Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Collagen alpha-1(XIV) chain

Gene

Col14a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-2022090 Assembly of collagen fibrils and other multimeric structures
R-MMU-8948216 Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Collagen alpha-1(XIV) chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Col14a1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1341272 Col14a1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000578629 – 1797Collagen alpha-1(XIV) chainAdd BLAST1769

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi373N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1385N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1389N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Lysines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in all cases and bind carbohydrates.By similarity
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.By similarity
May contain numerous cysteine residues involved in inter- and intramolecular disulfide bonding.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q80X19

PRoteomics IDEntifications database

More...
PRIDEi
Q80X19

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q80X19

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q80X19

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000022371 Expressed in 211 organ(s), highest expression level in membranous labyrinth

CleanEx database of gene expression profiles

More...
CleanExi
MM_COL14A1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q80X19 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q80X19 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-2992 Collagen type XIV trimer

Protein interaction database and analysis system

More...
IntActi
Q80X19, 1 interactor

Molecular INTeraction database

More...
MINTi
Q80X19

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000105850

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q80X19

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q80X19

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 122Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST91
Domaini159 – 331VWFA 1PROSITE-ProRule annotationAdd BLAST173
Domaini356 – 445Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST90
Domaini446 – 537Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST92
Domaini538 – 625Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST88
Domaini627 – 716Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST90
Domaini738 – 830Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST93
Domaini832 – 922Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST91
Domaini923 – 1014Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST92
Domaini1033 – 1206VWFA 2PROSITE-ProRule annotationAdd BLAST174
Domaini1230 – 1425Laminin G-likeAdd BLAST196
Domaini1463 – 1511Collagen-like 1Add BLAST49
Domaini1515 – 1571Collagen-like 2Add BLAST57
Domaini1572 – 1610Collagen-like 3Add BLAST39
Domaini1655 – 1706Collagen-like 4Add BLAST52
Domaini1708 – 1758Collagen-like 5Add BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1218 – 1459Nonhelical region (NC4)Add BLAST242
Regioni1460 – 1611Triple-helical region 1 (COL2)Add BLAST152
Regioni1655 – 1780Triple-helical region 2 (COL1)Add BLAST126

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1608 – 1610Cell attachment siteSequence analysis3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3544 Eukaryota
ENOG410Y01G LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153769

