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UniProtKB - Q80WQ9 (ZBED4_MOUSE)
Protein
Zinc finger BED domain-containing protein 4
Gene
Zbed4
Organism
Mus musculus (Mouse)
Status
Functioni
Transcriptional regulator that binds to poly-guanine tracts in gene promoters and activates transcription (By similarity).
Able to bind single- and double-stranded DNA and RNA (PubMed:22693546).
By similarity1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 135 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 138 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 159 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 164 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 305 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 308 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 329 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 334 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 477 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 480 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 500 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 505 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 578 | Zinc 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 581 | Zinc 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 602 | Zinc 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 607 | Zinc 4PROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 114 – 171 | BED-type 1PROSITE-ProRule annotationAdd BLAST | 58 | |
Zinc fingeri | 284 – 341 | BED-type 2PROSITE-ProRule annotationAdd BLAST | 58 | |
Zinc fingeri | 456 – 512 | BED-type 3PROSITE-ProRule annotationAdd BLAST | 57 | |
Zinc fingeri | 557 – 614 | BED-type 4PROSITE-ProRule annotationAdd BLAST | 58 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: ARUK-UCL
- identical protein binding Source: MGI
- metal ion binding Source: UniProtKB-KW
- protein dimerization activity Source: InterPro
- RNA binding Source: UniProtKB
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: ARUK-UCL
- transcription cis-regulatory region binding Source: UniProtKB
GO - Biological processi
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
Keywordsi
Molecular function | Activator, DNA-binding, RNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger BED domain-containing protein 4 |
Gene namesi | Name:Zbed4 Synonyms:Kiaa0637 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2682302, Zbed4 |
VEuPathDBi | HostDB:ENSMUSG00000034333 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Nucleus
- Nucleus 1 Publication
Other locations
- Photoreceptor inner segment By similarity
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: MGI
- photoreceptor inner segment Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000391794 | 1 – 1168 | Zinc finger BED domain-containing protein 4Add BLAST | 1168 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 42 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 489 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 623 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q80WQ9 |
jPOSTi | Q80WQ9 |
PaxDbi | Q80WQ9 |
PeptideAtlasi | Q80WQ9 |
PRIDEi | Q80WQ9 |
ProteomicsDBi | 275336 |
PTM databases
iPTMneti | Q80WQ9 |
PhosphoSitePlusi | Q80WQ9 |
Expressioni
Tissue specificityi
Expressed in the thymus (PubMed:19369242). In the retina, expressed in the cone photoreceptors (PubMed:19369242, PubMed:22693546).2 Publications
Gene expression databases
Bgeei | ENSMUSG00000034333, Expressed in embryo and 282 other tissues |
Genevisiblei | Q80WQ9, MM |
Interactioni
Subunit structurei
Homodimer; via C-terminus (By similarity).
Interacts with MYH9 (By similarity).
Interacts with SAFB/SAFB1 (By similarity).
By similarityGO - Molecular functioni
- identical protein binding Source: MGI
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000035437 |
Miscellaneous databases
RNActi | Q80WQ9, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 22 – 55 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 362 – 443 | DisorderedSequence analysisAdd BLAST | 82 | |
Regioni | 1040 – 1059 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1083 – 1168 | Required for homodimerization and nuclear accumulationBy similarityAdd BLAST | 86 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 372 – 443 | Polar residuesSequence analysisAdd BLAST | 72 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 114 – 171 | BED-type 1PROSITE-ProRule annotationAdd BLAST | 58 | |
Zinc fingeri | 284 – 341 | BED-type 2PROSITE-ProRule annotationAdd BLAST | 58 | |
Zinc fingeri | 456 – 512 | BED-type 3PROSITE-ProRule annotationAdd BLAST | 57 | |
Zinc fingeri | 557 – 614 | BED-type 4PROSITE-ProRule annotationAdd BLAST | 58 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1121, Eukaryota |
GeneTreei | ENSGT00940000161365 |
HOGENOMi | CLU_006260_0_0_1 |
InParanoidi | Q80WQ9 |
OMAi | HMWRAHK |
OrthoDBi | 223749at2759 |
PhylomeDBi | Q80WQ9 |
TreeFami | TF322818 |
Family and domain databases
InterProi | View protein in InterPro IPR008906, HATC_C_dom IPR012337, RNaseH-like_sf IPR003656, Znf_BED IPR036236, Znf_C2H2_sf |
Pfami | View protein in Pfam PF05699, Dimer_Tnp_hAT, 1 hit PF02892, zf-BED, 4 hits |
SUPFAMi | SSF53098, SSF53098, 1 hit SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS50808, ZF_BED, 4 hits |
i Sequence
Sequence statusi: Complete.
