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Entry version 131 (12 Aug 2020)
Sequence version 1 (01 Jun 2003)
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Protein

Dixin

Gene

Dixdc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Developmental protein
Biological processWnt signaling pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dixin
Alternative name(s):
Coiled-coil protein DIX1
Short name:
Coiled-coil-DIX1
DIX domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dixdc1
Synonyms:Ccd1, Kiaa1735
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2679721, Dixdc1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002872241 – 711DixinAdd BLAST711

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei212PhosphoserineCombined sources1
Modified residuei257PhosphoserineCombined sources1
Modified residuei618PhosphoserineBy similarity1
Isoform 4 (identifier: Q80Y83-4)
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycineBy similarity1
Isoform 11 (identifier: Q80Y83-11)
Modified residuei13PhosphoserineCombined sources1
Isoform 12 (identifier: Q80Y83-12)
Modified residuei13PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine and serine residues.By similarity
Polyubiquitinated, leading to its proteasomal degradation. WNT3A signaling increases DIXDC1 protein levels by inhibiting its ubiquitination and subsequent degradation (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q80Y83

PeptideAtlas

More...
PeptideAtlasi
Q80Y83

PRoteomics IDEntifications database

More...
PRIDEi
Q80Y83

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q80Y83

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q80Y83

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundantly expressed in brain and testis and to a lower extent in lung, kidney, colon, ovary and urinary bladder. Expressed in brain, liver, testis and spleen (at protein level). Expressed throughout the brain with strong expression in main and accessory olfactory bulbs, cerebral cortex, piriform cortex, hippocampus, habenular nucleus, dorsal thalamus, superior and inferior colliculi and cerebellum.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in embryonic brain, liver and spleen (at protein level). First detected at 7.5 dpc in the node. Expressed in the cephalic mesenchyme and tail bud at 8.5 dpc, and in the branchial arch and forelimb bud at 9.5 dpc. In the central nervous system, expression begins and persists in the regions where the neurons differentiate. Expression is also strong in the peripheral nervous system, including sensory cranial ganglia, dorsal root ganglia, and autonomic ganglia, and in the sensory organs, such as the inner nuclear layer of the neural retina, saccule and cochlea of the inner ear, and nasal epithelium. Outside the nervous system, expression is detected in the cartilage, tongue, lung bud, stomach, and gonad from 12.5 dpc to 14.5 dpc, and in the tooth bud, bronchial epithelium, and kidney at 17.5 dpc.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000032064, Expressed in pes and 295 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q80Y83, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q80Y83, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May bind filamentous actin. Directly interacts (via DIX domain) with DVL2 (via DIX domain).

Interacts with gamma-tubulin (By similarity).

Interacts with the complex composed of DVL2 and Rac.

Interacts with AXIN1; competes with MAP3K1.

Interacts with MAP3K4 preventing MAP3K4 interaction with AXIN1.

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
237048, 2 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q80Y83

Protein interaction database and analysis system

More...
IntActi
Q80Y83, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000034566

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q80Y83, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1711
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q80Y83

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 153Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST134
Domaini600 – 680DIXPROSITE-ProRule annotationAdd BLAST81

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni153 – 326Actin-bindingBy similarityAdd BLAST174

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili279 – 452Sequence analysisAdd BLAST174

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The coiled-coil domain mediates interaction with MAP3K4 and inhibition of AXIN1-mediated JNK activation through MAP3K4.By similarity
The DIX domain mediates interaction with AXIN1 and inhibition of AXIN1-mediated JNK activation through MAP3K1. Mediates interaction with DVL2; this interaction is required for activation of Wnt signaling (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DIXDC1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RD5G, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182903

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_025678_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q80Y83

Identification of Orthologs from Complete Genome Data

More...
OMAi
CKQEIRN

Database of Orthologous Groups

More...
OrthoDBi
949210at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q80Y83

TreeFam database of animal gene trees

More...
TreeFami
TF318198

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit
3.10.20.380, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR001158, DIX
IPR038207, DIX_dom_sf
IPR015506, Dsh/Dvl-rel
IPR029071, Ubiquitin-like_domsf

