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Entry version 126 (02 Jun 2021)
Sequence version 3 (27 Jul 2011)
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Protein

Nebulin-related-anchoring protein

Gene

Nrap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix.

3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nebulin-related-anchoring protein
Short name:
N-RAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NrapImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1098765, Nrap

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002488591 – 1728Nebulin-related-anchoring proteinAdd BLAST1728

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei203PhosphothreonineCombined sources1
Modified residuei1078PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q80XB4

PRoteomics IDEntifications database

More...
PRIDEi
Q80XB4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
293891 [Q80XB4-1]
293892 [Q80XB4-2]
293893 [Q80XB4-3]
293894 [Q80XB4-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q80XB4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q80XB4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in cardiac and skeletal muscle. Not detected in kidney, spleen, liver, brain, lung, stomach or uterus.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression significantly increased from 10.5 dpc to 16.5 dpc, and subsequently remained constant until 21 days after birth. In 9.5 dpc to 10.5 dpc embryonic heart, expression is primarily associated with developing premyofibril structures containing alpha-actinin.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000049134, Expressed in soleus muscle and 151 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q80XB4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q80XB4, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with actin, alpha-actinin, KLHL41, TLN1 and VCL.

Interacts with CSRP3.

By similarity4 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
201842, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q80XB4, 1 interactor

Molecular INTeraction database

More...
MINTi
Q80XB4

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000073228

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q80XB4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q80XB4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 64LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST61
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati173 – 200Nebulin 1Sequence analysisAdd BLAST28
Repeati201 – 235Nebulin 2Sequence analysisAdd BLAST35
Repeati244 – 271Nebulin 3Sequence analysisAdd BLAST28
Repeati313 – 340Nebulin 4Sequence analysisAdd BLAST28
Repeati345 – 379Nebulin 5Sequence analysisAdd BLAST35
Repeati386 – 414Nebulin 6Sequence analysisAdd BLAST29
Repeati416 – 450Nebulin 7Sequence analysisAdd BLAST35
Repeati484 – 518Nebulin 8Sequence analysisAdd BLAST35
Repeati519 – 553Nebulin 9Sequence analysisAdd BLAST35
Repeati555 – 589Nebulin 10Sequence analysisAdd BLAST35
Repeati599 – 623Nebulin 11Sequence analysisAdd BLAST25
Repeati624 – 658Nebulin 12Sequence analysisAdd BLAST35
Repeati659 – 689Nebulin 13Sequence analysisAdd BLAST31
Repeati699 – 721Nebulin 14Sequence analysisAdd BLAST23
Repeati723 – 757Nebulin 15Sequence analysisAdd BLAST35
Repeati758 – 792Nebulin 16Sequence analysisAdd BLAST35
Repeati794 – 828Nebulin 17Sequence analysisAdd BLAST35
Repeati841 – 866Nebulin 18Sequence analysisAdd BLAST26
Repeati867 – 893Nebulin 19Sequence analysisAdd BLAST27
Repeati898 – 932Nebulin 20Sequence analysisAdd BLAST35
Repeati943 – 960Nebulin 21Sequence analysisAdd BLAST18
Repeati966 – 1000Nebulin 22Sequence analysisAdd BLAST35
Repeati1001 – 1035Nebulin 23Sequence analysisAdd BLAST35
Repeati1037 – 1071Nebulin 24Sequence analysisAdd BLAST35
Repeati1075 – 1109Nebulin 25Sequence analysisAdd BLAST35
Repeati1110 – 1136Nebulin 26Sequence analysisAdd BLAST27
Repeati1141 – 1175Nebulin 27Sequence analysisAdd BLAST35
Repeati1180 – 1203Nebulin 28Sequence analysisAdd BLAST24
Repeati1209 – 1243Nebulin 29Sequence analysisAdd BLAST35
Repeati1244 – 1278Nebulin 30Sequence analysisAdd BLAST35
Repeati1280 – 1314Nebulin 31Sequence analysisAdd BLAST35
Repeati1318 – 1352Nebulin 32Sequence analysisAdd BLAST35
Repeati1353 – 1379Nebulin 33Sequence analysisAdd BLAST27
Repeati1384 – 1418Nebulin 34Sequence analysisAdd BLAST35
Repeati1425 – 1446Nebulin 35Sequence analysisAdd BLAST22
Repeati1452 – 1478Nebulin 36Sequence analysisAdd BLAST27
Repeati1487 – 1521Nebulin 37Sequence analysisAdd BLAST35
Repeati1523 – 1557Nebulin 38Sequence analysisAdd BLAST35
Repeati1561 – 1595Nebulin 39Sequence analysisAdd BLAST35
Repeati1596 – 1630Nebulin 40Sequence analysisAdd BLAST35
Repeati1637 – 1661Nebulin 41Sequence analysisAdd BLAST25

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1702, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158418

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003010_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q80XB4

Database of Orthologous Groups

More...
OrthoDBi
1549538at2759

TreeFam database of animal gene trees

More...
TreeFami
TF313758

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013998, Nebulin-like
IPR000900, Nebulin_repeat
IPR001781, Znf_LIM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00412, LIM, 1 hit
PF00880, Nebulin, 13 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00510, NEBULIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00132, LIM, 1 hit
SM00227, NEBU, 42 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00478, LIM_DOMAIN_1, 1 hit
PS50023, LIM_DOMAIN_2, 1 hit
PS51216, NEBULIN, 41 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q80XB4-1) [UniParc]FASTAAdd to basket
Also known as: S1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNVQACSRCG YGVYPAEKIS CIDQTWHKAC FHCEVCKMML SVNNFVSHQK
60 70 80 90 100
KPYCHAHNPK NNTFTSVYHT PLNLTLKKSV AAMGGIDGKE DGEPFKSVLH
110 120 130 140 150
WDMKSKAGAG AASRLMNERD YWPGYAEGNT WCPGALPDPE IVRMVEARQS
160 170 180 190 200
LGEGYTEDRE QQQGKGSFPA MITPAYQRAK AANQLASQVQ YKRGHDERVS
210 220 230 240 250
TFTPVADTPE LLRAKAGGQL QNDVRYTEDG GQQRGKGSFP AMITPAYQIA
260 270 280 290 300
KRATELASDV RYHQQYHREM KGMASPVGAE GGMTKDSVDR CGQVYSEECD
310 320 330 340 350
EPRGKGSFPA MITPAYQNAK KANELVSDIK YRQDFHKMKG AAHFHSLAAQ
360 370 380 390 400
DNLVLKRAQS VSKLVSEVEY KKGLENSKGH SINYCETPQF RNVSKISKFT
410 420 430 440 450
SDNKYKENYQ TQLRGHYDGV GMDRRMLHAL KVGSLASNVA YKADYKHDVV
460 470 480 490 500
DYNYLATATP FYQTTMRLVP LKDVNYRQNI DRMKFSSVTN TPQIVQAKIN
510 520 530 540 550
AQQLSHVNYR ADYERNKLNY TLPQDAPQLL KAKANAELFS EVKYKEGWQK
560 570 580 590 600
TKGKGFEMKL DAMSLLAAKA SGELASSVKY KEEYEKMKGR ALGATDSKLL
610 620 630 640 650
HSLQVAKMSS EVEYKKGFEE SKTHFNLPMD MVNLRHAKKA QALASDLDYR
660 670 680 690 700
KKLHDYTVLP EDMKTQWAKK AYGLQSELQY KADLAWMRGV GWLTEGSLNL
710 720 730 740 750
EQAKKAGQLI SEKNYRQRVD ELKFTSVADS SQMEHAKKSQ GLQNAVAYKA
760 770 780 790 800
GNEQSVHQYT ISKDEPLFLR ARANAAQLSE TLYKSSWEKQ KAKGFELRLD
810 820 830 840 850
SLAFLTAKAK RDLASEVKYK EDYERSRGKL IGAKSAQGDS QMSHSLQMSK
860 870 880 890 900
LQSDLEYKKG FEDTRSQCHI SLDMVHLVHA RQAQHLATDV GYRTASHCFT
910 920 930 940 950
ALPTDMKVEW AKKAYGLQSD NQYRADMKWM KGTGWVATGS LHVEQAKKAG
960 970 980 990 1000
ELISEKKYRQ HPDALKFTSI KDTPEMVQAR ISYTQAVDRL YREQGENVKH
1010 1020 1030 1040 1050
HYTQTADLPE VLLAKLNAMN ISETRYKESW SRLRDGGYKL RLDALPFQAA
1060 1070 1080 1090 1100
KASSEVISDY KYKEAFERMK GQMLGSRSLE DDLSLAHSVH ATSLQSDVNY
1110 1120 1130 1140 1150
KKGFEHAKAH FHLPLDMVTL VHAKKAQTLA SDQDYRHPLP QHTVLAEDLR
1160 1170 1180 1190 1200
LSCAKKAHKL QSENLYRSDL NFMRGVPCVV PGTLEIEGRK KASELISESK
1210 1220 1230 1240 1250
YRQHPGSFKY TAVTDTPNLL HAKYSNQITN ERLYKAAGED ARHQYTMTLG
1260 1270 1280 1290 1300
LPEFIRAKTN AANLSEAKYK EAWHNLRAQG YKLTIDALPF QAARASGDIA
1310 1320 1330 1340 1350
SDFLYRHEFV KERGQLIGVR NVSDDPRLLH CLRMGQLQSE NQYRKEAASS
1360 1370 1380 1390 1400
QAQCHLPMDM MYLVHARKAQ ALASDHDYRT QCHEFTALPE DLKMAWAKKA
1410 1420 1430 1440 1450
HALQSEFRYK ADLMGMKGTG WLALQSPQIE SAKKAGDLIS ETKYRKKPDS
1460 1470 1480 1490 1500
IKFTTVVDSP DLIHAKESYM HCNERLYRLG DAASLHRYTP IPDHPDFTRA
1510 1520 1530 1540 1550
RMNAMHLSDK VYRNAWEQSR AGGYDFRLDA IPFQTARVSR DIASDFRYKE
1560 1570 1580 1590 1600
AFLRDRGLQI GYRSISDDPR TTHFLRVGRL QSDNEYRKAF AKGRSQFHSR
1610 1620 1630 1640 1650
ADQPGFLQAK RSQQLASDVL YRQPLPQHTS DPEQLGLKHA RKAHQLQSDV
1660 1670 1680 1690 1700
KYKSDLNLTR GVGWTPPGSY KVEMARRAAE LANRRGPGIR GASVEPEAAA
1710 1720
ALGDHQSRGV NPDASEILHI HKKKTLLM
Length:1,728
Mass (Da):195,756
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFD21BDD3925FFE4F
GO
Isoform 21 Publication (identifier: Q80XB4-2) [UniParc]FASTAAdd to basket
Also known as: C1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     368-402: Missing.

