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Protein

Protein FAM76B

Gene

Fam76b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM76B
Gene namesi
Name:Fam76b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1920076 Fam76b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002457642 – 339Protein FAM76BAdd BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei22PhosphoserineBy similarity1
Modified residuei148PhosphoserineBy similarity1
Modified residuei193PhosphoserineCombined sources1
Modified residuei215PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ80XP8
PaxDbiQ80XP8
PeptideAtlasiQ80XP8
PRIDEiQ80XP8

PTM databases

iPTMnetiQ80XP8
PhosphoSitePlusiQ80XP8

Expressioni

Gene expression databases

BgeeiENSMUSG00000037808 Expressed in 284 organ(s), highest expression level in paneth cell
CleanExiMM_2810485I05RIK
ExpressionAtlasiQ80XP8 baseline and differential
GenevisibleiQ80XP8 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062642

Structurei

3D structure databases

ProteinModelPortaliQ80XP8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili248 – 328Sequence analysisAdd BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi151 – 160Poly-Ser10
Compositional biasi167 – 187His-richAdd BLAST21
Compositional biasi171 – 180Poly-His10

Domaini

The polyhistidine repeat acts as a targeting signal to nuclear speckles.By similarity

Sequence similaritiesi

Belongs to the FAM76 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3990 Eukaryota
ENOG410YE53 LUCA
GeneTreeiENSGT00390000014462
HOGENOMiHOG000231316
HOVERGENiHBG080224
InParanoidiQ80XP8
OMAiKYGPPVQ
OrthoDBiEOG091G0LJR
PhylomeDBiQ80XP8
TreeFamiTF313644

Family and domain databases

InterProiView protein in InterPro
IPR032017 FAM76
IPR029661 FAM76B
PANTHERiPTHR12606:SF24 PTHR12606:SF24, 1 hit
PfamiView protein in Pfam
PF16046 FAM76, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q80XP8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAASALYACT KCTQRYPFEE LSQGQQLCKE CRIAHPIVKC TYCRSEFQQE
60 70 80 90 100
SKTNTICKKC AQNVKQFGTP KPCQYCNIIA AFIGTKCQRC TNSEKKYGAP
110 120 130 140 150
QTCEQCKQQC AFDRKEEGRR KVDGKLLCWL CTLSYKRVLQ KTKEQRKSLG
160 170 180 190 200
SSHSNSSSSS LTEKDQHHSK HHHHHHHHHH RHSSGHHKVS SLSPEQEQGL
210 220 230 240 250
WKQSHKSSAA IQNETPKKKP KLESKPSNGD SSSINQSADS GGTDNFVLIS
260 270 280 290 300
QLKEEVMSLK RLLQQRDQTI LEKDKKLTEL KADFQYQESN LRTKMNSMEK
310 320 330
AHKETVEQLQ AKNRELLKQV AALSKGKKFD KSGSVLTSP
Length:339
Mass (Da):38,556
Last modified:June 1, 2003 - v1
Checksum:i9A64D910ECC71178
GO
Isoform 2 (identifier: Q80XP8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-208: Missing.
     209-230: AAIQNETPKKKPKLESKPSNGD → MQFEHLQIFLLLYVIPFYFFLF
     311-319: AKNRELLKQ → VNGVIYVRC
     320-339: Missing.

Note: No experimental confirmation available.
Show »
Length:111
Mass (Da):13,087
Checksum:iE2399A1A537E3669
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SQS5A0A1L1SQS5_MOUSE
Protein FAM76B
Fam76b
74Annotation score:
D6RG49D6RG49_MOUSE
Protein FAM76B
Fam76b 2810485I05Rik, mCG_113475
233Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti180H → HH in BAE26192 (PubMed:16141072).Curated1
Sequence conflicti233Missing in AAH50870 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0197741 – 208Missing in isoform 2. 1 PublicationAdd BLAST208
Alternative sequenceiVSP_019775209 – 230AAIQN…PSNGD → MQFEHLQIFLLLYVIPFYFF LF in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_019776311 – 319AKNRELLKQ → VNGVIYVRC in isoform 2. 1 Publication9
Alternative sequenceiVSP_019777320 – 339Missing in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK145026 mRNA Translation: BAE26192.1
BC036328 mRNA Translation: AAH36328.1
BC043120 mRNA Translation: AAH43120.1
BC050870 mRNA Translation: AAH50870.1
CCDSiCCDS22819.1 [Q80XP8-1]
RefSeqiNP_789806.1, NM_176836.3 [Q80XP8-1]
XP_006510693.1, XM_006510630.3
UniGeneiMm.246174

Genome annotation databases

EnsembliENSMUST00000059579; ENSMUSP00000062642; ENSMUSG00000037808 [Q80XP8-1]
GeneIDi72826
KEGGimmu:72826
UCSCiuc009oef.1 mouse [Q80XP8-1]
uc009oeh.1 mouse [Q80XP8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK145026 mRNA Translation: BAE26192.1
BC036328 mRNA Translation: AAH36328.1
BC043120 mRNA Translation: AAH43120.1
BC050870 mRNA Translation: AAH50870.1
CCDSiCCDS22819.1 [Q80XP8-1]
RefSeqiNP_789806.1, NM_176836.3 [Q80XP8-1]
XP_006510693.1, XM_006510630.3
UniGeneiMm.246174

3D structure databases

ProteinModelPortaliQ80XP8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062642

PTM databases

iPTMnetiQ80XP8
PhosphoSitePlusiQ80XP8

Proteomic databases

EPDiQ80XP8
PaxDbiQ80XP8
PeptideAtlasiQ80XP8
PRIDEiQ80XP8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059579; ENSMUSP00000062642; ENSMUSG00000037808 [Q80XP8-1]
GeneIDi72826
KEGGimmu:72826
UCSCiuc009oef.1 mouse [Q80XP8-1]
uc009oeh.1 mouse [Q80XP8-2]

Organism-specific databases

CTDi143684
MGIiMGI:1920076 Fam76b

Phylogenomic databases

eggNOGiKOG3990 Eukaryota
ENOG410YE53 LUCA
GeneTreeiENSGT00390000014462
HOGENOMiHOG000231316
HOVERGENiHBG080224
InParanoidiQ80XP8
OMAiKYGPPVQ
OrthoDBiEOG091G0LJR
PhylomeDBiQ80XP8
TreeFamiTF313644

Miscellaneous databases

PROiPR:Q80XP8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037808 Expressed in 284 organ(s), highest expression level in paneth cell
CleanExiMM_2810485I05RIK
ExpressionAtlasiQ80XP8 baseline and differential
GenevisibleiQ80XP8 MM

Family and domain databases

InterProiView protein in InterPro
IPR032017 FAM76
IPR029661 FAM76B
PANTHERiPTHR12606:SF24 PTHR12606:SF24, 1 hit
PfamiView protein in Pfam
PF16046 FAM76, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFA76B_MOUSE
AccessioniPrimary (citable) accession number: Q80XP8
Secondary accession number(s): Q3UMA6, Q80YR1, Q8CI69
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: June 1, 2003
Last modified: September 12, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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