The PANTHER Classification System

More...
PANTHERi
PTHR10878, PTHR10878, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 1 hit
PF00778, DIX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 1 hit
SM00021, DAX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit
SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021, CH, 1 hit
PS50841, DIX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (16+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 16 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 16 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q80Y83-1) [UniParc]FASTAAdd to basket
Also known as: Abeta1L

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLACLTRGNL LDVLQEGFNE QQLQAYVAWV NAQLKKRPSV KPVQDLRQDL
60 70 80 90 100
RDGVILAYLI EIVGQLALDS DASVDERTDF FLLHSPFKAA GEKLTGVQLS
110 120 130 140 150
PSNQQEMKSN VERVLQFVAS KKIRMHQTSA KDIVEGNLKS IMRLVLALAA
160 170 180 190 200
HFKPGSSRTV SQGRDSKAPV QSHQPHCATA VAQGAAAALA DVCHDVSRSG
210 220 230 240 250
RDVFRYRQRN ASVDGEIENP YWSVRALVQQ YEGQQKSPSE SSCSSLTSPS
260 270 280 290 300
PIHSAKSESI ITQAEEKADF VIIPSEGIEN RTDEPDSPSS RDWRPGSRGT
310 320 330 340 350
YLEATWEEQL LEQQEHLEKE MEEAKKMISG LQALLLNGSL PEDEQERPVA
360 370 380 390 400
LCEPGVNPEE QLIIIRSRLD QSVEENQDLK KELLKCKQEA RNLQGIKDAL
410 420 430 440 450
QQRLTQQDTS VLQLKQELLR ANMDKDELHN QNVDLQRKLE ERNRLLGEYK
460 470 480 490 500
KELGQKDRLF QQQQAKLEEA LRKLSDASYQ QVDLERELEQ KDVLLAHCMK
510 520 530 540 550
GETDEVTNYN SHSSQRNGFV LPVAGRGATT VTHRGPQTSD LQLVRDALRS
560 570 580 590 600
LRNSFSGHDP QHHTIDSLEQ GISSLMERLH VVETQKKQER KVGGRSPRNQ
610 620 630 640 650
ASSEYRASWP PNSTLPHSQS SPAVSSTCTK VLYFTDRSLT PFMVNIPKRL
660 670 680 690 700
GEVTLKDFKA AIDREGNHRY HFKALDPEFG TVKEEVFHDD DAIPGWEGKI
710
VAWVEEDHRE N
Length:711
Mass (Da):80,215
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i153063F1B995EB8C
GO
Isoform 2 (identifier: Q80Y83-2) [UniParc]FASTAAdd to basket
Also known as: Abeta1S

The sequence of this isoform differs from the canonical sequence as follows:
     506-535: Missing.

Show »
Length:681
Mass (Da):77,048
Checksum:i644FC11062E8C3AE
GO
Isoform 3 (identifier: Q80Y83-3) [UniParc]FASTAAdd to basket
Also known as: Aalpha1L

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MLACLTRGNLLDVLQEGFNE → MGTQVVMRVCNSSMPGAPS

Show »
Length:710
Mass (Da):79,931
Checksum:i313D5838DE1B658A
GO
Isoform 4 (identifier: Q80Y83-4) [UniParc]FASTAAdd to basket
Also known as: Aalpha1S

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MLACLTRGNLLDVLQEGFNE → MGTQVVMRVCNSSMPGAPS
     506-535: Missing.

Show »
Length:680
Mass (Da):76,764
Checksum:i66D1643B1903D044
GO
Isoform 5 (identifier: Q80Y83-5) [UniParc]FASTAAdd to basket
Also known as: Abeta2L

The sequence of this isoform differs from the canonical sequence as follows:
     64-89: Missing.

Note: Major isoform.Curated
Show »
Length:685
Mass (Da):77,353
Checksum:iC49B303441826CE6
GO
Isoform 6 (identifier: Q80Y83-6) [UniParc]FASTAAdd to basket
Also known as: Abeta2S

The sequence of this isoform differs from the canonical sequence as follows:
     64-89: Missing.
     506-535: Missing.

Show »
Length:655
Mass (Da):74,186
Checksum:iF21678E676FB57D4
GO
Isoform 7 (identifier: Q80Y83-7) [UniParc]FASTAAdd to basket
Also known as: Aalpha2L

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MLACLTRGNLLDVLQEGFNE → MGTQVVMRVCNSSMPGAPS
     64-89: Missing.

