UniProtKB - Q80XN0 (BDH_MOUSE)
Protein
D-beta-hydroxybutyrate dehydrogenase, mitochondrial
Gene
Bdh1
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
- EC:1.1.1.30By similarity
Activity regulationi
Requires phosphatidylcholine as an allosteric activator for enzymatic activity.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 196 | SubstrateBy similarity | 1 | |
Active sitei | 209 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 60 – 84 | NADBy similarityAdd BLAST | 25 |
GO - Molecular functioni
- 3-hydroxybutyrate dehydrogenase activity Source: MGI
- phospholipid binding Source: MGI
Keywordsi
Molecular function | Allosteric enzyme, Oxidoreductase |
Ligand | NAD |
Enzyme and pathway databases
Reactomei | R-MMU-77108, Utilization of Ketone Bodies R-MMU-77111, Synthesis of Ketone Bodies |
Names & Taxonomyi
Protein namesi | Recommended name: D-beta-hydroxybutyrate dehydrogenase, mitochondrialCurated (EC:1.1.1.30By similarity)Alternative name(s): 3-hydroxybutyrate dehydrogenaseBy similarity Short name: BDHBy similarity |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1919161, Bdh1 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity
- Mitochondrion matrix By similarity
Mitochondrion
- matrix side of mitochondrial inner membrane Source: UniProtKB
- mitochondrial inner membrane Source: MGI
- mitochondrial matrix Source: UniProtKB-SubCell
- mitochondrion Source: MGI
Nucleus
- nucleoplasm Source: MGI
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 46 | MitochondrionBy similarityAdd BLAST | 46 | |
ChainiPRO_0000031961 | 47 – 343 | D-beta-hydroxybutyrate dehydrogenase, mitochondrialAdd BLAST | 297 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 73 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 97 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 103 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 103 | N6-succinyllysine; alternateCombined sources | 1 | |
Modified residuei | 132 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 177 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 212 | N6-acetyllysineCombined sources | 1 | |
Glycosylationi | 219 | O-linked (GlcNAc) serineBy similarity | 1 | |
Modified residuei | 246 | PhosphoserineBy similarity | 1 | |
Modified residuei | 258 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 259 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 259 | N6-succinyllysine; alternateCombined sources | 1 | |
Modified residuei | 280 | N6-acetyllysineCombined sources | 1 |
Post-translational modificationi
Acetylation of Lys-132 is observed in liver mitochondria from fasted mice but not from fed mice.
Keywords - PTMi
Acetylation, Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q80XN0 |
jPOSTi | Q80XN0 |
MaxQBi | Q80XN0 |
PaxDbi | Q80XN0 |
PeptideAtlasi | Q80XN0 |
PRIDEi | Q80XN0 |
PTM databases
GlyGeni | Q80XN0, 1 site |
iPTMneti | Q80XN0 |
PhosphoSitePlusi | Q80XN0 |
SwissPalmi | Q80XN0 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000046598, Expressed in liver and 315 other tissues |
ExpressionAtlasi | Q80XN0, baseline and differential |
Genevisiblei | Q80XN0, MM |
Interactioni
Subunit structurei
Homotetramer.
By similarityProtein-protein interaction databases
BioGRIDi | 215024, 6 interactors |
IntActi | Q80XN0, 6 interactors |
MINTi | Q80XN0 |
STRINGi | 10090.ENSMUSP00000110882 |
Miscellaneous databases
RNActi | Q80XN0, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG1610, Eukaryota |
GeneTreei | ENSGT00940000156929 |
HOGENOMi | CLU_010194_2_0_1 |
InParanoidi | Q80XN0 |
OrthoDBi | 1390068at2759 |
TreeFami | TF325617 |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR020904, Sc_DH/Rdtase_CS IPR002347, SDR_fam |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00061, ADH_SHORT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q80XN0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLAARLSRPL SQLPGKALSV RDRENGTRHT LLFYPASFSP DTRRTYASQA
60 70 80 90 100
DAASGKAILI TGCDSGFGFS LAKHLHSKGF LVFAGCLMKD KGDAGVKELD
