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Entry version 143 (08 May 2019)
Sequence version 3 (24 Jul 2007)
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Protein

Protein crumbs homolog 2

Gene

Crb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Apical polarity protein that plays a central role during the epithelial-to-mesenchymal transition (EMT) at gastrulation, when newly specified mesodermal cells move inside the embryo (PubMed:26496195, PubMed:27870829). Acts by promoting cell ingression, the process by which cells leave the epithelial epiblast and move inside the embryo to form a new tissue layer (PubMed:27870829). The anisotropic distribution of CRB2 and MYH10/myosin-IIB at cell edges define which cells will ingress: cells with high apical CRB2 are probably extruded from the epiblast by neighboring cells with high levels of apical MYH10/myosin-IIB (PubMed:27870829). Also required for maintenance of the apical polarity complex during development of the cortex.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processGastrulation
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein crumbs homolog 2Curated
Short name:
crumbs21 Publication
Alternative name(s):
Crumbs-like protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Crb2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2679260 Crb2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini36 – 1221ExtracellularCuratedAdd BLAST1186
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1222 – 1242HelicalSequence analysisAdd BLAST21
Topological domaini1243 – 1282CytoplasmicCuratedAdd BLAST40

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonic lethality due impaired gastrulation (PubMed:22072575, PubMed:27870829). Mesoderm formation is disrupted, and cells do not ingress (PubMed:27870829). Instead, a single layer forms, and the embryo fails to properly establish its body plan, leading to embryonic arrest (PubMed:27870829). Conditional deletion in the developing retina leads to progressive disorganization during late retinal development: retina show progressive thinning of the photoreceptor layer and sites of cellular mislocalization (PubMed:23001562). Conditional deletion in the dorsal telencephalon leads to defects in the maintenance of the apical complex (PubMed:26802325).4 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 35Sequence analysisAdd BLAST35
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000005562636 – 1282Protein crumbs homolog 2Sequence analysisAdd BLAST1247

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi75 ↔ 86PROSITE-ProRule annotation
Disulfide bondi80 ↔ 98PROSITE-ProRule annotation
Disulfide bondi100 ↔ 109PROSITE-ProRule annotation
Disulfide bondi116 ↔ 127PROSITE-ProRule annotation
Disulfide bondi121 ↔ 136PROSITE-ProRule annotation
Disulfide bondi138 ↔ 147PROSITE-ProRule annotation
Disulfide bondi154 ↔ 165PROSITE-ProRule annotation
Disulfide bondi159 ↔ 174PROSITE-ProRule annotation
Disulfide bondi176 ↔ 185PROSITE-ProRule annotation
Disulfide bondi192 ↔ 203PROSITE-ProRule annotation
Disulfide bondi197 ↔ 212PROSITE-ProRule annotation
Disulfide bondi214 ↔ 224PROSITE-ProRule annotation
Disulfide bondi231 ↔ 242PROSITE-ProRule annotation
Disulfide bondi236 ↔ 251PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi239N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi253 ↔ 262PROSITE-ProRule annotation
Disulfide bondi269 ↔ 280PROSITE-ProRule annotation
Glycosylationi271O-linked (Glc...) serine1 Publication1
Disulfide bondi274 ↔ 310PROSITE-ProRule annotation
Disulfide bondi312 ↔ 321PROSITE-ProRule annotation
Disulfide bondi328 ↔ 339PROSITE-ProRule annotation
Disulfide bondi333 ↔ 348PROSITE-ProRule annotation
Disulfide bondi350 ↔ 359PROSITE-ProRule annotation
Disulfide bondi366 ↔ 377PROSITE-ProRule annotation
Disulfide bondi371 ↔ 386PROSITE-ProRule annotation
Disulfide bondi388 ↔ 397PROSITE-ProRule annotation
Disulfide bondi404 ↔ 415PROSITE-ProRule annotation
Disulfide bondi409 ↔ 428PROSITE-ProRule annotation
Disulfide bondi430 ↔ 439PROSITE-ProRule annotation
Glycosylationi442N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi583 ↔ 607PROSITE-ProRule annotation
Disulfide bondi613 ↔ 624PROSITE-ProRule annotation
Disulfide bondi618 ↔ 633PROSITE-ProRule annotation
Disulfide bondi635 ↔ 644PROSITE-ProRule annotation
Glycosylationi672N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi693N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi769 ↔ 808PROSITE-ProRule annotation
Glycosylationi789N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi803N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi814 ↔ 825PROSITE-ProRule annotation
Disulfide bondi819 ↔ 834PROSITE-ProRule annotation
Disulfide bondi836 ↔ 845PROSITE-ProRule annotation
Glycosylationi839N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi889N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi929N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1006N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1010 ↔ 1051PROSITE-ProRule annotation
Disulfide bondi1057 ↔ 1068PROSITE-ProRule annotation
Disulfide bondi1062 ↔ 1077PROSITE-ProRule annotation
Disulfide bondi1079 ↔ 1088PROSITE-ProRule annotation
Disulfide bondi1095 ↔ 1105PROSITE-ProRule annotation
Disulfide bondi1100 ↔ 1115PROSITE-ProRule annotation
Disulfide bondi1117 ↔ 1126PROSITE-ProRule annotation
Disulfide bondi1135 ↔ 1147PROSITE-ProRule annotation
Glycosylationi1138N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1141 ↔ 1156PROSITE-ProRule annotation
Glycosylationi1155N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1158 ↔ 1167PROSITE-ProRule annotation
Disulfide bondi1174 ↔ 1185PROSITE-ProRule annotation
Disulfide bondi1179 ↔ 1194PROSITE-ProRule annotation
Disulfide bondi1196 ↔ 1205PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glucosylated by POGLUT1 at Ser-271; consists of an O-glucose trisaccharide, in which the O-glucose is elongated by the addition of two xylose residues (PubMed:26496195). O-glucosylation is required for localization at the plasma membrane (PubMed:26496195).1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q80YA8

