UniProtKB - Q80WC7 (AGFG2_MOUSE)

BLAST

>sp|Q80WC7|AGFG2_MOUSE Arf-GAP domain and FG repeat-containing protein 2 OS=Mus musculus OX=10090 GN=Agfg2 PE=1 SV=1
MVMAAKKGPGPGGGVGGSKAEAEAASEVWCRRVRELGGCSQAGNRHCFECAQRGVTYVDI
TVGSFVCTTCSGLLRGLNPPHRVKSISMTTFTEPEVLFLQSRGNEVCRKIWLGLFDARTS
LIPDSRDPQKVKEFLQEKYEKKRWYVPPEQVKGPSYSKGSVSATPVQGSVPEGKPIRTLL
GDPVPSLSDPASTSSQPGSQSQARSSSQARSSQPPSHSSTKKASTDLLADIGGDPFAAPQ
VVPAFASFPGFGVGQTPAHGGFANFDAFSSSPSSSTFGSLPPSVQAPFQAQPTPAGSGQM
SAFGVAPLAAASQPNNLADVGGLLGPRMAAGGLPGSVFGMPSQVPALQSAVPGVSGSGGL
PFGAYTNPFATPAQAQLPSTNPFQPNGLASGPGFGMSSVRPGLLQPVPPSGAFASPFSAP
VFPTQAGLADQQNGSSFGDLGTSKLGQRPLSQPAGISTNPFMTGSSAFASKPPTTNPFL

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History
Entry version 108 (07 Nov 2018)
Sequence version 1 (01 Jun 2003)
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Protein

Arf-GAP domain and FG repeat-containing protein 2

Gene

Agfg2

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	47 – 70	C4-typePROSITE-ProRule annotationAdd BLAST		24

GO - Molecular functionⁱ

GTPase activator activity Source: InterPro
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Arf-GAP domain and FG repeat-containing protein 2 Alternative name(s): HIV-1 Rev-binding protein-like protein Rev/Rex activation domain-binding protein related Short name: RAB-R
Gene namesⁱ	Name:Agfg2 Synonyms:Hrbl, Rabr
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:2443267 Agfg2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000204829	1 – 479	Arf-GAP domain and FG repeat-containing protein 2Add BLAST		479

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	174	N6-acetyllysineBy similarity		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

PaxDbⁱ	Q80WC7
PRIDEⁱ	Q80WC7

PTM databases

iPTMnetⁱ	Q80WC7
PhosphoSitePlusⁱ	Q80WC7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000029722 Expressed in 262 organ(s), highest expression level in thymus
ExpressionAtlasⁱ	Q80WC7 baseline and differential
Genevisibleⁱ	Q80WC7 MM

Interactionⁱ

Subunit structureⁱ

Interacts with EPS15R.1 Publication

Protein-protein interaction databases

BioGridⁱ	231167, 1 interactor
STRINGⁱ	10090.ENSMUSP00000031736

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q80WC7
SMRⁱ	Q80WC7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	27 – 153	Arf-GAPPROSITE-ProRule annotationAdd BLAST		127

Domainⁱ

Contains FG repeats and 4 N-P-F repeats.

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	47 – 70	C4-typePROSITE-ProRule annotationAdd BLAST		24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG0702 Eukaryota ENOG41122WA LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00560000077249
HOGENOMⁱ	HOG000253009
HOVERGENⁱ	HBG006551
InParanoidⁱ	Q80WC7
OMAⁱ	SDCKRNK
PhylomeDBⁱ	Q80WC7
TreeFamⁱ	TF325357

