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Protein

Hyaluronan and proteoglycan link protein 3

Gene

Hapln3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function in hyaluronic acid binding.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandHyaluronic acid

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronan and proteoglycan link protein 3
Gene namesi
Name:Hapln3
Synonyms:Lpr3
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1914916 Hapln3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000001319118 – 359Hyaluronan and proteoglycan link protein 3Sequence analysisAdd BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi70 ↔ 146By similarity
Disulfide bondi188 ↔ 259By similarity
Disulfide bondi212 ↔ 233By similarity
Disulfide bondi286 ↔ 355By similarity
Disulfide bondi311 ↔ 332By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ80WM5
PRIDEiQ80WM5

PTM databases

PhosphoSitePlusiQ80WM5

Expressioni

Gene expression databases

BgeeiENSMUSG00000030606 Expressed in 62 organ(s), highest expression level in placenta
CleanExiMM_HAPLN3
ExpressionAtlasiQ80WM5 baseline and differential
GenevisibleiQ80WM5 MM

Structurei

3D structure databases

ProteinModelPortaliQ80WM5
SMRiQ80WM5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 164Ig-like V-typeCuratedAdd BLAST117
Domaini166 – 261Link 1PROSITE-ProRule annotationCuratedAdd BLAST96
Domaini266 – 357Link 2PROSITE-ProRule annotationCuratedAdd BLAST92

Sequence similaritiesi

Belongs to the HAPLN family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IG4T Eukaryota
ENOG410Z8AC LUCA
GeneTreeiENSGT00760000119025
HOGENOMiHOG000234353
HOVERGENiHBG051922
InParanoidiQ80WM5
KOiK06852
OMAiIKWWKLS
OrthoDBiEOG091G09EL
TreeFamiTF332134

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.100.10, 2 hits
InterProiView protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR000538 Link_dom
PfamiView protein in Pfam
PF07686 V-set, 1 hit
PF00193 Xlink, 2 hits
PRINTSiPR01265 LINKMODULE
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SM00445 LINK, 2 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF56436 SSF56436, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS01241 LINK_1, 2 hits
PS50963 LINK_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q80WM5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLLFLVLLS PFPCVLGLPF YNGFYYSNDL SGRTLGNGYG EGLFNGVKLV
60 70 80 90 100
VETTEESLFS HQGASVTLPC HYHYEPALAS PRHVRVKWWK LSENGAPEQD
110 120 130 140 150
VLVVIGQRHR SFGDYQGRVQ LRQDKQQEVS LELRDLRLED SGRYRCEVID
160 170 180 190 200
GLEDESGLVE LELRGVVFPY QSREGRYQLN FHEAQQACQE QGAMVATFEQ
210 220 230 240 250
LFRAWEEGLD WCNAGWLQDA SVQYPIVLPR QPCGGLGLAP GVRSYGQRHH
260 270 280 290 300
RLHRYDVFCF AAALKGRVYY LENPKKLTLL EAREACQEDG AQISTVGQLF
310 320 330 340 350
AAWKFRGLDR CDAGWLADGS ARYPIVHPRL NCGPPEPGVR TFGFPDPHTR

YGVYCYVQH
Length:359
Mass (Da):40,740
Last modified:July 27, 2011 - v3
Checksum:i81E8F78DA76BB1E3
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RNW2A0A0U1RNW2_MOUSE
Hyaluronan and proteoglycan link pr...
Hapln3
250Annotation score:
A0A0X1KG57A0A0X1KG57_MOUSE
Hyaluronan and proteoglycan link pr...
Hapln3
113Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12F → L in AAP12624 (Ref. 2) Curated1
Sequence conflicti29 – 31DLS → GLR in AAP12624 (Ref. 2) Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY262757 mRNA Translation: AAP22049.1
AY269788 mRNA Translation: AAP12624.1
AK136956 mRNA Translation: BAE23187.1
CH466543 Genomic DNA Translation: EDL07078.1
CCDSiCCDS21378.1
RefSeqiNP_839986.2, NM_178255.3
XP_006541190.1, XM_006541127.3
XP_006541191.1, XM_006541128.3
UniGeneiMm.178759

Genome annotation databases

EnsembliENSMUST00000206092; ENSMUSP00000146090; ENSMUSG00000030606
GeneIDi67666
KEGGimmu:67666
UCSCiuc009hxy.1 mouse

Similar proteinsi

Entry informationi

Entry nameiHPLN3_MOUSE
AccessioniPrimary (citable) accession number: Q80WM5
Secondary accession number(s): Q3UVT2, Q80XX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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