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Protein

Rabenosyn-5

Gene

Rbsn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3). Plays a role in the recycling of transferrin receptor to the plasma membrane (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri14 – 37C2H2-typeAdd BLAST24
Zinc fingeri156 – 259FYVE-typePROSITE-ProRule annotationAdd BLAST104

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • nucleic acid binding Source: InterPro
  • Rab GTPase binding Source: MGI

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-168138 Toll Like Receptor 9 (TLR9) Cascade
R-MMU-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Rabenosyn-5By similarity
Alternative name(s):
FYVE finger-containing Rab5 effector protein rabenosyn-5
RAB effector RBSNBy similarity
Zinc finger FYVE domain-containing protein 20
Gene namesi
Name:RbsnBy similarity
Synonyms:Zfyve20Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1925537 Rbsn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000987122 – 783Rabenosyn-5Add BLAST782

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei3PhosphoserineBy similarity1
Modified residuei214PhosphoserineCombined sources1
Modified residuei218PhosphoserineBy similarity1
Modified residuei225PhosphoserineBy similarity1
Modified residuei229PhosphoserineCombined sources1
Modified residuei686PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Phosphoprotein

Proteomic databases

EPDiQ80Y56
MaxQBiQ80Y56
PaxDbiQ80Y56
PeptideAtlasiQ80Y56
PRIDEiQ80Y56

PTM databases

iPTMnetiQ80Y56
PhosphoSitePlusiQ80Y56

Expressioni

Gene expression databases

BgeeiENSMUSG00000014550 Expressed in 244 organ(s), highest expression level in ear vesicle
CleanExiMM_ZFYVE20
ExpressionAtlasiQ80Y56 baseline and differential
GenevisibleiQ80Y56 MM

Interactioni

Subunit structurei

Interacts with EHD1, RAB4A, RAB5A, RAB22A, RAB24 and VPS45. Binds simultaneously to RAB4A and RAB5A in vitro. Interacts with RAB4A and RAB5A that has been activated by GTP binding (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000014694

Structurei

3D structure databases

ProteinModelPortaliQ80Y56
SMRiQ80Y56
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini495 – 514UIMCuratedAdd BLAST20

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni99 – 262Necessary for the correct targeting to endosomesBy similarityAdd BLAST164
Regioni263 – 783Necessary for interaction with EHD1By similarityAdd BLAST521
Regioni263 – 499Necessary for interaction with RAB4ABy similarityAdd BLAST237
Regioni627 – 783Necessary for interaction with RAB5ABy similarityAdd BLAST157

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili377 – 412Sequence analysisAdd BLAST36
Coiled coili471 – 531Sequence analysisAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi203 – 238Ser-richAdd BLAST36
Compositional biasi668 – 671Poly-Glu4
Compositional biasi680 – 718Pro-richAdd BLAST39

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri14 – 37C2H2-typeAdd BLAST24
Zinc fingeri156 – 259FYVE-typePROSITE-ProRule annotationAdd BLAST104

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG1842 Eukaryota
ENOG410XP0U LUCA
GeneTreeiENSGT00390000007159
HOGENOMiHOG000154082
HOVERGENiHBG067237
InParanoidiQ80Y56
KOiK12481
OMAiYSLEHAN
OrthoDBiEOG091G06L4
PhylomeDBiQ80Y56
TreeFamiTF106125

