UniProtKB - Q80WT4 (GP176_MOUSE)
Protein
G-protein coupled receptor 176
Gene
Gpr176
Organism
Mus musculus (Mouse)
Status
Functioni
Orphan receptor involved in normal circadian rhythm behavior (PubMed:26882873). Acts through the G-protein subclass G(z)-alpha and has an agonist-independent basal activity to repress cAMP production (PubMed:26882873).1 Publication
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB
GO - Biological processi
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: MGI
- circadian behavior Source: UniProtKB
- G protein-coupled receptor signaling pathway Source: UniProtKB
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Biological rhythms |
Enzyme and pathway databases
Reactomei | R-MMU-418555, G alpha (s) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: G-protein coupled receptor 176Alternative name(s): G-protein coupled receptor AGR9 |
Gene namesi | Name:Gpr176 Synonyms:Agr9, Gm1012 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2685858, Gpr176 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 41 | ExtracellularSequence analysisAdd BLAST | 41 | |
Transmembranei | 42 – 64 | Helical; Name=1Sequence analysisAdd BLAST | 23 | |
Topological domaini | 65 – 77 | CytoplasmicCuratedAdd BLAST | 13 | |
Transmembranei | 78 – 98 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 99 – 108 | ExtracellularCurated | 10 | |
Transmembranei | 109 – 129 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 130 – 157 | CytoplasmicCuratedAdd BLAST | 28 | |
Transmembranei | 158 – 177 | Helical; Name=4Sequence analysisAdd BLAST | 20 | |
Topological domaini | 178 – 204 | ExtracellularCuratedAdd BLAST | 27 | |
Transmembranei | 205 – 225 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 226 – 264 | CytoplasmicCuratedAdd BLAST | 39 | |
Transmembranei | 265 – 285 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 286 – 301 | ExtracellularCuratedAdd BLAST | 16 | |
Transmembranei | 302 – 322 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 323 – 515 | CytoplasmicCuratedAdd BLAST | 193 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Deficient mice exhibit a significantly shorter circadian period.1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 140 – 141 | DR → RD: Decreases expression; No reduction of cAMP upon induction. 1 Publication | 2 | |
Mutagenesisi | 145 | V → R: No reduction of cAMP upon induction. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069657 | 1 – 515 | G-protein coupled receptor 176Add BLAST | 515 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 4 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 11 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 17 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 26 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MaxQBi | Q80WT4 |
PaxDbi | Q80WT4 |
PRIDEi | Q80WT4 |
PTM databases
GlyGeni | Q80WT4, 4 sites |
iPTMneti | Q80WT4 |
PhosphoSitePlusi | Q80WT4 |
Expressioni
Tissue specificityi
Expressed mainly in the brain, with prominent expression in the SCN (at protein level) (PubMed:26882873).1 Publication
Developmental stagei
Fluctuates in a circadian fashion, with highest level in night and lowest in the morning (at protein level).1 Publication
Gene expression databases
Bgeei | ENSMUSG00000040133, Expressed in stria vascularis of cochlear duct and 176 other tissues |
Genevisiblei | Q80WT4, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000037586 |
Miscellaneous databases
RNActi | Q80WT4, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00950000182998 |
HOGENOMi | CLU_045778_0_0_1 |
InParanoidi | Q80WT4 |
OMAi | ASPVHTC |
OrthoDBi | 602137at2759 |
PhylomeDBi | Q80WT4 |
TreeFami | TF331506 |
Family and domain databases
CDDi | cd15006, 7tmA_GPR176, 1 hit |
InterProi | View protein in InterPro IPR043523, GPCR_176_Rhodpsn_7TM IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q80WT4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGHNSSWVSP NTSHPRNTSG AEAGANLSAF GELSEAQLYR QFTTTVQVVI
60 70 80 90 100
FIGSLLGNFM VLWSTCRTTV FKSVTNRFIK NLACSGICAS VVCVPFDIIL
110 120 130 140 150
SSSPHCCWWI YTMLFCKVLK FLHKVFCSVT VLSFPAIALD RYYSVLYPLE
160 170 180 190 200
RKISDAKSRE LVMYIWAHAV VASVPVFAVT NVADIYAMST CTEVWSNSLG
210 220 230 240 250
HLVYVLIYNV TTVIVPVAVV FLFLILIRRA LSASQKKKVI IAALRTPQNT
260 270 280 290 300
ISIPYASQRE AELHATLLSM VTVFILCSVP YATLVVYQTV LNVPNTSVFL
310 320 330 340 350
LLTAIWLPKV SLLANPVLFL TVNKSVRKCL VGTLVQLHHR YSRRNVVSTG
360 370 380 390 400
SGVAEPSLEP SMRSGSQLLE MFHIGQQQIF KPSEDEEESE AKYLGSADFQ
410 420 430 440 450
AKEVLTSCPE GEQEPPQLAP SVPPPGTVDS EPRVSPVAPM ESGIFPDKYS
460 470 480 490 500
LQFGFGPFEL PPQWLSETRN SKKRLLPPLG NTPEELIQTK VPRVNRVERK
510
MSRNNKVSIF PKVDS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC052037 mRNA Translation: AAH52037.1 AY255554 mRNA Translation: AAO85066.1 |
CCDSi | CCDS16575.1 |
RefSeqi | NP_958755.1, NM_201367.3 |
Genome annotation databases
Ensembli | ENSMUST00000039160; ENSMUSP00000037586; ENSMUSG00000040133 |
GeneIDi | 381413 |
KEGGi | mmu:381413 |
UCSCi | uc008lru.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC052037 mRNA Translation: AAH52037.1 AY255554 mRNA Translation: AAO85066.1 |
CCDSi | CCDS16575.1 |
RefSeqi | NP_958755.1, NM_201367.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000037586 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q80WT4, 4 sites |
iPTMneti | Q80WT4 |
PhosphoSitePlusi | Q80WT4 |
Proteomic databases
MaxQBi | Q80WT4 |
PaxDbi | Q80WT4 |
PRIDEi | Q80WT4 |
Protocols and materials databases
Antibodypediai | 9997, 179 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000039160; ENSMUSP00000037586; ENSMUSG00000040133 |
GeneIDi | 381413 |
KEGGi | mmu:381413 |
UCSCi | uc008lru.2, mouse |
Organism-specific databases
CTDi | 11245 |
MGIi | MGI:2685858, Gpr176 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00950000182998 |
HOGENOMi | CLU_045778_0_0_1 |
InParanoidi | Q80WT4 |
OMAi | ASPVHTC |
OrthoDBi | 602137at2759 |
PhylomeDBi | Q80WT4 |
TreeFami | TF331506 |
Enzyme and pathway databases
Reactomei | R-MMU-418555, G alpha (s) signalling events |
Miscellaneous databases
BioGRID-ORCSi | 381413, 0 hits in 17 CRISPR screens |
ChiTaRSi | Gpr176, mouse |
PROi | PR:Q80WT4 |
RNActi | Q80WT4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000040133, Expressed in stria vascularis of cochlear duct and 176 other tissues |
Genevisiblei | Q80WT4, MM |
Family and domain databases
CDDi | cd15006, 7tmA_GPR176, 1 hit |
InterProi | View protein in InterPro IPR043523, GPCR_176_Rhodpsn_7TM IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GP176_MOUSE | |
Accessioni | Q80WT4Primary (citable) accession number: Q80WT4 Secondary accession number(s): Q80UC4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2005 |
Last sequence update: | June 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries