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Protein

Serine protease inhibitor A3F

Gene

Serpina3f

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

The single human alpha1-antichymotrypsin gene (SERPINA3) is represented by a cluster of 14 individual murine paralogs.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei371 – 372Reactive bondBy similarity2

GO - Molecular functioni

  • serine-type endopeptidase inhibitor activity Source: GO_Central

GO - Biological processi

  • negative regulation of endopeptidase activity Source: GO_Central
  • response to bacterium Source: MGI
  • response to cytokine Source: MGI
  • response to peptide hormone Source: MGI

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-6798695 Neutrophil degranulation

Protein family/group databases

MEROPSiI04.045

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease inhibitor A3F
Short name:
Serpin A3F
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2182838 Serpina3f

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000940971 – 445Serine protease inhibitor A3FAdd BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi174N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi259N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ80X76
PaxDbiQ80X76
PRIDEiQ80X76

PTM databases

iPTMnetiQ80X76

Expressioni

Gene expression databases

BgeeiENSMUSG00000066363 Expressed in 15 organ(s), highest expression level in liver

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098641

Structurei

3D structure databases

ProteinModelPortaliQ80X76
SMRiQ80X76
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni357 – 382RCLAdd BLAST26

Domaini

The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the serpin reactive site and the protease. The resulting inactive serpin-protease complex is highly stable (By similarity). Variability within the reactive center loop (RCL) sequences of Serpina3 paralogs may determine target protease specificity.By similarity

Sequence similaritiesi

Belongs to the serpin family.Curated

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118839
HOGENOMiHOG000238521
HOVERGENiHBG005957
InParanoidiQ80X76
KOiK04525
OMAiQEHANGH
OrthoDBiEOG091G0ION
TreeFamiTF343201

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q80X76-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGVSPAVFG CPDVTLGRNT AVREVQENIT SVDSLTLASS NTDFAFSLYK
60 70 80 90 100
ELVLKNPDEN VVFSPFSICT ALALLSLGAK SNTLKEILEG LKFNLTETPE
110 120 130 140 150
PDIHQGFRYL LDLLSQPGNQ VQISTGSALF IEKHLQILAE FKEKARALYQ
160 170 180 190 200
AEAFTADFQQ PLEATKLIND YVSNHTQGKI KELISDLDKR TLMVLVNYIY
210 220 230 240 250
FKGKWEMPFD PDDTCKSEFY LDENRSVKVP MMKINNLTTP YFRDEELSCT
260 270 280 290 300
VVELKYTGNA SAMFILPDQG KMQQVEASLQ PETLRNWKDS LKPRLINELC
310 320 330 340 350
LPKFSISTDY SLEHILPELG IRELFSTQAD LSAITGTKDL RTSQVVHKAV
360 370 380 390 400
LDVAETGTEA AAGTGYQNLQ CCQGVIYSMK IYFDRPFLMI ISDTNTHIAL
410 420 430 440
FMAKVSNPES DENFLNVEYA FPQVLEIMPE YRSVCTCCLP CLTRQ
Length:445
Mass (Da):50,003
Last modified:July 27, 2011 - v3
Checksum:iA6FA96BBBA6F39E1
GO

Sequence cautioni

The sequence AAH49975 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73A → T in AAH49975 (PubMed:15489334).Curated1
Sequence conflicti175H → Q in AAH49975 (PubMed:15489334).Curated1
Sequence conflicti297N → D in AAH49975 (PubMed:15489334).Curated1
Sequence conflicti406S → T in AAH49975 (PubMed:15489334).Curated1
Sequence conflicti444R → T in AAH49975 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC049975 mRNA Translation: AAH49975.1 Different initiation.
BC139132 mRNA Translation: AAI39133.1
BC139133 mRNA Translation: AAI39134.1
CCDSiCCDS26149.1
RefSeqiNP_001028507.2, NM_001033335.3
NP_001161766.1, NM_001168294.1
NP_001161767.1, NM_001168295.1
UniGeneiMm.483584

Genome annotation databases

EnsembliENSMUST00000101080; ENSMUSP00000098641; ENSMUSG00000066363
ENSMUST00000121337; ENSMUSP00000113945; ENSMUSG00000066363
ENSMUST00000167049; ENSMUSP00000126520; ENSMUSG00000066363
GeneIDi238393
KEGGimmu:238393
UCSCiuc007oww.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC049975 mRNA Translation: AAH49975.1 Different initiation.
BC139132 mRNA Translation: AAI39133.1
BC139133 mRNA Translation: AAI39134.1
CCDSiCCDS26149.1
RefSeqiNP_001028507.2, NM_001033335.3
NP_001161766.1, NM_001168294.1
NP_001161767.1, NM_001168295.1
UniGeneiMm.483584

3D structure databases

ProteinModelPortaliQ80X76
SMRiQ80X76
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098641

Protein family/group databases

MEROPSiI04.045

PTM databases

iPTMnetiQ80X76

Proteomic databases

MaxQBiQ80X76
PaxDbiQ80X76
PRIDEiQ80X76

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000101080; ENSMUSP00000098641; ENSMUSG00000066363
ENSMUST00000121337; ENSMUSP00000113945; ENSMUSG00000066363
ENSMUST00000167049; ENSMUSP00000126520; ENSMUSG00000066363
GeneIDi238393
KEGGimmu:238393
UCSCiuc007oww.2 mouse

Organism-specific databases

CTDi238393
MGIiMGI:2182838 Serpina3f

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118839
HOGENOMiHOG000238521
HOVERGENiHBG005957
InParanoidiQ80X76
KOiK04525
OMAiQEHANGH
OrthoDBiEOG091G0ION
TreeFamiTF343201

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

PROiPR:Q80X76
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000066363 Expressed in 15 organ(s), highest expression level in liver

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPA3F_MOUSE
AccessioniPrimary (citable) accession number: Q80X76
Secondary accession number(s): B2RT49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 114 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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