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Entry version 120 (26 Feb 2020)
Sequence version 2 (13 Jun 2012)
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Protein

Atrial natriuretic peptide-converting enzyme

Gene

Corin

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei908Charge relay systemPROSITE-ProRule annotation1
Active sitei957Charge relay systemPROSITE-ProRule annotation1
Active sitei1050Charge relay systemPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-5578768 Physiological factors

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S01.019

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Atrial natriuretic peptide-converting enzyme (EC:3.4.21.-)
Alternative name(s):
Corin
Pro-ANP-converting enzyme
Cleaved into the following 3 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Corin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
727887 Corin

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 112CytoplasmicSequence analysisAdd BLAST112
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei113 – 133Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini134 – 1111ExtracellularSequence analysisAdd BLAST978

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi866R → A: Impairs proteolytic processing and activation. 1 Publication1
Mutagenesisi968N → S: Prevents proteolytic processing and activation; when associated with S-1087. 1 Publication1
Mutagenesisi1087N → S: Prevents proteolytic processing and activation; when associated with S-968. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003917621 – 1111Atrial natriuretic peptide-converting enzymeAdd BLAST1111
ChainiPRO_00003917631 – 866Atrial natriuretic peptide-converting enzyme, N-terminal propeptideCuratedAdd BLAST866
ChainiPRO_0000417988? – 866Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragmentBy similarity
ChainiPRO_0000391764867 – 1111Atrial natriuretic peptide-converting enzyme, activated protease fragmentCuratedAdd BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi147N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi204 ↔ 264By similarity
Disulfide bondi212 ↔ 257By similarity
Disulfide bondi248 ↔ 288By similarity
Disulfide bondi277 ↔ 322By similarity
Disulfide bondi281 ↔ 305By similarity
Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi335 ↔ 348By similarity
Disulfide bondi343 ↔ 361By similarity
Disulfide bondi355 ↔ 370By similarity
Disulfide bondi372 ↔ 384By similarity
Disulfide bondi379 ↔ 397By similarity
Disulfide bondi391 ↔ 406By similarity
Disulfide bondi408 ↔ 421By similarity
Glycosylationi409N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi416 ↔ 434By similarity
Disulfide bondi428 ↔ 443By similarity
Disulfide bondi445 ↔ 458By similarity
Disulfide bondi453 ↔ 471By similarity
Disulfide bondi465 ↔ 480By similarity
Disulfide bondi521 ↔ 584By similarity
Disulfide bondi529 ↔ 577By similarity
Glycosylationi535N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi568 ↔ 606By similarity
Disulfide bondi595 ↔ 636By similarity
Disulfide bondi599 ↔ 623By similarity
Disulfide bondi646 ↔ 658By similarity
Disulfide bondi653 ↔ 671By similarity
Disulfide bondi665 ↔ 680By similarity
Disulfide bondi682 ↔ 696By similarity
Disulfide bondi690 ↔ 709By similarity
Disulfide bondi703 ↔ 718By similarity
Disulfide bondi721 ↔ 733By similarity
Disulfide bondi728 ↔ 746By similarity
Disulfide bondi740 ↔ 755By similarity
Glycosylationi763N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi855 ↔ 977Interchain (between N-terminal propeptide and activated protease fragment chains)PROSITE-ProRule annotation
Disulfide bondi893 ↔ 909By similarity
Disulfide bondi991 ↔ 1056By similarity
Disulfide bondi1020 ↔ 1035By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated; required for processing and activation.1 Publication
Activated through proteolytic processing by a trypsin-like protease; cleaved into a N-terminal propeptide and an activated corin protease fragment. Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment is produced by cleavage by ADAM10. Cleavage by ADAM10 to produce soluble 180 kDa soluble fragment takes place after the transmembrane region and before FZ 1 (Probable).1 Publication
A disulfide bond links the activated corin protease fragment and the N-terminal propeptide. The disulfide bond also links the activated corin protease fragment with Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment (Probable).Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei866 – 867CleavageCurated2

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q80YN4

PRoteomics IDEntifications database

More...
PRIDEi
Q80YN4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specifically expressed in heart. Also detected in kidney, aorta, brain and testis. In kidney, present in epithelial cells, with segmental expression in the proximal tubule, thick ascending limb, connecting tubule, and throughout the collecting duct (at protein level).1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated upon experimental heart failure.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000061602