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q80YA8

PeptideAtlas

More...
PeptideAtlasi
Q80YA8

PRoteomics IDEntifications database

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PRIDEi
Q80YA8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q80YA8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q80YA8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In the adult eye, strongly expressed in the outer nuclear layer, containing the cell bodies of the photoreceptor cells, and in the inner nuclear layer, containing the cell bodies of the horizontal, bipolar, amacrine, and Mueller glial cells (PubMed:15851977). Also expressed in some cells in the ganglion cell layer (or may be displaced amacrine cells rather than ganglion cells) (PubMed:15851977).1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in early embryonic cells, more specifically in embryonic regions undergoing dramatic rearrangement, such as the developing neuroepithelium which proceeds with neural tube closure, the anterior splitting lateral plate mesoderm that wraps the pericardial cavity and the differentiating somite epithelium. Widely expressed throughout the epiblast and the lateral plate mesoderm at 7 dpc. At 7.5 dpc-7.75 dpc, continues to be expressed in these regions, and expression is also found on the apical side of the embryonic endoderm, and extraembryonic amnion and allantois. At 8-8.5 dpc, expression is also detected in the heart tube, foregut and the apical side of the somite epithelium. Stronger expression is detected on the apical sides of the splitting lateral plate mesoderm, and the apical side of the neural ectoderm at trunk region. Not expressed in the notochord plate or the extra-embryonic endoderm.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000035403 Expressed in 22 organ(s), highest expression level in brain

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q80YA8 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000058007

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q80YA8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini71 – 110EGF-like 1PROSITE-ProRule annotationAdd BLAST40
Domaini112 – 148EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini150 – 186EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini188 – 225EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST38
Domaini227 – 263EGF-like 5PROSITE-ProRule annotationAdd BLAST37
Domaini265 – 322EGF-like 6PROSITE-ProRule annotationAdd BLAST58
Domaini324 – 360EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini362 – 398EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini400 – 440EGF-like 9PROSITE-ProRule annotationAdd BLAST41
Domaini444 – 607Laminin G-like 1PROSITE-ProRule annotationAdd BLAST164
Domaini609 – 645EGF-like 10PROSITE-ProRule annotationAdd BLAST37
Domaini649 – 808Laminin G-like 2PROSITE-ProRule annotationAdd BLAST160
Domaini810 – 846EGF-like 11PROSITE-ProRule annotationAdd BLAST37
Domaini872 – 1051Laminin G-like 3PROSITE-ProRule annotationAdd BLAST180
Domaini1053 – 1089EGF-like 12PROSITE-ProRule annotationAdd BLAST37
Domaini1091 – 1127EGF-like 13PROSITE-ProRule annotationAdd BLAST37
Domaini1131 – 1168EGF-like 14PROSITE-ProRule annotationAdd BLAST38
Domaini1170 – 1206EGF-like 15PROSITE-ProRule annotationAdd BLAST37

