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UniProtKB - Q80XD1 (CHIO_MOUSE)
Protein
Beta-chimaerin
Gene
Chn2
Organism
Mus musculus (Mouse)
Status
Functioni
GTPase-activating protein for p21-rac.
By similarityActivity regulationi
In the inactive state, the N terminus protrudes into the active site of the Rho-GAP domain, sterically blocking Rac binding. Phospholipid binding to the Phorbol-ester/DAG-type zinc-finger/C1 domain triggers the cooperative dissociation of these interactions, allowing the N-terminus to move out of the active site and thereby activating the enzyme (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 78 – 128 | Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST | 51 |
GO - Molecular functioni
- GTPase activator activity Source: MGI
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- intracellular signal transduction Source: InterPro
- positive regulation of GTPase activity Source: InterPro
- regulation of GTPase activity Source: GO_Central
Keywordsi
Molecular function | GTPase activation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-9013149, RAC1 GTPase cycle |
Names & Taxonomyi
Protein namesi | Recommended name: Beta-chimaerinAlternative name(s): Beta-chimerin Rho GTPase-activating protein 3 |
Gene namesi | Name:Chn2 Synonyms:Arhgap3, Bch |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1917243, Chn2 |
VEuPathDBi | HostDB:ENSMUSG00000004633 |
Subcellular locationi
Other locations
- Membrane Curated; Peripheral membrane protein Curated
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056698 | 1 – 332 | Beta-chimaerinAdd BLAST | 332 |
Proteomic databases
MaxQBi | Q80XD1 |
PaxDbi | Q80XD1 |
PRIDEi | Q80XD1 |
ProteomicsDBi | 283828 [Q80XD1-1] 283829 [Q80XD1-2] 283830 [Q80XD1-3] |
PTM databases
PhosphoSitePlusi | Q80XD1 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000004633, Expressed in testis and 266 other tissues |
ExpressionAtlasi | Q80XD1, baseline and differential |
Genevisiblei | Q80XD1, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 213803, 71 interactors |
IntActi | Q80XD1, 4 interactors |
MINTi | Q80XD1 |
STRINGi | 10090.ENSMUSP00000035908 |
Miscellaneous databases
RNActi | Q80XD1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 141 – 332 | Rho-GAPPROSITE-ProRule annotationAdd BLAST | 192 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 78 – 128 | Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST | 51 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG1453, Eukaryota |
GeneTreei | ENSGT01030000234635 |
InParanoidi | Q80XD1 |
PhylomeDBi | Q80XD1 |
Family and domain databases
CDDi | cd00029, C1, 1 hit cd04372, RhoGAP_chimaerin, 1 hit |
Gene3Di | 1.10.555.10, 1 hit |
InterProi | View protein in InterPro IPR020454, DAG/PE-bd IPR002219, PE/DAG-bd IPR008936, Rho_GTPase_activation_prot IPR037860, RhoGAP_chimaerin IPR000198, RhoGAP_dom |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF00620, RhoGAP, 1 hit |
PRINTSi | PR00008, DAGPEDOMAIN |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00324, RhoGAP, 1 hit |
SUPFAMi | SSF48350, SSF48350, 1 hit |
PROSITEi | View protein in PROSITE PS50238, RHOGAP, 1 hit PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q80XD1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MCSQELWLEN ERKCAMVRKS KPSRKRQELL AIAFGVKVGL KGGFLWSPLK
60 70 80 90 100
LFACSQISSL VRRAALTHND NHFNYEKTHN FKVHTFRGPH WCEYCANFMW
110 120 130 140 150
GLIAQGVRCS DCGLNVHKQC SKHVPNDCQP DLKRIKKVYC CDLTTLVKAH
160 170 180 190 200
NTQRPMVVDI CIREIEARGL KSEGLYRVSG FTEHIEDVKM AFDRDGEKAD
210 220 230 240 250
ISANIYPDIN IITGALKLYF RDLPIPIITY DTYSKFIEAA KISNADERLE
260 270 280 290 300
AVHEVLMLLP PAHYETLRYL MIHLKKVTMN EKDNLMNAEN LGIVFGPTLM
310 320 330
RPPEDSTLTT LHDMRYQKLI VQILIENEDV LF
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ3V2R3 | Q3V2R3_MOUSE | Chimaerin | Chn2 | 468 | Annotation score: | ||
D3YXQ4 | D3YXQ4_MOUSE | Beta-chimaerin | Chn2 | 103 | Annotation score: | ||
A0A0N4SVE7 | A0A0N4SVE7_MOUSE | Beta-chimaerin | Chn2 | 58 | Annotation score: | ||
H7BXA9 | H7BXA9_MOUSE | Beta-chimaerin | Chn2 | 225 | Annotation score: | ||
A0A0N4SV96 | A0A0N4SV96_MOUSE | Beta-chimaerin | Chn2 | 197 | Annotation score: | ||
A0A0N4SVT0 | A0A0N4SVT0_MOUSE | Beta-chimaerin | Chn2 | 286 | Annotation score: | ||
