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Entry version 152 (02 Jun 2021)
Sequence version 1 (01 Jun 2003)
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Protein

Rho GTPase-activating protein 33

Gene

Arhgap33

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in several stages of intracellular trafficking (By similarity).

Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation
Biological processProtein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-194840, Rho GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GTPase-activating protein 33
Alternative name(s):
Rho-type GTPase-activating protein 33
Sorting nexin-26
Tc10/CDC42 GTPase-activating protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Arhgap33
Synonyms:Snx26, Tcgap
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2673998, Arhgap33

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000567221 – 1305Rho GTPase-activating protein 33Add BLAST1305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei32PhosphoserineCombined sources1
Modified residuei594PhosphoserineCombined sources1
Modified residuei660PhosphoserineCombined sources1
Modified residuei749PhosphoserineCombined sources1
Modified residuei1188PhosphotyrosineCombined sources1
Modified residuei1263Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q80YF9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q80YF9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q80YF9

PRoteomics IDEntifications database

More...
PRIDEi
Q80YF9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
254967

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q80YF9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q80YF9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in brain and testis. Also expressed in white adipose tissue (WAT) and muscle at a low level.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Dramatically induced during adipocyte differentiation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000036882, Expressed in striatum and 187 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q80YF9, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Specifically interacts with CDC42 and RHOQ/TC10 through its Rho-GAP domain.

Interacts with NEK6 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
231366, 26 interactors

Protein interaction database and analysis system

More...
IntActi
Q80YF9, 12 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000038412

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q80YF9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q80YF9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini83 – 192PX; atypicalAdd BLAST110
Domaini210 – 272SH3PROSITE-ProRule annotationAdd BLAST63
Domaini339 – 534Rho-GAPPROSITE-ProRule annotationAdd BLAST196

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 64DisorderedSequence analysisAdd BLAST64
Regioni575 – 818DisorderedSequence analysisAdd BLAST244
Regioni864 – 1054DisorderedSequence analysisAdd BLAST191
Regioni1115 – 1305DisorderedSequence analysisAdd BLAST191

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi594 – 610Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi645 – 672Polar residuesSequence analysisAdd BLAST28
Compositional biasi698 – 736Polar residuesSequence analysisAdd BLAST39
Compositional biasi773 – 792Pro residuesSequence analysisAdd BLAST20
Compositional biasi864 – 881Polar residuesSequence analysisAdd BLAST18
Compositional biasi892 – 917Pro residuesSequence analysisAdd BLAST26
Compositional biasi929 – 944Polar residuesSequence analysisAdd BLAST16
Compositional biasi995 – 1016Polar residuesSequence analysisAdd BLAST22
Compositional biasi1039 – 1054Polar residuesSequence analysisAdd BLAST16
Compositional biasi1152 – 1166Pro residuesSequence analysisAdd BLAST15
Compositional biasi1197 – 1212Polar residuesSequence analysisAdd BLAST16
Compositional biasi1213 – 1228Pro residuesSequence analysisAdd BLAST16
Compositional biasi1237 – 1255Pro residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal PX domain interacts specifically with phosphatidylinositol 4,5-bisphosphate.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PX domain-containing GAP family.Curated

Keywords - Domaini

SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1449, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155110

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009183_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q80YF9

Database of Orthologous Groups

More...
OrthoDBi
1300981at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q80YF9

TreeFam database of animal gene trees

More...
TreeFami
TF351451

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035510, ARHGAP33
IPR036871, PX_dom_sf
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

