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Entry version 133 (02 Jun 2021)
Sequence version 2 (29 Mar 2005)
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Protein

Aftiphilin

Gene

Aftph

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of clathrin-coated vesicles (By similarity).

Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aftiphilin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Aftph
Synonyms:Afth
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1923012, Aftph

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000644891 – 931AftiphilinAdd BLAST931

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei151PhosphoserineBy similarity1
Modified residuei395PhosphoserineCombined sources1
Modified residuei613PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q80WT5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q80WT5

PeptideAtlas

More...
PeptideAtlasi
Q80WT5

PRoteomics IDEntifications database

More...
PRIDEi
Q80WT5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
285621 [Q80WT5-1]
285622 [Q80WT5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q80WT5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q80WT5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000049659, Expressed in adult mammalian kidney and 292 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q80WT5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q80WT5, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Self-associates (By similarity).

Interacts with GGA1 (via GAE domain) (By similarity).

Interacts with GGA3 (via GAE domain), AP1G1 (via GAE domain) and AP1G2 (via GAE domain) (By similarity).

Component of the aftiphilin/p200/gamma-synergin complex, at least composed of AFTPH/aftiphilin, HEATR5B/p200a and SYNRG/gamma-synergin, which plays a role in the AP1G1/AP-1-mediated protein trafficking from early to recycling endosomes (By similarity). Within the complex interacts with HEATR5B/p200a and SYNRG/gamma-synergin; the interactions are direct (By similarity).

Interacts with AP1G1/AP-1; the interaction is required to recruit AFTPH/aftiphilin to the perinuclear region of the cell (By similarity).

Interacts with CLTCL1/Clathrin (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
229758, 2 interactors

Molecular INTeraction database

More...
MINTi
Q80WT5

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000036778

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q80WT5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q80WT5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 49DisorderedSequence analysisAdd BLAST49
Regioni371 – 454DisorderedSequence analysisAdd BLAST84
Regioni494 – 561DisorderedSequence analysisAdd BLAST68
Regioni599 – 636DisorderedSequence analysisAdd BLAST38
Regioni821 – 825Clathrin-bindingSequence analysis5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi28 – 31WXXF motif 14
Motifi433 – 436WXXF motif 24
Motifi476 – 479WXXF motif 34
Motifi712 – 714CLTCL1/Clathrin-bindingBy similarity3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi379 – 393Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi405 – 425Polar residuesSequence analysisAdd BLAST21
Compositional biasi518 – 532Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi535 – 561Polar residuesSequence analysisAdd BLAST27
Compositional biasi602 – 627Polar residuesSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is tuned by the acidic context surrounding the motif and the properties of the second residue of the motif itself (By similarity).By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QPXF, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154186

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_017041_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q80WT5

Database of Orthologous Groups

More...
OrthoDBi
155710at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q80WT5

TreeFam database of animal gene trees

More...
TreeFami
TF331532

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029205, Clathrin-bd

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15045, Clathrin_bdg, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q80WT5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPDIIRMYS SSPPPLDNGA EDDEEDEFGE FGGFSEVSPS GVGFVDFDTP
60 70 80 90 100
DYTRPKEDFV PSNHFMPIHE YSEDVDSLTS FKSVQNGNDK DITAELSTPV
110 120 130 140 150
KSQSDVVLST TSKEMIPSKT LDPSIDGMES LEDLDKVVVQ GPSTGQLRSF
160 170 180 190 200
SPGDFRTDKN IVHQTKQLES CNGEKPPCLE ILTNGFAGLE TVNPQGTDDL
210 220 230 240 250
DNVADSKGSK PLNTCGTECI LESAASHATE FADFSTFSQT ERTQLEEIEC
260 270 280 290 300
PVLNDGDTLT IQGNSKGPRV KELNCVKEVT LDGSFEDTGN TEREHQVCVS
310 320 330 340 350
EIHAVADRGL SVEKQDLQTL QQDEFLNSRI QSEAWSLVDS SENSEAITKE
360 370 380 390 400
RCKMEKNDLF ASKCADLSMD SVKTSDVNEI GSSKEENRKL TNPKSPDPDP
410 420 430 440 450
TGQNALDDSA ASMKNGDSGN GFVTCHDTNE DDFGDFGTAN GTTPPFVTST
460 470 480 490 500
QDSMSDVTFE DSSEHFLHLS EPGDDFGEFE DTNAVSCQEE MRFTESDLRQ
510 520 530 540 550
TSDGLSEECP LAGESGGKDS KPDSKLKNGQ DSEFGDFDSV PNTQGSAFQD
560 570 580 590 600
SDDFADFSSA GPSQAVDWNA FEDEQKDGCS WAAFGDQQET ESHHLKEVWQ
610 620 630 640 650
SQRTDETMGT LGTPKMHSVS SAASKGAVAS GHLQEPGTSV QTALLNRLER
660 670 680 690 700
IFEACFPSVF VPDVEEEVSS LKHLLETHSS PAKTREALAD RGELRGVWTE
710 720 730 740 750
LQDIHDAHGL RYQWGGSHSN KKLLCSLGID TRNILFTGNK KQPVIVPMYA
760 770 780 790 800
AGLGMLEPTK EPLKPLSAAE KIASIGQTTV MTPEINTCTS DPFQESLPPV
810 820 830 840 850
QFDWSSSGLT NPLDASGGST LLNLDFFGPV DDSSSSSSTI PGVDPELYEL
860 870 880 890 900
TTAKLETSTS SLRVTDAFAK LMSTVEKTST STRKPKREEH LSEEAMKVIA
910 920 930
SLPDLTFMHA KVLMFPATLT PSMSSQEQAD A
Length:931
Mass (Da):101,131
Last modified:March 29, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFE1C64F3B7270620
GO
Isoform 2 (identifier: Q80WT5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     815-841: Missing.