A0A0N4SWG3 | A0A0N4SWG3_MOUSE | Beta-chimaerin | Chn2 | 260 | Annotation score: | ||
A0A0N4SV75 | A0A0N4SV75_MOUSE | Beta-chimaerin | Chn2 | 274 | Annotation score: | ||
A0A0N4SVZ7 | A0A0N4SVZ7_MOUSE | Beta-chimaerin | Chn2 | 228 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 138 | V → G in AAH51139 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_014243 | 1 – 55 | Missing in isoform 3. 1 PublicationAdd BLAST | 55 | |
Alternative sequenceiVSP_014244 | 1 – 50 | Missing in isoform 2. 1 PublicationAdd BLAST | 50 | |
Alternative sequenceiVSP_014245 | 51 – 56 | LFACSQ → MALQCR in isoform 2. 1 Publication | 6 | |
Alternative sequenceiVSP_014246 | 56 | Q → M in isoform 3. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ279014 mRNA Translation: CAC08453.1 Frameshift. AK006398 mRNA Translation: BAB24568.1 BC051139 mRNA Translation: AAH51139.1 |
CCDSi | CCDS20154.1 [Q80XD1-1] CCDS80535.1 [Q80XD1-2] CCDS80536.1 [Q80XD1-3] |
RefSeqi | NP_001298062.1, NM_001311133.1 [Q80XD1-2] NP_001298063.1, NM_001311134.1 [Q80XD1-3] NP_076032.2, NM_023543.2 [Q80XD1-1] |
Genome annotation databases
Ensembli | ENSMUST00000067741; ENSMUSP00000066078; ENSMUSG00000004633 [Q80XD1-1] ENSMUST00000114401; ENSMUSP00000110043; ENSMUSG00000004633 [Q80XD1-3] ENSMUST00000146114; ENSMUSP00000114476; ENSMUSG00000004633 [Q80XD1-2] |
GeneIDi | 69993 |
KEGGi | mmu:69993 |
UCSCi | uc009bzr.2, mouse [Q80XD1-2] uc009bzt.2, mouse [Q80XD1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ279014 mRNA Translation: CAC08453.1 Frameshift. AK006398 mRNA Translation: BAB24568.1 BC051139 mRNA Translation: AAH51139.1 |
CCDSi | CCDS20154.1 [Q80XD1-1] CCDS80535.1 [Q80XD1-2] CCDS80536.1 [Q80XD1-3] |
RefSeqi | NP_001298062.1, NM_001311133.1 [Q80XD1-2] NP_001298063.1, NM_001311134.1 [Q80XD1-3] NP_076032.2, NM_023543.2 [Q80XD1-1] |
3D structure databases
SMRi | Q80XD1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 213803, 71 interactors |
IntActi | Q80XD1, 4 interactors |
MINTi | Q80XD1 |
STRINGi | 10090.ENSMUSP00000035908 |
PTM databases
PhosphoSitePlusi | Q80XD1 |
Proteomic databases
MaxQBi | Q80XD1 |
PaxDbi | Q80XD1 |
PRIDEi | Q80XD1 |
ProteomicsDBi | 283828 [Q80XD1-1] 283829 [Q80XD1-2] 283830 [Q80XD1-3] |
Protocols and materials databases
DNASUi | 69993 |
Genome annotation databases
Ensembli | ENSMUST00000067741; ENSMUSP00000066078; ENSMUSG00000004633 [Q80XD1-1] ENSMUST00000114401; ENSMUSP00000110043; ENSMUSG00000004633 [Q80XD1-3] ENSMUST00000146114; ENSMUSP00000114476; ENSMUSG00000004633 [Q80XD1-2] |
GeneIDi | 69993 |
KEGGi | mmu:69993 |
UCSCi | uc009bzr.2, mouse [Q80XD1-2] uc009bzt.2, mouse [Q80XD1-1] |
Organism-specific databases
CTDi | 1124 |
MGIi | MGI:1917243, Chn2 |
VEuPathDBi | HostDB:ENSMUSG00000004633 |
Phylogenomic databases
eggNOGi | KOG1453, Eukaryota |
GeneTreei | ENSGT01030000234635 |
InParanoidi | Q80XD1 |
PhylomeDBi | Q80XD1 |
Enzyme and pathway databases
Reactomei | R-MMU-9013149, RAC1 GTPase cycle |
Miscellaneous databases
BioGRID-ORCSi | 69993, 1 hit in 65 CRISPR screens |
ChiTaRSi | Chn2, mouse |
PROi | PR:Q80XD1 |
RNActi | Q80XD1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000004633, Expressed in testis and 266 other tissues |
ExpressionAtlasi | Q80XD1, baseline and differential |
Genevisiblei | Q80XD1, MM |
Family and domain databases
CDDi | cd00029, C1, 1 hit cd04372, RhoGAP_chimaerin, 1 hit |
Gene3Di | 1.10.555.10, 1 hit |
InterProi | View protein in InterPro IPR020454, DAG/PE-bd IPR002219, PE/DAG-bd IPR008936, Rho_GTPase_activation_prot IPR037860, RhoGAP_chimaerin IPR000198, RhoGAP_dom |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF00620, RhoGAP, 1 hit |
PRINTSi | PR00008, DAGPEDOMAIN |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00324, RhoGAP, 1 hit |
SUPFAMi | SSF48350, SSF48350, 1 hit |
PROSITEi | View protein in PROSITE PS50238, RHOGAP, 1 hit PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CHIO_MOUSE | |
Accessioni | Q80XD1Primary (citable) accession number: Q80XD1 Secondary accession number(s): Q9D9W2, Q9ER57 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 21, 2005 |
Last sequence update: | June 21, 2005 | |
Last modified: | February 23, 2022 | |
This is version 145 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot