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Entry version 142 (02 Jun 2021)
Sequence version 1 (01 Jun 2003)
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Protein

Zinc phosphodiesterase ELAC protein 2

Gene

Elac2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.By similarity EC:3.1.26.11

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processtRNA processing
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.26.11, 3474

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc phosphodiesterase ELAC protein 2 (EC:3.1.26.11)
Alternative name(s):
ElaC homolog protein 2
Ribonuclease Z 2
Short name:
RNase Z 2
tRNA 3 endonuclease 2
tRNase Z 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Elac2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1890496, Elac2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Mitochondrion, Mitochondrion nucleoid, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 16MitochondrionSequence analysisAdd BLAST16
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000015583017 – 831Zinc phosphodiesterase ELAC protein 2Add BLAST815

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei191PhosphoserineCombined sources1
Modified residuei195PhosphoserineCombined sources1
Modified residuei200PhosphoserineCombined sources1
Modified residuei204PhosphoserineBy similarity1
Modified residuei732PhosphoserineBy similarity1
Modified residuei792PhosphothreonineCombined sources1
Modified residuei797PhosphoserineCombined sources1
Modified residuei815PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q80Y81

PRoteomics IDEntifications database

More...
PRIDEi
Q80Y81

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
300462 [Q80Y81-1]
300463 [Q80Y81-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q80Y81

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q80Y81

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000020549, Expressed in ear and 294 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q80Y81, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q80Y81, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with PTCD1.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
212960, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q80Y81, 1 interactor

Molecular INTeraction database

More...
MINTi
Q80Y81

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000071788

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q80Y81, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni15 – 47DisorderedSequence analysisAdd BLAST33
Regioni179 – 227DisorderedSequence analysisAdd BLAST49
Regioni791 – 831DisorderedSequence analysisAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi25 – 40Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi183 – 219Polar residuesSequence analysisAdd BLAST37
Compositional biasi799 – 818Basic and acidic residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RNase Z family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2121, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111191

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q80Y81

Identification of Orthologs from Complete Genome Data

More...
OMAi
CFEDSIL

Database of Orthologous Groups

More...
OrthoDBi
454909at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q80Y81

TreeFam database of animal gene trees

More...
TreeFami
TF105797

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.60.15.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001279, Metallo-B-lactamas
IPR036866, RibonucZ/Hydroxyglut_hydro
IPR027794, tRNase_Z_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12706, Lactamase_B_2, 1 hit
PF13691, Lactamase_B_4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56281, SSF56281, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q80Y81-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWALRSLLRP LGLRTMSQGS ARRPRPSKDP LRHLRTREKR GPGPGGPNTV
60 70 80 90 100
YLQVVAAGGR DAGAALYVFS EYNRYLFNCG EGVQRLMQEH KLKVARLDNI
110 120 130 140 150
FLTRMHWSNV GGLCGMILTL KETGLPKCVL SGPPQLEKYL EAIKIFSGPL
160 170 180 190 200
KGIELAVRPH SAPEYKDETM TVYQVPIHSE RRCGKQQPSQ SPRTSPNRLS
210 220 230 240 250
PKQSSDSGSA ENGQCPPEDS SAGANRKAWG RDPSLVVAFV CKLHLRKGNF
260 270 280 290 300
LVLKAKELGL PVGTAAIAPI IAAVKDGKSI TYEGREIAAE ELCTPPDPGL
310 320 330 340 350
VFIVVECPDE GFILPICEND TFKRYQAEAD APVALVVHIA PESVLIDSRY
360 370 380 390 400
QQWMERFGPD TQHLILNENC PSVHNLRSHK IQTQLSLIHP DIFPQLTSFY
410 420 430 440 450
SKEEGSTLSV PTVRGECLLK YQLRPKREWQ RDTTLDCNTD EFIAEALELP
460 470 480 490 500
SFQESVEEYR KNVQENPAPA EKRSQYPEIV FLGTGSAIPM KIRNVSSTLV
510 520 530 540 550
NLSPDKSVLL DCGEGTFGQL CRHYGQQIDR VLCSLTAVFV SHLHADHHTG
560 570 580 590 600
LLNILLQREH ALASLGKPFQ PLLVVAPTQL RAWLQQYHNH CQEILHHVSM
610 620 630 640 650
IPAKCLQKGA EVSNTTLERL ISLLLETCDL EEFQTCLVRH CKHAFGCALV
660 670 680 690 700
HSSGWKVVYS GDTMPCEALV QMGKDATLLI HEATLEDGLE EEAVEKTHST
710 720 730 740 750
TSQAINVGMR MNAEFIMLNH FSQRYAKIPL FSPDFNEKVG IAFDHMKVCF
760 770 780 790 800
GDFPTVPKLI PPLKALFAGD IEEMVERREK RELRLVRAAL LTQQADSPED
810 820 830
REPQQKRAHT DEPHSPQSKK ESVANTLGAR V
Length:831
Mass (Da):92,719
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i77E3876AE2862224
GO
Isoform 2 (identifier: Q80Y81-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     821-831: ESVANTLGARV → VRAQ