Note: Major isoform.Curated
Show »
Length:684
Mass (Da):77,068
Checksum:i8A467968A31CC9CD
GO
Isoform 8 (identifier: Q80Y83-8) [UniParc]FASTAAdd to basket
Also known as: Aalpha2S

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MLACLTRGNLLDVLQEGFNE → MGTQVVMRVCNSSMPGAPS
     64-89: Missing.
     506-535: Missing.

Show »
Length:654
Mass (Da):73,902
Checksum:i0753993D739AFC84
GO
Isoform 9 (identifier: Q80Y83-9) [UniParc]FASTAAdd to basket
Also known as: BbetaL

The sequence of this isoform differs from the canonical sequence as follows:
     1-234: Missing.
     235-245: QKSPSESSCSS → MMIILQSKLIT

Show »
Length:477
Mass (Da):54,487
Checksum:iA4C5B03A794D05F6
GO
Isoform 10 (identifier: Q80Y83-10) [UniParc]FASTAAdd to basket
Also known as: BbetaS

The sequence of this isoform differs from the canonical sequence as follows:
     1-234: Missing.
     235-245: QKSPSESSCSS → MMIILQSKLIT
     506-535: Missing.

Show »
Length:447
Mass (Da):51,321
Checksum:i51567F8E0072EAD9
GO
Isoform 11 (identifier: Q80Y83-11) [UniParc]FASTAAdd to basket
Also known as: BalphaL

The sequence of this isoform differs from the canonical sequence as follows:
     1-237: Missing.
     238-245: PSESSCSS → MGGTQVKC

Note: Major isoform.Curated
Show »
Length:474
Mass (Da):54,019
Checksum:iC196BF5788A0CEED
GO
Isoform 12 (identifier: Q80Y83-12) [UniParc]FASTAAdd to basket
Also known as: BalphaS

The sequence of this isoform differs from the canonical sequence as follows:
     1-237: Missing.
     238-245: PSESSCSS → MGGTQVKC
     506-535: Missing.

Show »
Length:444
Mass (Da):50,853
Checksum:i83FE9CCFC405E81F
GO
Isoform 13 (identifier: Q80Y83-13) [UniParc]FASTAAdd to basket
Also known as: CL

The sequence of this isoform differs from the canonical sequence as follows:
     1-320: Missing.

Show »
Length:391
Mass (Da):44,724
Checksum:iB6C49B325B438E2F
GO
Isoform 14 (identifier: Q80Y83-14) [UniParc]FASTAAdd to basket
Also known as: CS

The sequence of this isoform differs from the canonical sequence as follows:
     1-320: Missing.
     506-535: Missing.

Show »
Length:361
Mass (Da):41,558
Checksum:i4EFD96029308CE46
GO
Isoform 15 (identifier: Q80Y83-15) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-272: Missing.
     273-282: IPSEGIENRT → MNYGSTFHLA
     614-615: TL → KA
     616-711: Missing.

Show »
Length:343
Mass (Da):39,375
Checksum:i5441871A12784754
GO
Isoform 16 (identifier: Q80Y83-16) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MLACLTRGNLLDVLQEGFNE → MGTQVVMRVCNSSMPGAPS
     90-117: AGEKLTGVQLSPSNQQEMKSNVERVLQF → GCSFFRMHGNSVGKYLKVLALVNLRVGQ
     118-711: Missing.

