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Protein

Cystatin-like 1

Gene

Cstl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-like 1Imported
Gene namesi
Name:Cstl1Imported
Synonyms:Rcet11 Publication
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2652834 Cstl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500936904724 – 140Cystatin-like 1Add BLAST117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi94 ↔ 104By similarity
Disulfide bondi117 ↔ 137By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ80Y72
PRIDEiQ80Y72

PTM databases

iPTMnetiQ80Y72
PhosphoSitePlusiQ80Y72

Expressioni

Tissue specificityi

Highly expressed in testis where it localizes to spermatogonium, spermatocyes and round spermatids. Not detected in spermatozoa. Also detected in epididymis, cerebrum and pituitary.1 Publication

Developmental stagei

In testis, expression levels increase from postnatal week 4 onwards with peak levels at postnatal week 8. Expression remains high thereafter.1 Publication

Gene expression databases

BgeeiENSMUSG00000055177 Expressed in 16 organ(s), highest expression level in testis

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105578

Structurei

3D structure databases

ProteinModelPortaliQ80Y72
SMRiQ80Y72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 126CystatinSequence analysisAdd BLAST95

Sequence similaritiesi

Belongs to the cystatin family.UniRule annotationCurated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX7C Eukaryota
ENOG41119TA LUCA
GeneTreeiENSGT00900000141212
HOGENOMiHOG000231754
HOVERGENiHBG096719
InParanoidiQ80Y72
OMAiQLWNNSC
OrthoDBiEOG091G0TP1
PhylomeDBiQ80Y72

Family and domain databases

CDDicd00042 CY, 1 hit
InterProiView protein in InterPro
IPR027214 Cystatin
IPR000010 Cystatin_dom
PANTHERiPTHR11413 PTHR11413, 1 hit
PfamiView protein in Pfam
PF00031 Cystatin, 1 hit
SMARTiView protein in SMART
SM00043 CY, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 21 Publication (identifier: Q80Y72-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEMKARGLRI PLLLLLVTVV VMAKVNHIQR WGGFKEKAMS KKNINSTLHF
60 70 80 90 100
FIRSYNNASN DTYLYQVQKL IQGQMQLTTG VEYLVTVKIG RTKCKKNETK
110 120 130 140
KASCPLQSSK LKKSLICKSL IYSVPWMNYY QLWNNSCQES
Length:140
Mass (Da):16,199
Last modified:June 1, 2003 - v1
Checksum:i32633E99C4697DA0
GO
Isoform 11 Publication (identifier: Q80Y72-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-77: Missing.

Show »
Length:88
Mass (Da):10,026
Checksum:i8179EBF72976DEF1
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2Q2AAE3A0A2Q2AAE3_MOUSE
Cystatin
Cstl1
88Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25V → L in AAU20812 (PubMed:18300157).Curated1
Sequence conflicti77L → M in BAE20810 (PubMed:16141072).Curated1
Sequence conflicti85V → A in BAE20810 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05894726 – 77Missing in isoform 1. Add BLAST52

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY706755 mRNA Translation: AAU20811.1
AY706756 mRNA Translation: AAU20812.1
AY707915 mRNA Translation: AAU20814.1
AK131797 mRNA Translation: BAE20810.1
AK132807 mRNA Translation: BAE21368.1
AL844519 Genomic DNA No translation available.
CH466519 Genomic DNA Translation: EDL28541.1
BC048646 mRNA Translation: AAH48646.1
CCDSiCCDS16844.1 [Q80Y72-1]
RefSeqiNP_808323.1, NM_177655.3 [Q80Y72-1]
XP_006499365.1, XM_006499302.1 [Q80Y72-1]
XP_006499366.1, XM_006499303.3 [Q80Y72-1]
UniGeneiMm.189390

Genome annotation databases

EnsembliENSMUST00000109952; ENSMUSP00000105578; ENSMUSG00000055177 [Q80Y72-1]
ENSMUST00000109955; ENSMUSP00000105581; ENSMUSG00000055177 [Q80Y72-1]
GeneIDi228756
KEGGimmu:228756
UCSCiuc008mtj.1 mouse [Q80Y72-1]
uc008mtk.1 mouse

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY706755 mRNA Translation: AAU20811.1
AY706756 mRNA Translation: AAU20812.1
AY707915 mRNA Translation: AAU20814.1
AK131797 mRNA Translation: BAE20810.1
AK132807 mRNA Translation: BAE21368.1
AL844519 Genomic DNA No translation available.
CH466519 Genomic DNA Translation: EDL28541.1
BC048646 mRNA Translation: AAH48646.1
CCDSiCCDS16844.1 [Q80Y72-1]
RefSeqiNP_808323.1, NM_177655.3 [Q80Y72-1]
XP_006499365.1, XM_006499302.1 [Q80Y72-1]
XP_006499366.1, XM_006499303.3 [Q80Y72-1]
UniGeneiMm.189390

3D structure databases

ProteinModelPortaliQ80Y72
SMRiQ80Y72
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105578

PTM databases

iPTMnetiQ80Y72
PhosphoSitePlusiQ80Y72

Proteomic databases

PaxDbiQ80Y72
PRIDEiQ80Y72

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109952; ENSMUSP00000105578; ENSMUSG00000055177 [Q80Y72-1]
ENSMUST00000109955; ENSMUSP00000105581; ENSMUSG00000055177 [Q80Y72-1]
GeneIDi228756
KEGGimmu:228756
UCSCiuc008mtj.1 mouse [Q80Y72-1]
uc008mtk.1 mouse

Organism-specific databases

CTDi128817
MGIiMGI:2652834 Cstl1

Phylogenomic databases

eggNOGiENOG410IX7C Eukaryota
ENOG41119TA LUCA
GeneTreeiENSGT00900000141212
HOGENOMiHOG000231754
HOVERGENiHBG096719
InParanoidiQ80Y72
OMAiQLWNNSC
OrthoDBiEOG091G0TP1
PhylomeDBiQ80Y72

Miscellaneous databases

PROiPR:Q80Y72
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055177 Expressed in 16 organ(s), highest expression level in testis

Family and domain databases

CDDicd00042 CY, 1 hit
InterProiView protein in InterPro
IPR027214 Cystatin
IPR000010 Cystatin_dom
PANTHERiPTHR11413 PTHR11413, 1 hit
PfamiView protein in Pfam
PF00031 Cystatin, 1 hit
SMARTiView protein in SMART
SM00043 CY, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCSTL1_MOUSE
AccessioniPrimary (citable) accession number: Q80Y72
Secondary accession number(s): Q3V2I7, Q64FK4, Q64FK5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2017
Last sequence update: June 1, 2003
Last modified: October 10, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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