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Entry version 116 (02 Jun 2021)
Sequence version 2 (23 Oct 2007)
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Protein

Myomegalin

Gene

Pde4dip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity).

By similarity

Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome. In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myomegalin
Alternative name(s):
Phosphodiesterase 4D-interacting protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pde4dip
Synonyms:Kiaa0454
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1891434, Pde4dip

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003076911 – 2224MyomegalinAdd BLAST2224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei705PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q80YT7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q80YT7

PRoteomics IDEntifications database

More...
PRIDEi
Q80YT7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
287595 [Q80YT7-1]
287596 [Q80YT7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q80YT7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q80YT7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000038170, Expressed in muscle tissue and 291 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q80YT7, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PDE4D (By similarity).

Isoform 2 interacts with MAPRE1 and MAPRE3. Isoform 2 forms a pericentrosomal complex with AKAP9, CDK5RAP2 and EB1/MAPRE1; within this complex, may mediate MAPRE1-binding to CDK5RAP2. Interaction with AKAP9 stabilizes both proteins. Isoform 2 interacts (via N-terminus) with CAMSAP2; this interaction is much stronger in the presence of AKAP9. In complex with AKAP9, Isoform 2 recruits CAMSAP2 to the Golgi apparatus.

Isoform 2 interacts with unglycosylated LGALS3BP; this interaction may connect the pericentrosomal complex to the gamma-tubulin ring complex (gamma-TuRC) to promote microtubule assembly and acetylation (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
219963, 185 interactors

Protein interaction database and analysis system

More...
IntActi
Q80YT7, 179 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000040905

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q80YT7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q80YT7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1497 – 1588OlduvaiPROSITE-ProRule annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni206 – 236DisorderedSequence analysisAdd BLAST31
Regioni703 – 751DisorderedSequence analysisAdd BLAST49
Regioni1098 – 1128DisorderedSequence analysisAdd BLAST31
Regioni1141 – 1161DisorderedSequence analysisAdd BLAST21
Regioni1270 – 1298DisorderedSequence analysisAdd BLAST29
Regioni1576 – 1637DisorderedSequence analysisAdd BLAST62
Regioni1736 – 1757DisorderedSequence analysisAdd BLAST22
Regioni1805 – 1824DisorderedSequence analysisAdd BLAST20
Regioni1962 – 2001DisorderedSequence analysisAdd BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili41 – 97Sequence analysisAdd BLAST57
Coiled coili162 – 205Sequence analysisAdd BLAST44
Coiled coili236 – 318Sequence analysisAdd BLAST83
Coiled coili350 – 682Sequence analysisAdd BLAST333
Coiled coili745 – 822Sequence analysisAdd BLAST78
Coiled coili856 – 886Sequence analysisAdd BLAST31
Coiled coili949 – 986Sequence analysisAdd BLAST38
Coiled coili1159 – 1187Sequence analysisAdd BLAST29
Coiled coili1295 – 1331Sequence analysisAdd BLAST37
Coiled coili1377 – 1401Sequence analysisAdd BLAST25
Coiled coili1769 – 1958Sequence analysisAdd BLAST190
Coiled coili2148 – 2191Sequence analysisAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi703 – 745Polar residuesSequence analysisAdd BLAST43
Compositional biasi1102 – 1122Polar residuesSequence analysisAdd BLAST21
Compositional biasi1279 – 1298Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi1586 – 1616Polar residuesSequence analysisAdd BLAST31
Compositional biasi1806 – 1824Polar residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

residues 1-150 are involved in AKAP9-binding.By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QPV2, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183190

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_302801_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q80YT7

Database of Orthologous Groups

More...
OrthoDBi
15127at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q80YT7

