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Entry version 121 (08 May 2019)
Sequence version 1 (01 Jun 2003)
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Protein

Serine/threonine-protein kinase LMTK1

Gene

Aatk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in neuronal differentiation.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei157ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei254Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi132 – 140ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase LMTK1 (EC:2.7.11.1)
Alternative name(s):
Apoptosis-associated tyrosine kinase
Short name:
AATYK
Brain apoptosis-associated tyrosine kinase
Lemur tyrosine kinase 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Aatk
Synonyms:Aatyk, Kiaa0641, Lmr1, Lmtk1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1197518 Aatk

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei32 – 52HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell projection, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi254D → V: Significant decrease in autophosphorylation. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002483011 – 1365Serine/threonine-protein kinase LMTK1Add BLAST1365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei500PhosphoserineBy similarity1
Modified residuei1035PhosphoserineCombined sources1
Modified residuei1156PhosphothreonineCombined sources1
Modified residuei1159PhosphoserineCombined sources1
Modified residuei1162PhosphoserineCombined sources1
Modified residuei1175PhosphoserineCombined sources1
Modified residuei1178PhosphoserineCombined sources1
Modified residuei1253PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated. Phosphorylated by CDK5 (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q80YE4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q80YE4

PeptideAtlas

More...
PeptideAtlasi
Q80YE4

PRoteomics IDEntifications database

More...
PRIDEi
Q80YE4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q80YE4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q80YE4

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q80YE4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, and, to a lower extent, in kidney, heart, lung and skeletal muscle. In the brain, expressed in the olfactory bulb, cerebellum, striatum, hippocampal formation, thalamus, hypothalamus, and pontine nuclei (at protein level).4 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform 2 is predominantly expressed in adult stage. Isoform 3 is up-regulated during postnatal development.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated during the apoptotic death of myeloid cells induced by cytokine withdrawal, such as IL3, and during G-CSF-induced terminal differentiation of myeloblasts to granulocytes.2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CDK5.By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q80YE4, 1 interactor

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000099309

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q80YE4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini126 – 396Protein kinasePROSITE-ProRule annotationAdd BLAST271

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi84 – 87Poly-Ala4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGQE Eukaryota
ENOG410XQFM LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000049266

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q80YE4

KEGG Orthology (KO)

More...
KOi
K17480

Database of Orthologous Groups

More...
OrthoDBi
53680at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07714 Pkinase_Tyr, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00109 TYRKINASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q80YE4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSSFFNPSF AFSSHFDPDG APLSELSWSS SLAVVAVSFS GIFTVVILML
60 70 80 90 100
ACLCCKKGGI GFKEFENAEG DEYVADFSEQ GSPAAAAQTG PDVYVLPLTE
110 120 130 140 150
VSLPMAKQPG RSVQLLKSTD LGRHSLLYLK EIGHGWFGKV FLGEVHSGVS
160 170 180 190 200
GTQVVVKELK VSASVQEQMQ FLEEAQPYRA LQHSNLLQCL AQCAEVTPYL
210 220 230 240 250
LVMEFCPLGD LKGYLRSCRV TESMAPDPLT LQRMACEVAC GVLHLHRHNY
260 270 280 290 300
VHSDLALRNC LLTADLTVKV GDYGLSHCKY REDYLVTADQ LWVPLRWIAP
310 320 330 340 350
ELVDEVHGNL LVVDQTKSSN VWSLGVTIWE LFELGAQPYP QHSDRQVLAY
360 370 380 390 400
AVREQQLKLP KPQLQLALSD RWYEVMQFCW LQPEQRPTAE EVHLLLSYLC
410 420 430 440 450
AKGTTELEEE FERRWRSLRP GGSTGLGSGS AAPAAATAAS AELTAASSFP
460 470 480 490 500
LLERFTSDGF HVDSDDVLTV TETSHGLNFE YKWEAGCGAE EYPPSGAASS
510 520 530 540 550
PGSAARLQEL CAPDSSPPGV VPVLSAHSPS VGSEYFIRLE GAVPAAGHDP
560 570 580 590 600
DCAGCAPSPQ AVTDQDNNSE ESTVASLAME PLLGHAPPTE GLWGPCDHHS
610 620 630 640 650
HRRQGSPCPS RSPSPGTPML PAEDIDWGVA TFCPPFFDDP LGASPSGSPG
660 670 680 690 700
AQPSPSDEEP EEGKVGLAAQ CGHWSSNMSA NNNSASRDPE SWDPGYVSSF
710 720 730 740 750
TDSYRDDCSS LEQTPRASPE VGHLLSQEDP RDFLPGLVAV SPGQEPSRPF
760 770 780 790 800
NLLPLCPAKG LAPAACLITS PWTEGAVGGA ENPIVEPKLA QEAEGSAEPQ
810 820 830 840 850
LPLPSVPSPS CEGASLPSEE ASAPDILPAS PTPAAGSWVT VPEPAPTLES
860 870 880 890 900
SGSSLGQEAP SSEDEDTTEA TSGVFTDLSS DGPHTEKSGI VPALRSLQKQ
910 920 930 940 950
VGTPDSLDSL DIPSSASDGG CEVLSPSAAG PPGGQPRAVD SGYDTENYES
960 970 980 990 1000
PEFVLKEAHE SSEPEAFGEP ASEGESPGPD PLLSVSLGGL SKKSPYRDSA
1010 1020 1030 1040 1050
YFSDLDAESE PTFGPEKHSG IQDSQKEQDL RSPPSPGHQS VQAFPRSAVS
1060 1070 1080 1090 1100
SEVLSPPQQS EEPLPEVPRP EPLGAQGPVG VQPVPGPSHS KCFPLTSVPL
1110 1120 1130 1140 1150
ISEGSGTEPQ GPSGQLSGRA QQGQMGNPST PRSPLCLALP GHPGALEGRP
1160 1170 1180 1190 1200
EEDEDTEDSE ESDEELRCYS VQEPSEDSEE EPPAVPVVVA ESQSARNLRS
1210 1220 1230 1240 1250
LLKMPSLLSE AFCDDLERKK KAVSFFDDVT VYLFDQESPT RETGEPFPST
1260 1270 1280 1290 1300
KESLPTFLEG GPSSPSATGL PLRAGHSPDS SAPEPGSRFE WDGDFPLVPG
1310 1320 1330 1340 1350
KAALVTELDP ADPVLAAPPT PAAPFSRFTV SPTPASRFSI THISDSDAQS
1360
VGGPAAGAGG RYTEA
Length:1,365
Mass (Da):144,607
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i051A53505EDAF502
GO
Isoform 2 (identifier: Q80YE4-2) [UniParc]FASTAAdd to basket
Also known as: AATYK1A

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.

Show »
Length:1,317
Mass (Da):139,551
Checksum:i578C9F925CCF9408
GO
Isoform 3 (identifier: Q80YE4-3) [UniParc]FASTAAdd to basket
Also known as: AATYK1B

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLIALLALAM

Show »
Length:1,374
Mass (Da):145,517
Checksum:iC1292D7311141628
GO
Isoform 4 (identifier: Q80YE4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-168: Missing.
     1354-1365: PAAGAGGRYTEA → MSVVGAEVEQRDTTNGDL

Note: No experimental confirmation available.
Show »
Length:1,203
Mass (Da):127,544
Checksum:i747436FFC8A3B4BF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AZF3B1AZF3_MOUSE
Serine/threonine-protein kinase LMT...
Aatk
1,374Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AZF9B1AZF9_MOUSE
Apoptosis-associated tyrosine kinas...
Aatk mCG_15033
1,317Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC41437 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti270V → D in BAC29541 (PubMed:16141072).Curated1
Sequence conflicti345R → G in BAC29541 (PubMed:16141072).Curated1
Sequence conflicti345R → G in BAE27789 (PubMed:16141072).Curated1
Sequence conflicti345R → G in BAE33045 (PubMed:16141072).Curated1
Sequence conflicti345R → G in AAH80846 (PubMed:15489334).Curated1
Sequence conflicti773T → K in BAE33045 (PubMed:16141072).Curated1
Sequence conflicti988G → S in BAE27789 (PubMed:16141072).Curated1
Sequence conflicti1317A → S in BAC29541 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0202291 – 168Missing in isoform 4. 1 PublicationAdd BLAST168
Alternative sequenceiVSP_0202301 – 48Missing in isoform 2. 4 PublicationsAdd BLAST48
Alternative sequenceiVSP_0202311M → MLIALLALAM in isoform 3. 2 Publications1
Alternative sequenceiVSP_0202321354 – 1365PAAGA…RYTEA → MSVVGAEVEQRDTTNGDL in isoform 4. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF011908 mRNA Translation: AAB71837.1
AY236858 mRNA Translation: AAO92350.1
AY236859 mRNA Translation: AAO92351.1
AB288871 mRNA Translation: BAF64832.1
AB093253 mRNA Translation: BAC41437.2 Different initiation.
AK036705 mRNA Translation: BAC29541.1
AK147239 mRNA Translation: BAE27789.1
AK155100 mRNA Translation: BAE33045.1
BC080846 mRNA Translation: AAH80846.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS25725.1 [Q80YE4-2]
CCDS56826.1 [Q80YE4-3]

Protein sequence database of the Protein Information Resource

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PIRi
T03748

NCBI Reference Sequences

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RefSeqi
NP_001185714.1, NM_001198785.1
NP_001185716.1, NM_001198787.1
NP_031403.2, NM_007377.4

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
11302

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:11302

UCSC genome browser

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UCSCi
uc007mrn.3 mouse [Q80YE4-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011908 mRNA Translation: AAB71837.1
AY236858 mRNA Translation: AAO92350.1
AY236859 mRNA Translation: AAO92351.1
AB288871 mRNA Translation: BAF64832.1
AB093253 mRNA Translation: BAC41437.2 Different initiation.
AK036705 mRNA Translation: BAC29541.1
AK147239 mRNA Translation: BAE27789.1
AK155100 mRNA Translation: BAE33045.1
BC080846 mRNA Translation: AAH80846.1
CCDSiCCDS25725.1 [Q80YE4-2]
CCDS56826.1 [Q80YE4-3]
PIRiT03748
RefSeqiNP_001185714.1, NM_001198785.1
NP_001185716.1, NM_001198787.1
NP_031403.2, NM_007377.4

3D structure databases

SMRiQ80YE4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ80YE4, 1 interactor
STRINGi10090.ENSMUSP00000099309

PTM databases

iPTMnetiQ80YE4
PhosphoSitePlusiQ80YE4
SwissPalmiQ80YE4

Proteomic databases

jPOSTiQ80YE4
PaxDbiQ80YE4
PeptideAtlasiQ80YE4
PRIDEiQ80YE4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi11302
KEGGimmu:11302
UCSCiuc007mrn.3 mouse [Q80YE4-4]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9625
MGIiMGI:1197518 Aatk

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiENOG410IGQE Eukaryota
ENOG410XQFM LUCA
HOGENOMiHOG000049266
InParanoidiQ80YE4
KOiK17480
OrthoDBi53680at2759

Miscellaneous databases

Protein Ontology

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PROi
PR:Q80YE4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLMTK1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80YE4
Secondary accession number(s): A6BLY8
, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 2003
Last modified: May 8, 2019
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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