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000015812

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051060

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q80X19

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q80X19

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 7 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 8 hits
3.40.50.410, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR001791 Laminin_G
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01391 Collagen, 4 hits
PF00041 fn3, 8 hits
PF00092 VWA, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 8 hits
SM00210 TSPN, 1 hit
SM00327 VWA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 5 hits
SSF49899 SSF49899, 1 hit
SSF53300 SSF53300, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 8 hits
PS50234 VWFA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q80X19-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMIWQCKMRD WLILAFLAAA CFCTIVRGQV APPTRLRYNV ISHDSIQISW
60 70 80 90 100
KAPRGKFGGY KLLVAPASGG KTNQMNLQNT ATKAIIQGLL PEQNYTVQLI
110 120 130 140 150
AYYKDKESKP AQGQFRIKDL EKRKDPTKPK VKVVDKGNGS KPTSPEEVKF
160 170 180 190 200
FCETPAIADI VILVDGSWSI GRFNFRLVRN FLENLVTAFN VGSEKTRIGL
210 220 230 240 250
AQYSGDPRIE WHLNAFNTKD EVIDAVRSLP YKGGNTLTGL ALNFIFENSF
260 270 280 290 300
KPEAGSRSGV SKIGILITDG KSQDDIIPPS RNLRESGVEL FAIGVKNADL
310 320 330 340 350
SELQEIASEP DSTHVYNVAE FDLMHTVVES LTRTVCSRVE EQDKEIKASA
360 370 380 390 400
LATIGPPTEL ITSEVTARSF MVNWTQSPGK VEKYRVVYYP TRGGKPEEVV
410 420 430 440 450
VDGSVSSTVL KNLMSSTEYQ IAVFAVSAHT ASEGLRGAET TLALPMASDL
460 470 480 490 500
ELYDVTENSM RVRWDAVPGA TGYLILYAPL TEGLAGDEKE MKIGETHTDI
510 520 530 540 550
ELSGLFPNTE YTVTVYAMFG EEASDPATGQ ETTLPLTPPR NLRISNVGSN
560 570 580 590 600
SARLTWDPAS GKISGYRIVY TSADGTEINE VEVDPITTFP LKGLTPLTEY
610 620 630 640 650
SIAIFSIYEE GQSLPLVGEF TTEEVPAQQY LEIDEVKTDS FRVTWHPLSA
660 670 680 690 700
EEGQHKLMWI PVYGGKTQEV DLKEEQDSYV IEGLDPGTEY EVSLLAVLDD
710 720 730 740 750
GSESEVVTAV GTTLDDFWTE APTAIEPTSP VTSVLQTGIR NLVVDDETAT
760 770 780 790 800
SLRVSWDISD SNVEQFRVTY LKAQGDPMEE VVGTVMVPGV QNSLLLKALL
810 820 830 840 850
PDTEYKVTVT PVYTVGEGVS VSAPGKTLPS SGPQNLRVSE EWYNRVRITW
860 870 880 890 900
DPPSGPVKGY RIVYKPVSVP GQTLETFVGA DINTIVMTNL LSGMDYNVKI
910 920 930 940 950
FASQASGFSD ALTGLVQTLF LGVTDLQANQ VEMTSLCARW QIHRHATAYR
960 970 980 990 1000
IVLESLQDTQ AQESTVGGGV NRHCFYGLQP DSEYKISVYT KLQELEGPSV
1010 1020 1030 1040 1050
SIMQKTQSLP TEPPTFPPTI PPAKEVCKAA KADLVFMVDG SWSIGDDNFN
1060 1070 1080 1090 1100
KIINFLYSTV GALDKIGADG TQVAMVQFTD DPRTEFKLDS YKTKETLLDA
1110 1120 1130 1140 1150
IRHISYKGGN TKTGKAIKHV RDTLFTSDSG TRRGIPKVIV VITDGRSQDD
1160 1170 1180 1190 1200
VNKISREMQA DGFNIFAIGV ADADYSELVQ IGSKPSSRHV FFVDDFDAFK
1210 1220 1230 1240 1250
KIEDELITFV CETASATCPM VHKDGVDLAG FKMMEMFGLV EKDFSAVEGV
1260 1270 1280 1290 1300
SMEPGTFNLF PCYQIHKDAL VSQPTKYLHP EGLPSDYTMS FLFRILPDTP
1310 1320 1330 1340 1350
QEPFALWEIL NKNSEPLVGI ILDNGGKTLT YFNYDYTGDF QTVTFEGPDI
1360 1370 1380 1390 1400
RKMFYGSFHK LHVVVSKTLA KVVVDCKEVG QKAINASANI TSDGVEVLGR
1410 1420 1430 1440 1450
MVRSRGPNGN SAPFQLQMFD IVCSTSWASK DRCCELPGLR DEESCPDLPR
1460 1470 1480 1490 1500
SCSCSETNEV ALGPAGPPGG PGLRGPKGQQ GEQGPKGPEG PRGETGPAGP
1510 1520 1530 1540 1550
QGPPGPQGPS GLSIQGMPGM PGDKGDKGDA GLPGPQGVPG GVGSPGRDGS
1560 1570 1580 1590 1600
PGQRGFPGKD GSSGPPGPPG PIGIPGAPGV PGITGSMGPQ GALGPPGVPG
1610 1620 1630 1640 1650
AKGERGERGD LQSQAMVRAV ARQVCEQLIQ SHMARYTAIL NQIPSQSSSI
1660 1670 1680 1690 1700
RTIQGPPGEP GRPGSPGTPG EQGPPGTPGF PGNAGVPGTP GERGLTGVKG
1710 1720 1730 1740 1750
EKGNPGIGTQ GPRGPPGPAG PSGESRPGSP GPPGSPGPRG PPGHLGVPGP
1760 1770 1780 1790
QGPSGQPGYC DPSSCSAYGV GVSHPDQPEF TPVQDEQEAM DLWSAGI
Length:1,797
Mass (Da):193,013
Last modified:May 1, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i67DAF37398EC49CC
GO
Isoform 2Curated (identifier: Q80X19-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1772-1797: VSHPDQPEFTPVQDEQEAMDLWSAGI → DLIPYNDYQH

