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q80Z10

PRoteomics IDEntifications database

More...PRIDEi		Q80Z10

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		277259 [Q80Z10-1]
277260 [Q80Z10-2]
277261 [Q80Z10-3]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2137, 1 N-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q80Z10, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q80Z10

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q80Z10

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in cerebellum granule neurons; not detected in astroglia (at protein level). Detected primarily in cerebellum, and at lower levels in brain cortex, olfactory bulb, hindbrain and hippocampus dentate gyrus. Between 6 and 10 days after birth, when granule cell migration occurs in the cerebellum, detected in granule cell precursors in the external germinal layer, the molecular layer, the internal granule layer and in Purkinje neurons. Detected in postmitotic neurons in adult cerebellum.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected at low levels in embryonic brain. Highly expressed 6 and 10 days after birth, when granule cell migration occurs in the cerebellum; expression in cerebellum is considerably higher than in brain cortex. Expressed at lower levels in adult cerebellum.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000028373, Expressed in Ammon's horn and 109 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q80Z10, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ASTN1; the interaction is not calcium-dependent.

1 Publication

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q80Z10, 1 interactor

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000065786

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q80Z10, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q80Z10

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini523 – 563EGF-like 1Add BLAST41
Domaini664 – 708EGF-like 2Add BLAST45
Domaini712 – 764EGF-like 3Add BLAST53
Domaini1079 – 1201Fibronectin type-IIIAdd BLAST123

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 31DisorderedSequence analysisAdd BLAST31
Regioni308 – 327DisorderedSequence analysisAdd BLAST20
Regioni375 – 421DisorderedSequence analysisAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi311 – 327Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi376 – 390Polar residuesSequence analysisAdd BLAST15
Compositional biasi406 – 421Polar residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal region after the fibronectin type-III domain presents structural similarity to annexin domains and binds calcium ions.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the astrotactin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502R4QT, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000003140

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q80Z10

Identification of Orthologs from Complete Genome Data

More...OMAi		YIKDFPQ

Database of Orthologous Groups

More...OrthoDBi		39300at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q80Z10

TreeFam database of animal gene trees

More...TreeFami		TF332034

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063, FN3, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR040685, Annexin-like
IPR040510, ASTN_2_hairpin
IPR026995, Astrotactin
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR020864, MACPF

The PANTHER Classification System

More...PANTHERi		PTHR16592, PTHR16592, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF18411, Annexin_like, 1 hit
PF18577, ASTN_2_hairpin, 1 hit
PF01823, MACPF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00457, MACPF, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49265, SSF49265, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q80Z10-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAGARRSP GRGLGLRGRP RLGFHPGPPP PPPPPLLLLF LLLLPPPPLL 
        60         70         80         90        100
AGATAAAASR EPDSPCRLKT VTVSTLPALR ESDIGWSGAR TGAAAGAGAG 
       110        120        130        140        150
TGAGAGAAAA AASAASPGSA GSAGTAAESR LLLFVRNELP GRIAVQDDLD 
       160        170        180        190        200
NTELPFFTLE MSGTAADISL VHWRQQWLEN GTLYFHVSMS SSGQLAQATA 
       210        220        230        240        250
PTLQEPSEIV EEQMHILHIS VMGGLIALLL LLLVFTVALY AQRRWQKRRR 
       260        270        280        290        300
IPQKSASTEA THEIHYIPSV LLGPQARESF RSSRLQTHNS VIGVPIRETP 
       310        320        330        340        350
ILDDYDYEEE EEPPRRANHV SREDEFGSQM THALDSLGRP GEEKVEFEKK 
       360        370        380        390        400
AAAEATQETV ESLMQKFKES FRANTPVEIG QLQPASRSST SAGKRKRRNK 
       410        420        430        440        450
SRGGISFGRT KGTSGSEADD ETQLTFYTEQ YRSRRRSKGL LKSPVNKTAL 
       460        470        480        490        500
TLIAVSSCIL AMVCGNQMSC PLTVKVTLHV PEHFIADGSS FVVSEGSYLD 
       510        520        530        540        550
ISDWLNPAKL SLYYQINATS PWVRDLCGQR TTDACEQLCD PDTGECSCHE 
       560        570        580        590        600
GYAPDPVHRH LCVRSDWGQS EGPWPYTTLE RGYDLVTGEQ APEKILRSTF 
       610        620        630        640        650
SLGQGLWLPV SKSFVVPPVE LSINPLASCK TDVLVTEDPA DVREEAMLST 
       660        670        680        690        700
YFETINDLLS SFGPVRDCSR NNGGCTRNFK CVSDRQVDSS GCVCPEELKP 
       710        720        730        740        750
MKDGSGCYDH SKGIDCSDGF NGGCEQLCLQ QTLPLPYDTT SSTIFMFCGC 
       760        770        780        790        800
VEEYKLAPDG KSCLMLSDVC EGPKCLKPDS KFNDTLFGEM LHGYNNRTQH 
       810        820        830        840        850
VNQGQVFQMT FRENNFIKDF PQLADGLLVI PLPVEEQCRG VLSEPLPDLQ 
       860        870        880        890        900
LLTGDIRYDE AMGYPMVQQW RVRSNLYRVK LSTITLSAGF TNVLKILTKE 
       910        920        930        940        950
SSRDELLSFI QHYGSHYIAE ALYGSELTCI IHFPSKKVQQ QLWLQYQKET 
       960        970        980        990       1000
TELGSKKELK SMPFITYLSG LLTAQMLSDD QLISGVEIRC EEKGRCPSTC 
      1010       1020       1030       1040       1050
HLCRRPGKEQ LSPTPVLLEI NRVVPLYTLI QDNGTKEAFK NALMSSYWCS 
      1060       1070       1080       1090       1100
GKGDVIDDWC RCDLSAFDAS GLPNCSPLPQ PVLRLSPTVE PSSTVVSLEW 
      1110       1120       1130       1140       1150
VDVQPAIGTK VSDYILQHKK VDEYTDTDLY TGEFLSFADD LLSGLGTSCV 
      1160       1170       1180       1190       1200
AAGRSHGEVP EVSIYSVIFK CLEPDGLYKF TLYAVDTRGR HSELSTVTLR 
      1210       1220       1230       1240       1250
TACPLVDDNK AEEIADKIYN LYNGYTSGKE QQTAYNTLME VSASMLFRVQ 
      1260       1270       1280       1290       1300
HHYNSHYEKF GDFVWRSEDE LGPRKAHLIL RRLERVSSHC SSLLRSAYIQ 
      1310       1320       1330       1340       1350
SRVDTIPYLF CRSEEVRPAG MVWYSILKDT KITCEEKMVS MARNTYGETK 

GR
Length:1,352
Mass (Da):149,390
Last modified:February 20, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i76D88651761FB04B
GO
Isoform 2 (identifier: Q80Z10-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     597-600: Missing.

Show »
Length:1,348
Mass (Da):148,899
Checksum:i853D6999CE67B941
GO
Isoform 3 (identifier: Q80Z10-3) [UniParc]FASTAAdd to basket
Also known as: a1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     351-402: Missing.

Show »
Length:1,300
Mass (Da):143,643
Checksum:iF486B7A43E81E372
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD32265 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_058454351 – 402Missing in isoform 3. 1 PublicationCuratedAdd BLAST52
Alternative sequenceiVSP_028938597 – 600Missing in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK172987 mRNA Translation: BAD32265.1 Different initiation.
AL691438 Genomic DNA No translation available.
AL691454 Genomic DNA No translation available.
AL691456 Genomic DNA No translation available.
AL691474 Genomic DNA No translation available.
AL691475 Genomic DNA No translation available.
AL713878 Genomic DNA No translation available.
AL731829 Genomic DNA No translation available.
AL837523 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS18268.1 [Q80Z10-3]
CCDS18269.1 [Q80Z10-1]

NCBI Reference Sequences

More...RefSeqi		NP_062387.2, NM_019514.3 [Q80Z10-3]
NP_996992.1, NM_207109.2 [Q80Z10-1]
XP_006538167.1, XM_006538104.3 [Q80Z10-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000068214; ENSMUSP00000065786; ENSMUSG00000028373 [Q80Z10-1]
ENSMUST00000084496; ENSMUSP00000081540; ENSMUSG00000028373 [Q80Z10-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		56079

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:56079

UCSC genome browser

More...UCSCi		uc008thn.1, mouse [Q80Z10-1]
uc008tho.1, mouse
uc008thp.1, mouse [Q80Z10-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172987 mRNA Translation: BAD32265.1 Different initiation.
AL691438 Genomic DNA No translation available.
AL691454 Genomic DNA No translation available.
AL691456 Genomic DNA No translation available.
AL691474 Genomic DNA No translation available.
AL691475 Genomic DNA No translation available.
AL713878 Genomic DNA No translation available.
AL731829 Genomic DNA No translation available.
AL837523 Genomic DNA No translation available.
CCDSiCCDS18268.1 [Q80Z10-3]
CCDS18269.1 [Q80Z10-1]
RefSeqiNP_062387.2, NM_019514.3 [Q80Z10-3]
NP_996992.1, NM_207109.2 [Q80Z10-1]
XP_006538167.1, XM_006538104.3 [Q80Z10-2]

3D structure databases

SMRiQ80Z10
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ80Z10, 1 interactor
STRINGi10090.ENSMUSP00000065786

PTM databases

GlyConnecti2137, 1 N-Linked glycan (1 site)
GlyGeniQ80Z10, 3 sites
iPTMnetiQ80Z10
PhosphoSitePlusiQ80Z10

Proteomic databases

PaxDbiQ80Z10
PRIDEiQ80Z10
ProteomicsDBi277259 [Q80Z10-1]
277260 [Q80Z10-2]
277261 [Q80Z10-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		15627, 119 antibodies

Genome annotation databases

EnsembliENSMUST00000068214; ENSMUSP00000065786; ENSMUSG00000028373 [Q80Z10-1]
ENSMUST00000084496; ENSMUSP00000081540; ENSMUSG00000028373 [Q80Z10-3]
GeneIDi56079
KEGGimmu:56079
UCSCiuc008thn.1, mouse [Q80Z10-1]
uc008tho.1, mouse
uc008thp.1, mouse [Q80Z10-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23245
MGIiMGI:1889277, Astn2

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiENOG502R4QT, Eukaryota
GeneTreeiENSGT00390000003140
InParanoidiQ80Z10
OMAiYIKDFPQ
OrthoDBi39300at2759
PhylomeDBiQ80Z10
TreeFamiTF332034

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		56079, 2 hits in 23 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Astn2, mouse

Protein Ontology

More...PROi		PR:Q80Z10
RNActiQ80Z10, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000028373, Expressed in Ammon's horn and 109 other tissues
GenevisibleiQ80Z10, MM

Family and domain databases

CDDicd00063, FN3, 1 hit
InterProiView protein in InterPro
IPR040685, Annexin-like
IPR040510, ASTN_2_hairpin
IPR026995, Astrotactin
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR020864, MACPF
PANTHERiPTHR16592, PTHR16592, 1 hit
PfamiView protein in Pfam
PF18411, Annexin_like, 1 hit
PF18577, ASTN_2_hairpin, 1 hit
PF01823, MACPF, 1 hit
SMARTiView protein in SMART
SM00457, MACPF, 1 hit
SUPFAMiSSF49265, SSF49265, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiASTN2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80Z10
Secondary accession number(s): E9Q8T4
, Q6A031, Q811X9, Q811Y0, Q811Y1, Q811Y2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 20, 2007
Last modified: June 2, 2021
This is version 114 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again