Show »
Length:904
Mass (Da):98,490
Checksum:i506C3468B7BD598E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BJH7H3BJH7_MOUSE
Aftiphilin
Aftph
822Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BKM5H3BKM5_MOUSE
Aftiphilin
Aftph
685Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BIZ9H3BIZ9_MOUSE
Aftiphilin
Aftph
292Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAI24910 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI25738 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_013242815 – 841Missing in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL663115, AL645599 Genomic DNA Translation: CAI25737.1
AL663115, AL645599 Genomic DNA Translation: CAI25738.1 Sequence problems.
AL645599, AL663115 Genomic DNA Translation: CAI24909.1
AL645599, AL663115 Genomic DNA Translation: CAI24910.1 Sequence problems.
BC004630 mRNA Translation: AAH04630.1
BC052036 mRNA Translation: AAH52036.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS24459.1 [Q80WT5-2]
CCDS70146.1 [Q80WT5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001239432.1, NM_001252503.2
NP_001277474.1, NM_001290545.1 [Q80WT5-1]
NP_852076.1, NM_181411.4 [Q80WT5-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000035350; ENSMUSP00000036778; ENSMUSG00000049659 [Q80WT5-2]
ENSMUST00000146722; ENSMUSP00000121612; ENSMUSG00000049659 [Q80WT5-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
216549

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:216549

UCSC genome browser

More...
UCSCi
uc007idh.3, mouse [Q80WT5-2]
uc056yjx.1, mouse [Q80WT5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL663115, AL645599 Genomic DNA Translation: CAI25737.1
AL663115, AL645599 Genomic DNA Translation: CAI25738.1 Sequence problems.
AL645599, AL663115 Genomic DNA Translation: CAI24909.1
AL645599, AL663115 Genomic DNA Translation: CAI24910.1 Sequence problems.
BC004630 mRNA Translation: AAH04630.1
BC052036 mRNA Translation: AAH52036.1
CCDSiCCDS24459.1 [Q80WT5-2]
CCDS70146.1 [Q80WT5-1]
RefSeqiNP_001239432.1, NM_001252503.2
NP_001277474.1, NM_001290545.1 [Q80WT5-1]
NP_852076.1, NM_181411.4 [Q80WT5-2]

3D structure databases

SMRiQ80WT5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi229758, 2 interactors
MINTiQ80WT5
STRINGi10090.ENSMUSP00000036778

PTM databases

iPTMnetiQ80WT5
PhosphoSitePlusiQ80WT5

Proteomic databases

jPOSTiQ80WT5
PaxDbiQ80WT5
PeptideAtlasiQ80WT5
PRIDEiQ80WT5
ProteomicsDBi285621 [Q80WT5-1]
285622 [Q80WT5-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
30831, 102 antibodies

The DNASU plasmid repository

More...
DNASUi
216549

Genome annotation databases

EnsembliENSMUST00000035350; ENSMUSP00000036778; ENSMUSG00000049659 [Q80WT5-2]
ENSMUST00000146722; ENSMUSP00000121612; ENSMUSG00000049659 [Q80WT5-1]
GeneIDi216549
KEGGimmu:216549
UCSCiuc007idh.3, mouse [Q80WT5-2]
uc056yjx.1, mouse [Q80WT5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54812
MGIiMGI:1923012, Aftph

Phylogenomic databases

eggNOGiENOG502QPXF, Eukaryota
GeneTreeiENSGT00940000154186
HOGENOMiCLU_017041_0_0_1
InParanoidiQ80WT5
OrthoDBi155710at2759
PhylomeDBiQ80WT5
TreeFamiTF331532

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
216549, 2 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Aftph, mouse

Protein Ontology

More...
PROi
PR:Q80WT5
RNActiQ80WT5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000049659, Expressed in adult mammalian kidney and 292 other tissues
ExpressionAtlasiQ80WT5, baseline and differential
GenevisibleiQ80WT5, MM

Family and domain databases

InterProiView protein in InterPro
IPR029205, Clathrin-bd
PfamiView protein in Pfam
PF15045, Clathrin_bdg, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAFTIN_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80WT5
Secondary accession number(s): Q5SSE6, Q99KJ1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: June 2, 2021
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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