Family and domain databases

Gene3Dⁱ	3.30.40.160, 1 hit
InterProⁱ	View protein in InterPro IPR037278 ARFGAP/RecO IPR001164 ArfGAP_dom IPR038508 ArfGAP_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01412 ArfGap, 1 hit
PRINTSⁱ	PR00405 REVINTRACTNG
SMARTⁱ	View protein in SMART SM00105 ArfGap, 1 hit
SUPFAMⁱ	SSF57863 SSF57863, 1 hit
PROSITEⁱ	View protein in PROSITE PS50115 ARFGAP, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q80WC7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVMAAKKGPG PGGGVGGSKA EAEAASEVWC RRVRELGGCS QAGNRHCFEC 
        60         70         80         90        100
AQRGVTYVDI TVGSFVCTTC SGLLRGLNPP HRVKSISMTT FTEPEVLFLQ 
       110        120        130        140        150
SRGNEVCRKI WLGLFDARTS LIPDSRDPQK VKEFLQEKYE KKRWYVPPEQ 
       160        170        180        190        200
VKGPSYSKGS VSATPVQGSV PEGKPIRTLL GDPVPSLSDP ASTSSQPGSQ 
       210        220        230        240        250
SQARSSSQAR SSQPPSHSST KKASTDLLAD IGGDPFAAPQ VVPAFASFPG 
       260        270        280        290        300
FGVGQTPAHG GFANFDAFSS SPSSSTFGSL PPSVQAPFQA QPTPAGSGQM 
       310        320        330        340        350
SAFGVAPLAA ASQPNNLADV GGLLGPRMAA GGLPGSVFGM PSQVPALQSA 
       360        370        380        390        400
VPGVSGSGGL PFGAYTNPFA TPAQAQLPST NPFQPNGLAS GPGFGMSSVR 
       410        420        430        440        450
PGLLQPVPPS GAFASPFSAP VFPTQAGLAD QQNGSSFGDL GTSKLGQRPL 
       460        470 
SQPAGISTNP FMTGSSAFAS KPPTTNPFL

Length:479

Mass (Da):48,968

Last modified:June 1, 2003 - v1

Checksum:ⁱBE299F70C28D6457

Isoform 2 (identifier: Q80WC7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
253-289: VGQTPAHGGFANFDAFSSSPSSSTFGSLPPSVQAPFQ → GKYYPGAGTRLRRICITAKTSLVHRGLTFLCGWGQGA
290-479: Missing.

« Hide

        10         20         30         40         50
MVMAAKKGPG PGGGVGGSKA EAEAASEVWC RRVRELGGCS QAGNRHCFEC 
        60         70         80         90        100
AQRGVTYVDI TVGSFVCTTC SGLLRGLNPP HRVKSISMTT FTEPEVLFLQ 
       110        120        130        140        150
SRGNEVCRKI WLGLFDARTS LIPDSRDPQK VKEFLQEKYE KKRWYVPPEQ 
       160        170        180        190        200
VKGPSYSKGS VSATPVQGSV PEGKPIRTLL GDPVPSLSDP ASTSSQPGSQ 
       210        220        230        240        250
SQARSSSQAR SSQPPSHSST KKASTDLLAD IGGDPFAAPQ VVPAFASFPG 
       260        270        280 
FGGKYYPGAG TRLRRICITA KTSLVHRGLT FLCGWGQGA

Show »

Length:289

Mass (Da):30,735

Checksum:ⁱ0BE1EF4FB343774B

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q3U2K8	Q3U2K8_MOUSE	Arf-GAP domain and FG repeat-contai... Arf-GAP domain and FG repeat-containing protein 2	Agfg2 Hrbl	490	Annotation score:
Q3TBU7	Q3TBU7_MOUSE	Arf-GAP domain and FG repeat-contai... Arf-GAP domain and FG repeat-containing protein 2	Agfg2 Hrbl	406	Annotation score:
A0A0G2JFR2	A0A0G2JFR2_MOUSE	Arf-GAP domain and FG repeat-contai... Arf-GAP domain and FG repeat-containing protein 2	Agfg2	114	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_010669	253 – 289	VGQTP…QAPFQ → GKYYPGAGTRLRRICITAKT SLVHRGLTFLCGWGQGA in isoform 2. 1 PublicationAdd BLAST		37
Alternative sequenceⁱVSP_010670	290 – 479	Missing in isoform 2. 1 PublicationAdd BLAST		190

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC003330 mRNA Translation: AAH03330.1 BC046788 mRNA Translation: AAH46788.1 AK050881 mRNA Translation: BAC34441.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS19774.1 [Q80WC7-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_835456.1, NM_178162.3 [Q80WC7-1]
UniGeneⁱ	Mm.260869

