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Entry version 126 (07 Apr 2021)
Sequence version 1 (01 Jun 2003)
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Protein

DNA polymerase epsilon catalytic subunit

Gene

Pole

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA polymerase II participates in chromosomal DNA replication.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

[4Fe-4S] clusterUniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingUniRule annotation, DNA-directed DNA polymeraseUniRule annotationARBA annotation, Nucleotidyltransferase, Transferase
Biological processDNA replicationUniRule annotation
Ligand4Fe-4SUniRule annotationARBA annotation, Iron, Iron-sulfur, Metal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymerase epsilon catalytic subunitUniRule annotation (EC:2.7.7.7UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PoleImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1196391, Pole

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusUniRule annotationARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q80XH7

PRoteomics IDEntifications database

More...
PRIDEi
Q80XH7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1524 – 1924DUF1744InterPro annotationAdd BLAST401

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 32DisorderedSequence analysisAdd BLAST32
Regioni1935 – 1968DisorderedSequence analysisAdd BLAST34
Regioni2014 – 2041DisorderedSequence analysisAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1280 – 1300Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1945 – 1968AcidicSequence analysisAdd BLAST24
Compositional biasi2022 – 2041PolarSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-B family.UniRule annotationARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerUniRule annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
VYDLDMK

Database of Orthologous Groups

More...
OrthoDBi
39650at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.132.60, 1 hit
3.30.420.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006172, DNA-dir_DNA_pol_B
IPR006133, DNA-dir_DNA_pol_B_exonuc
IPR006134, DNA-dir_DNA_pol_B_multi_dom
IPR043502, DNA/RNA_pol_sf
IPR042087, DNA_pol_B_C
IPR013697, DNA_pol_e_suA_C
IPR029703, POL2
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10670, PTHR10670, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00136, DNA_pol_B, 1 hit
PF03104, DNA_pol_B_exo1, 1 hit
PF08490, DUF1744, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01159, DUF1744, 1 hit
SM00486, POLBc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53098, SSF53098, 1 hit
SSF56672, SSF56672, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q80XH7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLRNSGRRH PEPGADGEGS RDDGPSSSVS ALKRLERSQW TDKMDLRFGF
60 70 80 90 100
ERLKEPGERT GWLINMHPTE ILDEDKRLVS AVDYYFIQDD GSRFKVALPY
110 120 130 140 150
MPYFYIAARK GCDREVSSFL SKKFQGKIAK LENVPKEDLD LPNHLVGLKR
160 170 180 190 200
SYIKLSFHTV EDLVKVRKEI SPAVKKNREQ DHASDEYTTM LSSILQGGSV
210 220 230 240 250
ITDEDETSKK IADQLDNIVD MREYDVPYHI RLSIDLRIHV AHWYNVRFRG
260 270 280 290 300
NAFPVEITRR DDLVERPDPV VLAFDIETTK LPLKFPDAET DQIMMISYMI
310 320 330 340 350
DGQGYLITNR EIVSEDIEDF EFTPKPEYEG PFCVFNEPDE VHLIQRWFEH
360 370 380 390 400
IQETKPTIMV TYNGDFFDWP FVEARAAIHG LSMYQEIGFQ KDSQGEYKAP
410 420 430 440 450
QCIHMDCLRW VKRDSYLPVG SHNLKAAAKA KLGYDPVELD PEDMCRMATE
460 470 480 490 500
QPQTLATYSV SDAVATYYLY MKYVHPFIFA LCTIIPMEPD EVLRKGSGTL
510 520 530 540 550
CEALLMVQAF HANIIFPNKQ EQEFNKLTDD GHMLDAETYV GGHVEALESG
560 570 580 590 600
VFRSDIPCRF RMNPAAFDFL LQRVEKTMRH SIEEEEKVPV EQATNFQEVC
610 620 630 640 650
EQIKTKLTSL KDVPNRIECP LIYHLDVGAM YPNIILTNRL QPSAIVDEAT
660 670 680 690 700
CAACDFNKPG ASCQRKMAWQ WRGEFMPASR SEYHRIQHQL ESEKFPPLFP
710 720 730 740 750
EGPARAFHEL SREEQAKYEK RRLADYCRKA YKKIHVTKVE ERLTTICQRE
760 770 780 790 800
NSFYVDTVRA FRDRRYEFKG LHKVWKKKLS AAVEVGDASE VKRCKNMEIL
810 820 830 840 850
YDSLQLAHKC ILNSFYGYVM RKGARWYSME MAGIVCFTGA NIITQARELI
860 870 880 890 900
EQIGRPLELD TDGIWCVLPN SFPENFVIKT TNAKKPKLTI SYPGAMLNIM
910 920 930 940 950
VKEGFTNHQY QELTEPSSLT YVTHSENSIF FEVDGPYLAM ILPASKEEGK
960 970 980 990 1000
KLKKRYAVFN EDGSLAELKG FEVKRRGELQ LIKIFQSSVF EAFLKGSTLE
1010 1020 1030 1040 1050
EVYGSVAKVA DYWLDVLYSK AANMPDSELF ELISENRSMS RKLEDYGEQK
1060 1070 1080 1090 1100
STSISTAKRL AEFLGDQMVK DAGLSCRYII SRKPEGSPVT ERAIPLAIFQ
1110 1120 1130 1140 1150
AEPTVRKHFL RKWLKSSSLQ DFDIRTILDW DYYIERLGSA IQKIITIPAA
1160 1170 1180 1190 1200
LQQVKNPVPR VKHPDWLHKK LLEKNDIYKQ KKISELFVLE GKRQIVMAQA
1210 1220 1230 1240 1250
SENSLSLCTP DMEDIGLTKP HHSTVPVATK RKRVWETQKE SQDIALTVPW
1260 1270 1280 1290 1300
QEVLGQPPSL GTTQEEWLVW LQFHKKKWQL QAQQRLALRK KQRLESAEDM
1310 1320 1330 1340 1350
PRLGPIREGP STGLGSFLRR TARSIMDLPW QIIQISETRQ AGLFRLWAII
1360 1370 1380 1390 1400
GNDLHCIKLS IPRVFYVNQR VAKAEDGPAY RKVNRALPRS NIVYNLYEYS
1410 1420 1430 1440 1450
VPEDMYQEHI NEINTELSVP DIEGVYETQV PLLFRALVQL GCVCVVNKQL
1460 1470 1480 1490 1500
TRHLSGWEAE TFALEHLEMR SLAQFSYLEP GSIRHIYLYH HTQGHKALFG
1510 1520 1530 1540 1550
VFIPSQRRAS VFVLDTVRSN QMPGLSALYS SEHSLLLDKV DPKLLPPPKH
1560 1570 1580 1590 1600
TFEVRAETNL KTICRAIQRF LLAYKEERRG PTLIAVQSSW ELCRLTSEIP
1610 1620 1630 1640 1650
VLEEFPLVPI RVADKISYAV LDWQRHGARR MIRHYLNLDL CLSQAFEMSR
1660 1670 1680 1690 1700
YFHIPVGNLP EDISTFGSDL FFARHLQHHN HLLWLSPTSR PDLGGKEADD
1710 1720 1730 1740 1750
NRLVMEFDDR ATVEINSSGC YSTVCVELDI QNLAVNTILQ SHHVNDMEGA
1760 1770 1780 1790 1800
GSMGISFDVI QQASLEDMVT GNQAASALAN YDETALCSST FRILKSMVVG
1810 1820 1830 1840 1850
WVKEITQYHN IYADNQVMHF YRWLQSPCSL LHDPALHRTL HNMMKKLFLQ
1860 1870 1880 1890 1900
LIAEFKRLGS SVVYANFNRI ILCTKKRRIE DALAYVEYIT NSIHSKEIFH
1910 1920 1930 1940 1950
SLTISFSRCW EFLLWMDPSN YGGIKGKVPS SIHCGQVKEQ DSQAREETDE
1960 1970 1980 1990 2000
EEEDKEKDEE EEGMGESEVE DLLENNWNIL QFLPQAASCQ SYFLMIVSAY
2010 2020 2030 2040 2050
IVAVYQSMKE ELRHSAPGST PVKRKGASQF SQESEGATGS LPGMITFSQD
2060 2070 2080 2090 2100
YVANELTQSF FTITQKIQKK VTGSRNTTEP SEMFPVLPGS HLLLNNPALE
2110 2120 2130 2140 2150
FIKYVCKVLS LDTNITNQVN KLNRDLLRLV DVGEFSEEAQ FRDPCHSYVL
2160 2170 2180 2190 2200
PEVICHSCNF CRDLDLCKDS SFSQDGAILP QWLCSNCQAP YDSSAIESAL
2210 2220 2230 2240 2250
VEALQRKLMA FTLQDLVCLK CRGMKETHMP VYCSCAGDFT LTIRTEVFME
2260 2270 2280
QIRIFQNIAK YYSMSYLQET IEWLLQTSPV SNC
Length:2,283
Mass (Da):262,116
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7DEEA60E799006A0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC048166 mRNA Translation: AAH48166.1
BC063246 mRNA Translation: AAH63246.1

NCBI Reference Sequences

More...
RefSeqi
NP_035262.2, NM_011132.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
18973

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:18973

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC048166 mRNA Translation: AAH48166.1
BC063246 mRNA Translation: AAH63246.1
RefSeqiNP_035262.2, NM_011132.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiQ80XH7
PRIDEiQ80XH7

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
18973

Genome annotation databases

GeneIDi18973
KEGGimmu:18973

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5426
MGIiMGI:1196391, Pole

Phylogenomic databases

OMAiVYDLDMK
OrthoDBi39650at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
18973, 19 hits in 50 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Pole, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

Gene3Di1.10.132.60, 1 hit
3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR006172, DNA-dir_DNA_pol_B
IPR006133, DNA-dir_DNA_pol_B_exonuc
IPR006134, DNA-dir_DNA_pol_B_multi_dom
IPR043502, DNA/RNA_pol_sf
IPR042087, DNA_pol_B_C
IPR013697, DNA_pol_e_suA_C
IPR029703, POL2
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf
PANTHERiPTHR10670, PTHR10670, 1 hit
PfamiView protein in Pfam
PF00136, DNA_pol_B, 1 hit
PF03104, DNA_pol_B_exo1, 1 hit
PF08490, DUF1744, 1 hit
SMARTiView protein in SMART
SM01159, DUF1744, 1 hit
SM00486, POLBc, 1 hit
SUPFAMiSSF53098, SSF53098, 1 hit
SSF56672, SSF56672, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ80XH7_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80XH7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: April 7, 2021
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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