Show »
Length:1,693
Mass (Da):191,738
Checksum:i0D606F46C7D7DB51
GO
Isoform 31 Publication (identifier: Q80XB4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-402: Missing.
     1443-1650: Missing.

Show »
Length:1,485
Mass (Da):167,522
Checksum:i8188C4FCF9F98450
GO
Isoform 41 Publication (identifier: Q80XB4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.
     368-402: Missing.

Show »
Length:1,611
Mass (Da):182,451
Checksum:iFF4C8408D15FF30A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q641E9Q641_MOUSE
Nebulin-related-anchoring protein
Nrap
1,485Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PZF4E9PZF4_MOUSE
Nebulin-related-anchoring protein
Nrap
1,692Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7CXG1F7CXG1_MOUSE
Nebulin-related-anchoring protein
Nrap
387Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC53323 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti51K → M in AAC53323 (PubMed:9295142).Curated1
Sequence conflicti85G → R in AAO47075 (PubMed:12789664).Curated1
Sequence conflicti109A → T in AAC53323 (PubMed:9295142).Curated1
Sequence conflicti209P → A in AAC53323 (PubMed:9295142).Curated1
Sequence conflicti318N → T in AAC53323 (PubMed:9295142).Curated1
Sequence conflicti908V → A in AAC53323 (PubMed:9295142).Curated1
Sequence conflicti924R → G in AAO47076 (PubMed:12789664).Curated1
Sequence conflicti956K → E in AAO47076 (PubMed:12789664).Curated1
Sequence conflicti1158H → R in AAO47075 (PubMed:12789664).Curated1
Sequence conflicti1383H → R in AAC53323 (PubMed:9295142).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0521591 – 82Missing in isoform 4. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_052160368 – 402Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsAdd BLAST35
Alternative sequenceiVSP_0521621443 – 1650Missing in isoform 3. 1 PublicationAdd BLAST208

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U76618 mRNA Translation: AAC53323.1 Frameshift.
AY177622 mRNA Translation: AAO47075.1
AY177623 mRNA Translation: AAO47076.1
AC115771 Genomic DNA No translation available.
AK138925 mRNA Translation: BAE23819.1
AK138975 mRNA Translation: BAE23843.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS29913.1 [Q80XB4-1]
CCDS29914.1 [Q80XB4-2]