TreeFam database of animal gene trees

More...
TreeFami
TF329233

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012943, Cnn_1N
IPR010630, Olduvai_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07989, Cnn_1N, 1 hit
PF06758, Olduvai, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01148, DUF1220, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51316, ODV, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q80YT7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSNGYRTLSQ HLNDLKKENF SLKLRIYFLE ERMQQKYEVS REDVYKRNIE
60 70 80 90 100
LKVEVESLKR ELQDRKQHLD KTWADAEDLN SQNEAELRRQ VEERQQETEH
110 120 130 140 150
VYELLGNKIQ LLQEEPRLAK NEATEMETLV EAEKRCNLEL SERWTNAAKN
160 170 180 190 200
REDAAGDQEK PDQYSEALAQ RDRRIEELRQ SLAAQEGLVE QLSQEKRQLL
210 220 230 240 250
HLLEEPASME VQPVPKGLPT QQKPDLHETP TTQPPVSESH LAELQDKIQQ
260 270 280 290 300
TEATNKILQE KLNDLSCELK SAQESSQKQD TTIQSLKEML KSRESETEEL
310 320 330 340 350
YQVIEGQNDT MAKLREMLHQ SQLGQLHSSE GIAPAQQQVA LLDLQSALFC
360 370 380 390 400
SQLEIQRLQR LVRQKERQLA DGKRCVQLVE AAAQEREHQK EAAWKHNQEL
410 420 430 440 450
RKALQHLQGE LHSKSQQLHV LEAEKYNEIR TQGQNIQHLS HSLSHKEQLI
460 470 480 490 500
QELQELLQYR DNADKTLDTN EVFLEKLRQR IQDRAVALER VIDEKFSALE
510 520 530 540 550
EKDKELRQLR LAVRDRDHDL ERLRCVLSAN EATMQSMESL LRARGLEVEQ
560 570 580 590 600
LTATCQNLQW LKEELETKFG HWQKEQESII QQLQTSLHDR NKEVEDLSAT
610 620 630 640 650
LLCKLGPGQS EVAEELCQRL QRKERMLQDL LSDRNKQAVE HEMEIQGLLQ
660 670 680 690 700
SMGTREQERQ AAAEKMVQAF MERNSELQAL RQYLGGKELM TSSQTFISNQ
710 720 730 740 750
PAGVTSIGPH HGEQTDQGSM QMPSRDDSTS LTAREEASIP RSTLGDSDTV
760 770 780 790 800
AGLEKELSNA KEELELMAKK ERESQMELSA LQSMMAMQEE ELQVQAADLE
810 820 830 840 850
SLTRNVQIKE DLIKDLQMQL VDPEDIPAME RLTQEVLLLR EKVASVEPQG
860 870 880 890 900
QEVSGNKRQQ LLLMLEGLVD ERSRLNEALQ AERQLYSSLV KFHAQPENSE
910 920 930 940 950
RDGTLQVELE GAQVLRTRLE EVLGRSLERL SRLESLAAIG GGELESVQAQ
960 970 980 990 1000
EMLHLRAEIH QHLEEKRKAE VELKELKAQI EEAGFSSVSH ISRNTMLSLC
1010 1020 1030 1040 1050
LENAELKEQM GEAMSDGWEV EEDKEKGEVM LETVVAKGCL NENSLQAEFR
1060 1070 1080 1090 1100
KVQGKLKSAY NIINLLKEQL LLRSSEGNSK EMPELLVRLA REVDRMNTGL
1110 1120 1130 1140 1150
PSLGKHQHQE QENTTTARPG SRPQSLPLGA ALSVDGYQLE NKSQAQDSGH
1160 1170 1180 1190 1200
QPEFSLPGST KHLRSQLAQC RQRYQDLQEK LLISEATVFA QANQLEKYRA
1210 1220 1230 1240 1250
VFSESLVKQD SKQIQVDLQD LGYETCGRSE NEAEREETTS PECEEHNNLR
1260 1270 1280 1290 1300
PVVLMEGLCS EQGYLDPVLV SPPAKKPLEN KPGKQEEFRA HGTPDDSSLL
1310 1320 1330 1340 1350
RKDIRDLKAQ LQNANKVIQN LRSRVRSLSA TSDYSSSLER PRKLRAVATL
1360 1370 1380 1390 1400
EGASPHSVTD EDEGWLSDGT GAFYPPGLQA KKDLESLIQR VSQLEAQLPK
1410 1420 1430 1440 1450
TGLEGKLAEE LRCASWPGKY DSLIQDQARE LSYLRQKIRE GRGICYLLTQ
1460 1470 1480 1490 1500
HAKDTVKSFE DLLRSNDIDY YLGQSFREQL AQGGQLTERL TSKLSTKDHK
1510 1520 1530 1540 1550
SEKEEAGLEP LALRLSRELQ EKEKVIEVLQ AKLDTRSLSP PSSHAVSDSH
1560 1570 1580 1590 1600
RSASTTSFLS DDIEACSDMD VASEYTHYDE KKPSPSHSAA SASQGLKGES
1610 1620 1630 1640 1650
SSSPISLPTP QNPPKEASQA HPGFHFHSIP KPASLSQTPM HSALPSFVPF
1660 1670 1680 1690 1700
SPSGPPLLGC CETPMVSLAE AQQELQMLQK QLGESVSIAP PASTSTLLSN
1710 1720 1730 1740 1750
QTEASSPHYI NPAQPHTPTR STIELGRILE PGYLGSSGQW DMMRPQKGSV
1760 1770 1780 1790 1800
SGELSSGSSM YQLNSKPTGA DLLEEHLGEI RNLRQRLEES ICVNDRLREQ
1810 1820 1830 1840 1850
LQHRLSSTAR ENGSTSHFYS QGLESMPQLY NENRALREEN QSLQTRLSHA
1860 1870 1880 1890 1900
SRGHSQEVDH LREALLSSRS QLQELEKELE QQKAERQQLS LQSELQIYES
1910 1920 1930 1940 1950
LCENPKKALK AFSLDSCHQV PGELSCLVAE IRALRGQLEQ SIEVNNRLRL
1960 1970 1980 1990 2000
QLEQQMDRGA GKASLGPIAV GQSFPDKAEP ANLHQGSAAS PPVRDVGLNS
2010 2020 2030 2040 2050
PAMVLPNSSC SAPGSDHAIV TRTNNELSSD DSAAMKNPPK LEVDATDGPF
2060 2070 2080 2090 2100
ANKHGRHVIG HVDDYDALQQ QIGEGKLLIQ KILSLMRSAR SIPGQEAQDT
2110 2120 2130 2140 2150
EAPGNISAHE LRSSAKALNH ALEESTSLLN MFWRAALPNT HGPVLVGKEG
2160 2170 2180 2190 2200
QLMEKELLDL RAQVSQQEQI LQNTAARLKR ANQRKKSMEQ FIVSHLTRTH
2210 2220
DVLKKARTNL EMKSFRALTC TPAL
Length:2,224
Mass (Da):250,631
Last modified:October 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD3EA6F593ACD2445
GO
Isoform 2 (identifier: Q80YT7-2) [UniParc]FASTAAdd to basket
Also known as: Myomegalin variant 8, MMG, MMG8, Short myomegalin-like EB1 binding protein, SMYLE

