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Protein

Tenascin

Gene

Tnc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth when provided to neurons in culture. May play a role in supporting the growth of epithelial tumors. Ligand for integrins ITGA8:ITGB1, ITGA9:ITGB1, ITGAV:ITGB3 and ITGAV:ITGB6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-216083 Integrin cell surface interactions
R-MMU-3000178 ECM proteoglycans
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tenascin
Short name:
TN
Alternative name(s):
Hexabrachion
Tenascin-C
Short name:
TN-C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TncImported
Synonyms:HxbImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:101922 Tnc

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice show enhanced novelty-induced activity, reduced anxiety, delayed resynchronization to daylight reversal and weaker muscle strength.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22By similarityAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000024860723 – 2110TenascinBy similarityAdd BLAST2088

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei65PhosphoserineBy similarity1
Modified residuei70PhosphoserineBy similarity1
Modified residuei72PhosphoserineBy similarity1
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi190 ↔ 200Sequence analysis
Disulfide bondi194 ↔ 205Sequence analysis
Disulfide bondi207 ↔ 216Sequence analysis
Disulfide bondi221 ↔ 231Sequence analysis
Disulfide bondi225 ↔ 236Sequence analysis
Disulfide bondi238 ↔ 247Sequence analysis
Disulfide bondi252 ↔ 263Sequence analysis
Disulfide bondi256 ↔ 268Sequence analysis
Disulfide bondi270 ↔ 279Sequence analysis
Disulfide bondi284 ↔ 294Sequence analysis
Disulfide bondi288 ↔ 299Sequence analysis
Disulfide bondi301 ↔ 310Sequence analysis
Disulfide bondi315 ↔ 325Sequence analysis
Disulfide bondi319 ↔ 330Sequence analysis
Glycosylationi327N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi332 ↔ 341Sequence analysis
Disulfide bondi346 ↔ 356Sequence analysis
Disulfide bondi350 ↔ 361Sequence analysis
Disulfide bondi363 ↔ 372Sequence analysis
Disulfide bondi377 ↔ 387Sequence analysis
Disulfide bondi381 ↔ 392Sequence analysis
Disulfide bondi394 ↔ 403Sequence analysis
Disulfide bondi408 ↔ 418Sequence analysis
Disulfide bondi412 ↔ 423Sequence analysis
Disulfide bondi425 ↔ 434Sequence analysis
Disulfide bondi439 ↔ 449Sequence analysis
Disulfide bondi443 ↔ 454Sequence analysis
Disulfide bondi456 ↔ 465Sequence analysis
Disulfide bondi470 ↔ 480Sequence analysis
Disulfide bondi474 ↔ 485Sequence analysis
Disulfide bondi487 ↔ 496Sequence analysis
Disulfide bondi501 ↔ 511Sequence analysis
Disulfide bondi505 ↔ 516Sequence analysis
Disulfide bondi518 ↔ 527Sequence analysis
Disulfide bondi532 ↔ 542Sequence analysis
Disulfide bondi536 ↔ 547Sequence analysis
Disulfide bondi549 ↔ 558Sequence analysis
Disulfide bondi563 ↔ 573Sequence analysis
Disulfide bondi567 ↔ 578Sequence analysis
Disulfide bondi580 ↔ 589Sequence analysis
Disulfide bondi594 ↔ 604Sequence analysis
Disulfide bondi598 ↔ 609Sequence analysis
Disulfide bondi611 ↔ 620Sequence analysis
Glycosylationi788N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei905PhosphothreonineBy similarity1
Glycosylationi1018N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1079N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1093N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1119N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1184N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1210N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1275N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1301N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1354N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1364N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1394N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1443N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1718N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1969N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2071N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q80YX1

PeptideAtlas

More...
PeptideAtlasi
Q80YX1

PRoteomics IDEntifications database

More...
PRIDEi
Q80YX1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q80YX1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q80YX1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in kidney, aortic valve, corneal limbus, periosteum around the ribs, cerebellum, stomach and intestine (PubMed:14709716). High levels of isoform 2 in lung and brain of newborn mice. High levels of isoform 5 in thymus, moderate levels in brain of newborn and adult mice. Low level of isoform 2 in adult brain.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

