UniProtKB - Q80WC7 (AGFG2_MOUSE)
Protein
Arf-GAP domain and FG repeat-containing protein 2
Gene
Agfg2
Organism
Mus musculus (Mouse)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 47 – 70 | C4-typePROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- GTPase activator activity Source: InterPro
- metal ion binding Source: UniProtKB-KW
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Arf-GAP domain and FG repeat-containing protein 2Alternative name(s): HIV-1 Rev-binding protein-like protein Rev/Rex activation domain-binding protein related Short name: RAB-R |
Gene namesi | Name:Agfg2 Synonyms:Hrbl, Rabr |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2443267, Agfg2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204829 | 1 – 479 | Arf-GAP domain and FG repeat-containing protein 2Add BLAST | 479 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 174 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
PaxDbi | Q80WC7 |
PRIDEi | Q80WC7 |
PTM databases
iPTMneti | Q80WC7 |
PhosphoSitePlusi | Q80WC7 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000029722, Expressed in thymus and 282 other tissues |
Genevisiblei | Q80WC7, MM |
Interactioni
Subunit structurei
Interacts with EPS15R.
1 PublicationProtein-protein interaction databases
BioGRIDi | 231167, 3 interactors |
STRINGi | 10090.ENSMUSP00000031736 |
Miscellaneous databases
RNActi | Q80WC7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 153 | Arf-GAPPROSITE-ProRule annotationAdd BLAST | 127 |
Domaini
Contains FG repeats and 4 N-P-F repeats.
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 47 – 70 | C4-typePROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG0702, Eukaryota |
GeneTreei | ENSGT00940000161071 |
HOGENOMi | CLU_027801_1_0_1 |
InParanoidi | Q80WC7 |
OMAi | SDCKRNK |
PhylomeDBi | Q80WC7 |
TreeFami | TF325357 |
Family and domain databases
Gene3Di | 3.30.40.160, 1 hit |
InterProi | View protein in InterPro IPR037278, ARFGAP/RecO IPR001164, ArfGAP_dom IPR038508, ArfGAP_dom_sf |
Pfami | View protein in Pfam PF01412, ArfGap, 1 hit |
PRINTSi | PR00405, REVINTRACTNG |
SMARTi | View protein in SMART SM00105, ArfGap, 1 hit |
SUPFAMi | SSF57863, SSF57863, 1 hit |
PROSITEi | View protein in PROSITE PS50115, ARFGAP, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q80WC7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVMAAKKGPG PGGGVGGSKA EAEAASEVWC RRVRELGGCS QAGNRHCFEC
60 70 80 90 100
AQRGVTYVDI TVGSFVCTTC SGLLRGLNPP HRVKSISMTT FTEPEVLFLQ
110 120 130 140 150
SRGNEVCRKI WLGLFDARTS LIPDSRDPQK VKEFLQEKYE KKRWYVPPEQ
160 170 180 190 200
VKGPSYSKGS VSATPVQGSV PEGKPIRTLL GDPVPSLSDP ASTSSQPGSQ
210 220 230 240 250
SQARSSSQAR SSQPPSHSST KKASTDLLAD IGGDPFAAPQ VVPAFASFPG
260 270 280 290 300
FGVGQTPAHG GFANFDAFSS SPSSSTFGSL PPSVQAPFQA QPTPAGSGQM
310 320 330 340 350
SAFGVAPLAA ASQPNNLADV GGLLGPRMAA GGLPGSVFGM PSQVPALQSA
360 370 380 390 400
VPGVSGSGGL PFGAYTNPFA TPAQAQLPST NPFQPNGLAS GPGFGMSSVR
410 420 430 440 450
PGLLQPVPPS GAFASPFSAP VFPTQAGLAD QQNGSSFGDL GTSKLGQRPL
460 470
SQPAGISTNP FMTGSSAFAS KPPTTNPFL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ3U2K8 | Q3U2K8_MOUSE | Arf-GAP domain and FG repeat-contai... | Agfg2 Hrbl | 490 | Annotation score: | ||
Q3TBU7 | Q3TBU7_MOUSE | Arf-GAP domain and FG repeat-contai... | Agfg2 Hrbl | 406 | Annotation score: | ||
A0A0G2JFR2 | A0A0G2JFR2_MOUSE | Arf-GAP domain and FG repeat-contai... | Agfg2 | 114 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010669 | 253 – 289 | VGQTP…QAPFQ → GKYYPGAGTRLRRICITAKT SLVHRGLTFLCGWGQGA in isoform 2. 1 PublicationAdd BLAST | 37 | |
Alternative sequenceiVSP_010670 | 290 – 479 | Missing in isoform 2. 1 PublicationAdd BLAST | 190 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC003330 mRNA Translation: AAH03330.1 BC046788 mRNA Translation: AAH46788.1 AK050881 mRNA Translation: BAC34441.1 |
CCDSi | CCDS19774.1 [Q80WC7-1] |
RefSeqi | NP_835456.1, NM_178162.3 [Q80WC7-1] |
Genome annotation databases
Ensembli | ENSMUST00000031736; ENSMUSP00000031736; ENSMUSG00000029722 [Q80WC7-1] |
GeneIDi | 231801 |
KEGGi | mmu:231801 |
UCSCi | uc009adl.2, mouse [Q80WC7-1] uc009ado.3, mouse [Q80WC7-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC003330 mRNA Translation: AAH03330.1 BC046788 mRNA Translation: AAH46788.1 AK050881 mRNA Translation: BAC34441.1 |
CCDSi | CCDS19774.1 [Q80WC7-1] |
RefSeqi | NP_835456.1, NM_178162.3 [Q80WC7-1] |
3D structure databases
SMRi | Q80WC7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 231167, 3 interactors |
STRINGi | 10090.ENSMUSP00000031736 |
PTM databases
iPTMneti | Q80WC7 |
PhosphoSitePlusi | Q80WC7 |
Proteomic databases
PaxDbi | Q80WC7 |
PRIDEi | Q80WC7 |
Protocols and materials databases
Antibodypediai | 16493, 141 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000031736; ENSMUSP00000031736; ENSMUSG00000029722 [Q80WC7-1] |
GeneIDi | 231801 |
KEGGi | mmu:231801 |
UCSCi | uc009adl.2, mouse [Q80WC7-1] uc009ado.3, mouse [Q80WC7-2] |
Organism-specific databases
CTDi | 3268 |
MGIi | MGI:2443267, Agfg2 |
Phylogenomic databases
eggNOGi | KOG0702, Eukaryota |
GeneTreei | ENSGT00940000161071 |
HOGENOMi | CLU_027801_1_0_1 |
InParanoidi | Q80WC7 |
OMAi | SDCKRNK |
PhylomeDBi | Q80WC7 |
TreeFami | TF325357 |
Miscellaneous databases
BioGRID-ORCSi | 231801, 0 hits in 17 CRISPR screens |
PROi | PR:Q80WC7 |
RNActi | Q80WC7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029722, Expressed in thymus and 282 other tissues |
Genevisiblei | Q80WC7, MM |
Family and domain databases
Gene3Di | 3.30.40.160, 1 hit |
InterProi | View protein in InterPro IPR037278, ARFGAP/RecO IPR001164, ArfGAP_dom IPR038508, ArfGAP_dom_sf |
Pfami | View protein in Pfam PF01412, ArfGap, 1 hit |
PRINTSi | PR00405, REVINTRACTNG |
SMARTi | View protein in SMART SM00105, ArfGap, 1 hit |
SUPFAMi | SSF57863, SSF57863, 1 hit |
PROSITEi | View protein in PROSITE PS50115, ARFGAP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AGFG2_MOUSE | |
Accessioni | Q80WC7Primary (citable) accession number: Q80WC7 Secondary accession number(s): Q8BKS5, Q99J67 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 21, 2004 |
Last sequence update: | June 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 118 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot