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Protein

Transmembrane protein 106B

Gene

Tmem106b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 106B
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1919150 Tmem106b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 97CytoplasmicSequence analysisAdd BLAST96
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Topological domaini119 – 275LumenalSequence analysisAdd BLAST157

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002426512 – 275Transmembrane protein 106BAdd BLAST274

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Modified residuei34PhosphoserineBy similarity1
Glycosylationi146N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi152N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi257N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ80X71
MaxQBiQ80X71
PaxDbiQ80X71
PeptideAtlasiQ80X71
PRIDEiQ80X71

PTM databases

iPTMnetiQ80X71
PhosphoSitePlusiQ80X71
SwissPalmiQ80X71

Expressioni

Gene expression databases

BgeeiENSMUSG00000029571 Expressed in 259 organ(s), highest expression level in vestibular membrane of cochlear duct
CleanExiMM_TMEM106B
ExpressionAtlasiQ80X71 baseline and differential
GenevisibleiQ80X71 MM

Interactioni

Subunit structurei

Interacts with MAP6.By similarity

Protein-protein interaction databases

BioGridi215015, 1 interactor
STRINGi10090.ENSMUSP00000031556

Structurei

3D structure databases

ProteinModelPortaliQ80X71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM106 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEC7 Eukaryota
ENOG410ZX7B LUCA
GeneTreeiENSGT00390000013076
HOGENOMiHOG000230966
HOVERGENiHBG055025
InParanoidiQ80X71
OMAiMKQIDYM
OrthoDBiEOG091G0KDT
PhylomeDBiQ80X71
TreeFamiTF328907

Family and domain databases

InterProiView protein in InterPro
IPR009790 DUF1356_TMEM106
PANTHERiPTHR28556 PTHR28556, 1 hit
PfamiView protein in Pfam
PF07092 DUF1356, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q80X71-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKSLSHLPL HSNKEDGYDG VTSTDNMRNG LVSSEVHNED GRNGDVSQFP
60 70 80 90 100
YVEFTGRDSV TCPTCQGTGR IPRGQENQLV ALIPYSDQRL RPRRTKLYVM
110 120 130 140 150
ASVFVCLLLS GLAVFFLFPR SIEVKYIGVK SAYVSYDAEK RTIYLNITNT
160 170 180 190 200
LNITNNNYYS VEVENITAQV QFSKTVIGKA RLNNITNIGP LDMKQIDYTV
210 220 230 240 250
PTVIAEEMSY MYDFCTLLSI KVHNIVLMMQ VTVTTAYFGH SEQISQERYQ
260 270
YVDCGRNTTY QLAQSEYLNV LQPQQ
Length:275
Mass (Da):31,172
Last modified:June 1, 2003 - v1
Checksum:i4075221F1280EC4A
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z191D3Z191_MOUSE
Transmembrane protein 106B
Tmem106b
185Annotation score:
D3Z0M2D3Z0M2_MOUSE
Transmembrane protein 106B
Tmem106b
93Annotation score:
D3Z6E0D3Z6E0_MOUSE
Transmembrane protein 106B
Tmem106b
70Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti219S → Y in BAB26411 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009646 mRNA Translation: BAB26411.1
BC050246 mRNA Translation: AAH50246.1
CCDSiCCDS19914.1
RefSeqiNP_082268.2, NM_027992.3
XP_006505232.1, XM_006505169.3
UniGeneiMm.27742

Genome annotation databases

EnsembliENSMUST00000031556; ENSMUSP00000031556; ENSMUSG00000029571
GeneIDi71900
KEGGimmu:71900
UCSCiuc009ayk.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009646 mRNA Translation: BAB26411.1
BC050246 mRNA Translation: AAH50246.1
CCDSiCCDS19914.1
RefSeqiNP_082268.2, NM_027992.3
XP_006505232.1, XM_006505169.3
UniGeneiMm.27742

3D structure databases

ProteinModelPortaliQ80X71
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215015, 1 interactor
STRINGi10090.ENSMUSP00000031556

PTM databases

iPTMnetiQ80X71
PhosphoSitePlusiQ80X71
SwissPalmiQ80X71

Proteomic databases

EPDiQ80X71
MaxQBiQ80X71
PaxDbiQ80X71
PeptideAtlasiQ80X71
PRIDEiQ80X71

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031556; ENSMUSP00000031556; ENSMUSG00000029571
GeneIDi71900
KEGGimmu:71900
UCSCiuc009ayk.2 mouse

Organism-specific databases

CTDi54664
MGIiMGI:1919150 Tmem106b

Phylogenomic databases

eggNOGiENOG410IEC7 Eukaryota
ENOG410ZX7B LUCA
GeneTreeiENSGT00390000013076
HOGENOMiHOG000230966
HOVERGENiHBG055025
InParanoidiQ80X71
OMAiMKQIDYM
OrthoDBiEOG091G0KDT
PhylomeDBiQ80X71
TreeFamiTF328907

Miscellaneous databases

PROiPR:Q80X71
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029571 Expressed in 259 organ(s), highest expression level in vestibular membrane of cochlear duct
CleanExiMM_TMEM106B
ExpressionAtlasiQ80X71 baseline and differential
GenevisibleiQ80X71 MM

Family and domain databases

InterProiView protein in InterPro
IPR009790 DUF1356_TMEM106
PANTHERiPTHR28556 PTHR28556, 1 hit
PfamiView protein in Pfam
PF07092 DUF1356, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiT106B_MOUSE
AccessioniPrimary (citable) accession number: Q80X71
Secondary accession number(s): Q9D737
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2003
Last modified: September 12, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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