At day E11.5, expressed in maxillary process. at, E14.5, also detected in the stomach and at E15.5 expressed in developing bones. During embryogenesis, also expressed in lung, cartilages, liver, brain and peripheral nerves (PubMed:14709716). In kidney, isoform 2 is expressed at birth and isoform 5 at 2 weeks of age. In intestine, isoform 5 is expressed at E13 and isoform 2 at birth. In cerebellum, high levels of isoform 2 at E17 are down-regulated to moderate levels in newborn mice and undetectable levels in adult mice. Similarly, moderate levels of isoform 2 expressed in cerebrum of E17 are gradually down-regulated to undetectable levels in adult mice.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000028364 Expressed in 268 organ(s), highest expression level in hindlimb long bone

CleanEx database of gene expression profiles

More...
CleanExi
MM_TNC

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q80YX1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q80YX1 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
204237, 1 interactor

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-471 Tenascin-C complex

Protein interaction database and analysis system

More...
IntActi
Q80YX1, 1 interactor

Molecular INTeraction database

More...
MINTi
Q80YX1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q80YX1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q80YX1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini174 – 185EGF-like 1; incompletePROSITE-ProRule annotationAdd BLAST12
Domaini186 – 216EGF-like 2PROSITE-ProRule annotationAdd BLAST31
Domaini217 – 247EGF-like 3PROSITE-ProRule annotationAdd BLAST31
Domaini248 – 279EGF-like 4PROSITE-ProRule annotationAdd BLAST32
Domaini280 – 310EGF-like 5PROSITE-ProRule annotationAdd BLAST31
Domaini311 – 341EGF-like 6PROSITE-ProRule annotationAdd BLAST31
Domaini342 – 372EGF-like 7PROSITE-ProRule annotationAdd BLAST31
Domaini373 – 403EGF-like 8PROSITE-ProRule annotationAdd BLAST31
Domaini404 – 434EGF-like 9PROSITE-ProRule annotationAdd BLAST31
Domaini435 – 465EGF-like 10PROSITE-ProRule annotationAdd BLAST31
Domaini466 – 496EGF-like 11PROSITE-ProRule annotationAdd BLAST31
Domaini497 – 527EGF-like 12PROSITE-ProRule annotationAdd BLAST31
Domaini528 – 558EGF-like 13PROSITE-ProRule annotationAdd BLAST31
Domaini559 – 589EGF-like 14PROSITE-ProRule annotationAdd BLAST31
Domaini590 – 621EGF-like 15PROSITE-ProRule annotationAdd BLAST32
Domaini625 – 715Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST91
Domaini716 – 804Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST89
Domaini805 – 894Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST90
Domaini895 – 988Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST94
Domaini989 – 1077Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST89
Domaini1078 – 1165Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST88
Domaini1167 – 1259Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST93
Domaini1260 – 1348Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST89
Domaini1349 – 1440Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST92
Domaini1442 – 1530Fibronectin type-III 10PROSITE-ProRule annotationAdd BLAST89
Domaini1531 – 1620Fibronectin type-III 11PROSITE-ProRule annotationAdd BLAST90
Domaini1621 – 1710Fibronectin type-III 12PROSITE-ProRule annotationAdd BLAST90
Domaini1711 – 1797Fibronectin type-III 13PROSITE-ProRule annotationAdd BLAST87
Domaini1798 – 1886Fibronectin type-III 14PROSITE-ProRule annotationAdd BLAST89
Domaini1884 – 2099Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST216

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili118 – 142Sequence analysisAdd BLAST25

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tenascin family.Sequence analysis

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155188

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234355

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG008949

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q80YX1

KEGG Orthology (KO)

More...
KOi
K06252

Database of Orthologous Groups

More...
OrthoDBi
18592at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q80YX1

TreeFam database of animal gene trees

More...
TreeFami
TF329915

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 14 hits
cd00087 FReD, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 14 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR033078 TNC

The PANTHER Classification System

More...
PANTHERi
PTHR19143:SF38 PTHR19143:SF38, 8 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07974 EGF_2, 5 hits
PF00147 Fibrinogen_C, 1 hit
PF00041 fn3, 14 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 14 hits
SM00186 FBG, 1 hit
SM00060 FN3, 14 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 11 hits
SSF56496 SSF56496, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 15 hits
PS01186 EGF_2, 14 hits
PS50026 EGF_3, 5 hits
PS51406 FIBRINOGEN_C_2, 1 hit
PS50853 FN3, 14 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q80YX1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGAVTWLLPG IFLALFALTP EGGVLKKIIR HKRESGLNMT LPEENQPVVF
60 70 80 90 100
NHIYNIKLPM GSQCSVDLES ASGEKDLTPT PESSGSFQEH TVDGENQIVF
110 120 130 140 150
THRINIPRRA CGCAAAPDVK ELLSRLEELE LLVSSLREQC TMGTGCCLQP
160 170 180 190 200
AEGRLDTRPF CSGRGNFSAE GCGCVCEPGW KGPNCSEPDC PGNCNLRGQC
210 220 230 240 250
LDGQCICDEG FTGEDCSQLA CPNDCNDQGR CVNGVCVCFE GYAGPDCGLE
260 270 280 290 300
VCPVPCSEEH GMCVDGRCVC KDGFAGEDCN EPLCLNNCYN RGRCVENECV
310 320 330 340 350
CDEGFTGEDC SELICPNDCF DRGRCINGTC YCEEGFTGED CGELTCPNDC
360 370 380 390 400
QGRGQCEEGQ CVCNEGFAGA DCSEKRCPAD CHHRGRCLNG QCECDDGFTG
410 420 430 440 450
ADCGDLQCPN GCSGHGRCVN GQCVCDEGYT GEDCSQRRCP NDCHNRGLCV
460 470 480 490 500
QGKCICEQGF KGFDCSEMSC PNDCHQHGRC VNGMCICDDD YTGEDCRDRR
510 520 530 540 550
CPRDCSQRGR CVDGQCICED GFTGPDCAEL SCPSDCHGHG RCVNGQCICH
560 570 580 590 600
EGFTGKDCKE QRCPSDCHGQ GRCEDGQCIC HEGFTGLDCG QRSCPNDCSN
610 620 630 640 650
QGQCVSGRCI CNEGYTGIDC SEVSPPKDLI VTEVTEETVN LAWDNEMRVT
660 670 680 690 700
EYLIMYTPTH ADGLEMQFRV PGDQTSTTIR ELEPGVEYFI RVFAILENKR
710 720 730 740 750
SIPVSARVAT YLPAPEGLKF KSIKETSVEV EWDPLDIAFE TWEIIFRNMN
760 770 780 790 800
KEDEGEITKS LRRPETSYRQ TGLAPGQEYE ISLHIVKNNT RGPGLKKVTT
810 820 830 840 850
TRLDAPSHIE VKDVTDTTAL ITWFKPLAEI DSIELSYGIK DVPGDRTTID
860 870 880 890 900
LTHEDNQYSI GNLRPDTEYE VSLISRRVDM ASNPAKETFI TGLDAPRNLR
910 920 930 940 950
RVSQTDNSIT LEWRNVKADI DSYRIKYAPI SGGDHAEIDV PKSQQATTKT
960 970 980 990 1000
TLTGLRPGTE YGIGVSAVKG DKESDPATIN AATEIDAPKD LRVSETTQDS
1010 1020 1030 1040 1050
LTFFWTTPLA KFDRYRLNYS LPTGQSMEVQ LPKDATSHVL TDLEPGQEYT
1060 1070 1080 1090 1100
VLLIAEKGRH KSKPARVKAS TEEVPSLENL TVTEAGWDGL RLNWTADDLA
1110 1120 1130 1140 1150
YEYFVIQVQE ANNVETAHNF TVPGNLRAAD IPGLKVATSY RVSIYGVARG
1160 1170 1180 1190 1200
YRTPVLSAET STGTTPNLGE VTVAEVGWDA LTLNWTAPEG AYKNFFIQVL
1210 1220 1230 1240 1250
EADTTQTVQN LTVPGGLRSV DLPGLKAATR YYITLRGVTQ DFGTAPLSVE
1260 1270 1280 1290 1300
VLTEDLPQLG GLSVTEVSWD GLTLNWTTDD LAYKHFVVQV QEANNVEAAQ
1310 1320 1330 1340 1350
NLTVPGSLRA VDIPGLKADT PYRVSIYGVI QGYRTPMLST DVSTAREPEI
1360 1370 1380 1390 1400
GNLNVSDVTP KSFNLSWTAT DGIFDMFTIE IIDSNRLLQT AEHNISGAER
1410 1420 1430 1440 1450
TAHISGLPPS TDFIVYLSGI APSIRTKTIS TTATTEALPL LENLTISDTN
1460 1470 1480 1490 1500
PYGFTVSWTA SENAFDSFLV TVVDSGKLLD PQEFTLSGTQ RKLELRGLIT
1510 1520 1530 1540 1550
GIGYEVLVSG FTQGHQTKPL RAETITEAEP EVDNLLVSDA TPDGFRLSWT
1560 1570 1580 1590 1600
ADEGIFDSFV IRIRDTKKQS EPQEISLPSP ERTRDITGLR EATEYEIELY
1610 1620 1630 1640 1650
GISRGRRSQP VSAIATTAMG SPKEIMFSDI TENAATVSWR APTAQVESFR
1660 1670 1680 1690 1700
ITYVPMTGGA PSMVTVDGTD TETRLVKLTP GVEYRVSVIA MKGFEESDPV
1710 1720 1730 1740 1750
SGTLITALDG PSGLLIANIT DSEALAMWQP AIATVDSYVI SYTGERVPEV
1760 1770 1780 1790 1800
TRTVSGNTVE YELHDLEPAT EYILSIFAEK GQQKSSTIAT KFTTDLDSPR
1810 1820 1830 1840 1850
EFTATEVQSE TALLTWRPPR ASVTGYLLVY ESVDGTVKEV IVGPDTTSYS
1860 1870 1880 1890 1900
LADLSPSTHY SARIQALSGS LRSKLIQTIF TTIGLLYPFP RDCSQAMLNG
1910 1920 1930 1940 1950
DTTSGLYTIY INGDKTQALE VYCDMTSDGG GWIVFLRRKN GREDFYRNWK
1960 1970 1980 1990 2000
AYAAGFGDRR EEFWLGLDNL SKITAQGQYE LRVDLQDHGE SAYAVYDRFS
2010 2020 2030 2040 2050
VGDAKSRYKL KVEGYSGTAG DSMNYHNGRS FSTYDKDTDS AITNCALSYK
2060 2070 2080 2090 2100
GAFWYKNCHR VNLMGRYGDN NHSQGVNWFH WKGHEYSIQF AEMKLRPSNF
2110
RNLEGRRKRA
Length:2,110
Mass (Da):231,807
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA1FEA96F8BC2FE51
GO
Isoform 21 Publication (identifier: Q80YX1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1436-1526: Missing.

