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Protein

B box and SPRY domain-containing protein

Gene

Bspry

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate epithelial calcium transport by inhibiting TRPV5 activity.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri65 – 113B box-typeAdd BLAST49

GO - Molecular functioni

GO - Biological processi

  • calcium ion transport Source: UniProtKB-KW
  • cellular response to leukemia inhibitory factor Source: MGI

Keywordsi

Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Metal-binding, Vitamin D, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
B box and SPRY domain-containing protein
Gene namesi
Name:Bspry
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2177191 Bspry

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002442581 – 473B box and SPRY domain-containing proteinAdd BLAST473

Proteomic databases

PaxDbiQ80YW5
PRIDEiQ80YW5

PTM databases

PhosphoSitePlusiQ80YW5

Expressioni

Tissue specificityi

According to PubMed:10978534, testis-specific. According to PubMed:16371431, broadly expressed.2 Publications

Developmental stagei

Expression starts at E19 in brain.1 Publication

Inductioni

Down-regulated by vitamin D.1 Publication

Gene expression databases

BgeeiENSMUSG00000028392 Expressed in 141 organ(s), highest expression level in seminiferous tubule of testis
CleanExiMM_BSPRY
ExpressionAtlasiQ80YW5 baseline and differential
GenevisibleiQ80YW5 MM

Interactioni

Subunit structurei

Interacts with YWHAZ/14-3-3 protein zeta (By similarity). Interacts with TRPV5 and TRPV6.By similarity1 Publication

Protein-protein interaction databases

BioGridi228643, 1 interactor
IntActiQ80YW5, 1 interactor
MINTiQ80YW5
STRINGi10090.ENSMUSP00000030088

Structurei

3D structure databases

ProteinModelPortaliQ80YW5
SMRiQ80YW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini259 – 455B30.2/SPRYPROSITE-ProRule annotationAdd BLAST197

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi16 – 52Pro-richAdd BLAST37

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri65 – 113B box-typeAdd BLAST49

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITF8 Eukaryota
ENOG4111EI7 LUCA
GeneTreeiENSGT00840000129835
HOGENOMiHOG000057290
HOVERGENiHBG080574
InParanoidiQ80YW5
OMAiWVFSRYD
TreeFamiTF351014

Family and domain databases

InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR003877 SPRY_dom
IPR000315 Znf_B-box
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00589 PRY, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform 1 (identifier: Q80YW5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSADVSGTES GSESGPEPEP GPEPGPESRP ESRPKPGPGP EPRPESGPEP
60 70 80 90 100
GPRSGLRRGP KQGSERSQLC PEHFEPLSWF CLSERRPVCA TCAGFGGRCH
110 120 130 140 150
RHRIRRAEEH AEELRNKIVD QCERLQLQSA GISKYMAEVL QGKNQKAVVM
160 170 180 190 200
ASAARDLIIQ RLSLVRSLCE SEEQRLLEQV HGEEERAHQS ILTQRAHWVD
210 220 230 240 250
AVQKLDTLRT NMVDMITHLD DLQLIQREQE IFERAEEAEG ILDPQDSEKL
260 270 280 290 300
SFNEKCAWSP LLTQLWAASV LGSLSGVEEV LIDERTVSPL LHLSEDRRTL
310 320 330 340 350
TFIAKKSKVC SDEPERFDHW PNALAATAFQ TGLHAWIVNV KHSCAYKVGV
360 370 380 390 400
ASDQLPRKGS GNDCRLGHNA FSWVFSRYDQ EFCFSHNGYH EPLPLLRCPA
410 420 430 440 450
QLGMLLDLQA GELVFYEPAS GTVLHIHRAS FPQVLFPVFA VADQLISIVR
460 470
GPLATVRLDS PPHHPCRSGH ASR
Length:473
Mass (Da):52,751
Last modified:June 1, 2003 - v1
Checksum:i60FBC4A61A8F4A8E
GO
Isoform 2 (identifier: Q80YW5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     467-473: RSGHASR → SIRRTTCQDTVGQNVVVGVW

Show »
Length:486
Mass (Da):54,199
Checksum:iF9682B73348E417F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RIR4D6RIR4_MOUSE
B box and SPRY domain-containing pr...
Bspry
123Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17E → F in BAC29115 (PubMed:16141072).Curated1
Sequence conflicti137A → D in BAE36097 (PubMed:16141072).Curated1
Sequence conflicti169C → S in BAE36097 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019529467 – 473RSGHASR → SIRRTTCQDTVGQNVVVGVW in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276690 mRNA Translation: CAC09325.1
AK035588 mRNA Translation: BAC29115.1
AK160930 mRNA Translation: BAE36097.1
AL732594 Genomic DNA No translation available.
BC003992 mRNA Translation: AAH03992.2
CCDSiCCDS18241.1 [Q80YW5-2]
RefSeqiNP_619594.1, NM_138653.1 [Q80YW5-2]
UniGeneiMm.29808

Genome annotation databases

EnsembliENSMUST00000030088; ENSMUSP00000030088; ENSMUSG00000028392 [Q80YW5-2]
ENSMUST00000107449; ENSMUSP00000103073; ENSMUSG00000028392 [Q80YW5-1]
GeneIDi192120
KEGGimmu:192120
UCSCiuc008tex.1 mouse [Q80YW5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiBSPRY_MOUSE
AccessioniPrimary (citable) accession number: Q80YW5
Secondary accession number(s): Q3TU74
, Q8BZF0, Q99KV7, Q9ER70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2003
Last modified: September 12, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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