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR036531 Rbsn_Rab-bd_sf
IPR021565 Rbsn_Rab_binding_dom
IPR013087 Znf_C2H2_type
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
PF11464 Rbsn, 2 hits
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SUPFAMiSSF140125 SSF140125, 2 hits
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50178 ZF_FYVE, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q80Y56-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASLDDPGEV REGFLCPLCL KDLQSFYQLQ SHYEEEHLED RDVKGQIKNL
60 70 80 90 100
VQKARKAKNK LLKREGDDRV EPGTQGYESF SYGGVDPYMW EPQELGAMRS
110 120 130 140 150
HLSDFKKHRA ARIDHYVVEV NKLIIRLEKL TAFDRTNTET SKIRAIEKSV
160 170 180 190 200
VPWVNDQDVP FCPDCGNKFS IRNRRHHCRL CGSIMCKKCM ELIGLPLAHK
210 220 230 240 250
LTSASKDSLS THTSPSQSPN SVHGSRRGSI SSMSSVSSVL DEKDDDRIRC
260 270 280 290 300
CTHCKDKLLK REQQMDEKEH TPDIVKLYEK LRLCMEKVDQ KAPEYIRMAA
310 320 330 340 350
SLNAGETTYN LEHANDLRVE VQKVYELIDA LSKKILTLGL NQDPSPHPNT
360 370 380 390 400
LRLQRMIRYS ATLFVQEKLL GLMSLPTKEQ FEELKKKRKQ DLEQKRTVER
410 420 430 440 450
QAALESRRKL EERQSGLASH TANGDVRSLR GIPPPLRKAE GWLPLSEGQG
460 470 480 490 500
QSEDPDPLLQ QIYNITSFIR QAKAAGRTDE VRTLQENLRQ LQDEYDQQQT
510 520 530 540 550
EKAIELSRKQ AEEEELQREQ LQMLRKRELE REQEQFLAAS LQTRTRVLEL
560 570 580 590 600
REVIPFQLEA SRGPHIDLSY SLDQDSSPVQ SSTAPDILTP GSALAPMHLW
610 620 630 640 650
SGPPALGQET LPQSTMSQQS DKASLNPFDE DDLSSPTEGA ISPAAVEAFL
660 670 680 690 700
GPPAAVTKEY NPFEEDAEEE EVAELGAGNP FTDPDSPAPN PFDEDDGPRP
710 720 730 740 750
ASPAAPGNPF EECPSTNPFE VDSDSGMEAE EHIEEELLLQ QIDNIKAYIF
760 770 780
DAKQCGRMDE VEVLTENLRE LKCTLAKQKG APN
Length:783
Mass (Da):88,491
Last modified:June 1, 2003 - v1
Checksum:i80103992F296CCD6
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0N4SUN4A0A0N4SUN4_MOUSE
Rabenosyn-5
Rbsn
142Annotation score:
D3Z0E7D3Z0E7_MOUSE
Rabenosyn-5
Rbsn
45Annotation score:
A0A0N4SV43A0A0N4SV43_MOUSE
Rabenosyn-5
Rbsn
20Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti227R → Q in AAH31135 (PubMed:15489334).Curated1
Sequence conflicti698P → S in AAH31135 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031135 mRNA Translation: AAH31135.1
BC049106 mRNA Translation: AAH49106.1
AK019909 mRNA Translation: BAB31910.1
CCDSiCCDS20374.1
RefSeqiNP_084357.2, NM_030081.2
XP_006506831.1, XM_006506768.3
UniGeneiMm.290734

Genome annotation databases

EnsembliENSMUST00000014694; ENSMUSP00000014694; ENSMUSG00000014550
GeneIDi78287
KEGGimmu:78287
UCSCiuc009cyv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031135 mRNA Translation: AAH31135.1
BC049106 mRNA Translation: AAH49106.1
AK019909 mRNA Translation: BAB31910.1
CCDSiCCDS20374.1
RefSeqiNP_084357.2, NM_030081.2
XP_006506831.1, XM_006506768.3
UniGeneiMm.290734

3D structure databases

ProteinModelPortaliQ80Y56
SMRiQ80Y56
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000014694

PTM databases

iPTMnetiQ80Y56
PhosphoSitePlusiQ80Y56

Proteomic databases

EPDiQ80Y56
MaxQBiQ80Y56
PaxDbiQ80Y56
PeptideAtlasiQ80Y56
PRIDEiQ80Y56

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000014694; ENSMUSP00000014694; ENSMUSG00000014550
GeneIDi78287
KEGGimmu:78287
UCSCiuc009cyv.1 mouse

Organism-specific databases

CTDi64145
MGIiMGI:1925537 Rbsn

Phylogenomic databases

eggNOGiKOG1842 Eukaryota
ENOG410XP0U LUCA
GeneTreeiENSGT00390000007159
HOGENOMiHOG000154082
HOVERGENiHBG067237
InParanoidiQ80Y56
KOiK12481
OMAiYSLEHAN
OrthoDBiEOG091G06L4
PhylomeDBiQ80Y56
TreeFamiTF106125

Enzyme and pathway databases

ReactomeiR-MMU-168138 Toll Like Receptor 9 (TLR9) Cascade
R-MMU-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

PROiPR:Q80Y56
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000014550 Expressed in 244 organ(s), highest expression level in ear vesicle
CleanExiMM_ZFYVE20
ExpressionAtlasiQ80Y56 baseline and differential
GenevisibleiQ80Y56 MM

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR036531 Rbsn_Rab-bd_sf
IPR021565 Rbsn_Rab_binding_dom
IPR013087 Znf_C2H2_type
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
PF11464 Rbsn, 2 hits
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SUPFAMiSSF140125 SSF140125, 2 hits
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50178 ZF_FYVE, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRBNS5_MOUSE
AccessioniPrimary (citable) accession number: Q80Y56
Secondary accession number(s): Q8K0L6, Q9CTW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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