Q80WQ9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEDKQETCPK GDSDFVSDKV NFKTEEDDDQ TPCHSLEQVD FKSESEDMRQ
60 70 80 90 100
TDSGDEQADI RAASCACQPS GKFLAAESED DYGSLFSQYS STLYSVAMEA
110 120 130 140 150
VTQSLLSSRH ISSRKKSPAW KHFFISPRDS TKAICTYCMK EFSRGKNEKD
160 170 180 190 200
LSTSCLMRHV RRAHPTKLIQ ENGSLSAGSS FSPPSLLLPP QPADVGDLST
210 220 230 240 250
VLSPVRLVQK MAPKIPSPDQ IMEESVTVVS SEELSSDVSV TEKYSREEAL
260 270 280 290 300
AGSSPNLSML HYDDASETMA DRNLSLPKST SGSRRRSAVW KHFYLSPLDS
310 320 330 340 350
SKAVCVHCMN EFSRGKNGKD LGTSCLIRHM WRAHRSIVLQ ENGGNTGIPP
360 370 380 390 400
LYPMPPTLLP ALLPPEGDLN SASLSPGKQV KESPSASSSP ERLPEDLSSH
410 420 430 440 450
TNPGDVSRED VSMLSSSDDL GEASVVSSPE KQPADTVNPR FESGTVFQQN
460 470 480 490 500
KKVMRRLKSE VWHHFSLAPM DSLKAVCRYC SCVISRGKKG DVGTSCLMRH
510 520 530 540 550
LYRRHPEVVG NQKDFLGASL ANSPYATLAS AESSSKLTDL PAVVRKNHQG
560 570 580 590 600
VFPTNSKKTS KLWNHFSICS ADSTKVVCLH CGRTISRGKK PTNLGTSCLL
610 620 630 640 650
RHLQRFHGHV LKNDVSEATL SRSPGIRRPL GIELSGPSSF RDSTEKFYDS
660 670 680 690 700
HPVAKKITSL IAEMIALDLQ PYSLVDNVGF NRLLEYLKPQ YSLPSPSYFS
710 720 730 740 750
RTAIPGMYDN VKQIIMSHLK EAESGVVHFT SGIWMSSQTR EYLTLTAHWV
760 770 780 790 800
TFASAVRPHC EDHHCSALLD VSQIDCDYSG NSIQKQLECW WEAWVTSIGL
810 820 830 840 850
QIGITVTDNP SIGKMLSEGE HSSVQCFSHT VNLIVSEAIK SQRMVQNLLS
860 870 880 890 900
IARKLCERVH RSPRAREKLA ELQKEYELPQ HQLIQDVPSK WSTSFHMLER
910 920 930 940 950
LIEQKRAVNE VSIECNFREL ISCDQWEVMQ SVCHVLRPFD AASREMSAHM
960 970 980 990 1000
STLSQVIPMI HILSRKVEML FGETMGIDTM LKSLKEAMAS RLSATLHDPR
1010 1020 1030 1040 1050
YIFATLLDPR YKASLFTEEE AEQYRQDLIR ELEILNSTSE DTATSNGCDS
1060 1070 1080 1090 1100
GSPLKDTGTE ESLWSLAPIK RDQREKLPED MVLAYLEEEV LEHSCDPLTY
1110 1120 1130 1140 1150
WNLKRSSWPG LSTLAVRFLG CPPSTVPSEK LFSTPMDAGS FGQPRLMMEH
1160
FEKLIFLKVN LPLICFQY
Sequence cautioni
The sequence BAC65617 differs from that shown. The sequence differs from that shown because it seems to be derived from a pre-mRNA.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 743 | L → P in BAC65617 (PubMed:12693553).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK122335 Transcribed RNA Translation: BAC65617.1 Sequence problems. AK143488 mRNA Translation: BAE25396.1 BC026763 mRNA Translation: AAH26763.1 BC052174 mRNA Translation: AAH52174.1 |
CCDSi | CCDS27731.1 |
RefSeqi | NP_852077.1, NM_181412.3 XP_006520903.1, XM_006520840.3 XP_006520904.1, XM_006520841.3 |
Genome annotation databases
