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Entry version 112 (31 Jul 2019)
Sequence version 1 (01 Jun 2003)
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Protein

Interphotoreceptor matrix proteoglycan 2

Gene

Impg2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix; may participate in the maturation and maintenance of the light-sensitive photoreceptor outer segment. Binds heparin.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHeparin-binding, Receptor

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interphotoreceptor matrix proteoglycan 2
Alternative name(s):
Sialoprotein associated with cones and rods proteoglycan
Short name:
Spacrcan
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Impg2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3044955 Impg2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini28 – 1106ExtracellularSequence analysisAdd BLAST1079
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1107 – 1127HelicalSequence analysisAdd BLAST21
Topological domaini1128 – 1243CytoplasmicSequence analysisAdd BLAST116

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi255R → H: Decreased-binding affinity to hyaluronan. 1 Publication1
Mutagenesisi263R → H: Decreased-binding affinity to hyaluronan. 1 Publication1
Mutagenesisi1083R → Q: Decreased-binding affinity to hyaluronan. 1 Publication1
Mutagenesisi1091R → Q: Decreased-binding affinity to hyaluronan. 1 Publication1
Mutagenesisi1136 – 1139RRER → SSES: Most important decrease in binding affinity to hyaluronan. 1 Publication4
Mutagenesisi1147R → G: Important decrease in binding affinity to hyaluronan. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000032015028 – 1243Interphotoreceptor matrix proteoglycan 2Add BLAST1216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi225N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi297N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi316N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi366N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi427O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi428O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi429O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi582N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi701O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi704O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi712O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi817O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi888O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi945N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi959N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1017 ↔ 1028PROSITE-ProRule annotation
Disulfide bondi1022 ↔ 1039PROSITE-ProRule annotation
Disulfide bondi1041 ↔ 1053PROSITE-ProRule annotation
Disulfide bondi1057 ↔ 1070PROSITE-ProRule annotation
Disulfide bondi1064 ↔ 1080PROSITE-ProRule annotation
Disulfide bondi1082 ↔ 1095PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q80XH2

PRoteomics IDEntifications database

More...
PRIDEi
Q80XH2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q80XH2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q80XH2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the retina and pineal gland.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Increasing expression in retina from 15 dpc to adulthood: expressed at P8 when photoreceptor outer segments are in active stages of elongation; elevated expression at P10 in the developing IPM and at P15 in the region adjacent to the retina pigment epithelium (RPE). From P18 to P35, more homogeneously present in the IPM surrounding both cones and rods.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000035270 Expressed in 23 organ(s), highest expression level in embryo

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000063648

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini235 – 349SEA 1PROSITE-ProRule annotationAdd BLAST115
Domaini900 – 1013SEA 2PROSITE-ProRule annotationAdd BLAST114
Domaini1013 – 1054EGF-like 1PROSITE-ProRule annotationAdd BLAST42
Domaini1055 – 1096EGF-like 2PROSITE-ProRule annotationAdd BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni255 – 263Hyaluronan-binding motif involved in chondroitin sulfate A-binding9
Regioni1083 – 1091Hyaluronan-binding motif involved in chondroitin sulfate C-binding9
Regioni1128 – 1136Hyaluronan-binding motif involved in chondroitin sulfate A- and C-binding9
Regioni1139 – 1147Hyaluronan-binding motif involved in chondroitin sulfate C-binding9
Regioni1212 – 1220Hyaluronan-binding motif involved in chondroitin sulfate A- and C-binding motif9

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IH0G Eukaryota
ENOG410Y9FF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063503

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113064

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q80XH2

KEGG Orthology (KO)

More...
KOi
K19017

Identification of Orthologs from Complete Genome Data

More...
OMAi
SGDQANP

Database of Orthologous Groups

More...
OrthoDBi
112459at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q80XH2

TreeFam database of animal gene trees

More...
TreeFami
TF331340

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.960, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR039861 IMPG
IPR032975 IMPG2
IPR000082 SEA_dom
IPR036364 SEA_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12199 PTHR12199, 1 hit
PTHR12199:SF4 PTHR12199:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01390 SEA, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00200 SEA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82671 SSF82671, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS50024 SEA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q80XH2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIMFLPVGRM SLGILILFLT GGNLVSASEE RQEPMHAVSV LSPEKSTDLS
60 70 80 90 100
LPTRKRQLLD ATETGRRWLL RRRRSILFPN GVKICSSETV AEAVANHVKY
110 120 130 140 150
FKARVCQEAI WEAFRTFWDR LPGRDEYRHW MNLCEDGVTS VFEMGAHFSQ
160 170 180 190 200
SVEHRNLIMK KLAYTREAES SSCKDQSCGP ELSFPVPIGE TSTLTGAVSS
210 220 230 240 250
ASYPGLASES SAASPQESIS NEIENVTEEP TQPAAEQIAE FSIQLLGKRY
260 270 280 290 300
SEELRDPSSA LYRLLVEEFI SEVEKAFTGL PGYKGIRVLE FRAPEENDSG
310 320 330 340 350
IDVHYAVTFN GEAISNTTWD LISLHSNKVE NHGLVEMDDK PTAVYTISNF
360 370 380 390 400
RDYIAETLHQ NFLMGNSSLN PDPKSLQLIN VRGVLLPQTE DIVWNTQSSS
410 420 430 440 450
LQVTTSSILD NTLQAEWLSA DTTTTTTTTI SPFGFSSSSP SATGRELQSQ
460 470 480 490 500
SALRDVVSTS KLASPTKVVL SSLPEILGGS SLTLHSVTPA VLQPDLPVAP
510 520 530 540 550
EGRTSGSFIL EDGLASTEEL EDTSIDGLPS SPLIQPVPKE TVPPMEDSDT
560 570 580 590 600
ALLSTPHLTS SAIEDLTKDI GTPSGLESLA SNISDQLEVI PWFPDTSVEK
610 620 630 640 650
DFIFESGLGS GSGKDVDVID WPWSETSLEK TTKPLSKSWS EEQDALLPTE
660 670 680 690 700
GREKLHIDGR VDSTEQIIES SEHRYGDRPI HFIEEESHVR STIPIFVESA
710 720 730 740 750
TPPTSPIFSK HTSDVPDIDS YSLTKPPFLP VTIAIPASTK KTDEVLKEDM
760 770 780 790 800
VHTESSSHKE LDSEVPVSRP DMQPVWTMLP ESDTVWTRTS SLGKLSRDTL
810 820 830 840 850
ASTPESTDRL WLKASMTQST ELPSTTHSTQ LEEEVIMAVQ DISLELDQVG
860 870 880 890 900
TDYYQSELTE EQHGKADSYV EMSTSVHYTE MPIVALPTKG GVLSHTQTAG
910 920 930 940 950
ALVVFFSLRV TNMLFSEDLF NKNSLEYKAL EQRFLELLVP YLQSNLSGFQ
960 970 980 990 1000
NLEILSFRNG SIVVNSRVRF AESAPPNVNK AMYRILEDFC TTAYQTMNLD
1010 1020 1030 1040 1050
IDKYSLDVES GDEANPCKFQ ACNEFSECLV NPWSGEAKCK CYPGYLSVDE
1060 1070 1080 1090 1100
LPCQSLCDLQ PDFCLNDGKC DIMPGHGAIC RCRVGSNWWY RGQHCEEFVS
1110 1120 1130 1140 1150
EPFVIGITIA SVVSFLLVAS AVVFFLVKML QAQNVRRERQ RPTSSSRHPD
1160 1170 1180 1190 1200
SLSSVENAMK YNPAYESHLA GCELYEKSYS QHPFYSSASE EVIGGLSREE
1210 1220 1230 1240
IRQMYESSDL SKEEIQERMR ILELYANDPE FAAFVREHQM EEL
Length:1,243
Mass (Da):138,102
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i26C647136491E4D5
GO
Isoform 2 (identifier: Q80XH2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     381-489: Missing.

Show »
Length:1,134
Mass (Da):126,711
Checksum:iAC73BF2D09D69CFB
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAO21221 differs from that shown. Reason: Frameshift at position 1236.Curated
The sequence AAO21221 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_031612381 – 489Missing in isoform 2. 1 PublicationAdd BLAST109

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY174061 mRNA Translation: AAO21221.1 Sequence problems.
BC048863 mRNA Translation: AAH48863.1
AK047356 mRNA Translation: BAC33032.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS37358.1 [Q80XH2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_777365.2, NM_174876.3 [Q80XH2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000069936; ENSMUSP00000063648; ENSMUSG00000035270 [Q80XH2-1]
ENSMUST00000160116; ENSMUSP00000125135; ENSMUSG00000035270 [Q80XH2-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
224224

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:224224

UCSC genome browser

More...
UCSCi
uc007zmm.1 mouse [Q80XH2-1]
uc012agq.1 mouse [Q80XH2-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY174061 mRNA Translation: AAO21221.1 Sequence problems.
BC048863 mRNA Translation: AAH48863.1
AK047356 mRNA Translation: BAC33032.1
CCDSiCCDS37358.1 [Q80XH2-1]
RefSeqiNP_777365.2, NM_174876.3 [Q80XH2-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063648

PTM databases

iPTMnetiQ80XH2
PhosphoSitePlusiQ80XH2

Proteomic databases

PaxDbiQ80XH2
PRIDEiQ80XH2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069936; ENSMUSP00000063648; ENSMUSG00000035270 [Q80XH2-1]
ENSMUST00000160116; ENSMUSP00000125135; ENSMUSG00000035270 [Q80XH2-2]
GeneIDi224224
KEGGimmu:224224
UCSCiuc007zmm.1 mouse [Q80XH2-1]
uc012agq.1 mouse [Q80XH2-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
50939
MGIiMGI:3044955 Impg2

Phylogenomic databases

eggNOGiENOG410IH0G Eukaryota
ENOG410Y9FF LUCA
GeneTreeiENSGT00530000063503
HOGENOMiHOG000113064
InParanoidiQ80XH2
KOiK19017
OMAiSGDQANP
OrthoDBi112459at2759
PhylomeDBiQ80XH2
TreeFamiTF331340

Miscellaneous databases

Protein Ontology

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PROi
PR:Q80XH2

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000035270 Expressed in 23 organ(s), highest expression level in embryo

Family and domain databases

Gene3Di3.30.70.960, 1 hit
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR039861 IMPG
IPR032975 IMPG2
IPR000082 SEA_dom
IPR036364 SEA_dom_sf
PANTHERiPTHR12199 PTHR12199, 1 hit
PTHR12199:SF4 PTHR12199:SF4, 1 hit
PfamiView protein in Pfam
PF01390 SEA, 2 hits
SMARTiView protein in SMART
SM00200 SEA, 2 hits
SUPFAMiSSF82671 SSF82671, 2 hits
PROSITEiView protein in PROSITE
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS50024 SEA, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIMPG2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80XH2
Secondary accession number(s): Q810Y3, Q8C8E4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2003
Last modified: July 31, 2019
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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