Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 110 (08 May 2019)
Sequence version 2 (27 Jul 2011)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Claspin

Gene

Clspn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, DNA damage, DNA repair

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-111465 Apoptotic cleavage of cellular proteins
R-MMU-176187 Activation of ATR in response to replication stress
R-MMU-5689880 Ub-specific processing proteases
R-MMU-5693607 Processing of DNA double-strand break ends

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Claspin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Clspn
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2445153 Clspn

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000898761 – 1315ClaspinAdd BLAST1315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei26PhosphoserineCombined sources1
Modified residuei42PhosphoserineCombined sources1
Modified residuei46PhosphoserineCombined sources1
Modified residuei53PhosphoserineCombined sources1
Modified residuei65PhosphoserineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Modified residuei109PhosphoserineCombined sources1
Modified residuei112PhosphoserineCombined sources1
Modified residuei119PhosphoserineCombined sources1
Modified residuei220PhosphoserineBy similarity1
Modified residuei255PhosphoserineBy similarity1
Modified residuei522PhosphoserineBy similarity1
Modified residuei698PhosphoserineBy similarity1
Modified residuei701PhosphoserineBy similarity1
Modified residuei709PhosphoserineBy similarity1
Modified residuei722PhosphoserineBy similarity1
Modified residuei740PhosphoserineBy similarity1
Modified residuei785PhosphoserineBy similarity1
Modified residuei787PhosphoserineBy similarity1
Modified residuei810PhosphoserineBy similarity1
Modified residuei816PhosphoserineCombined sources1
Modified residuei823PhosphoserineCombined sources1
Modified residuei868N6-acetyllysineBy similarity1
Modified residuei893Phosphothreonine; by CHEK1By similarity1
Modified residuei932PhosphoserineBy similarity1
Modified residuei990PhosphoserineBy similarity1
Modified residuei996PhosphoserineBy similarity1
Modified residuei998PhosphoserineBy similarity1
Modified residuei1133PhosphoserineCombined sources1
Modified residuei1265PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Undergoes ATR-dependent phosphorylation by CHEK1 during activation of DNA replication or damage checkpoints. Phosphorylation by CSNK1G1/CK1 promotes CHEK1 binding (By similarity).By similarity
Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) during G1 phase, leading to its degradation by the proteasome. Ubiquitination is mediated via its interaction with FZR1/CDH1. Following DNA damage, it is deubiquitinated by USP28 in G2 phase, preventing its degradation (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q80YR7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q80YR7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q80YR7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q80YR7

PeptideAtlas

More...
PeptideAtlasi
Q80YR7

PRoteomics IDEntifications database

More...
PRIDEi
Q80YR7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q80YR7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q80YR7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000042489 Expressed in 160 organ(s), highest expression level in pes

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q80YR7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q80YR7 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (phosphorylation-dependent) with CHEK1; regulates CLSPN function in checkpoint for DNA damage and replication.

Interacts with ATR and RAD9A and these interactions are slightly reduced during checkpoint activation.

Interacts with BRCA1 and this interaction increases during checkpoint activation.

Interacts with TIMELESS (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
234671, 17 interactors

Protein interaction database and analysis system

More...
IntActi
Q80YR7, 16 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000045344

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q80YR7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati887 – 896CKB motif 110
Repeati917 – 926CKB motif 210
Repeati954 – 963CKB motif 310

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili159 – 187Sequence analysisAdd BLAST29
Coiled coili599 – 626Sequence analysisAdd BLAST28
Coiled coili1001 – 1036Sequence analysisAdd BLAST36

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminus of the protein contains 3 potential CHEK1-binding motifs (CKB motifs). Potential phosphorylation sites within CKB motif 1 and CKB motif 2 are required for interaction with CHEK1 (By similarity).By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the claspin family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4156 Eukaryota
ENOG410Y041 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012738

