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Protein

Proline-rich acidic protein 1

Gene

Prap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play an important role in maintaining normal growth homeostasis in epithelial cells.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-rich acidic protein 1
Alternative name(s):
Pregnancy-specific uterine protein
Uterine-specific proline-rich acidic protein
Gene namesi
Name:Prap1
Synonyms:Upa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:893573 Prap1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000029941721 – 149Proline-rich acidic protein 1Add BLAST129

Proteomic databases

MaxQBiQ80XD8
PaxDbiQ80XD8
PeptideAtlasiQ80XD8
PRIDEiQ80XD8

PTM databases

PhosphoSitePlusiQ80XD8

Expressioni

Tissue specificityi

Abundantly expressed in the uterus during late pregnancy by uterus epithelial cells. After birth expression rapidly decreases and is no longer found in the uterus by the third day. Also highly expressed in the small intestine where it shows a proximal-distal graded expression.2 Publications

Gene expression databases

BgeeiENSMUSG00000025467 Expressed in 53 organ(s), highest expression level in uterus
CleanExiMM_PRAP1
GenevisibleiQ80XD8 MM

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3WZ Eukaryota
ENOG4111CMU LUCA
GeneTreeiENSGT00390000012626
HOGENOMiHOG000000692
HOVERGENiHBG099538
InParanoidiQ80XD8
KOiK21250
OMAiKAWVETE
OrthoDBiEOG091G198T
PhylomeDBiQ80XD8
TreeFamiTF337049

Family and domain databases

InterProiView protein in InterPro
IPR027922 PRAP
PANTHERiPTHR37861 PTHR37861, 1 hit
PfamiView protein in Pfam
PF15314 PRAP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80XD8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRFLLATCL VAALLWEAGA APAHQVPVKT KGKHVFPEQE TEKVWDTRAL
60 70 80 90 100
EPLEKDNQLG PLLPEPKQKP AAAEEKRPDA MTWVETEDIL SHLRSPLQGP
110 120 130 140
ELDLDSIDHP MSDDVQDEEV PQSRPILYRQ VLQGPEEDLD HLAHSMEDS
Length:149
Mass (Da):16,798
Last modified:June 1, 2003 - v1
Checksum:i38D4FD997E0C90C0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21A → R in AAC24897 (PubMed:9065197).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28486 mRNA Translation: AAC24897.1
BC051092 mRNA Translation: AAH51092.1
CCDSiCCDS21963.1
RefSeqiNP_033501.2, NM_009475.2
UniGeneiMm.439707

Genome annotation databases

EnsembliENSMUST00000026540; ENSMUSP00000026540; ENSMUSG00000025467
GeneIDi22264
KEGGimmu:22264
UCSCiuc009kgt.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28486 mRNA Translation: AAC24897.1
BC051092 mRNA Translation: AAH51092.1
CCDSiCCDS21963.1
RefSeqiNP_033501.2, NM_009475.2
UniGeneiMm.439707

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSitePlusiQ80XD8

Proteomic databases

MaxQBiQ80XD8
PaxDbiQ80XD8
PeptideAtlasiQ80XD8
PRIDEiQ80XD8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026540; ENSMUSP00000026540; ENSMUSG00000025467
GeneIDi22264
KEGGimmu:22264
UCSCiuc009kgt.2 mouse

Organism-specific databases

CTDi118471
MGIiMGI:893573 Prap1

Phylogenomic databases

eggNOGiENOG410J3WZ Eukaryota
ENOG4111CMU LUCA
GeneTreeiENSGT00390000012626
HOGENOMiHOG000000692
HOVERGENiHBG099538
InParanoidiQ80XD8
KOiK21250
OMAiKAWVETE
OrthoDBiEOG091G198T
PhylomeDBiQ80XD8
TreeFamiTF337049

Miscellaneous databases

PROiPR:Q80XD8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025467 Expressed in 53 organ(s), highest expression level in uterus
CleanExiMM_PRAP1
GenevisibleiQ80XD8 MM

Family and domain databases

InterProiView protein in InterPro
IPR027922 PRAP
PANTHERiPTHR37861 PTHR37861, 1 hit
PfamiView protein in Pfam
PF15314 PRAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRAP1_MOUSE
AccessioniPrimary (citable) accession number: Q80XD8
Secondary accession number(s): Q60874
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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