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Protein

Splicing regulator RBM11

Gene

Rbm11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5' splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1 (By similarity).By similarity

GO - Molecular functioni

  • poly(U) RNA binding Source: MGI
  • protein homodimerization activity Source: MGI
  • single-stranded RNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, RNA-binding
Biological processDifferentiation, mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Splicing regulator RBM11
Alternative name(s):
RNA-binding motif protein 11
Gene namesi
Name:Rbm11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2447622 Rbm11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004161161 – 238Splicing regulator RBM11Add BLAST238

Proteomic databases

PaxDbiQ80YT9
PRIDEiQ80YT9

PTM databases

PhosphoSitePlusiQ80YT9

Expressioni

Tissue specificityi

Selectively expressed in brain, cerebellum and testis, and to a lower extent in kidney.1 Publication

Developmental stagei

Peaks perinatally in brain and cerebellum, and at puberty in testis, in concomitance with differentiation events occurring in neurons and germ cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000032940 Expressed in 84 organ(s), highest expression level in white adipose tissue
ExpressionAtlasiQ80YT9 baseline and differential
GenevisibleiQ80YT9 MM

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038956

Structurei

3D structure databases

ProteinModelPortaliQ80YT9
SMRiQ80YT9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 87RRMPROSITE-ProRule annotationAdd BLAST78

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi202 – 237Bipartite nuclear localization signalCuratedAdd BLAST36

Phylogenomic databases

eggNOGiENOG410IY0E Eukaryota
ENOG4111UDH LUCA
GeneTreeiENSGT00870000136493
HOGENOMiHOG000146448
HOVERGENiHBG061506
InParanoidiQ80YT9
OrthoDBiEOG091G15TA

Family and domain databases

CDDicd12593 RRM_RBM11, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034501 RBM11_RRM
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q80YT9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFPAQEEADR TVFVGNLEAR VREEILYELF LQAGPLTKVT LCKDRDGKPK
60 70 80 90 100
SFGFVCFKHP ESVSYAIALL NGIRLYGRPI NVQYRFGSSR SSEPANQSFE
110 120 130 140 150
SCAKINSHSF RNDEMAGRPS FPVPFFPITS AALPQEYFFF QKMPWYAHSP
160 170 180 190 200
VLQPPFCEMP APLPNSVPGS CALNHSPGPE AGPSSYEWTH QPPSDPDLYP
210 220 230
RNKRKRQRPD SDSDSSSEDK RGNEGSQKCR KCKKKKRY
Length:238
Mass (Da):26,945
Last modified:June 1, 2003 - v1
Checksum:i70A402DC4194E194
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H9KUZ7H9KUZ7_MOUSE
Splicing regulator RBM11
Rbm11
238Annotation score:

Sequence cautioni

The sequence EDK98269 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC166995 Genomic DNA No translation available.
CH466521 Genomic DNA Translation: EDK98269.1 Different initiation.
BC050779 mRNA Translation: AAH50779.1
AK039297 mRNA Translation: BAC30309.1
CCDSiCCDS37377.1
RefSeqiNP_938044.1, NM_198302.2
UniGeneiMm.273214

Genome annotation databases

EnsembliENSMUST00000046378; ENSMUSP00000038956; ENSMUSG00000032940
ENSMUST00000114253; ENSMUSP00000109891; ENSMUSG00000032940
GeneIDi224344
KEGGimmu:224344
UCSCiuc007zro.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC166995 Genomic DNA No translation available.
CH466521 Genomic DNA Translation: EDK98269.1 Different initiation.
BC050779 mRNA Translation: AAH50779.1
AK039297 mRNA Translation: BAC30309.1
CCDSiCCDS37377.1
RefSeqiNP_938044.1, NM_198302.2
UniGeneiMm.273214

3D structure databases

ProteinModelPortaliQ80YT9
SMRiQ80YT9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038956

PTM databases

PhosphoSitePlusiQ80YT9

Proteomic databases

PaxDbiQ80YT9
PRIDEiQ80YT9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046378; ENSMUSP00000038956; ENSMUSG00000032940
ENSMUST00000114253; ENSMUSP00000109891; ENSMUSG00000032940
GeneIDi224344
KEGGimmu:224344
UCSCiuc007zro.1 mouse

Organism-specific databases

CTDi54033
MGIiMGI:2447622 Rbm11

Phylogenomic databases

eggNOGiENOG410IY0E Eukaryota
ENOG4111UDH LUCA
GeneTreeiENSGT00870000136493
HOGENOMiHOG000146448
HOVERGENiHBG061506
InParanoidiQ80YT9
OrthoDBiEOG091G15TA

Miscellaneous databases

PROiPR:Q80YT9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032940 Expressed in 84 organ(s), highest expression level in white adipose tissue
ExpressionAtlasiQ80YT9 baseline and differential
GenevisibleiQ80YT9 MM

Family and domain databases

CDDicd12593 RRM_RBM11, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034501 RBM11_RRM
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRBM11_MOUSE
AccessioniPrimary (citable) accession number: Q80YT9
Secondary accession number(s): D3Z0X9, Q8BYK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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