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Protein

Glutaredoxin-related protein 5, mitochondrial

Gene

Glrx5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (By similarity). Involved in protein lipoylation, acting in the pathway that provides an iron-sulfur cluster to lipoate synthase (By similarity). Required for normal iron homeostasis (By similarity). Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 (By similarity). May protect cells against apoptosis due to reactive oxygen species and oxidative stress (PubMed:19442627).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei55GlutathioneBy similarity1
Metal bindingi63Iron-sulfur (2Fe-2S); shared with dimeric partnerBy similarity1
Binding sitei105Glutathione; via amide nitrogen and carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Ligand2Fe-2S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-1362409 Mitochondrial iron-sulfur cluster biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaredoxin-related protein 5, mitochondrial
Alternative name(s):
Monothiol glutaredoxin-5
Gene namesi
Name:Glrx5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1920296 Glrx5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 31MitochondrionSequence analysisAdd BLAST31
ChainiPRO_000014165132 – 152Glutaredoxin-related protein 5, mitochondrialAdd BLAST121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei55N6-succinyllysineCombined sources1
Modified residuei151PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ80Y14
MaxQBiQ80Y14
PaxDbiQ80Y14
PeptideAtlasiQ80Y14
PRIDEiQ80Y14

PTM databases

iPTMnetiQ80Y14
PhosphoSitePlusiQ80Y14
SwissPalmiQ80Y14

Expressioni

Tissue specificityi

Detected in bone, liver, muscle and kidney.1 Publication

Developmental stagei

Ubiquitously expressed at 7.5 dpc. At 8.5 dpc, preferential expression in yolk sac blood islands. Progressive down-regulation in maturing primitive red cells between 10.5 and 12.5 dpc. High expression in fetal liver at 12.5 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000021102 Expressed in 235 organ(s), highest expression level in blood
CleanExiMM_GLRX5
ExpressionAtlasiQ80Y14 baseline and differential
GenevisibleiQ80Y14 MM

Interactioni

Subunit structurei

Homodimer. Interacts with ISCU. Interacts with BOLA1.By similarity

Protein-protein interaction databases

BioGridi215731, 1 interactor
IntActiQ80Y14, 4 interactors
STRINGi10090.ENSMUSP00000021522

Structurei

3D structure databases

ProteinModelPortaliQ80Y14
SMRiQ80Y14
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 141GlutaredoxinPROSITE-ProRule annotationAdd BLAST104

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni93 – 97Glutathione bindingBy similarity5
Regioni118 – 119Glutathione bindingBy similarity2

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi8 – 11Poly-Ala4
Compositional biasi20 – 23Poly-Gly4

Sequence similaritiesi

Keywords - Domaini

Redox-active center, Transit peptide

Phylogenomic databases

eggNOGiKOG0911 Eukaryota
COG0278 LUCA
GeneTreeiENSGT00550000075082
HOGENOMiHOG000095211
InParanoidiQ80Y14
KOiK07390
OMAiVDKATMD
OrthoDBiEOG091G0YN0
PhylomeDBiQ80Y14
TreeFamiTF318988

Family and domain databases

CDDicd03028 GRX_PICOT_like, 1 hit
InterProiView protein in InterPro
IPR002109 Glutaredoxin
IPR033658 GRX_PICOT-like
IPR014434 Monothiol_GRX
IPR004480 Monothiol_GRX-rel
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR10293 PTHR10293, 1 hit
PfamiView protein in Pfam
PF00462 Glutaredoxin, 1 hit
PIRSFiPIRSF005894 Monothiol_GRX, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR00365 TIGR00365, 1 hit
PROSITEiView protein in PROSITE
PS51354 GLUTAREDOXIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q80Y14-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSASLSRAAA ALLRWGRSAG GGGLPGAGVR AASSGGQAEQ LDALVKKDKV
60 70 80 90 100
VVFLKGTPEQ PQCGFSNAVV QILRLHGVRD YAAYNVLDDP ELRQGIKDYS
110 120 130 140 150
NWPTIPQVYL NGEFVGGCDI LLQMHQNGDL VEELKKLGIR SALVDEKDQD

SK
Length:152
Mass (Da):16,292
Last modified:February 1, 2005 - v2
Checksum:i76EBEAA30F482825
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VN70A0A1Y7VN70_MOUSE
Glutaredoxin-related protein 5, mit...
Glrx5
118Annotation score:

Sequence cautioni

The sequence AAH50937 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ083330 mRNA Translation: AAZ30730.1
AK013761 mRNA Translation: BAB28985.1
AK050883 mRNA Translation: BAC34443.1
BC050937 mRNA Translation: AAH50937.1 Different initiation.
BC058371 mRNA Translation: AAH58371.1
CCDSiCCDS26154.1
RefSeqiNP_082695.1, NM_028419.3
UniGeneiMm.29128
Mm.490286

Genome annotation databases

EnsembliENSMUST00000021522; ENSMUSP00000021522; ENSMUSG00000021102
GeneIDi73046
KEGGimmu:73046
UCSCiuc007oxu.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ083330 mRNA Translation: AAZ30730.1
AK013761 mRNA Translation: BAB28985.1
AK050883 mRNA Translation: BAC34443.1
BC050937 mRNA Translation: AAH50937.1 Different initiation.
BC058371 mRNA Translation: AAH58371.1
CCDSiCCDS26154.1
RefSeqiNP_082695.1, NM_028419.3
UniGeneiMm.29128
Mm.490286

3D structure databases

ProteinModelPortaliQ80Y14
SMRiQ80Y14
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215731, 1 interactor
IntActiQ80Y14, 4 interactors
STRINGi10090.ENSMUSP00000021522

PTM databases

iPTMnetiQ80Y14
PhosphoSitePlusiQ80Y14
SwissPalmiQ80Y14

Proteomic databases

EPDiQ80Y14
MaxQBiQ80Y14
PaxDbiQ80Y14
PeptideAtlasiQ80Y14
PRIDEiQ80Y14

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021522; ENSMUSP00000021522; ENSMUSG00000021102
GeneIDi73046
KEGGimmu:73046
UCSCiuc007oxu.1 mouse

Organism-specific databases

CTDi51218
MGIiMGI:1920296 Glrx5

Phylogenomic databases

eggNOGiKOG0911 Eukaryota
COG0278 LUCA
GeneTreeiENSGT00550000075082
HOGENOMiHOG000095211
InParanoidiQ80Y14
KOiK07390
OMAiVDKATMD
OrthoDBiEOG091G0YN0
PhylomeDBiQ80Y14
TreeFamiTF318988

Enzyme and pathway databases

ReactomeiR-MMU-1362409 Mitochondrial iron-sulfur cluster biogenesis

Miscellaneous databases

ChiTaRSiGlrx5 mouse
PROiPR:Q80Y14
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021102 Expressed in 235 organ(s), highest expression level in blood
CleanExiMM_GLRX5
ExpressionAtlasiQ80Y14 baseline and differential
GenevisibleiQ80Y14 MM

Family and domain databases

CDDicd03028 GRX_PICOT_like, 1 hit
InterProiView protein in InterPro
IPR002109 Glutaredoxin
IPR033658 GRX_PICOT-like
IPR014434 Monothiol_GRX
IPR004480 Monothiol_GRX-rel
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR10293 PTHR10293, 1 hit
PfamiView protein in Pfam
PF00462 Glutaredoxin, 1 hit
PIRSFiPIRSF005894 Monothiol_GRX, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR00365 TIGR00365, 1 hit
PROSITEiView protein in PROSITE
PS51354 GLUTAREDOXIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGLRX5_MOUSE
AccessioniPrimary (citable) accession number: Q80Y14
Secondary accession number(s): Q3YML1, Q9D6E9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: November 7, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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