The PANTHER Classification System

More...
PANTHERi
PTHR15729:SF11, PTHR15729:SF11, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00620, RhoGAP, 1 hit
PF14604, SH3_9, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00324, RhoGAP, 1 hit
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350, SSF48350, 1 hit
SSF50044, SSF50044, 1 hit
SSF64268, SSF64268, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50238, RHOGAP, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q80YF9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLQAQKQSDP ILPWGASWAG RGQTLRARST DSLDGPGEGS VQPVPTTGGP
60 70 80 90 100
GTKGKPGKRL SAPRGPFPRL ADCAHFHYEN VDFGHIQLLL SPEREGPSLS
110 120 130 140 150
GENELVFGVQ VTCQGRSWPV LRSYDDFRSL DAHLHRCIFD RRFSCLPELP
160 170 180 190 200
PPPEGTRAAQ MLVPLLLQYL ETLSGLVDSN LNCGPVLTWM ELDNHGRRLL
210 220 230 240 250
LSEEASLNIP AVAAAHVVKR YTAQAPDELS FEVGDIVSVI DMPPTEDRSW
260 270 280 290 300
WRGKRGFQVG FFPSECVELF TERPGPGLKA DADSPLCGIP APQGISSLTS
310 320 330 340 350
AVPRPRGKLA GLLRTFMRSR PSRQRLRQRG ILRQRVFGCD LGEHLSNSGQ
360 370 380 390 400
DVPQVLRCCS EFIEAHGVVD GIYRLSGVSS NIQRLRHEFD SERIPELSGP
410 420 430 440 450
AFLQDIHSVS SLCKLYFREL PNPLLTYQLY GKFSEAMSVP GEEERLVRVH
460 470 480 490 500
DVIQQLPPPH YRTLEYLLRH LARMARHSAN TSMHARNLAI VWAPNLLRSM
510 520 530 540 550
ELESVGLGGA AAFREVRVQS VVVEFLLTHV EVLFSDTFTS AGLDPAGRCL
560 570 580 590 600
LPRPKSLAGS SPSTRLLTLE EAQARTQGRL GTPTEPTTPK TPASPVERRK
610 620 630 640 650
RERAEKQRKP GGSSWKTFFA LGRGPSIPRK KPLPWLGGSR APPQPSGSRP
660 670 680 690 700
DTVTLRSAKS EESLSSQASG AGLQRLHRLR RPHSSSDAFP VGPAPAGSCE
710 720 730 740 750
SLSSSSSSSS SSSSSSSSES SAGGLGPLSG SPSHRTSAWL DDGDDLDFSP
760 770 780 790 800
PRCLEGLRGL DFDPLTFRCS SPTPGDPAPP ASPAPPASAS AFPPRATPQA
810 820 830 840 850
LSPHGPTKPA SPTALDISEP LAVSVPPAVL ELLGAGGTPA SATPTPALSP
860 870 880 890 900
HLIPLLLRGA EAQLSDTCQQ EISSKLAPTR GAPGQQSPGG MDSPLLPPPL
910 920 930 940 950
PLLRPGGAPP PPPKNPARLM ALALAERAQQ VAEQQSQQEQ GGTPPAPHSP
960 970 980 990 1000
FRRSLSLEVG GEPVGTSGSG IHPPSLAHPG AWAPGPPPYL PRQQSDGSLV
1010 1020 1030 1040 1050
RSQRPLGTSR RSPRGPSQVS AHLRASGAYR DAPEMAAQSP CSVPSQGSNP
1060 1070 1080 1090 1100
SFFSTPRECL PPFLGVPKQG LYSLGPPSFP PSSPAPVWRN SLGAPSALDR
1110 1120 1130 1140 1150
GENLYYEIGV GEGTSYSGPS RSWSPFRSMP PDRHNASYGM LGQSPPLHRS
1160 1170 1180 1190 1200
PDFLLSYPPP PSCFPPEHLT HSVSQRLARR PTRPEPLYVN LALGPRGPSP
1210 1220 1230 1240 1250
ASSSSSSPPA HPRSRSDPGP PVPRLPQKQR APWGPHTPHR VPGPWGSPEP
1260 1270 1280 1290 1300
FLLYRPAPPS YGRGGEVRGS LYRNGGHRGE GAGPPPPYPT PSWSLHSEGQ

TRSYC
Length:1,305
Mass (Da):139,801
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAA8723BDF4A3CBB6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140LHW2A0A140LHW2_MOUSE
Rho GTPase-activating protein 33
Arhgap33
1,281Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140LIY1A0A140LIY1_MOUSE
Rho GTPase-activating protein 33
Arhgap33
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140LIC8A0A140LIC8_MOUSE
Rho GTPase-activating protein 33
Arhgap33
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH61471 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti357R → C in AAH61471 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY217764 mRNA Translation: AAO89073.1
BC065086 mRNA Translation: AAH65086.1
BC065166 mRNA Translation: AAH65166.1
BC066047 mRNA Translation: AAH66047.1
BC061471 mRNA Translation: AAH61471.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS21095.1

NCBI Reference Sequences

More...
RefSeqi
NP_001276599.1, NM_001289670.1
NP_001276611.1, NM_001289682.1
NP_839983.1, NM_178252.3
XP_006539951.1, XM_006539888.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000044338; ENSMUSP00000038412; ENSMUSG00000036882
ENSMUST00000207860; ENSMUSP00000146602; ENSMUSG00000036882
ENSMUST00000208538; ENSMUSP00000146767; ENSMUSG00000036882

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
233071

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:233071

UCSC genome browser

More...
UCSCi
uc009geq.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY217764 mRNA Translation: AAO89073.1
BC065086 mRNA Translation: AAH65086.1
BC065166 mRNA Translation: AAH65166.1
BC066047 mRNA Translation: AAH66047.1
BC061471 mRNA Translation: AAH61471.1 Different initiation.
CCDSiCCDS21095.1
RefSeqiNP_001276599.1, NM_001289670.1
NP_001276611.1, NM_001289682.1
NP_839983.1, NM_178252.3
XP_006539951.1, XM_006539888.3

3D structure databases

SMRiQ80YF9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi231366, 26 interactors
IntActiQ80YF9, 12 interactors
STRINGi10090.ENSMUSP00000038412

PTM databases

iPTMnetiQ80YF9
PhosphoSitePlusiQ80YF9

Proteomic databases

EPDiQ80YF9
MaxQBiQ80YF9
PaxDbiQ80YF9
PRIDEiQ80YF9
ProteomicsDBi254967

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
29527, 134 antibodies

The DNASU plasmid repository

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DNASUi
233071

Genome annotation databases

EnsembliENSMUST00000044338; ENSMUSP00000038412; ENSMUSG00000036882
ENSMUST00000207860; ENSMUSP00000146602; ENSMUSG00000036882
ENSMUST00000208538; ENSMUSP00000146767; ENSMUSG00000036882
GeneIDi233071
KEGGimmu:233071
UCSCiuc009geq.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
115703
MGIiMGI:2673998, Arhgap33

Phylogenomic databases

eggNOGiKOG1449, Eukaryota
GeneTreeiENSGT00940000155110
HOGENOMiCLU_009183_0_0_1
InParanoidiQ80YF9
OrthoDBi1300981at2759
PhylomeDBiQ80YF9
TreeFamiTF351451

Enzyme and pathway databases

ReactomeiR-MMU-194840, Rho GTPase cycle

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
233071, 1 hit in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Arhgap33, mouse

Protein Ontology

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PROi
PR:Q80YF9
RNActiQ80YF9, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000036882, Expressed in striatum and 187 other tissues
GenevisibleiQ80YF9, MM

Family and domain databases

Gene3Di1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR035510, ARHGAP33
IPR036871, PX_dom_sf
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PANTHERiPTHR15729:SF11, PTHR15729:SF11, 1 hit
PfamiView protein in Pfam
PF00620, RhoGAP, 1 hit
PF14604, SH3_9, 1 hit
SMARTiView protein in SMART
SM00324, RhoGAP, 1 hit
SM00326, SH3, 1 hit
SUPFAMiSSF48350, SSF48350, 1 hit
SSF50044, SSF50044, 1 hit
SSF64268, SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50238, RHOGAP, 1 hit
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHG33_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80YF9
Secondary accession number(s): Q6P7W6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2003
Last modified: June 2, 2021
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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