Genome annotation databases

Ensemblⁱ	ENSMUST00000031736; ENSMUSP00000031736; ENSMUSG00000029722 [Q80WC7-1]
GeneIDⁱ	231801
KEGGⁱ	mmu:231801
UCSC genome browser More...UCSCⁱ	uc009adl.2 mouse [Q80WC7-1] uc009ado.3 mouse [Q80WC7-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
Q80WC7	Arf-GAP domain and FG repeat-containing protein 2		MOUSE		490	UniRef90_Q80WC7
Uncharacterized protein		NEOLE		74
ArfGAP with FG repeats 2		RAT		488
UPI000A31782C		MUSCR		489
UPI00067AFD1F		MICOH		472
+8

Protein	Similar proteins		Species	Score	Length	Source
Q80WC7	Arf-GAP domain and FG repeat-containing protein 2		HUMAN		481	UniRef50_O95081
Arf-GAP domain and FG repeat-containing protein 2		CALJA		481
AGFG2 isoform 1		PANTR		480
Uncharacterized protein		PANPA		480
Uncharacterized protein		MANLE		479
+279

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC003330 mRNA Translation: AAH03330.1 BC046788 mRNA Translation: AAH46788.1 AK050881 mRNA Translation: BAC34441.1
CCDSⁱ	CCDS19774.1 [Q80WC7-1]
RefSeqⁱ	NP_835456.1, NM_178162.3 [Q80WC7-1]
UniGeneⁱ	Mm.260869

3D structure databases

ProteinModelPortalⁱ	Q80WC7
SMRⁱ	Q80WC7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	231167, 1 interactor
STRINGⁱ	10090.ENSMUSP00000031736

PTM databases

iPTMnetⁱ	Q80WC7
PhosphoSitePlusⁱ	Q80WC7

Proteomic databases

PaxDbⁱ	Q80WC7
PRIDEⁱ	Q80WC7

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000031736; ENSMUSP00000031736; ENSMUSG00000029722 [Q80WC7-1]
GeneIDⁱ	231801
KEGGⁱ	mmu:231801
UCSCⁱ	uc009adl.2 mouse [Q80WC7-1] uc009ado.3 mouse [Q80WC7-2]

Organism-specific databases

CTDⁱ	3268
MGIⁱ	MGI:2443267 Agfg2

Phylogenomic databases

eggNOGⁱ	KOG0702 Eukaryota ENOG41122WA LUCA
GeneTreeⁱ	ENSGT00560000077249
HOGENOMⁱ	HOG000253009
HOVERGENⁱ	HBG006551
InParanoidⁱ	Q80WC7
OMAⁱ	SDCKRNK
PhylomeDBⁱ	Q80WC7
TreeFamⁱ	TF325357

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q80WC7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000029722 Expressed in 262 organ(s), highest expression level in thymus
ExpressionAtlasⁱ	Q80WC7 baseline and differential
Genevisibleⁱ	Q80WC7 MM

Family and domain databases

Gene3Dⁱ	3.30.40.160, 1 hit
InterProⁱ	View protein in InterPro IPR037278 ARFGAP/RecO IPR001164 ArfGAP_dom IPR038508 ArfGAP_dom_sf
Pfamⁱ	View protein in Pfam PF01412 ArfGap, 1 hit
PRINTSⁱ	PR00405 REVINTRACTNG
SMARTⁱ	View protein in SMART SM00105 ArfGap, 1 hit
SUPFAMⁱ	SSF57863 SSF57863, 1 hit
PROSITEⁱ	View protein in PROSITE PS50115 ARFGAP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AGFG2_MOUSE
Accessionⁱ	Q80WC7Primary (citable) accession number: Q80WC7 Secondary accession number(s): Q8BKS5, Q99J67
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 21, 2004
	Last sequence update:	June 1, 2003
	Last modified:	November 7, 2018
	This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q80WC7 (AGFG2_MOUSE)

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Arf-GAP domain and FG repeat-containing protein 2

Agfg2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