Note: No experimental confirmation available.Curated
Show »
Length:1,781
Mass (Da):191,363
Checksum:i2C6E82F8DE1027DF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZNH7B7ZNH7_MOUSE
Collagen alpha-1(XIV) chain
Col14a1 mCG_11867
1,794Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K3W4R4K3W4R4_MOUSE
Collagen alpha-1(XIV) chain
Col14a1
1,798Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7D5Y4F7D5Y4_MOUSE
Collagen alpha-1(XIV) chain
Col14a1
521Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti406S → F in AAO64442 (PubMed:12853031).Curated1
Sequence conflicti782 – 784VGT → GKN in AAO64442 (PubMed:12853031).Curated3
Sequence conflicti1047D → H in BAE23197 (PubMed:16141072).Curated1
Sequence conflicti1389N → S in BAE23197 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0516521772 – 1797VSHPD…WSAGI → DLIPYNDYQH in isoform 2. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY221110 mRNA Translation: AAO64442.1
AC131337 Genomic DNA No translation available.
AC133156 Genomic DNA No translation available.
AK052963 mRNA Translation: BAC35222.1
AK136987 mRNA Translation: BAE23197.1
AJ131395 mRNA Translation: CAB44661.1

NCBI Reference Sequences

More...
RefSeqi
XP_006520447.1, XM_006520384.3 [Q80X19-1]
XP_006520448.1, XM_006520385.3 [Q80X19-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.297859

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000023053; ENSMUSP00000023053; ENSMUSG00000022371 [Q80X19-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
12818

UCSC genome browser

More...
UCSCi
uc007vsd.2 mouse [Q80X19-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY221110 mRNA Translation: AAO64442.1
AC131337 Genomic DNA No translation available.
AC133156 Genomic DNA No translation available.
AK052963 mRNA Translation: BAC35222.1
AK136987 mRNA Translation: BAE23197.1
AJ131395 mRNA Translation: CAB44661.1
RefSeqiXP_006520447.1, XM_006520384.3 [Q80X19-1]
XP_006520448.1, XM_006520385.3 [Q80X19-2]
UniGeneiMm.297859

3D structure databases

ProteinModelPortaliQ80X19
SMRiQ80X19
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-2992 Collagen type XIV trimer
IntActiQ80X19, 1 interactor
MINTiQ80X19
STRINGi10090.ENSMUSP00000105850

PTM databases

iPTMnetiQ80X19
PhosphoSitePlusiQ80X19

Proteomic databases

PaxDbiQ80X19
PRIDEiQ80X19

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023053; ENSMUSP00000023053; ENSMUSG00000022371 [Q80X19-1]
GeneIDi12818
UCSCiuc007vsd.2 mouse [Q80X19-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7373
MGIiMGI:1341272 Col14a1

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410Y01G LUCA
GeneTreeiENSGT00940000153769
HOGENOMiHOG000015812
HOVERGENiHBG051060
InParanoidiQ80X19
PhylomeDBiQ80X19

Enzyme and pathway databases

ReactomeiR-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-2022090 Assembly of collagen fibrils and other multimeric structures
R-MMU-8948216 Collagen chain trimerization

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q80X19

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000022371 Expressed in 211 organ(s), highest expression level in membranous labyrinth
CleanExiMM_COL14A1
ExpressionAtlasiQ80X19 baseline and differential
GenevisibleiQ80X19 MM

Family and domain databases

CDDicd00063 FN3, 7 hits
Gene3Di2.60.40.10, 8 hits
3.40.50.410, 2 hits
InterProiView protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR001791 Laminin_G
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01391 Collagen, 4 hits
PF00041 fn3, 8 hits
PF00092 VWA, 2 hits
SMARTiView protein in SMART
SM00060 FN3, 8 hits
SM00210 TSPN, 1 hit
SM00327 VWA, 2 hits
SUPFAMiSSF49265 SSF49265, 5 hits
SSF49899 SSF49899, 1 hit
SSF53300 SSF53300, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 8 hits
PS50234 VWFA, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOEA1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80X19
Secondary accession number(s): Q3UVS2, Q8C6X3, Q9WV05
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: May 1, 2007
Last modified: December 5, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again