Show »
Length:824
Mass (Da):92,076
Checksum:iFF19EBED86228B8A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1ATP7B1ATP7_MOUSE
ElaC homolog protein 2
Elac2
823Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1ATP9B1ATP9_MOUSE
Zinc phosphodiesterase ELAC protein...
Elac2
207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti27S → P in AAK29420 (PubMed:11175785).Curated1
Sequence conflicti27S → P in AAK29421 (PubMed:11175785).Curated1
Sequence conflicti397T → S in BAB23185 (PubMed:16141072).Curated1
Sequence conflicti435L → P in AAG24918 (PubMed:11175785).Curated1
Sequence conflicti714E → G in AAG24918 (PubMed:11175785).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_009173821 – 831ESVANTLGARV → VRAQ in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF308696 mRNA Translation: AAG24918.2
AF348157 Genomic DNA Translation: AAK29420.1
AF348157 Genomic DNA Translation: AAK29421.1
AL663045 Genomic DNA No translation available.
BC048235 mRNA Translation: AAH48235.1
AK003759 mRNA Translation: BAB22981.2
AK004136 mRNA Translation: BAB23185.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS24841.1 [Q80Y81-1]
CCDS88171.1 [Q80Y81-2]

NCBI Reference Sequences

More...
RefSeqi
NP_075968.2, NM_023479.2 [Q80Y81-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000071891; ENSMUSP00000071788; ENSMUSG00000020549 [Q80Y81-1]
ENSMUST00000101049; ENSMUSP00000098610; ENSMUSG00000020549 [Q80Y81-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
68626

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:68626

UCSC genome browser

More...
UCSCi
uc007jks.2, mouse [Q80Y81-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF308696 mRNA Translation: AAG24918.2
AF348157 Genomic DNA Translation: AAK29420.1
AF348157 Genomic DNA Translation: AAK29421.1
AL663045 Genomic DNA No translation available.
BC048235 mRNA Translation: AAH48235.1
AK003759 mRNA Translation: BAB22981.2
AK004136 mRNA Translation: BAB23185.1
CCDSiCCDS24841.1 [Q80Y81-1]
CCDS88171.1 [Q80Y81-2]
RefSeqiNP_075968.2, NM_023479.2 [Q80Y81-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi212960, 11 interactors
IntActiQ80Y81, 1 interactor
MINTiQ80Y81
STRINGi10090.ENSMUSP00000071788

PTM databases

iPTMnetiQ80Y81
PhosphoSitePlusiQ80Y81

Proteomic databases

PaxDbiQ80Y81
PRIDEiQ80Y81
ProteomicsDBi300462 [Q80Y81-1]
300463 [Q80Y81-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
13065, 197 antibodies

The DNASU plasmid repository

More...
DNASUi
68626

Genome annotation databases

EnsembliENSMUST00000071891; ENSMUSP00000071788; ENSMUSG00000020549 [Q80Y81-1]
ENSMUST00000101049; ENSMUSP00000098610; ENSMUSG00000020549 [Q80Y81-2]
GeneIDi68626
KEGGimmu:68626
UCSCiuc007jks.2, mouse [Q80Y81-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
60528
MGIiMGI:1890496, Elac2

Phylogenomic databases

eggNOGiKOG2121, Eukaryota
GeneTreeiENSGT00730000111191
InParanoidiQ80Y81
OMAiCFEDSIL
OrthoDBi454909at2759
PhylomeDBiQ80Y81
TreeFamiTF105797

Enzyme and pathway databases

BRENDAi3.1.26.11, 3474

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
68626, 23 hits in 53 CRISPR screens

Protein Ontology

More...
PROi
PR:Q80Y81
RNActiQ80Y81, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000020549, Expressed in ear and 294 other tissues
ExpressionAtlasiQ80Y81, baseline and differential
GenevisibleiQ80Y81, MM

Family and domain databases

Gene3Di3.60.15.10, 1 hit
InterProiView protein in InterPro
IPR001279, Metallo-B-lactamas
IPR036866, RibonucZ/Hydroxyglut_hydro
IPR027794, tRNase_Z_dom
PfamiView protein in Pfam
PF12706, Lactamase_B_2, 1 hit
PF13691, Lactamase_B_4, 1 hit
SUPFAMiSSF56281, SSF56281, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRNZ2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80Y81
Secondary accession number(s): B1ATP6
, Q99MF0, Q99MF1, Q9CTA2, Q9D1A8, Q9EPZ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2003
Last modified: June 2, 2021
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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