110 120 130 140 150
SLKSDRLRTI QLNVCNSEEV EKAVETIRSG LKDPEKGMWG LVNNAGISTF
160 170 180 190 200
GEVEFTSMET YKEVAEVNLW GTVRTTKSFL PLLRRAKGRV VNISSMLGRM
210 220 230 240 250
ANPARSPYCI TKFGIEAFSD CLRYEMHPLG VKVSVVEPGN FIAATSLYSP
260 270 280 290 300
ERIQAIAKKM WDDLPEVVRK DYGRKYFDEK IAKMETYCNS GSTDTSSVIN
310 320 330 340
AVTHALTAAT PYTRYHPMDY YWWLRMQIMT HFPGAISDKI YIH
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3Z2Y8 | D3Z2Y8_MOUSE | D-beta-hydroxybutyrate dehydrogenas... | Bdh1 | 265 | Annotation score: | ||
A0A338P6R2 | A0A338P6R2_MOUSE | D-beta-hydroxybutyrate dehydrogenas... | Bdh1 | 37 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 152 | E → G in BAC36453 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 215 | I → V in BAC36453 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 215 | I → V in BAE23523 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 215 | I → V in BAE26605 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK076718 mRNA Translation: BAC36453.1 AK137955 mRNA Translation: BAE23523.1 AK145711 mRNA Translation: BAE26605.1 AK146321 mRNA Translation: BAE27076.1 BC027063 mRNA Translation: AAH27063.1 BC043683 mRNA Translation: AAH43683.1 BC096457 mRNA Translation: AAH96457.1 |
CCDSi | CCDS28106.1 |
RefSeqi | NP_001116155.1, NM_001122683.1 NP_780386.3, NM_175177.4 |
Genome annotation databases
Ensembli | ENSMUST00000089759; ENSMUSP00000087192; ENSMUSG00000046598 ENSMUST00000115226; ENSMUSP00000110881; ENSMUSG00000046598 ENSMUST00000115227; ENSMUSP00000110882; ENSMUSG00000046598 |
GeneIDi | 71911 |
KEGGi | mmu:71911 |
UCSCi | uc007yxi.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK076718 mRNA Translation: BAC36453.1 AK137955 mRNA Translation: BAE23523.1 AK145711 mRNA Translation: BAE26605.1 AK146321 mRNA Translation: BAE27076.1 BC027063 mRNA Translation: AAH27063.1 BC043683 mRNA Translation: AAH43683.1 BC096457 mRNA Translation: AAH96457.1 |
CCDSi | CCDS28106.1 |
RefSeqi | NP_001116155.1, NM_001122683.1 NP_780386.3, NM_175177.4 |
3D structure databases
SMRi | Q80XN0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 215024, 6 interactors |
IntActi | Q80XN0, 6 interactors |
MINTi | Q80XN0 |
STRINGi | 10090.ENSMUSP00000110882 |
PTM databases
GlyGeni | Q80XN0, 1 site |
iPTMneti | Q80XN0 |
PhosphoSitePlusi | Q80XN0 |
SwissPalmi | Q80XN0 |
Proteomic databases
EPDi | Q80XN0 |
jPOSTi | Q80XN0 |
MaxQBi | Q80XN0 |
PaxDbi | Q80XN0 |
PeptideAtlasi | Q80XN0 |
PRIDEi | Q80XN0 |
Protocols and materials databases
Antibodypediai | 33961, 228 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000089759; ENSMUSP00000087192; ENSMUSG00000046598 ENSMUST00000115226; ENSMUSP00000110881; ENSMUSG00000046598 ENSMUST00000115227; ENSMUSP00000110882; ENSMUSG00000046598 |
GeneIDi | 71911 |
KEGGi | mmu:71911 |
UCSCi | uc007yxi.2, mouse |
Organism-specific databases
CTDi | 622 |
MGIi | MGI:1919161, Bdh1 |
Phylogenomic databases
eggNOGi | KOG1610, Eukaryota |
GeneTreei | ENSGT00940000156929 |
HOGENOMi | CLU_010194_2_0_1 |
InParanoidi | Q80XN0 |
OrthoDBi | 1390068at2759 |
TreeFami | TF325617 |
Enzyme and pathway databases
Reactomei | R-MMU-77108, Utilization of Ketone Bodies R-MMU-77111, Synthesis of Ketone Bodies |
Miscellaneous databases
BioGRID-ORCSi | 71911, 2 hits in 17 CRISPR screens |
ChiTaRSi | Bdh1, mouse |
PROi | PR:Q80XN0 |
RNActi | Q80XN0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000046598, Expressed in liver and 315 other tissues |
ExpressionAtlasi | Q80XN0, baseline and differential |
Genevisiblei | Q80XN0, MM |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR020904, Sc_DH/Rdtase_CS IPR002347, SDR_fam |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00061, ADH_SHORT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BDH_MOUSE | |
Accessioni | Q80XN0Primary (citable) accession number: Q80XN0 Secondary accession number(s): Q3UJS9 Q8R0C8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 156 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families