Protein sequence database of the Protein Information Resource

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PIRi
T37192

NCBI Reference Sequences

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RefSeqi
NP_001273481.1, NM_001286552.1
NP_032759.3, NM_008733.4 [Q80XB4-1]
NP_932307.2, NM_198059.3 [Q80XB4-2]
XP_006526811.1, XM_006526748.3 [Q80XB4-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000040711; ENSMUSP00000048364; ENSMUSG00000049134 [Q80XB4-2]
ENSMUST00000073536; ENSMUSP00000073228; ENSMUSG00000049134 [Q80XB4-1]
ENSMUST00000095947; ENSMUSP00000093640; ENSMUSG00000049134 [Q80XB4-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
18175

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:18175

UCSC genome browser

More...
UCSCi
uc008hyu.3, mouse [Q80XB4-1]
uc008hyv.3, mouse [Q80XB4-2]
uc012bnr.3, mouse [Q80XB4-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76618 mRNA Translation: AAC53323.1 Frameshift.
AY177622 mRNA Translation: AAO47075.1
AY177623 mRNA Translation: AAO47076.1
AC115771 Genomic DNA No translation available.
AK138925 mRNA Translation: BAE23819.1
AK138975 mRNA Translation: BAE23843.1
CCDSiCCDS29913.1 [Q80XB4-1]
CCDS29914.1 [Q80XB4-2]
PIRiT37192
RefSeqiNP_001273481.1, NM_001286552.1
NP_032759.3, NM_008733.4 [Q80XB4-1]
NP_932307.2, NM_198059.3 [Q80XB4-2]
XP_006526811.1, XM_006526748.3 [Q80XB4-4]

3D structure databases

SMRiQ80XB4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi201842, 8 interactors
IntActiQ80XB4, 1 interactor
MINTiQ80XB4
STRINGi10090.ENSMUSP00000073228

PTM databases

iPTMnetiQ80XB4
PhosphoSitePlusiQ80XB4

Proteomic databases

PaxDbiQ80XB4
PRIDEiQ80XB4
ProteomicsDBi293891 [Q80XB4-1]
293892 [Q80XB4-2]
293893 [Q80XB4-3]
293894 [Q80XB4-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
51692, 74 antibodies

The DNASU plasmid repository

More...
DNASUi
18175

Genome annotation databases

EnsembliENSMUST00000040711; ENSMUSP00000048364; ENSMUSG00000049134 [Q80XB4-2]
ENSMUST00000073536; ENSMUSP00000073228; ENSMUSG00000049134 [Q80XB4-1]
ENSMUST00000095947; ENSMUSP00000093640; ENSMUSG00000049134 [Q80XB4-4]
GeneIDi18175
KEGGimmu:18175
UCSCiuc008hyu.3, mouse [Q80XB4-1]
uc008hyv.3, mouse [Q80XB4-2]
uc012bnr.3, mouse [Q80XB4-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4892
MGIiMGI:1098765, Nrap

Phylogenomic databases

eggNOGiKOG1702, Eukaryota
GeneTreeiENSGT00940000158418
HOGENOMiCLU_003010_1_0_1
InParanoidiQ80XB4
OrthoDBi1549538at2759
TreeFamiTF313758

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
18175, 1 hit in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Nrap, mouse

Protein Ontology

More...
PROi
PR:Q80XB4
RNActiQ80XB4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000049134, Expressed in soleus muscle and 151 other tissues
ExpressionAtlasiQ80XB4, baseline and differential
GenevisibleiQ80XB4, MM

Family and domain databases

InterProiView protein in InterPro
IPR013998, Nebulin-like
IPR000900, Nebulin_repeat
IPR001781, Znf_LIM
PfamiView protein in Pfam
PF00412, LIM, 1 hit
PF00880, Nebulin, 13 hits
PRINTSiPR00510, NEBULIN
SMARTiView protein in SMART
SM00132, LIM, 1 hit
SM00227, NEBU, 42 hits
PROSITEiView protein in PROSITE
PS00478, LIM_DOMAIN_1, 1 hit
PS50023, LIM_DOMAIN_2, 1 hit
PS51216, NEBULIN, 41 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNRAP_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80XB4
Secondary accession number(s): E9QN76
, O35884, Q3UTY7, Q3UU10, Q80V40
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 27, 2011
Last modified: June 2, 2021
This is version 126 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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