Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Myelin-associated neurite-outgrowth inhibitor

Gene

Fam168b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin-associated neurite-outgrowth inhibitor
Short name:
Mani
Gene namesi
Name:Fam168b
Synonyms:Kiaa4042
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2448487 Fam168b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18CytoplasmicSequence analysisAdd BLAST18
Transmembranei19 – 41HelicalSequence analysisAdd BLAST23
Topological domaini42 – 141ExtracellularSequence analysisAdd BLAST100
Transmembranei142 – 163HelicalSequence analysisAdd BLAST22
Topological domaini164 – 194CytoplasmicSequence analysisAdd BLAST31

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003259791 – 194Myelin-associated neurite-outgrowth inhibitorAdd BLAST194

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei6PhosphoserineBy similarity1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ80XQ8
PRIDEiQ80XQ8

PTM databases

iPTMnetiQ80XQ8
PhosphoSitePlusiQ80XQ8

Expressioni

Tissue specificityi

Predominantly expressed in the brain, including olfactory bulb, cortex and cerebellum (at protein level).1 Publication

Developmental stagei

Specifically expressed in differentiated neurons, but absent from proliferating neural stem cells.1 Publication

Inductioni

Up-regulated by different neurotrophins, including NGF and BDNF, but not by growth factors, such as EGF.1 Publication

Gene expression databases

BgeeiENSMUSG00000037503
ExpressionAtlasiQ80XQ8 baseline and differential
GenevisibleiQ80XQ8 MM

Interactioni

Subunit structurei

May form homodimers (By similarity). May interact with DAZAP2, FAM168A, PRDX6, RBM6, TMTC1 and YPEL2 (By similarity). Interacts with CDC27.By similarity1 Publication

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM168 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000005140
HOGENOMiHOG000073527
HOVERGENiHBG052179
InParanoidiQ80XQ8
PhylomeDBiQ80XQ8
TreeFamiTF331128

Family and domain databases

InterProiView protein in InterPro
IPR029247 FAM168A/MANI
PANTHERiPTHR31844 PTHR31844, 1 hit
PfamiView protein in Pfam
PF14944 TCRP1, 2 hits

Sequencei

Sequence statusi: Complete.

Q80XQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPVYSPGSS GVPYANAKGI GYPAGFPVGY AAAPAYSPNM YPGANPTFQT
60 70 80 90 100
GYTPGTPYKV SCSPTSGAVP PYSSSPNPYQ TAVYPVRSAY PQQSPYAQQG
110 120 130 140 150
TYYTQPLYAA PPHVIHHTTV VQPNGMPATV YPAPIPPPRG SGVTMGMVAG
160 170 180 190
TTMAMSAGTL LTAHSPTPVA PHPVTVPTYR APGTPTYSYV PPQW
Length:194
Mass (Da):20,194
Last modified:June 1, 2003 - v1
Checksum:iB59FCF5407B00518
GO

Sequence cautioni

The sequence BAD90278 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49Q → L in BAE25820 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220453 mRNA Translation: BAD90278.1 Different initiation.
AK144298 mRNA Translation: BAE25820.1
BC040511 mRNA Translation: AAH40511.1
BC043098 mRNA Translation: AAH43098.1
BC059247 mRNA Translation: AAH59247.1
CCDSiCCDS14873.1
RefSeqiNP_001153707.1, NM_001160235.1
NP_001153708.1, NM_001160236.1
NP_778162.1, NM_174997.2
UniGeneiMm.120151

Genome annotation databases

EnsembliENSMUST00000047534; ENSMUSP00000042212; ENSMUSG00000037503
GeneIDi214469
KEGGimmu:214469
UCSCiuc007apj.2 mouse

Similar proteinsi

Entry informationi

Entry nameiF168B_MOUSE
AccessioniPrimary (citable) accession number: Q80XQ8
Secondary accession number(s): Q3UNC7, Q5DTR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2003
Last modified: February 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health