Show »
Length:2,019
Mass (Da):221,879
Checksum:i27C4BFFA2024304C
GO
Isoform 31 Publication (identifier: Q80YX1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1254-1616: Missing.

Show »
Length:1,747
Mass (Da):192,063
Checksum:i18733FA4332BC36B
GO
Isoform 41 Publication (identifier: Q80YX1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1163-1616: Missing.

Show »
Length:1,656
Mass (Da):182,340
Checksum:i1DC087F9641641AE
GO
Isoform 51 Publication (identifier: Q80YX1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1072-1616: Missing.

Show »
Length:1,565
Mass (Da):172,354
Checksum:iA8BA58FE720C4BBD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q80YX0Q80YX0_MOUSE
Tenascin
Tnc
832Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti202D → E in CAA39751 (PubMed:1703162).Curated1
Sequence conflicti318D → S in CAA39751 (PubMed:1703162).Curated1
Sequence conflicti1019Y → S in CAA39751 (PubMed:1703162).Curated1
Sequence conflicti1025Q → H in CAA39751 (PubMed:1703162).Curated1
Sequence conflicti1306G → S in CAA39751 (PubMed:1703162).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0521441072 – 1616Missing in isoform 5. 2 PublicationsAdd BLAST545
Alternative sequenceiVSP_0521451163 – 1616Missing in isoform 4. 1 PublicationAdd BLAST454
Alternative sequenceiVSP_0521461254 – 1616Missing in isoform 3. 1 PublicationAdd BLAST363
Alternative sequenceiVSP_0521471436 – 1526Missing in isoform 2. 2 PublicationsAdd BLAST91

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D90343 mRNA Translation: BAA14355.1
X56304 mRNA Translation: CAA39751.1
AL732556 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS18265.1 [Q80YX1-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
JQ1322

NCBI Reference Sequences

More...
RefSeqi
NP_035737.2, NM_011607.3 [Q80YX1-2]
XP_006537837.1, XM_006537774.1 [Q80YX1-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.454219
Mm.980

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000030056; ENSMUSP00000030056; ENSMUSG00000028364 [Q80YX1-2]
ENSMUST00000107372; ENSMUSP00000102995; ENSMUSG00000028364 [Q80YX1-1]
ENSMUST00000107377; ENSMUSP00000103000; ENSMUSG00000028364 [Q80YX1-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
21923

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:21923

UCSC genome browser

More...
UCSCi
uc008thg.2 mouse [Q80YX1-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90343 mRNA Translation: BAA14355.1
X56304 mRNA Translation: CAA39751.1
AL732556 Genomic DNA No translation available.
CCDSiCCDS18265.1 [Q80YX1-2]
PIRiJQ1322
RefSeqiNP_035737.2, NM_011607.3 [Q80YX1-2]
XP_006537837.1, XM_006537774.1 [Q80YX1-1]
UniGeneiMm.454219
Mm.980

3D structure databases

ProteinModelPortaliQ80YX1
SMRiQ80YX1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204237, 1 interactor
ComplexPortaliCPX-471 Tenascin-C complex
IntActiQ80YX1, 1 interactor
MINTiQ80YX1

PTM databases

iPTMnetiQ80YX1
PhosphoSitePlusiQ80YX1

Proteomic databases

jPOSTiQ80YX1
PeptideAtlasiQ80YX1
PRIDEiQ80YX1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030056; ENSMUSP00000030056; ENSMUSG00000028364 [Q80YX1-2]
ENSMUST00000107372; ENSMUSP00000102995; ENSMUSG00000028364 [Q80YX1-1]
ENSMUST00000107377; ENSMUSP00000103000; ENSMUSG00000028364 [Q80YX1-2]
GeneIDi21923
KEGGimmu:21923
UCSCiuc008thg.2 mouse [Q80YX1-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3371
MGIiMGI:101922 Tnc

Phylogenomic databases

GeneTreeiENSGT00940000155188
HOGENOMiHOG000234355
HOVERGENiHBG008949
InParanoidiQ80YX1
KOiK06252
OrthoDBi18592at2759
PhylomeDBiQ80YX1
TreeFamiTF329915

Enzyme and pathway databases

ReactomeiR-MMU-216083 Integrin cell surface interactions
R-MMU-3000178 ECM proteoglycans
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q80YX1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000028364 Expressed in 268 organ(s), highest expression level in hindlimb long bone
CleanExiMM_TNC
ExpressionAtlasiQ80YX1 baseline and differential
GenevisibleiQ80YX1 MM

Family and domain databases

CDDicd00063 FN3, 14 hits
cd00087 FReD, 1 hit
Gene3Di2.60.40.10, 14 hits
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR033078 TNC
PANTHERiPTHR19143:SF38 PTHR19143:SF38, 8 hits
PfamiView protein in Pfam
PF07974 EGF_2, 5 hits
PF00147 Fibrinogen_C, 1 hit
PF00041 fn3, 14 hits
SMARTiView protein in SMART
SM00181 EGF, 14 hits
SM00186 FBG, 1 hit
SM00060 FN3, 14 hits
SUPFAMiSSF49265 SSF49265, 11 hits
SSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 15 hits
PS01186 EGF_2, 14 hits
PS50026 EGF_3, 5 hits
PS51406 FIBRINOGEN_C_2, 1 hit
PS50853 FN3, 14 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTENA_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80YX1
Secondary accession number(s): Q64706, Q80YX2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 2003
Last modified: January 16, 2019
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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