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q80YN4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini199 – 325FZ 1PROSITE-ProRule annotationAdd BLAST127
Domaini334 – 371LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST38
Domaini371 – 407LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST37
Domaini407 – 444LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST38
Domaini444 – 481LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST38
Domaini516 – 639FZ 2PROSITE-ProRule annotationAdd BLAST124
Domaini645 – 681LDL-receptor class A 5PROSITE-ProRule annotationAdd BLAST37
Domaini681 – 719LDL-receptor class A 6PROSITE-ProRule annotationAdd BLAST39
Domaini720 – 756LDL-receptor class A 7PROSITE-ProRule annotationAdd BLAST37
Domaini756 – 851SRCRPROSITE-ProRule annotationAdd BLAST96
Domaini867 – 1100Peptidase S1PROSITE-ProRule annotationAdd BLAST234

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi93 – 96DDNN motif4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3577 Eukaryota
KOG3627 Eukaryota
COG5640 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q80YN4

KEGG Orthology (KO)

More...
KOi
K09614

Database of Orthologous Groups

More...
OrthoDBi
1314811at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07445 CRD_corin_1, 1 hit
cd07888 CRD_corin_2, 1 hit
cd00112 LDLa, 7 hits
cd00190 Tryp_SPc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.2000.10, 2 hits
4.10.400.10, 7 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017052 Corin
IPR041762 Corin_CRD_1
IPR041763 Corin_CRD_2
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR009003 Peptidase_S1_PA
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf
IPR001254 Trypsin_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01392 Fz, 2 hits
PF00057 Ldl_recept_a, 6 hits
PF15494 SRCR_2, 1 hit
PF00089 Trypsin, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036376 Corin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261 LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00063 FRI, 2 hits
SM00192 LDLa, 7 hits
SM00202 SR, 1 hit
SM00020 Tryp_SPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494 SSF50494, 1 hit
SSF56487 SSF56487, 1 hit
SSF57424 SSF57424, 7 hits
SSF63501 SSF63501, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50038 FZ, 2 hits
PS01209 LDLRA_1, 6 hits
PS50068 LDLRA_2, 7 hits
PS00420 SRCR_1, 1 hit
PS50287 SRCR_2, 1 hit
PS50240 TRYPSIN_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q80YN4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRVSFNVRV SSVRRARCSC PGRCYLSCRV PPTTALHALN GFGRAGVLGE
60 70 80 90 100
TAGGTVGLGP SGTRGFLSGS KFQASGSLKD CFGAPPAPDV LRADSSVGEG
110 120 130 140 150
CPQKLVTANL LRFLLLVLIP CICALIVLLA ILLSFVGTLK KVYFKSNDSE
160 170 180 190 200
PLVTDGEVRV PGVIHVNRYE NTGAPSMPPS QSIPAWTPRA PSLEDQSHGN
210 220 230 240 250
TSTCVNITHR QCQILPYHST LAPLLPIVKN MDTEKFLKFF TYLHRLGCYQ
260 270 280 290 300
HILLFGCSLA FPKCIVDGDD RHGLLPCRSF CEAAKEGCES VLGMVNSSWP
310 320 330 340 350
DSLRCSQFRY HTENNSDASR ICFSLQQEHG KQSLCGGGES FLCTSGLCIS
360 370 380 390 400
KKLQCNGYND CDDWSDEAHC NCSEDLFHCG TGKCLHHSLV CDGYDDCGDL
410 420 430 440 450
SDEQNCDCNL TKEHRCGDGR CIAAEWVCDG DHDCVDKSDE VNCSCPSQGL
460 470 480 490 500
VECRSGQCIP STFQCDGDED CKDGSDEENC SDRPTPCPGG DRGCLDSSCV
510 520 530 540 550
ESCAGSSLCD SDSSLSNCSH CEPITLELCM NLPYNLTHYP NYLGHRTQKE
560 570 580 590 600
ASISWESALF PALVQTNCYK YLMFFACTIL VPKCDVNTGQ RVPPCRLLCE
610 620 630 640 650
HSKERCESVL GIVGLQWPED TDCSQFPEQS SDNQTCLLPN EDVEECSPSH
660 670 680 690 700
FKCRSGRCVL GSRRCDGQAD CDDDSDEENC GCKERDLWEC PLNKQCLKHT
710 720 730 740 750
LICDGFPDCS DSMDEKNCSF CQDDELECAN HECVPRDLWC DGWTDCSDSS
760 770 780 790 800
DEWGCVTLSK NGNSSSFLTV HRSARDHHVC ADGWQETLSQ LACRQMGLGE
810 820 830 840 850
PSVTELVQGQ EGQQWLRLHS SWENLNGSTL QELLVHRRSC PSGSEISLLC
860 870 880 890 900
TKQDCGRRPA ARMNKRILGG RTSRPGRWPW QCSLQSEPSG HICGCVLIAK
910 920 930 940 950
KWVLTVAHCF EGREDADVWK VVFGINNLDH PSGFMQTRFV KTILLHPRYS
960 970 980 990 1000
RAVVDYDISV VELSDDINET SYVRPVCLPS PREFLEPDTY CYITGWGHMG
1010 1020 1030 1040 1050
NKMPFKLQEG EVRIIPLEQC QSYFDMKTIT NRMICAGYES GTVDSCMIDS
1060 1070 1080 1090 1100
GGPLVCERPG GQWTLFGLTS WGSVCFSKVL GPGVYSNVSY FVDWIERQIY
1110
IQTFLQKKSQ G
Length:1,111
Mass (Da):122,757
Last modified:June 13, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i44A738ACA6E0AC16
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QTE2J3QTE2_RAT
Atrial natriuretic peptide-converti...
Corin rCG_56944
1,111Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti178P → S in AAO86772 (PubMed:15155264).Curated1
Sequence conflicti320R → T in AAO86772 (PubMed:15155264).Curated1
Sequence conflicti1048I → G in AAO86772 (PubMed:15155264).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY251285 mRNA Translation: AAO86772.1
AC121481 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
NP_872279.1, NM_182473.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
289596