The sequence of this isoform differs from the canonical sequence as follows:
     1-211: MSNGYRTLSQ...LLEEPASMEV → MKEICRICAR...LCDEYLPIGF
     950-955: QEMLHL → RHKHAF
     956-2224: Missing.

Show »
Length:1,118
Mass (Da):126,615
Checksum:iDC39815A9629AD96
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q1A0E9Q1A0_MOUSE
Myomegalin
Pde4dip
2,412Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q3UR03Q3UR03_MOUSE
Myomegalin
Pde4dip
834Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BJ38H3BJ38_MOUSE
Myomegalin
Pde4dip
564Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JEX6A0A0G2JEX6_MOUSE
Myomegalin
Pde4dip
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3X9L9G3X9L9_MOUSE
Myomegalin
Pde4dip
2,463Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH25653 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAC65568 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti695T → A in AAI41173 (PubMed:15489334).Curated1
Sequence conflicti787M → V in AAI41173 (PubMed:15489334).Curated1
Sequence conflicti903G → R in AAI41173 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0287841 – 211MSNGY…ASMEV → MKEICRICARELCGNQRRWI FHTASKLNLQVLLSHVLGKD VSRDGKAEFACSKCAFMLDR IYRFDTVIARIEALSLERLQ KLLLEKDRLKFCIASMYRKN NDDSGEENKAGSGTVDISGL PDMRYAALLQEDFAYSGFEC WVENEDQINDSHSCHASEGP GNRPRRCRGCAALRVADSDY EAICKVPRKVARSISYAPSS RWSTSICTEEPALSEVGPPD LASTKVPPDGESMEEGTPGS SVESLDASVQASPPQQKDEE TERSAKELVKCDYCSDEQAP QHLCNHKLELALSMIKGLDY KPIQSPRGSKLPIPVKSILP GAKPGHILTNGVSSSFLNRP LKPLYRTPVSYPWEISDGQE LWDDLCDEYLPIGF in isoform 2. 2 PublicationsAdd BLAST211
Alternative sequenceiVSP_028785950 – 955QEMLHL → RHKHAF in isoform 2. 2 Publications6
Alternative sequenceiVSP_028786956 – 2224Missing in isoform 2. 2 PublicationsAdd BLAST1269

