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UniProtKB - Q80XC6 (NRDE2_MOUSE)

Entry version 125 (02 Dec 2020)
Sequence version 3 (27 Jul 2011)
Previous versions | rss
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Protein

Nuclear exosome regulator NRDE2

Gene

Nrde2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation. Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation. Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome. By preventing the degradation of RNAs in the nucleus, it promotes their export to the cytoplasm.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear exosome regulator NRDE2Curated
Alternative name(s):
Protein NRDE2 homologCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nrde2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2670969, Nrde2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000899082 – 1172Nuclear exosome regulator NRDE2Add BLAST1171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q80XC6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q80XC6

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q80XC6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q80XC6

PeptideAtlas

More...PeptideAtlasi		Q80XC6

PRoteomics IDEntifications database

More...PRIDEi		Q80XC6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q80XC6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q80XC6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000021179, Expressed in dorsal pancreas and 285 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q80XC6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q80XC6, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MTREX; the interaction is direct and stabilizes NRDE2.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		229964, 2 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000021596

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q80XC6, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati314 – 346HAT 1Add BLAST33
Repeati404 – 436HAT 2Add BLAST33
Repeati766 – 800HAT 3Add BLAST35
Repeati986 – 1018HAT 4Add BLAST33
Repeati1075 – 1109HAT 5Add BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni171 – 275MID/MTR4-interacting domainBy similarityAdd BLAST105

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili78 – 330Sequence analysisAdd BLAST253

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi86 – 93Poly-Lys8
Compositional biasi146 – 154Poly-Ala9

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The MID/MTR4-interacting domain is necessary and sufficient to mediate interaction with MTREX.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRDE2 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1972, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000005524

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007550_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q80XC6

Identification of Orthologs from Complete Genome Data

More...OMAi		VQVEFFE

Database of Orthologous Groups

More...OrthoDBi		833360at2759

TreeFam database of animal gene trees

More...TreeFami		TF323791

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003107, HAT
IPR013633, NRDE-2
IPR011990, TPR-like_helical_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR13471, PTHR13471, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08424, NRDE-2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00386, HAT, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48452, SSF48452, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q80XC6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALFPAFADV SEASGDGAFR KELDWLSNPS FRVGNLTSLS RQTEEVTALA 
        60         70         80         90        100
SEGSPPPRYS FIRSPLKSEL SGESNTSEKL AQTSRKKKKE KKKRRKHQHH 
       110        120        130        140        150
RKTKRRHEQL SSSGSESDTE AGKDRASRSI RDDQKEAEKP CQGSNAAAAV 
       160        170        180        190        200
AAAAGHRSIW LEDIHDLTDV FRTDKKPDPA NWEYKSLYRG DIARYKRKGD 
       210        220        230        240        250
SCLGINPKKQ CISWEGASAA KKHSHRHLER YFTKKNVGLM RTEGIAVCSN 
       260        270        280        290        300
PEPASSEPVT FIPVKDSAEA ATPVTSWLNP LGIYDQSTTQ WLQGQGPAEQ 
       310        320        330        340        350
ESKQPDSQQD RENAALKARV EEFNRRVREN PWDTQLWMAF VAFQDEVMRS 
       360        370        380        390        400
PGIYALGEGE QEKHRKSLKL LLEKKLAVLE RAIESNPGSV ELKLAKLQLC 
       410        420        430        440        450
SEFWEPSALA KEWQKLLFLH PNNTSLWQRY LSFCQSQFGT FSVSKLHSLY 
       460        470        480        490        500
GKCLSTLSAV KDGSMLSHPV LPGTEEAMFG LFLQQCHFLR QAGHSEKVIS 
       510        520        530        540        550
LFQAMVDFTF FKPDSVKELP TKVQVEFFEP FWDSGEPRVG EKGARGWRAW 
       560        570        580        590        600
MHQQERGGWV LITPDEDDEE PEEEDQEIKD KTLPRWQIWL AVERSRDQRH 
       610        620        630        640        650
WRPWRPDKTK KQTEEDCEDP ERQVLFDDIG QSLIRLSSPD LQFQLIQAFL 
       660        670        680        690        700
QFLGVPSGFL PPASCLYLAM DESSIFESEL YDEKPLTYFN PSFSGISCVG 
       710        720        730        740        750
SMEQLGRPRW TKGHNREGEE FVRNVFHLVL PLLAGKQKSQ LSLSWLRYEI 
       760        770        780        790        800
AKVIWCLHTK KKRLKSQGKS CKKLAKNLLK EPENRNNFCL WKQYAHLEWL 
       810        820        830        840        850
LGNTEDARKV FDTALSMAGS SELKDRELCE LSLLYAELEM ELSPDSRGAT 
       860        870        880        890        900
TGRAVHILTR LTESSPYGPY TGQVSSTQVL KARKAYELAL QDCLGQSCAS 
       910        920        930        940        950
SPAPAEALDC LGSLVRCFML FQYLTVGIDA AVQIYGRVFA KLKGSARLED 
       960        970        980        990       1000
PGPEDSTSSQ SLTNVLEAVS MMHTSLLRFH MNVCVYPLAP LRETLSDALK 
      1010       1020       1030       1040       1050
LYPGNQVLWR AYVQIQNKSH SANKTRRFFD TVTRSAKHLE PWLFAIEAEK 
      1060       1070       1080       1090       1100
LRKKLVESVQ RVGGREVHAT IPETGLTHRI RALFENAIRS DKGNQCPLLW 
      1110       1120       1130       1140       1150
RMYLNFLVSL GNKERSKGVF YKALQSCPWA KVLYMDAMEY FPDELQEILD 
      1160       1170 
VMTEKELRVR LPLEELELLL ED
Length:1,172
Mass (Da):133,467
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i060E2A1A0CE5739D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VLX9A0A1Y7VLX9_MOUSE
Nuclear exosome regulator NRDE2
Nrde2
228Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH25577 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH51175 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
The sequence BY182441 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti21 – 28KELDWLSN → VKVRLAEH in AAH51175 (PubMed:15489334).Curated8
Sequence conflicti707R → H in AAH25577 (PubMed:16141072).Curated1
Sequence conflicti741 – 742LS → VC in AAH25577 (PubMed:16141072).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BY182441 mRNA No translation available.
AC166349 Genomic DNA No translation available.
BC002230 mRNA Translation: AAH02230.1
BC025577 mRNA Translation: AAH25577.1 Different initiation.
BC051175 mRNA Translation: AAH51175.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS70414.1

NCBI Reference Sequences

More...RefSeqi		NP_001277232.1, NM_001290303.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000021596; ENSMUSP00000021596; ENSMUSG00000021179

Database of genes from NCBI RefSeq genomes

More...GeneIDi		217827

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:217827

UCSC genome browser

More...UCSCi		uc007oso.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BY182441 mRNA No translation available.
AC166349 Genomic DNA No translation available.
BC002230 mRNA Translation: AAH02230.1
BC025577 mRNA Translation: AAH25577.1 Different initiation.
BC051175 mRNA Translation: AAH51175.1 Sequence problems.
CCDSiCCDS70414.1
RefSeqiNP_001277232.1, NM_001290303.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi229964, 2 interactors
STRINGi10090.ENSMUSP00000021596

PTM databases

iPTMnetiQ80XC6
PhosphoSitePlusiQ80XC6

Proteomic databases

EPDiQ80XC6
jPOSTiQ80XC6
MaxQBiQ80XC6
PaxDbiQ80XC6
PeptideAtlasiQ80XC6
PRIDEiQ80XC6

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26518, 25 antibodies

Genome annotation databases

EnsembliENSMUST00000021596; ENSMUSP00000021596; ENSMUSG00000021179
GeneIDi217827
KEGGimmu:217827
UCSCiuc007oso.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55051
MGIiMGI:2670969, Nrde2

Phylogenomic databases

eggNOGiKOG1972, Eukaryota
GeneTreeiENSGT00390000005524
HOGENOMiCLU_007550_1_0_1
InParanoidiQ80XC6
OMAiVQVEFFE
OrthoDBi833360at2759
TreeFamiTF323791

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		217827, 6 hits in 13 CRISPR screens

Protein Ontology

More...PROi		PR:Q80XC6
RNActiQ80XC6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000021179, Expressed in dorsal pancreas and 285 other tissues
ExpressionAtlasiQ80XC6, baseline and differential
GenevisibleiQ80XC6, MM

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR003107, HAT
IPR013633, NRDE-2
IPR011990, TPR-like_helical_dom_sf
PANTHERiPTHR13471, PTHR13471, 1 hit
PfamiView protein in Pfam
PF08424, NRDE-2, 1 hit
SMARTiView protein in SMART
SM00386, HAT, 5 hits
SUPFAMiSSF48452, SSF48452, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNRDE2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80XC6
Secondary accession number(s): E9QKV8, Q8R3D7, Q99LT9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: July 27, 2011
Last modified: December 2, 2020
This is version 125 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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