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Protein

Zinc finger protein interacting with ribonucleoprotein K

Gene

Zik1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be a transcriptional repressor.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri215 – 237C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri243 – 265C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein interacting with ribonucleoprotein K
Gene namesi
Name:Zik1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:108070 Zik1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002867941 – 463Zinc finger protein interacting with ribonucleoprotein KAdd BLAST463

Proteomic databases

MaxQBiQ80YP6
PaxDbiQ80YP6
PRIDEiQ80YP6

PTM databases

iPTMnetiQ80YP6
PhosphoSitePlusiQ80YP6

Expressioni

Tissue specificityi

Expressed in ovary and liver, and at lower levels in brain and muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000030393 Expressed in 250 organ(s), highest expression level in membranous labyrinth
CleanExiMM_ZIK1
GenevisibleiQ80YP6 MM

Interactioni

Subunit structurei

Interacts with HNRPK.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032551

Structurei

3D structure databases

ProteinModelPortaliQ80YP6
SMRiQ80YP6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 89KRABPROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri215 – 237C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri243 – 265C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119107
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ80YP6
KOiK09228
OMAiSPETHMD
OrthoDBiEOG091G02KC
PhylomeDBiQ80YP6
TreeFamiTF339848

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequencei

Sequence statusi: Complete.

Q80YP6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAEMDMALM QGCVTFQDVA ICFSHEEWRL LDETQRLLYL SVMLQNFALI
60 70 80 90 100
NSQGCGHKTE DEERRVSTRA SKGLRSETTP KTNLCEKCVP ILQDILCLPG
110 120 130 140 150
LPGQKHSTEA SSKVDQHQDH NSTGKPLEKN ADRSSYLFYL SAKSFPSWDV
160 170 180 190 200
EKDLPDILSL LKSQVCPKTK KYRKSTEGRK ETSHESDKSE ECQSLSSQKQ
210 220 230 240 250
TLAHHPKTSN GKKLYECSKC GKTFRGKYSL DQHQRVHTGE RPWECRDCGK
260 270 280 290 300
FFSQTSHLND HRRIHTGERP YECSECGKLF RQNSSLVDHQ KTHTGARPYE
310 320 330 340 350
CSQCGKSFSQ KATLVKHKRV HTGERPYKCS ECGNSFSQSA ILNQHRRIHT
360 370 380 390 400
GVKPYECREC GKSFSQKATL IKHQRVHTGE RPYKCSECGK SFSQSSILIQ
410 420 430 440 450
HRRIHTGARP YECSQCGKSF SQKSGLIQHQ VVHTGERPYE CDTCGNSFSQ
460
CSSLIHHQKC HNA
Length:463
Mass (Da):52,727
Last modified:June 1, 2003 - v1
Checksum:i019059C0D27F5365
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti211G → E in AAC52877 (PubMed:8910362).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69133 mRNA Translation: AAC52877.1
AK146692 mRNA Translation: BAE27363.1
AK159077 mRNA Translation: BAE34796.1
BC050942 mRNA Translation: AAH50942.1
BC067196 mRNA Translation: AAH67196.1
CCDSiCCDS20792.1
RefSeqiNP_033603.2, NM_009577.3
UniGeneiMm.49441

Genome annotation databases

EnsembliENSMUST00000032551; ENSMUSP00000032551; ENSMUSG00000030393
GeneIDi22775
KEGGimmu:22775
UCSCiuc009fdf.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69133 mRNA Translation: AAC52877.1
AK146692 mRNA Translation: BAE27363.1
AK159077 mRNA Translation: BAE34796.1
BC050942 mRNA Translation: AAH50942.1
BC067196 mRNA Translation: AAH67196.1
CCDSiCCDS20792.1
RefSeqiNP_033603.2, NM_009577.3
UniGeneiMm.49441

3D structure databases

ProteinModelPortaliQ80YP6
SMRiQ80YP6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032551

PTM databases

iPTMnetiQ80YP6
PhosphoSitePlusiQ80YP6

Proteomic databases

MaxQBiQ80YP6
PaxDbiQ80YP6
PRIDEiQ80YP6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032551; ENSMUSP00000032551; ENSMUSG00000030393
GeneIDi22775
KEGGimmu:22775
UCSCiuc009fdf.1 mouse

Organism-specific databases

CTDi284307
MGIiMGI:108070 Zik1

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119107
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ80YP6
KOiK09228
OMAiSPETHMD
OrthoDBiEOG091G02KC
PhylomeDBiQ80YP6
TreeFamiTF339848

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSiZik1 mouse
PROiPR:Q80YP6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030393 Expressed in 250 organ(s), highest expression level in membranous labyrinth
CleanExiMM_ZIK1
GenevisibleiQ80YP6 MM

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZIK1_MOUSE
AccessioniPrimary (citable) accession number: Q80YP6
Secondary accession number(s): P70405
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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