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK122286 mRNA Translation: BAC65568.1 Different initiation.
AC130541 Genomic DNA No translation available.
AC153661 Genomic DNA No translation available.
BC025653 mRNA Translation: AAH25653.1 Sequence problems.
BC034266 mRNA Translation: AAH34266.1
BC050783 mRNA Translation: AAH50783.1
BC141172 mRNA Translation: AAI41173.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS38562.1 [Q80YT7-2]

NCBI Reference Sequences

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RefSeqi
NP_001034465.2, NM_001039376.2
NP_835181.2, NM_178080.4 [Q80YT7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000045243; ENSMUSP00000040905; ENSMUSG00000038170 [Q80YT7-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
83679

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:83679

UCSC genome browser

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UCSCi
uc008qpg.1, mouse [Q80YT7-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122286 mRNA Translation: BAC65568.1 Different initiation.
AC130541 Genomic DNA No translation available.
AC153661 Genomic DNA No translation available.
BC025653 mRNA Translation: AAH25653.1 Sequence problems.
BC034266 mRNA Translation: AAH34266.1
BC050783 mRNA Translation: AAH50783.1
BC141172 mRNA Translation: AAI41173.1
CCDSiCCDS38562.1 [Q80YT7-2]
RefSeqiNP_001034465.2, NM_001039376.2
NP_835181.2, NM_178080.4 [Q80YT7-2]

3D structure databases

SMRiQ80YT7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi219963, 185 interactors
IntActiQ80YT7, 179 interactors
STRINGi10090.ENSMUSP00000040905

PTM databases

iPTMnetiQ80YT7
PhosphoSitePlusiQ80YT7

Proteomic databases

EPDiQ80YT7
PaxDbiQ80YT7
PRIDEiQ80YT7
ProteomicsDBi287595 [Q80YT7-1]
287596 [Q80YT7-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
2152, 125 antibodies

The DNASU plasmid repository

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DNASUi
83679

Genome annotation databases

EnsembliENSMUST00000045243; ENSMUSP00000040905; ENSMUSG00000038170 [Q80YT7-2]
GeneIDi83679
KEGGimmu:83679
UCSCiuc008qpg.1, mouse [Q80YT7-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9659
MGIiMGI:1891434, Pde4dip

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiENOG502QPV2, Eukaryota
GeneTreeiENSGT00950000183190
HOGENOMiCLU_302801_0_0_1
InParanoidiQ80YT7
OrthoDBi15127at2759
PhylomeDBiQ80YT7
TreeFamiTF329233

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
83679, 2 hits in 51 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Pde4dip, mouse

Protein Ontology

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PROi
PR:Q80YT7
RNActiQ80YT7, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000038170, Expressed in muscle tissue and 291 other tissues
GenevisibleiQ80YT7, MM

Family and domain databases

InterProiView protein in InterPro
IPR012943, Cnn_1N
IPR010630, Olduvai_dom
PfamiView protein in Pfam
PF07989, Cnn_1N, 1 hit
PF06758, Olduvai, 1 hit
SMARTiView protein in SMART
SM01148, DUF1220, 1 hit
PROSITEiView protein in PROSITE
PS51316, ODV, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYOME_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80YT7
Secondary accession number(s): C4IXU1
, Q05CH5, Q80U00, Q8K240
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: June 2, 2021
This is version 116 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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