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Crumbs protein family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1217 Eukaryota
ENOG410XP6K LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000183101

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000230899

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q80YA8

KEGG Orthology (KO)

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KOi
K16681

Identification of Orthologs from Complete Genome Data

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OMAi
RCEQEVL

Database of Orthologous Groups

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OrthoDBi
111153at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q80YA8

TreeFam database of animal gene trees

More...
TreeFami
TF316224

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR001791 Laminin_G

Pfam protein domain database

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Pfami
View protein in Pfam
PF00008 EGF, 9 hits
PF12661 hEGF, 1 hit
PF02210 Laminin_G_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 15 hits
SM00179 EGF_CA, 13 hits
SM00282 LamG, 3 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49899 SSF49899, 3 hits
SSF57184 SSF57184, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 8 hits
PS00022 EGF_1, 14 hits
PS01186 EGF_2, 9 hits
PS50026 EGF_3, 15 hits
PS01187 EGF_CA, 5 hits
PS50025 LAM_G_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q80YA8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALVGPRIWG PRRDIYPLLL LLLLLLLLLL PWVPAGLVPP ETPSVCASDP
60 70 80 90 100
CAPGTKCQAT ESGGYTCEPS ELGGCATQPC HHGALCVPQG PDPNSFRCYC
110 120 130 140 150
VPGFQGPHCE LDIDECASRP CQHGGTCQNL ADHYECHCPL GYAGVTCEAE
160 170 180 190 200
VDECSSAPCL HGGSCLDGVG SYRCVCAPGY AGANCQLDVD ECQSQPCAHG
210 220 230 240 250
GVCHDLVNGF RCDCADTGYE GARCEQEVLE CASAPCAHNA SCLDGFRSFR
260 270 280 290 300
CLCWPGFSGE RCEVDEDECA SGPCQNGGQC LQRSDPTLYG GVQAIFPGAF
310 320 330 340 350
SFSHAAGFLC SCPLGFAGND CSMDVDECAS GPCLNGGSCQ DLPNGFQCYC
360 370 380 390 400
QDGYTGLTCQ EDMDECQSEP CLHGGTCSDT VAGYICQCPE AWGGHDCSVQ
410 420 430 440 450
LTGCQGHTCP LAATCIPTFK SGLHGYFCRC PPGTYGPFCG QNTTFSVVSG
460 470 480 490 500
SSVWGLVPAA ASLGLALRFR TTLLAGTLAT LKDTRDSLEL VLVGAVLQAT
510 520 530 540 550
LSRHGTAVLI LTLPDLALND GHWHQVEVTL HLGTLELRLW HEGCPGQLCV
560 570 580 590 600
ASGPVATGPT ASVASGPPGS YSIYLGGGVF AGCFQDVRVE GHLLLPEELK
610 620 630 640 650
GTVLLGCERR EPCQPLPCAH GGACVDLWTH FRCDCPRPYR GATCTDEVPA
660 670 680 690 700
ATFGLGGATS SASFLLHQLG PNLTVSFFLR TREPAGLLLQ FANDSVASLT
710 720 730 740 750
VFLSEGQIRA EGLGHPAVVL PGRWDDGLPH LVMLSFGPDQ LQDLGQRLYV
760 770 780 790 800
GGRFYPDDTQ LWGGPFRGCL QDLQLNSIHL PFFSSPMENS SWPSELEAGQ
810 820 830 840 850
SSNLTQGCVS EDTCNPNPCF NGGTCHVTWN DFYCTCSENF TGPTCAQQRW
860 870 880 890 900
CPRQPCLPPA TCEEVPDGFV CVAEATFREG PPAVFTGHNV SSSLSGLTLA
910 920 930 940 950
FRTRDSEAGL LRAVSAAGAH SNIWLAVRNG SLAGDVAGSV LPAPGPRVAD
960 970 980 990 1000
GAWHRVRLAR EFPQAAASRW LLWLDGAATP VALHGLGGDL GFLQGPGAVP
1010 1020 1030 1040 1050
LLLAENFTGC LGRVALGDFP LPLAPPRSGT VSGAREHFVA WPGSPAVSLG
1060 1070 1080 1090 1100
CRGGPVCSPS PCLHGGACRD LFDAFACSCG PAWEGPRCEI RADPCRSTPC
1110 1120 1130 1140 1150
VRGQCHARPD GRFECRCPPG FSGPRCRLPV LPQGCNLNST CKDGAPCEGG
1160 1170 1180 1190 1200
PLGTNCSCQE GLAGLRCQSL DKPCEASPCL NGGTCRVASG IFECTCSAGF
1210 1220 1230 1240 1250
SGQFCEVVKT LPLPLPFPLL EVAVPAACAC LLLLLLGLLS GILAARKRRQ
1260 1270 1280
SEGTYSPSQQ EVAGARLEMD SVLKVPPEER LI
Length:1,282
Mass (Da):134,760
Last modified:July 24, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9099A9AAD1FEC403
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0N4SUJ6A0A0N4SUJ6_MOUSE
Protein crumbs homolog 2
Crb2
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti842G → E in AAH62128 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL805959 Genomic DNA No translation available.
BC043114 mRNA Translation: AAH43114.1
BC062128 mRNA Translation: AAH62128.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS50580.1