Ensembli | ENSMUST00000041297; ENSMUSP00000035437; ENSMUSG00000034333 |
GeneIDi | 223773 |
KEGGi | mmu:223773 |
UCSCi | uc007xem.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK122335 Transcribed RNA Translation: BAC65617.1 Sequence problems. AK143488 mRNA Translation: BAE25396.1 BC026763 mRNA Translation: AAH26763.1 BC052174 mRNA Translation: AAH52174.1 |
CCDSi | CCDS27731.1 |
RefSeqi | NP_852077.1, NM_181412.3 XP_006520903.1, XM_006520840.3 XP_006520904.1, XM_006520841.3 |
3D structure databases
SMRi | Q80WQ9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000035437 |
PTM databases
iPTMneti | Q80WQ9 |
PhosphoSitePlusi | Q80WQ9 |
Proteomic databases
EPDi | Q80WQ9 |
jPOSTi | Q80WQ9 |
PaxDbi | Q80WQ9 |
PeptideAtlasi | Q80WQ9 |
PRIDEi | Q80WQ9 |
ProteomicsDBi | 275336 |
Protocols and materials databases
Antibodypediai | 59180, 10 antibodies from 6 providers |
Genome annotation databases
Ensembli | ENSMUST00000041297; ENSMUSP00000035437; ENSMUSG00000034333 |
GeneIDi | 223773 |
KEGGi | mmu:223773 |
UCSCi | uc007xem.1, mouse |
Organism-specific databases
CTDi | 9889 |
MGIi | MGI:2682302, Zbed4 |
VEuPathDBi | HostDB:ENSMUSG00000034333 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG1121, Eukaryota |
GeneTreei | ENSGT00940000161365 |
HOGENOMi | CLU_006260_0_0_1 |
InParanoidi | Q80WQ9 |
OMAi | HMWRAHK |
OrthoDBi | 223749at2759 |
PhylomeDBi | Q80WQ9 |
TreeFami | TF322818 |
Miscellaneous databases
BioGRID-ORCSi | 223773, 6 hits in 64 CRISPR screens |
ChiTaRSi | Zbed4, mouse |
PROi | PR:Q80WQ9 |
RNActi | Q80WQ9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000034333, Expressed in embryo and 282 other tissues |
Genevisiblei | Q80WQ9, MM |
Family and domain databases
InterProi | View protein in InterPro IPR008906, HATC_C_dom IPR012337, RNaseH-like_sf IPR003656, Znf_BED IPR036236, Znf_C2H2_sf |
Pfami | View protein in Pfam PF05699, Dimer_Tnp_hAT, 1 hit PF02892, zf-BED, 4 hits |
SUPFAMi | SSF53098, SSF53098, 1 hit SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS50808, ZF_BED, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZBED4_MOUSE | |
Accessioni | Q80WQ9Primary (citable) accession number: Q80WQ9 Secondary accession number(s): Q3UPJ9, Q80TV3, Q8R329 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 2, 2010 |
Last sequence update: | June 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 116 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot