Zik1

Functionⁱ

May be a transcriptional repressor.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	215 – 237	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	243 – 265	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	271 – 293	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	299 – 321	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	327 – 349	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	355 – 377	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	383 – 405	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	411 – 433	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	439 – 461	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of transcription, DNA-templated Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-212436 Generic Transcription Pathway

Reactomeⁱ

R-MMU-212436 Generic Transcription Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein interacting with ribonucleoprotein K
Gene namesⁱ	Name:Zik1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:108070 Zik1

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000286794	1 – 463	Zinc finger protein interacting with ribonucleoprotein KAdd BLAST		463

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q80YP6
PaxDbⁱ	Q80YP6
PRIDEⁱ	Q80YP6

PTM databases

iPTMnetⁱ	Q80YP6
PhosphoSitePlusⁱ	Q80YP6

Expressionⁱ

Tissue specificityⁱ

Expressed in ovary and liver, and at lower levels in brain and muscle.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000030393 Expressed in 250 organ(s), highest expression level in membranous labyrinth
CleanExⁱ	MM_ZIK1
Genevisibleⁱ	Q80YP6 MM

Interactionⁱ

Subunit structureⁱ

Interacts with HNRPK.1 Publication

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000032551

STRINGⁱ

10090.ENSMUSP00000032551

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q80YP6
SMRⁱ	Q80YP6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	14 – 89	KRABPROSITE-ProRule annotationAdd BLAST		76

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	215 – 237	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	243 – 265	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	271 – 293	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	299 – 321	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	327 – 349	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	355 – 377	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	383 – 405	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	411 – 433	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	439 – 461	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119107
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q80YP6
KEGG Orthology (KO) More...KOⁱ	K09228
OMAⁱ	SPETHMD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	Q80YP6
TreeFamⁱ	TF339848

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07765 KRAB_A-box, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 8 hits
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 9 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 5 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 9 hits PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q80YP6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTAEMDMALM QGCVTFQDVA ICFSHEEWRL LDETQRLLYL SVMLQNFALI 
        60         70         80         90        100
NSQGCGHKTE DEERRVSTRA SKGLRSETTP KTNLCEKCVP ILQDILCLPG 
       110        120        130        140        150
LPGQKHSTEA SSKVDQHQDH NSTGKPLEKN ADRSSYLFYL SAKSFPSWDV 
       160        170        180        190        200
EKDLPDILSL LKSQVCPKTK KYRKSTEGRK ETSHESDKSE ECQSLSSQKQ 
       210        220        230        240        250
TLAHHPKTSN GKKLYECSKC GKTFRGKYSL DQHQRVHTGE RPWECRDCGK 
       260        270        280        290        300
FFSQTSHLND HRRIHTGERP YECSECGKLF RQNSSLVDHQ KTHTGARPYE 
       310        320        330        340        350
CSQCGKSFSQ KATLVKHKRV HTGERPYKCS ECGNSFSQSA ILNQHRRIHT 
       360        370        380        390        400
GVKPYECREC GKSFSQKATL IKHQRVHTGE RPYKCSECGK SFSQSSILIQ 
       410        420        430        440        450
HRRIHTGARP YECSQCGKSF SQKSGLIQHQ VVHTGERPYE CDTCGNSFSQ 
       460 
CSSLIHHQKC HNA

Length:463

Mass (Da):52,727

Last modified:June 1, 2003 - v1

Checksum:ⁱ019059C0D27F5365

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	211	G → E in AAC52877 (PubMed:8910362).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U69133 mRNA Translation: AAC52877.1 AK146692 mRNA Translation: BAE27363.1 AK159077 mRNA Translation: BAE34796.1 BC050942 mRNA Translation: AAH50942.1 BC067196 mRNA Translation: AAH67196.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS20792.1
NCBI Reference Sequences More...RefSeqⁱ	NP_033603.2, NM_009577.3
UniGeneⁱ	Mm.49441

Genome annotation databases

Ensemblⁱ	ENSMUST00000032551; ENSMUSP00000032551; ENSMUSG00000030393
GeneIDⁱ	22775
KEGGⁱ	mmu:22775
UCSC genome browser More...UCSCⁱ	uc009fdf.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q80YP6	Zinc finger protein-interacting with ribonucleoprotein K-like		RAT		460	UniRef90_Q80YP6
UPI000A310D0B		MUSPA		467
UPI000A31498A		MUSCR		463

Protein	Similar proteins		Species	Score	Length	Source
Q80YP6	Zinc finger protein-interacting with ribonucleoprotein K-like		RAT		460	UniRef50_Q80YP6
Uncharacterized protein		FELCA		462
zinc finger protein 772-like isoform X3		URSMA		434
zinc finger protein 772-like isoform X1		LEPWE		434
zinc finger protein 772		NEOSC		376
+35

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U69133 mRNA Translation: AAC52877.1 AK146692 mRNA Translation: BAE27363.1 AK159077 mRNA Translation: BAE34796.1 BC050942 mRNA Translation: AAH50942.1 BC067196 mRNA Translation: AAH67196.1
CCDSⁱ	CCDS20792.1
RefSeqⁱ	NP_033603.2, NM_009577.3
UniGeneⁱ	Mm.49441

3D structure databases

ProteinModelPortalⁱ	Q80YP6
SMRⁱ	Q80YP6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000032551

STRINGⁱ

10090.ENSMUSP00000032551

PTM databases

iPTMnetⁱ	Q80YP6
PhosphoSitePlusⁱ	Q80YP6

Proteomic databases

MaxQBⁱ	Q80YP6
PaxDbⁱ	Q80YP6
PRIDEⁱ	Q80YP6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000032551; ENSMUSP00000032551; ENSMUSG00000030393
GeneIDⁱ	22775
KEGGⁱ	mmu:22775
UCSCⁱ	uc009fdf.1 mouse

Organism-specific databases

CTDⁱ	284307
MGIⁱ	MGI:108070 Zik1

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00760000119107
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q80YP6
KOⁱ	K09228
OMAⁱ	SPETHMD
OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	Q80YP6
TreeFamⁱ	TF339848

Enzyme and pathway databases

Reactomeⁱ	R-MMU-212436 Generic Transcription Pathway

Reactomeⁱ

R-MMU-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSⁱ	Zik1 mouse
Protein Ontology More...PROⁱ	PR:Q80YP6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000030393 Expressed in 250 organ(s), highest expression level in membranous labyrinth
CleanExⁱ	MM_ZIK1
Genevisibleⁱ	Q80YP6 MM

Family and domain databases

CDDⁱ	cd07765 KRAB_A-box, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 8 hits
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 9 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 5 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 9 hits PS50157 ZINC_FINGER_C2H2_2, 9 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZIK1_MOUSE
Accessionⁱ	Q80YP6Primary (citable) accession number: Q80YP6 Secondary accession number(s): P70405
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
	Last sequence update:	June 1, 2003
	Last modified:	November 7, 2018
	This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q80YP6 (ZIK1_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Zinc finger protein interacting with ribonucleoprotein K

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