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000049140

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q80YR7

Identification of Orthologs from Complete Genome Data

More...
OMAi
QDIREVR

Database of Orthologous Groups

More...
OrthoDBi
754103at2759

TreeFam database of animal gene trees

More...
TreeFami
TF328925

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024146 Claspin

The PANTHER Classification System

More...
PANTHERi
PTHR14396 PTHR14396, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q80YR7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGEVGSEVN LEVNDLKLLS QEAADSPVDS GQGSFETLEP LSERDSDEEI
60 70 80 90 100
FVSKKPKSRK VLQDSDSEAE DRDDAPEKPT YDDSAEDTQE NLHSGKSQSR
110 120 130 140 150
SFPKALADSD ESDMEETPSQ ESPETQEAPS LEPGHQTGHS VDFTTGRKLS
160 170 180 190 200
KTLLREGAEG KAKSKRRLEK EERTMEKIRR LKKKETRCEE SDADRPLNDS
210 220 230 240 250
GCLLEDSDLF ETGLEEENDS ALEDEESLES IRAAVKNKVK NRKKKEPTLE
260 270 280 290 300
SEAFSLEDGN ELSKGSARKE RKAARLSKEA LKKLHSETQR LVRESALNLP
310 320 330 340 350
YHMPESKTIH DFFKRKPRPT CQGSAMALLK SCKYQSGHYK ETVNPADAAG
360 370 380 390 400
MGAEDSSRGS EQRTGAGIAA ETNVLSEVSE EAGITAGSDE ACGKDPVRRG
410 420 430 440 450
ELEIEETEKH SDDRPYSPGD RSMSQQESSI PRIEDNEGHQ AGDLTESDPP
460 470 480 490 500
ALEGEELKTV EKTDAKEGMP EQKTQSAAAA AVAVVTAAAA PPEKVRRFTV
510 520 530 540 550
DRLRQLGVDV SSQPRLGADE DSFVILDEPK TNRELEALKQ RFWRHANPAA
560 570 580 590 600
SPRACQTVNV NIIVKDLGTN GKEELKAEVV PVTLAAEKLE GASHAKPGEK
610 620 630 640 650
LQMLKAKLQE AMKLRRLEER QKRQALFKLD NEDGFEEEEE EEEMTDESEE
660 670 680 690 700
DGEEETTEYL LGSEDTETKD EKETDKENTD TSSDIGKSVA LCVPKPLSSD
710 720 730 740 750
STLLLFKDSS SKMGYFPTEE KSETDEYLAK QSDKLDEDDS SSLLTKESSH
760 770 780 790 800
NSSFELIGST IPSYQPCNRQ IGRGASFLPT AGFRSPSPGL FRGSLISSAS
810 820 830 840 850
KSSGKLSEPS LPVEDSQDLY TASPEPKTLF LGAGDFQFCL EDDTQSQLLD
860 870 880 890 900
ADGFLNIRNH RHRYQAVKPQ LPLASMDENA MDANMDELLD LCTGQFTSQP
910 920 930 940 950
EEKCQPRKND KKENMEELLN LCSGKFPTQD ASPVAPLGLR SQEKESSTED
960 970 980 990 1000
PMEEALALCS GSFPTDREEE GEEEEFGDFQ LVSKENGFAS DEDEHSDSND
1010 1020 1030 1040 1050
EELALDLEDD EEELLKQSEK MKRQMRLKKY LEDEAEVSGS DVGSEDEYDG
1060 1070 1080 1090 1100
EEIDEYEEDV IDEVLPSDEE LESQIKKIHM KTMLDDDKRR LRLYQERYLA
1110 1120 1130 1140 1150
DGDLHSDGPG RTRKFRWKHI DDTSQMDLFH RDSDDDQVEE QLDETEAKWR
1160 1170 1180 1190 1200
KERIEREQWL REQAQQGKIA ADEEDIGDDS QFMMLAKKVT AKALQKNASH
1210 1220 1230 1240 1250
TVVVQESKSV LRNPFETIRP GGAHQLKTGS LLNQPKAVLQ KLAALSDLNP
1260 1270 1280 1290 1300
SAPRNSRNFV FHTLSPTKAE AAKDSSKPQV RRRGLSSMMS PSPKRLKTNG
1310
SSPGPKRSIF RYLES
Length:1,315
Mass (Da):146,715
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i762AA39E19D8EAA3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6S522F6S522_MOUSE
Claspin
Clspn
387Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1ARX7B1ARX7_MOUSE
Claspin
Clspn
261Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1ARX5B1ARX5_MOUSE
Claspin
Clspn
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti727Y → H in AAH50848 (PubMed:15489334).Curated1
Sequence conflicti1013E → EE in AAP97538 (Ref. 3) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL606935 Genomic DNA No translation available.
BC050848 mRNA Translation: AAH50848.1
AY324187 mRNA Translation: AAP97538.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS18655.1

NCBI Reference Sequences

More...
RefSeqi
NP_780763.3, NM_175554.4
XP_011238843.1, XM_011240541.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000048391; ENSMUSP00000045344; ENSMUSG00000042489

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
269582

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:269582

UCSC genome browser

More...
UCSCi
uc008utm.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606935 Genomic DNA No translation available.
BC050848 mRNA Translation: AAH50848.1
AY324187 mRNA Translation: AAP97538.1
CCDSiCCDS18655.1
RefSeqiNP_780763.3, NM_175554.4
XP_011238843.1, XM_011240541.2

3D structure databases

SMRiQ80YR7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi234671, 17 interactors
IntActiQ80YR7, 16 interactors
STRINGi10090.ENSMUSP00000045344

PTM databases

iPTMnetiQ80YR7
PhosphoSitePlusiQ80YR7

Proteomic databases

EPDiQ80YR7
jPOSTiQ80YR7
MaxQBiQ80YR7
PaxDbiQ80YR7
PeptideAtlasiQ80YR7
PRIDEiQ80YR7

Genome annotation databases

EnsembliENSMUST00000048391; ENSMUSP00000045344; ENSMUSG00000042489
GeneIDi269582
KEGGimmu:269582
UCSCiuc008utm.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
63967
MGIiMGI:2445153 Clspn

Phylogenomic databases

eggNOGiKOG4156 Eukaryota
ENOG410Y041 LUCA
GeneTreeiENSGT00390000012738
HOGENOMiHOG000049140
InParanoidiQ80YR7
OMAiQDIREVR
OrthoDBi754103at2759
TreeFamiTF328925

Enzyme and pathway databases

ReactomeiR-MMU-111465 Apoptotic cleavage of cellular proteins
R-MMU-176187 Activation of ATR in response to replication stress
R-MMU-5689880 Ub-specific processing proteases
R-MMU-5693607 Processing of DNA double-strand break ends

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Clspn mouse

Protein Ontology

More...
PROi
PR:Q80YR7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000042489 Expressed in 160 organ(s), highest expression level in pes
ExpressionAtlasiQ80YR7 baseline and differential
GenevisibleiQ80YR7 MM

Family and domain databases

InterProiView protein in InterPro
IPR024146 Claspin
PANTHERiPTHR14396 PTHR14396, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLSPN_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80YR7
Secondary accession number(s): B1ARX6, Q69GM2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 27, 2011
Last modified: May 8, 2019
This is version 110 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again