NCBI Reference Sequences

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RefSeqi
NP_001157038.1, NM_001163566.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000050372; ENSMUSP00000058007; ENSMUSG00000035403

Database of genes from NCBI RefSeq genomes

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GeneIDi
241324

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:241324

UCSC genome browser

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UCSCi
uc008jnf.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL805959 Genomic DNA No translation available.
BC043114 mRNA Translation: AAH43114.1
BC062128 mRNA Translation: AAH62128.1
CCDSiCCDS50580.1
RefSeqiNP_001157038.1, NM_001163566.1

3D structure databases

SMRiQ80YA8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058007

PTM databases

iPTMnetiQ80YA8
PhosphoSitePlusiQ80YA8

Proteomic databases

MaxQBiQ80YA8
PaxDbiQ80YA8
PeptideAtlasiQ80YA8
PRIDEiQ80YA8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050372; ENSMUSP00000058007; ENSMUSG00000035403
GeneIDi241324
KEGGimmu:241324
UCSCiuc008jnf.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
286204
MGIiMGI:2679260 Crb2

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
ENOG410XP6K LUCA
GeneTreeiENSGT00950000183101
HOGENOMiHOG000230899
InParanoidiQ80YA8
KOiK16681
OMAiRCEQEVL
OrthoDBi111153at2759
PhylomeDBiQ80YA8
TreeFamiTF316224

Miscellaneous databases

Protein Ontology

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PROi
PR:Q80YA8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000035403 Expressed in 22 organ(s), highest expression level in brain
ExpressionAtlasiQ80YA8 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00008 EGF, 9 hits
PF12661 hEGF, 1 hit
PF02210 Laminin_G_2, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 15 hits
SM00179 EGF_CA, 13 hits
SM00282 LamG, 3 hits
SUPFAMiSSF49899 SSF49899, 3 hits
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 8 hits
PS00022 EGF_1, 14 hits
PS01186 EGF_2, 9 hits
PS50026 EGF_3, 15 hits
PS01187 EGF_CA, 5 hits
PS50025 LAM_G_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRUM2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80YA8
Secondary accession number(s): A2ALU1, Q6P6N1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 24, 2007
Last modified: May 8, 2019
This is version 143 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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