Show »
Length:116
Mass (Da):12,850
Checksum:iBD7F6FF410958217
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z453F2Z453_MOUSE
Dixin
Dixdc1
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti278I → T in BAC98242 (PubMed:14621295).Curated1
Sequence conflicti474L → F in BAC98242 (PubMed:14621295).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0253831 – 320Missing in isoform 13 and isoform 14. 1 PublicationAdd BLAST320
Alternative sequenceiVSP_0253841 – 272Missing in isoform 15. 1 PublicationAdd BLAST272
Alternative sequenceiVSP_0253851 – 237Missing in isoform 11 and isoform 12. 1 PublicationAdd BLAST237
Alternative sequenceiVSP_0253861 – 234Missing in isoform 9 and isoform 10. 1 PublicationAdd BLAST234
Alternative sequenceiVSP_0253871 – 20MLACL…EGFNE → MGTQVVMRVCNSSMPGAPS in isoform 3, isoform 4, isoform 7, isoform 8 and isoform 16. 2 PublicationsAdd BLAST20
Alternative sequenceiVSP_02538864 – 89Missing in isoform 5, isoform 6, isoform 7 and isoform 8. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_02538990 – 117AGEKL…RVLQF → GCSFFRMHGNSVGKYLKVLA LVNLRVGQ in isoform 16. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_025390118 – 711Missing in isoform 16. 1 PublicationAdd BLAST594
Alternative sequenceiVSP_025391235 – 245QKSPSESSCSS → MMIILQSKLIT in isoform 9 and isoform 10. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_025392238 – 245PSESSCSS → MGGTQVKC in isoform 11 and isoform 12. 1 Publication8
Alternative sequenceiVSP_025393273 – 282IPSEGIENRT → MNYGSTFHLA in isoform 15. 1 Publication10
Alternative sequenceiVSP_025394506 – 535Missing in isoform 2, isoform 4, isoform 6, isoform 8, isoform 10, isoform 12 and isoform 14. CuratedAdd BLAST30
Alternative sequenceiVSP_025395614 – 615TL → KA in isoform 15. 1 Publication2
Alternative sequenceiVSP_025396616 – 711Missing in isoform 15. 1 PublicationAdd BLAST96

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY549883 mRNA Translation: AAT41660.1
AY549884 mRNA Translation: AAT41661.1
AY549885 mRNA Translation: AAT41662.1
AY549886 mRNA Translation: AAT41663.1
AY549887 mRNA Translation: AAT41664.1
AK082960 mRNA Translation: BAC38711.1
AK142668 mRNA Translation: BAE25153.1
AK164424 mRNA Translation: BAE37782.1
BC024834 mRNA Translation: AAH24834.1
BC048182 mRNA Translation: AAH48182.1
BC063085 mRNA Translation: AAH63085.1
AK129432 mRNA Translation: BAC98242.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS23169.1 [Q80Y83-1]
CCDS80995.1 [Q80Y83-3]
CCDS90563.1 [Q80Y83-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001297998.1, NM_001311069.1 [Q80Y83-3]
NP_835219.1, NM_178118.2 [Q80Y83-1]
XP_006510517.1, XM_006510454.3
XP_006510518.1, XM_006510455.3 [Q80Y83-2]
XP_006510519.1, XM_006510456.3 [Q80Y83-11]
XP_006510520.1, XM_006510457.3 [Q80Y83-13]
XP_017168928.1, XM_017313439.1 [Q80Y83-3]
XP_017168929.1, XM_017313440.1 [Q80Y83-3]
XP_017168930.1, XM_017313441.1 [Q80Y83-12]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000034566; ENSMUSP00000034566; ENSMUSG00000032064 [Q80Y83-1]
ENSMUST00000117093; ENSMUSP00000112654; ENSMUSG00000032064 [Q80Y83-16]
ENSMUST00000117646; ENSMUSP00000112431; ENSMUSG00000032064 [Q80Y83-5]
ENSMUST00000120622; ENSMUSP00000113934; ENSMUSG00000032064 [Q80Y83-15]
ENSMUST00000121634; ENSMUSP00000113089; ENSMUSG00000032064 [Q80Y83-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
330938

