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UniProtKB - Q80YP6 (ZIK1_MOUSE)
Protein
Zinc finger protein interacting with ribonucleoprotein K
Gene
Zik1
Organism
Mus musculus (Mouse)
Status
Functioni
May be a transcriptional repressor.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 215 – 237 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 243 – 265 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 271 – 293 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 299 – 321 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 327 – 349 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 355 – 377 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 383 – 405 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 411 – 433 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 439 – 461 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein interacting with ribonucleoprotein K |
Gene namesi | Name:Zik1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:108070, Zik1 |
VEuPathDBi | HostDB:ENSMUSG00000030393 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000286794 | 1 – 463 | Zinc finger protein interacting with ribonucleoprotein KAdd BLAST | 463 |
Proteomic databases
MaxQBi | Q80YP6 |
PaxDbi | Q80YP6 |
PRIDEi | Q80YP6 |
ProteomicsDBi | 299561 |
PTM databases
iPTMneti | Q80YP6 |
PhosphoSitePlusi | Q80YP6 |
Expressioni
Tissue specificityi
Expressed in ovary and liver, and at lower levels in brain and muscle.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000030393, Expressed in membranous labyrinth and 274 other tissues |
Genevisiblei | Q80YP6, MM |
Interactioni
Subunit structurei
Interacts with HNRPK.
1 PublicationProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000032551 |
Miscellaneous databases
RNActi | Q80YP6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 89 | KRABPROSITE-ProRule annotationAdd BLAST | 76 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 106 – 128 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 171 – 211 | DisorderedSequence analysisAdd BLAST | 41 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 110 – 127 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 171 – 192 | Basic and acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 193 – 207 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 215 – 237 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 243 – 265 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 271 – 293 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 299 – 321 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 327 – 349 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 355 – 377 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 383 – 405 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 411 – 433 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 439 – 461 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162907 |
HOGENOMi | CLU_002678_44_3_1 |
InParanoidi | Q80YP6 |
OMAi | WDVEKDL |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q80YP6 |
TreeFami | TF339848 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 8 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 9 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
i Sequence
Sequence statusi: Complete.
Q80YP6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTAEMDMALM QGCVTFQDVA ICFSHEEWRL LDETQRLLYL SVMLQNFALI
60 70 80 90 100
NSQGCGHKTE DEERRVSTRA SKGLRSETTP KTNLCEKCVP ILQDILCLPG
110 120 130 140 150
LPGQKHSTEA SSKVDQHQDH NSTGKPLEKN ADRSSYLFYL SAKSFPSWDV
160 170 180 190 200
EKDLPDILSL LKSQVCPKTK KYRKSTEGRK ETSHESDKSE ECQSLSSQKQ
210 220 230 240 250
TLAHHPKTSN GKKLYECSKC GKTFRGKYSL DQHQRVHTGE RPWECRDCGK
260 270 280 290 300
FFSQTSHLND HRRIHTGERP YECSECGKLF RQNSSLVDHQ KTHTGARPYE
310 320 330 340 350
CSQCGKSFSQ KATLVKHKRV HTGERPYKCS ECGNSFSQSA ILNQHRRIHT
360 370 380 390 400
GVKPYECREC GKSFSQKATL IKHQRVHTGE RPYKCSECGK SFSQSSILIQ
410 420 430 440 450
HRRIHTGARP YECSQCGKSF SQKSGLIQHQ VVHTGERPYE CDTCGNSFSQ
460
CSSLIHHQKC HNA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 211 | G → E in AAC52877 (PubMed:8910362).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U69133 mRNA Translation: AAC52877.1 AK146692 mRNA Translation: BAE27363.1 AK159077 mRNA Translation: BAE34796.1 BC050942 mRNA Translation: AAH50942.1 BC067196 mRNA Translation: AAH67196.1 |
CCDSi | CCDS20792.1 |
RefSeqi | NP_033603.2, NM_009577.3 |
Genome annotation databases
Ensembli | ENSMUST00000032551; ENSMUSP00000032551; ENSMUSG00000030393 |
GeneIDi | 22775 |
KEGGi | mmu:22775 |
UCSCi | uc009fdf.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U69133 mRNA Translation: AAC52877.1 AK146692 mRNA Translation: BAE27363.1 AK159077 mRNA Translation: BAE34796.1 BC050942 mRNA Translation: AAH50942.1 BC067196 mRNA Translation: AAH67196.1 |
CCDSi | CCDS20792.1 |
RefSeqi | NP_033603.2, NM_009577.3 |
3D structure databases
SMRi | Q80YP6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000032551 |
PTM databases
iPTMneti | Q80YP6 |
PhosphoSitePlusi | Q80YP6 |
Proteomic databases
MaxQBi | Q80YP6 |
PaxDbi | Q80YP6 |
PRIDEi | Q80YP6 |
ProteomicsDBi | 299561 |
Protocols and materials databases
Antibodypediai | 33273, 100 antibodies from 19 providers |
DNASUi | 22775 |
Genome annotation databases
Ensembli | ENSMUST00000032551; ENSMUSP00000032551; ENSMUSG00000030393 |
GeneIDi | 22775 |
KEGGi | mmu:22775 |
UCSCi | uc009fdf.1, mouse |
Organism-specific databases
CTDi | 284307 |
MGIi | MGI:108070, Zik1 |
VEuPathDBi | HostDB:ENSMUSG00000030393 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162907 |
HOGENOMi | CLU_002678_44_3_1 |
InParanoidi | Q80YP6 |
OMAi | WDVEKDL |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q80YP6 |
TreeFami | TF339848 |
Enzyme and pathway databases
Reactomei | R-MMU-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 22775, 1 hit in 64 CRISPR screens |
ChiTaRSi | Zik1, mouse |
PROi | PR:Q80YP6 |
RNActi | Q80YP6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030393, Expressed in membranous labyrinth and 274 other tissues |
Genevisiblei | Q80YP6, MM |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 8 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 9 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZIK1_MOUSE | |
Accessioni | Q80YP6Primary (citable) accession number: Q80YP6 Secondary accession number(s): P70405 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | June 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families