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:289596

UCSC genome browser

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UCSCi
RGD:727887 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY251285 mRNA Translation: AAO86772.1
AC121481 Genomic DNA No translation available.
RefSeqiNP_872279.1, NM_182473.1

3D structure databases

SMRiQ80YN4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061602

Protein family/group databases

MEROPSiS01.019

Proteomic databases

PaxDbiQ80YN4
PRIDEiQ80YN4

Genome annotation databases

GeneIDi289596
KEGGirno:289596
UCSCiRGD:727887 rat

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10699
RGDi727887 Corin

Phylogenomic databases

eggNOGiKOG3577 Eukaryota
KOG3627 Eukaryota
COG5640 LUCA
InParanoidiQ80YN4
KOiK09614
OrthoDBi1314811at2759

Enzyme and pathway databases

ReactomeiR-RNO-5578768 Physiological factors

Miscellaneous databases

Protein Ontology

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PROi
PR:Q80YN4

Family and domain databases

CDDicd07445 CRD_corin_1, 1 hit
cd07888 CRD_corin_2, 1 hit
cd00112 LDLa, 7 hits
cd00190 Tryp_SPc, 1 hit
Gene3Di1.10.2000.10, 2 hits
4.10.400.10, 7 hits
InterProiView protein in InterPro
IPR017052 Corin
IPR041762 Corin_CRD_1
IPR041763 Corin_CRD_2
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR009003 Peptidase_S1_PA
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf
IPR001254 Trypsin_dom
PfamiView protein in Pfam
PF01392 Fz, 2 hits
PF00057 Ldl_recept_a, 6 hits
PF15494 SRCR_2, 1 hit
PF00089 Trypsin, 1 hit
PIRSFiPIRSF036376 Corin, 1 hit
PRINTSiPR00261 LDLRECEPTOR
SMARTiView protein in SMART
SM00063 FRI, 2 hits
SM00192 LDLa, 7 hits
SM00202 SR, 1 hit
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF56487 SSF56487, 1 hit
SSF57424 SSF57424, 7 hits
SSF63501 SSF63501, 2 hits
PROSITEiView protein in PROSITE
PS50038 FZ, 2 hits
PS01209 LDLRA_1, 6 hits
PS50068 LDLRA_2, 7 hits
PS00420 SRCR_1, 1 hit
PS50287 SRCR_2, 1 hit
PS50240 TRYPSIN_DOM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCORIN_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80YN4
Secondary accession number(s): D3ZN44, F1LS60
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: June 13, 2012
Last modified: February 26, 2020
This is version 120 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
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