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:330938

UCSC genome browser

More...
UCSCi
uc009pkb.1, mouse [Q80Y83-11]
uc009pkc.2, mouse [Q80Y83-1]
uc009pkd.1, mouse [Q80Y83-3]
uc009pke.1, mouse [Q80Y83-15]
uc009pkh.1, mouse [Q80Y83-16]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY549883 mRNA Translation: AAT41660.1
AY549884 mRNA Translation: AAT41661.1
AY549885 mRNA Translation: AAT41662.1
AY549886 mRNA Translation: AAT41663.1
AY549887 mRNA Translation: AAT41664.1
AK082960 mRNA Translation: BAC38711.1
AK142668 mRNA Translation: BAE25153.1
AK164424 mRNA Translation: BAE37782.1
BC024834 mRNA Translation: AAH24834.1
BC048182 mRNA Translation: AAH48182.1
BC063085 mRNA Translation: AAH63085.1
AK129432 mRNA Translation: BAC98242.1
CCDSiCCDS23169.1 [Q80Y83-1]
CCDS80995.1 [Q80Y83-3]
CCDS90563.1 [Q80Y83-5]
RefSeqiNP_001297998.1, NM_001311069.1 [Q80Y83-3]
NP_835219.1, NM_178118.2 [Q80Y83-1]
XP_006510517.1, XM_006510454.3
XP_006510518.1, XM_006510455.3 [Q80Y83-2]
XP_006510519.1, XM_006510456.3 [Q80Y83-11]
XP_006510520.1, XM_006510457.3 [Q80Y83-13]
XP_017168928.1, XM_017313439.1 [Q80Y83-3]
XP_017168929.1, XM_017313440.1 [Q80Y83-3]
XP_017168930.1, XM_017313441.1 [Q80Y83-12]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5Y3BX-ray3.00A/B/C/D/E/F/G625-707[»]
SMRiQ80Y83
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi237048, 2 interactors
CORUMiQ80Y83
IntActiQ80Y83, 1 interactor
STRINGi10090.ENSMUSP00000034566

PTM databases

iPTMnetiQ80Y83
PhosphoSitePlusiQ80Y83

Proteomic databases

PaxDbiQ80Y83
PeptideAtlasiQ80Y83
PRIDEiQ80Y83

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
32094, 186 antibodies

Genome annotation databases

EnsembliENSMUST00000034566; ENSMUSP00000034566; ENSMUSG00000032064 [Q80Y83-1]
ENSMUST00000117093; ENSMUSP00000112654; ENSMUSG00000032064 [Q80Y83-16]
ENSMUST00000117646; ENSMUSP00000112431; ENSMUSG00000032064 [Q80Y83-5]
ENSMUST00000120622; ENSMUSP00000113934; ENSMUSG00000032064 [Q80Y83-15]
ENSMUST00000121634; ENSMUSP00000113089; ENSMUSG00000032064 [Q80Y83-3]
GeneIDi330938
KEGGimmu:330938
UCSCiuc009pkb.1, mouse [Q80Y83-11]
uc009pkc.2, mouse [Q80Y83-1]
uc009pkd.1, mouse [Q80Y83-3]
uc009pke.1, mouse [Q80Y83-15]
uc009pkh.1, mouse [Q80Y83-16]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
85458
MGIiMGI:2679721, Dixdc1

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiENOG502RD5G, Eukaryota
GeneTreeiENSGT00950000182903
HOGENOMiCLU_025678_0_0_1
InParanoidiQ80Y83
OMAiCKQEIRN
OrthoDBi949210at2759
PhylomeDBiQ80Y83
TreeFamiTF318198

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
330938, 0 hits in 13 CRISPR screens

Protein Ontology

More...
PROi
PR:Q80Y83
RNActiQ80Y83, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000032064, Expressed in pes and 295 other tissues
ExpressionAtlasiQ80Y83, baseline and differential
GenevisibleiQ80Y83, MM

Family and domain databases

CDDicd00014, CH, 1 hit
Gene3Di1.10.418.10, 1 hit
3.10.20.380, 1 hit
InterProiView protein in InterPro
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR001158, DIX
IPR038207, DIX_dom_sf
IPR015506, Dsh/Dvl-rel
IPR029071, Ubiquitin-like_domsf
PANTHERiPTHR10878, PTHR10878, 1 hit
PfamiView protein in Pfam
PF00307, CH, 1 hit
PF00778, DIX, 1 hit
SMARTiView protein in SMART
SM00033, CH, 1 hit
SM00021, DAX, 1 hit
SUPFAMiSSF47576, SSF47576, 1 hit
SSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50021, CH, 1 hit
PS50841, DIX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDIXC1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80Y83
Secondary accession number(s): Q3TPF4
, Q3UQ90, Q5DPZ2, Q5DPZ3, Q5DPZ4, Q5DPZ6, Q6ZPJ2, Q8C467, Q8R1C1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 2003
Last modified: August 12, 2020
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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